Clinical trials: Tracheal Extubation
Pediatric Post Extubation Dysphagia
The Use of PEDI_ EAT 10 Score Versus Nurse Performed Screening in the Assessment of Post Extubation Dysphagia
Invasive mechanical ventilation is one of the most common interventions in critically ill patients, and is invariably characteristic, if not defining, of ICU therapeutic regimen Much attention has been paid to complications…
- Trial name
- NCT05828537
- Testing
- endotracheal tube
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Respiratory Insufficiency
Incidence and Risk Factors of Extubation Failure in Pediatric Resuscitation
The failure of extubation in pediatric resuscitation is most often described as the need for reintubation within 48 hours after extubation.
- Trial name
- NCT03129802
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Strasbourg, France
Prematurity, Mechanical Ventilation
Comparison of Two Flow Rates of HHHFNC to Prevent Extubation Failure in Preterm Infants
This is a randomized controlled trial (RCT) to evaluate the influence of two flow rates (6 liter/min versus 3 liter/min) of Heated-Humidified High-Flow-Nasal-Cannula (HHHFNC) on rates of extubation failure in mechanically…
- Trial name
- NCT02681315
- Testing
- HHHFNC 6 liter minute, HHHFNC 3 liters/min
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Mansoura University Children Hospital
Need for Tracheal Tube Exchange, Presence of Post-extubation Laryngeal Oedema
"Cuffed Versus Uncuffed Tracheal Tubes in Small Children"
This randomized controlled multi-centre trial in children from birth up to < 5 years of age aims to demonstrate equivalence as to the major outcome of post-extubation airway injury (stridor) comparing uncuffed tracheal tubes to…
- Trial name
- NCT00221377
- Testing
- Intubation using tracheal tubes with or without cuff
- Where
- 24 sites in Austria, Belgium and 6 more
- Volunteers
- 4,000 people
- Sponsor
- University Children's Hospital, Zurich
Respiratory Insufficiency
Integrated Pulmonary Index (IPI) as a Determinate of Weaning Success and/or Failure in the Pediatric Population
Integrated pulmonary index (IPI) is a tool that monitors respiratory status. It takes into account four parameters: respiratory rate, end-tidal CO2, heart rate and O2 saturation using a pulse oximeter and specialized sidestream…
- Trial name
- IPI (NCT01795196)
- Where
- United States
- Sponsor
- Rush University Medical Center
Cervical Lesion
Risk Predictors of Extubation Failure for Cervico-medullary Junction Surgery
CVJ anomalies affecting skeleton might lead to the pressure on the neuraxis, and disturbance of the cerebrospinal fluid circulation and blood supply.
- Trial name
- CVJ-RISK (NCT03291119)
- Volunteers
- 100 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Severe Brain Injury
Evaluation of Risk Factors Regarding Extubation Failure in Severe Brain Injured Patients.
Severe brain-injured patients require prolonged mechanical ventilation. Weaning these patients from mechanical ventilation is challenging.
- Trial name
- NCT02426242
- Testing
- Collection of medical data from ICU patients
- Where
- 3 sites in France
- Volunteers
- 450 people
- Sponsor
- Nantes University Hospital
Respiratory Distress Syndrome
High Flow Nasal Cannula (HFNC) Versus Nasal Intermittent Mandatory Ventilation (NIMV)for Respiratory Distress Syndrome (RDS): a Randomized, Controlled, Prospective Study
The investigators hypothesize that while the extremely low birthweight (ELBW) infants (<1000 g) may need NIMV for the treatment of RDS, larger infants or the smaller ones post extubation may enjoy the comfort benefits associated…
- Trial name
- NCT01189162
- Testing
- NIMV with SLE ventilator vs HFNC via Vapotherm
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Bnai Zion Medical Center
Respiratory Distress Syndrome of Newborn
Modified Intubation-surfactant-extubation (InSurE) Technique in Preterm Neonates With Respiratory Distress Syndrome
This study evaluates the less invasive surfactant administration (LISA) combined with synchronized nasal intermittent positive pressure ventilation (SNIPPV) technique in the treatment of respiratory distress syndrome (RDS) of…
- Trial name
- NCT03989960
- Testing
- LISA+SNIPPV, traditional InSurE
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Respiratory Distress Syndrome, Bronchopulmonary Dysplasia
Post-extubation Pressures in Preterm Neonates: A CER Study
The optimal post-extubation pressure level on non-invasive respiratory support modes - irrespective of the choice of the specific non-invasive mode - that optimizes extubation success and improves clinical outcomes remains…
- Conditions
- Respiratory Distress Syndrome, Bronchopulmonary Dysplasia, Preterm Birth
- Trial name
- NCT06552455
- Volunteers
- 1,050 people
- Sponsor
- McMaster Children's Hospital
Prematurity, Respiratory Failure
Non-invasive Neurally Adjusted Ventilatory Assist Versus Nasal Intermittent Positive Pressure Ventilation for Preterm Infants After Extubation
Non-invasive respiratory support has been emerging in the management of respiratory distress syndrome (RDS) in preterm infants to minimise the risk of lung injury.
- Conditions
- Prematurity, Respiratory Failure, Ventilator Lung; Newborn
- Trial name
- NCT03388437
- Testing
- NI-NAVA, NIPPV
- Where
- Saudi Arabia
- Volunteers
- 36 people
- Sponsor
- King Fahad Armed Forces Hospital
Respiratory Distress Syndrome
n-CPAP Versus n-BiPAP and NIPPV for Postextubation in RDS in Preterms
non-invasive ventilation in preterms complaining from RDS a randomized, controlled trial to compare between capap, n-bipap and NIPPV
- Trial name
- NCT01770925
- Testing
- N-CPAP, n-BiPAP, NIPPV
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Ain Shams University
Intubated Infants Were Intend to Extubation Using Noninvasive Ventilation Strategies
A Trial Comparing Noninvasive Ventilation Strategies in Preterm Infants Following Extubation
Respiratory distress syndrome (RDS) is the main cause of respiratory failure in preterm neonates, its incidence varying from 80% to 25% depending on gestational age.When optimal prenatal care is provided, the best approach to…
- Trial name
- NCT03181958
- Testing
- NHFOV, NCPAP, NIPPV
- Where
- China
- Volunteers
- 1,493 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Anesthesia; Functional
Neuromuscular Blockade Reversal Agent Effect on Postoperative Cognitive Function and Behaviour in Children
The aim of this prospective randomized study is to investigate comparatively the effect of neostigmine-atropine versus sugammadex on speed and quality of recovery and on postoperative cognitive function \& behavior in children…
- Trial name
- NCT02455921
- Testing
- neostigmine - atropine, Sugammadex
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- Attikon Hospital
Invasive Mechanical Ventilation, Extubation
The External Diaphragm Pacemaker Assisted Extubation in Premature Infants With Invasive Mechanical Ventilation
With the development of perinatal medicine, more and more newborns with respiratory failure can be treated due to the use of respiratory support technology.
- Trial name
- NCT06404294
- Testing
- External Diaphragm Pacemaker treatment
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Children's Hospital of Chongqing Medical University
Premature
dTDI During a SBT to Predict Extubation Failure in Preterm Infants
Weaning from mechanical ventilation is a critical issue and the diaphragmatic disfunction has been demonstrated to play an important role in extubation failure.
- Trial name
- NCT05865977
- Testing
- diaphragmatic tissue Doppler imaging，dTDI
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Wang Jianhui
Infant, Premature, Diseases, Infant, Newborn, Disease
Noninvasive High Frequency Oscillatory Ventilation as a Post-extubation Respiratory Support in Neonates
A randomized controlled trial comparing Noninvasive high frequency oscillatory ventilation (NHFOV) and Noninvasive positive pressure ventilation (NIPPV) as post-extubation respiratory support in preterm neonates with respiratory…
- Conditions
- Infant, Premature, Diseases, Infant, Newborn, Disease, Respiratory Tract Diseases, RDS
- Trial name
- NCT05493527
- Testing
- noninvasive high frequency oscillatory ventilation, noninvasive positive pressure ventilation
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Respiratory Failure, Intensive Care Pediatric
The Effect of Music Therapy on Vital Signs and Heart Rate Variability of Pediatric Patients During the Extubation Process.
The extubation process is critical to the future health outcomes of the pediatric patient because it tests the ability of the respiratory system to function without the support of mechanical ventilation.
- Trial name
- NCT06591533
- Testing
- Music therapy + standard care, Standard Care (in control arm)
- Where
- 2 sites in Colombia
- Volunteers
- 82 people
- Sponsor
- Claudia Aristizábal
Neonates
Utility of Spontaneous Breathing Trial (SBT) Using ET-CPAP, in Predicting Extubation Failure in Neonates
Intubation and ventilation are lifesaving interventions in the neonatal intensive care unit (ICU), especially among preterm, low birth weight babies. However, timely extubation is also necessary.
- Trial name
- NCT03091387
- Testing
- Spontaneous Breathing Test
- Volunteers
- 110 people
- Sponsor
- Aga Khan University
Effect of Anesthesia in Postoperative Pain, Effect of Anesthesia in Extubation Time
Opioid Versus Non-opioid Anesthesia for Ambulatory Surgery in Children
The investigators intend to study the safety and effectiveness of opioid free anesthesia compared to opioid anesthesia in ambulatory surgery in children, regarding postoperative pain, hemodynamic stability, agitation and…
- Conditions
- Effect of Anesthesia in Postoperative Pain, Effect of Anesthesia in Extubation Time, Effect of Anesthesia in Discharge Time From Postanesthesia Care Unit, Effect of Anesthesia in Postoperative Adverse Events
- Trial name
- NCT03979469
- Testing
- Ketamine, dexmedetomidine, fentanyl, remifentanil
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Athens General Children's Hospital "Pan. & Aglaia Kyriakou"