Clinical trials: Thiamine
Thyrotoxicosis
Thiamine Supplement in Patients With Severe Hyperthyroidism
Thyrotoxicosis is a hypermetabolic state in which there is increased utilization of thiamine. Thiamine deficiency has been observed in association with hyperthyroidism.
- Trial name
- NCT02767245
- Testing
- Thiamine
- Where
- Thailand
- Volunteers
- 12 people
- Sponsor
- Ramathibodi Hospital
Heart Diseases
Effect of Thiamin Supplementation on Thiamin Status in Children With Heart Disease Receiving Diuretic Drugs
The purpose of this study is to determine effect of thiamin supplementation on thiamin status by measuring thiamin pyrophosphate effect in children with heart disease receiving diuretic drugs.
- Trial name
- NCT03989700
- Testing
- Thiamine Mononitrate
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Mahidol University
Chronic Heart Failure
Thiamine Supplementation in Heart Failure Patients Receiving Full Medical Therapy
The study is performed to consider the effect of thiamine supplementation on symptoms and signs of patients with heart failure and systolic and diastolic function of left ventricle.
- Trial name
- NCT01115504
- Testing
- Thiamine
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- Mashhad University of Medical Sciences
Major Depressive Disorder (MDD), Thiamine
Oral Thiamine (Vitamin B1) for Depression in Children and Adolescents
The goal of this study is to examine the effectiveness of thiamine in reducing depressive symptoms in children and adolescents. The investigators hypothesize that thiamine administration will alleviate depressive symptoms in…
- Conditions
- Major Depressive Disorder (MDD), Thiamine, Vitamin B1, Thiamine Diphosphate (TDP)
- Trial name
- B1Ped (NCT07793071)
- Testing
- thiamine hydrochloride 100 mg
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Thiamine Deficiency, Congenital Heart Disease
Thiamine Influenced on Substrate Energy Effectiveness in Indonesian Children Undergoing Cardiopulmonary Bypass
This is a randomized, double-blind, controlled trial design. It was conducted with a main purpose of evaluating the effect of thiamine supplementation on serum lactate and lactate-pyruvate ratio after surgery as direct indicators…
- Conditions
- Thiamine Deficiency, Congenital Heart Disease, Cardiopulmonary Bypass
- Trial name
- NCT04453761
- Testing
- Neurobion
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia
Thiamine Deficiency
Further Development and Assessment of Tools to Measure Risk Factors for and Treatment of Thiamine Deficiency Disorders
Thiamine deficiency, including the most severe form infantile beriberi, is a public health concern across South and Southeast Asia, where monotonous diets rely on thiamine-poor white rice.
- Trial name
- NCT05390086
- Testing
- Standard of care
- Where
- 2 sites in Laos
- Volunteers
- 42 people
- Sponsor
- University of California, Davis
Dry Beriberi
Study of Dry Beriberi in Mayotte, Comoro Archipelago
The purpose of this study is to assess the existence of a genetic factor, suspected to be involved, aside from likely food deficiency contribution, in occurrence of dry beriberi, in patients who experienced dry beriberi and in a…
- Trial name
- MABECO (NCT00934349)
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Groupe Hospitalier Sud Reunion
Congenital Heart Disease, Thiamine Deficiency
The Role of Thiamine After Transcatheter Closure in Children With Left-to-Right Shunt Congenital Heart Disease
Currently, research on the effect of thiamine administration during transcatheter closure on the structure and function of the left ventricle by examining levels of matrix metalloproteinase-9 and tissue inhibitor of…
- Conditions
- Congenital Heart Disease, Thiamine Deficiency, Patent Ductus Arteriosus, Ventricular Septal Defect
- Trial name
- NCT06298344
- Testing
- Thiamine
- Where
- Indonesia
- Volunteers
- 86 people
- Sponsor
- Universitas Sumatera Utara
HIV Infections
A Study to See if Certain Antioxidants and Vitamins Will Keep Lactate Levels Down in Patients Taking Anti-HIV Drugs
The purpose of this study is to see if certain vitamins (C, E, B1, and B2) can keep lactate levels from becoming too high in patients who are taking nucleoside reverse transcriptase inhibitor (NRTI) anti-HIV drugs.
- Trial name
- NCT00037063
- Testing
- Thiamine hydrochloride, Riboflavin, Ascorbic acid
- Where
- 4 sites in United States
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1
Baby Detect : Genomic Newborn Screening
Newborn screening (NBS) is a global initiative of systematic testing at birth to identify babies with pre-defined severe but treatable conditions.
- Conditions
- Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1, Phosphoglucomutase 1 Deficiency, Maturity Onset Diabetes of the Young
- Trial name
- BabyDetect (NCT05687474)
- Where
- Belgium
- Volunteers
- 6,824 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Liege
Eating Disorders
Thiamin (Vitamin B1) Levels in Eating Disorder Adolescent Patients
Vitamin B1 (Thiamine) is a water soluble essential nutrient; it is synthesized by a variety of plants and microorganisms. Since animals usually cannot synthesis it, humans must be supplied with exogenous vitamin B1 in the diet.
- Trial name
- NCT02164487
- Where
- Israel
- Volunteers
- 69 people
- Sponsor
- Assaf-Harofeh Medical Center
Malaria
Micronutrients and Child Health Study
The purpose of this study is to determine to what extent supplementation with zinc and other micronutrients are efficacious in preventing malaria in young Tanzanian children.
- Trial name
- MACH (NCT00623857)
- Testing
- Zinc, Vitamins and minerals other than zinc, Vitamins plus zinc and other minerals
- Where
- Tanzania
- Volunteers
- 612 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Meningitis, Bacteremia
THiamine for Recovery In Vulnerable Early-life Infections
To determine if the addition of thiamine to standard-of-care treatment will improve neurodevelopmental outcomes for infants with meningitis or bacteremia
- Trial name
- THRIVE (NCT07868679)
- Testing
- thiamine hydrochloride 100 mg
- Where
- 2 sites in United States
- Volunteers
- 240 people
- Sponsor
- Milton S. Hershey Medical Center
Primary Ciliary Dyskinesia
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia
Patients with primary ciliary dyskinesia (PCD) have trouble with clearing their bronchi from mucus, which in the long-term may produce severe damage to the lungs.
- Trial name
- NCT06959251
- Testing
- Glycine, Magnesium+thiamine
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Instituto Nacional de Enfermedades Respiratorias
HIV Infections
Vitamin B Therapy for Hyperlactatemia
The purpose of this study is to see if vitamin B can treat mild hyperlactatemia (a higher than normal level of lactate in the blood) in patients who take nucleoside reverse transcriptase inhibitors (NRTIs).
- Trial name
- NCT00031057
- Testing
- Thiamine hydrochloride, Riboflavin
- Where
- 3 sites in United States
- Volunteers
- 225 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Thiamine Deficiency
Thiamine Responsive Disorders (TRD) Among Infants in Lao PDR
A hospital- and community-based study in Luang Prabang, Lao PDR, which will include a group of hospitalized children 21 days to <18 months of age who are diagnosed with symptoms compatible with thiamine deficiency disorder (TDD).
- Trial name
- NCT03626337
- Testing
- Thiamine 100 MG/ML
- Where
- Laos
- Volunteers
- 1,394 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Obesity, Child
Thiamin Deficiency in Obese Thai Children
This study is aimed to assess the prevalence of thiamin deficiency in obese Thai children.
- Conditions
- Obesity, Child, Thiamine Deficiency
- Trial name
- NCT02464865
- Testing
- Thiamine 1, Non-thiamine, Thiamine 2
- Where
- Thailand
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Cancer, Neuropathy
Nutritional Supplement for Treating Chemotherapy Induced Neuropathy
Administration of a nutritional supplement containing palmitoyethanolamide, alpha lipoic acid, vitamin B12, vitamin B6 , vitamin B1, nicotinamide, magnesium, zinc, vitamin E, and superoxide of dismutase in individuals receiving…
- Conditions
- Cancer, Neuropathy, Chemotherapy Induced Pain Neuropathy, Chemotherapy-Induced Peripheral Neuropathy
- Trial name
- NCT07022938
- Testing
- Epineuron
- Where
- Greece
- Volunteers
- 71 people
- Sponsor
- Aristotle University Of Thessaloniki