Clinical trials: Syphilis
Syphilis, Treponema Pallidum
A Cross-sectional Investigational Study to Evaluate the Sensitivity, Specificity, and Utility of the MedMira Inc. Multiplo® Complete Syphilis (TP/nTP) Antibody Test (POCT) to Diagnose Infectious Syphilis in Participants Attending the Sexual Health Clinic in Ottawa, Ontario.
Due to the recent resurgence of infectious syphilis in Canada and the changing epidemiology of the disease to involve heterosexuals and females of child bearing age leading to a record number of congenital syphilis cases and…
- Trial name
- NCT06586905
- Testing
- Medical Device
- Where
- Canada
- Volunteers
- 1,300 people, healthy volunteers welcome
- Sponsor
- MedMira Laboratories Inc.
Syphilis
Modernizing Perinatal Syphilis Testing
The purpose of this study is to determine the testing performance of real-time quantitative polymerase chain reaction and transcription mediated amplification by comparing test performance of these novel molecular tests to…
- Trial name
- NCT06082453
- Testing
- Quantitative polymerase chain reaction (qPCR) assay for detection of Treponema pallidum, Aptima Treponema pallidum transcription-mediated amplification (TMA) assay for detection of Treponema pallidum, Center for Disease Control (CDC) Sexually Transmitted Infections (STI) 2021 Treatment Guidelines for diagnosis of syphilis
- Where
- 9 sites in United States
- Volunteers
- 924 people
- Sponsor
- The University of Texas Health Science Center, Houston
Sexually Transmitted Infection, Chlamydia
Investigating Point-of-care Diagnostics for Sexually Transmitted Infections and Antimicrobial Resistance in Primary Care in Zimbabwe
A prospective interventional study to evaluate a strategy of point-of-care testing for sexually transmitted infections including chlamydia, gonorrhoea, trichomoniasis, syphilis, and Hepatitis B with comprehensive case management…
- Conditions
- Sexually Transmitted Infection, Chlamydia, Gonorrhea, Trichomoniasis
- Trial name
- IPSAZ (NCT05541081)
- Testing
- Point-of-care STI testing
- Where
- Zimbabwe
- Volunteers
- 1,005 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Human Immunodeficiency Virus, Risk Reduction
Building Mobile HIV Prevention and Mental Health Support in Low-resource Settings
The purpose of this research study is to provide help and support for mental health and human immunodeficiency virus (HIV) risk reduction among Romanian gay and bisexual men.
- Conditions
- Human Immunodeficiency Virus, Risk Reduction, Alcohol Abuse, Depression, Anxiety
- Trial name
- NCT03912753
- Testing
- Comunică, Education Attention Control
- Where
- Romania
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Columbia University
Syphilis, Syphilis, Congenital
Congenital and Maternal Point of Care Rapid Testing for Syphilis Study, Uganda
Syphilis is an infection which affects about 1 in 25 pregnant women in Uganda. If the infection is not diagnosed and treated this can be a risk to the mother and unborn baby's health.
- Trial name
- COMPARTS (NCT07173764)
- Where
- Uganda
- Volunteers
- 24 people
- Sponsor
- St George's, University of London
HIV Infections, Immune Activation
The University of Zimbabwe College of Health Science (UZ-CHS) BIRTH COHORT Study
Background Commencement of lifelong highly active antiretroviral therapy (HAART) immediately after HIV diagnosis (option B+), for treatment of human immunodeficiency virus (HIV), has greatly improved maternal-infant health in sub…
- Conditions
- HIV Infections, Immune Activation, Comorbidities
- Trial name
- UZ-CHS-BC (NCT04087239)
- Testing
- HIV
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Zimbabwe
Point-of-Care Testing, HIV
Ayaangwaamiziwin Initiative: Carefulness and Preparedness
The goal of this clinical trial is to implement a test, treat, and connect intervention approach using HIV and syphilis rapid point-of-care (POC) testing in 3 Canadian Prairie provinces (Alberta, Manitoba, and Saskatchewan)…
- Conditions
- Point-of-Care Testing, HIV, Syphilis
- Trial name
- AI (NCT06893159)
- Testing
- INSTI HIV-1/2 Antibody Test, INSTI Multiplex HIV-1/2 Syphilis Antibody Test, Multiplo Complete Syphilis (TP/nTP) Antibody Test
- Where
- 8 sites in Canada
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Syphilis Infection
Evaluation of the Diagnostic Sensitivity and Specificity of the Determine™ Syphilis Advanced Test.
This is a prospective, multi-centre study which will evaluate the diagnostic sensitivity and specificity of the Determine™ Syphilis Advanced test.
- Trial name
- NCT06584214
- Testing
- Diagnostic test: Determine™ Syphilis Advanced test
- Where
- Uganda
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Abbott Rapid Dx
Syphilis, Syphilis Infection
Retrospective Study of iStatis Syphilis Ab Test (POC)
The purpose of this retrospective clinical trial is to establish the clinical performance of the iStatis Syphilis AbTest. The data will be used to demonstrate the product is safe and effective for its intended use.
- Trial name
- NCT06367621
- Testing
- iStatis Syphilis Antibody Test
- Where
- South Africa
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- bioLytical Laboratories
Hiv, Syphilis
The TRIple Elimination Model Of Mother-to-child Transmission Program (TRI-MOM)
The TRI-MOM program aims to implement and evaluate a simplified (based on inexpensive rapid diagnostic tests), integrated (in governmental health facilities) and coordinated (between health care workers) strategy for the triple…
- Conditions
- Hiv, Syphilis, HBV
- Trial name
- TRI-MOM (NCT05951751)
- Testing
- TRI-MOM intervention
- Where
- 2 sites in Burkina Faso, The Gambia
- Volunteers
- 2,800 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche pour le Developpement
HIV Infections, Syphilis
Impact of COVID-19 on Provision and Uptake of Prevention of Mother-to-child Transmission of HIV Services in Zimbabwe
The COVID-19 pandemic and response are likely to lead to severe unintended consequences for the prevention of mother-to-child transmission (PMTCT) of HIV and syphilis.
- Trial name
- NCT04782739
- Testing
- None - Descriptive study
- Where
- 2 sites in Zimbabwe
- Volunteers
- 30 people
- Sponsor
- University of Zimbabwe
HIV Infections, Sexually Transmitted Diseases
Integrating Enhanced HIV PrEP Into a STI Clinic in Lilongwe
This is a prospective cohort study evaluating acceptability, feasibility, and effectiveness of integrating HIV pre-exposure prophylaxis (PrEP) into a sexually transmitted infection (STI) clinic alongside assisted partner…
- Conditions
- HIV Infections, Sexually Transmitted Diseases, Blood-Borne Infections, Communicable Disease
- Trial name
- NCT05307991
- Testing
- PrEP, STI testing, Assisted partner notification
- Where
- Malawi
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Congenital Syphilis
Congenital Syphilis in Switzerland
A retrospective national epidemiological Swiss study was conducted to establish a real prevalence and description of congenital syphilis, and to better classify the reported congenital syphilis.
- Trial name
- NCT05975502
- Testing
- Epidemiological study
- Where
- Switzerland
- Volunteers
- 265 people
- Sponsor
- University Hospital, Geneva
Syphilis, HIV Infections
Syphilis and HIV Point of Care Testing (POCT) in Saskatchewan
The goal of this clinical trial is to learn about Syphilis and HIV point of care testing among inner city, remote, rural and hard to reach populations in Saskatchewan. The main question[s] it aims to answer are: 1.
- Trial name
- SHIVER (NCT05863117)
- Testing
- Reveal Rapid TP (from MedMira)
- Where
- 2 sites in Canada
- Volunteers
- 1,650 people, healthy volunteers welcome
- Sponsor
- Wellness Wheel Medical Clinic
Chagas Disease, Syphilis
Implementation Strategy of Bio-molecular Techniques for Early Diagnose of Congenital Syphilis and Chagas Diseases
Chagas disease and syphilis are considered a mayor public health problem worldwide. Both pathologies affect socio-economic vulnerable population and they are both transmitted congenitally, causing an alarming increasing number of…
- Trial name
- NCT04084379
- Where
- Argentina
- Volunteers
- 560 people
- Sponsor
- Hospital de Niños R. Gutierrez de Buenos Aires
Syphilis Acquired, Syphilis Infection
Acquired Syphlis by Non Sexual Contact
Syphilis is classically described as a sexually transmitted disease. As this source of contagious has been described long ago -mainly though by observation- when children presents with acquired syphilis, child abuse is always…
- Trial name
- NCT04455425
- Where
- Argentina
- Volunteers
- 24 people
- Sponsor
- Hospital de Niños R. Gutierrez de Buenos Aires
Chlamydia Infections, Gonorrhea
Extraordinarily Fun Training Project in Compulsory Secondary Education - Sexually Transmitted Infections
Project FEDE-ITS will improve the STI knowledge and its treatment, of adolescents in the 1st and 2nd year of compulsory secondary education in the intervention group compared to compared to the control group, and will modify the…
- Conditions
- Chlamydia Infections, Gonorrhea, Syphilis Infection, Human Immunodeficiency Virus (HIV)
- Trial name
- FEDE-ITS (NCT05727033)
- Testing
- Participatory teaching group
- Where
- 4 sites in Spain
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Syphilis
Point of Care Tests for Syphilis and HIV
This study will evaluate the performance of two point-of-care dual syphilis and HIV tests [Multiplo TP/HIV test (MedMira Inc, Halifax, Nova Scotia) and the INSTI Multiplex HIV-1/HIV-2/Syphilis Antibody Test (bioLytical…
- Trial name
- PoSH (NCT04514848)
- Testing
- INSTI Multiplex HIV-1/2 Syphilis AB test, Multiplo Rapid TP/HIV test
- Where
- Canada
- Volunteers
- 1,526 people
- Sponsor
- University of Alberta
Syphilis, Congenital
Congenital Syphilis Prospective Cohort With Retrospective Evaluation
Syphilis is an infectious disease caused by Treponema pallidum. In children, there are two different forms of this disease; acquired syphilis and congenital syphilis, which results from transplacental transmission of spirochetes.
- Trial name
- NCT04137601
- Where
- Argentina
- Volunteers
- 62 people
- Sponsor
- Hospital de Niños R. Gutierrez de Buenos Aires
Syphilis, HIV
Introduction Study of Dual HIV & Syphilis Rapid Diagnostic Tests in Antenatal Clinics in Colombia
Global and regional initiatives have been launched for the dual elimination of mother-to-child transmission (MTCT) of HIV and syphilis.
- Trial name
- NCT02454816
- Testing
- Single HIV RDT and single syphilis RDT, Dual HIV/syphilis RDT
- Where
- Colombia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional de Colombia