Clinical trials: Stress Response
Stress Reaction; Acute
Racial Discrimination and Stress Response
The goal of this study is to learn about whether ethnic minority adolescents' racial discrimination experience is related to dysregulated biological responses to subtle racism, and how the relationship may be attenuated or…
- Trial name
- NCT05820659
- Testing
- peer rejection task, conversation about peer rejection, and impossible puzzle task
- Where
- United States
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- Western Kentucky University
Congenital Heart Disease in Children, Inflammatory Response
STeroids to REduce Systemic Inflammation After Infant Heart Surgery
This study's objective is to determine the pharmacokinetics (PK)/pharmacodynamics (PD), safety and efficacy of methylprednisolone in infants undergoing heart surgery with cardiopulmonary bypass.
- Trial name
- STRESS (NCT03229538)
- Testing
- Methylprednisolone, Isotonic saline
- Where
- 23 sites in United States
- Volunteers
- 1,263 people
- Sponsor
- Kevin Hill
Residential Characteristics, Emotions
Adolescent Responses to Varying Environments in Virtual Reality Simulations
The objective of this study, named THRIVE (The Research In Virtual Environments Study), is to test hypotheses for how neighborhood environments influence stress and emotion, as a mechanism by which they may influence health.
- Conditions
- Residential Characteristics, Emotions, Stress, Psychological, Stress, Physiological
- Trial name
- NCT04465240
- Testing
- Virtual reality
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Tobacco Use Cessation, Tobacco Use Disorder
Effectiveness of Bupropion for Treating Nicotine Dependence in Young People
Little is known about the best ways to help young people stop smoking. Bupropion (a medication marketed as Wellbutrin or Zyban) has proved helpful in treating adult smokers.
- Trial name
- NCT00129272
- Testing
- Bupropion-SR
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Immune System Diseases, Oxidative Stress
The Effect of Different Volumes of Physical Exercise on the Immune System
The investigators will do an intervention on four groups of previously sedentary post-menopausal women which consists: group 1 - 30 minutes per day of physical protocol; group 2 - 50 minutes per day of physical protocol; group 3…
- Trial name
- ProAFIM (NCT02331446)
- Testing
- Physical exercise intervention
- Volunteers
- 42 people
- Sponsor
- Federal University of Pelotas
Tetralogy of Fallot (TOF), Ventricular Septal Defects (VSD)
Measures to Lower the Stress Response in Pediatric Cardiac Surgery
Cardiac surgery induces a measurable stress response in patients which leads to increased morbidity and mortality post-operatively.
- Conditions
- Tetralogy of Fallot (TOF), Ventricular Septal Defects (VSD), Atrioventricular Septal Defects (AVSD)
- Trial name
- NCT00848393
- Testing
- Fentanyl (High Dose), Fentanyl (Low Dose), Fentanyl (Low Dose) + Dexmedetomidine
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Nationwide Children's Hospital
Malaria, Seizures
Aggressive Antipyretics for Fever Reduction in CNS Malaria
The study will examine whether prophylactic and scheduled treatment with acetaminophen and ibuprofen can decrease the maximum temperature experienced during the acute illness in children with CNS malaria.
- Conditions
- Malaria, Seizures, Coma, Parasitemia
- Trial name
- NCT03399318
- Testing
- Acetaminophen, Ibuprofen
- Where
- 3 sites in Malawi, Zambia
- Volunteers
- 256 people
- Sponsor
- University of Rochester
Congenital Heart Disease
Stress Response and Neurodevelopmental Outcome After Cardiac Surgery Utilizing CPB in Children: A Prospective, Double Blinded and Randomized Study
The overall goal of this project is to determine the role of anesthetic management in children undergoing cardiac surgery utilizing CPB in the setting of fast tracking and early extubation.
- Trial name
- NCT02492269
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Aymen N Naguib
Adrenal Insufficiency, Critical Illness
Pilot Study Assessing Oxidative Stress in Children
Role fo oxidative stress in adrenal insufficiency has not been studied. The degree of oxidative stress and it's role in pediatric critical illness is unknown.
- Trial name
- OxStress (NCT01052207)
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Emory University
Prematurity, Stress Reaction
Pilot Study of Nursing Touch and Biobehavioral Stress
Randomized cross-over clinical trial to determine the effect of a nurse-administered comforting touch intervention on the biobehavioral stress responses of preterm infants hospitalized in the neonatal intensive care unit.
- Trial name
- P-NAT-BIO (NCT05030233)
- Testing
- Nurse-Administered Touch Intervention
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Ohio State University
Sepsis
The CRISIS Prevention Study
Despite strict hand washing, sterile technique, and antibiotic-coated catheters, nosocomial infection and sepsis remain the leading acquired causes of morbidity and mortality in critically ill children.
- Trial name
- CRISIS (NCT00395161)
- Testing
- Metoclopramide, Zinc, Glutamine
- Where
- 7 sites in United States
- Volunteers
- 293 people
- Sponsor
- Michael Dean