Clinical trials: Solid Organ Transplant Complications
Complications of Transplanted Organs and Tissue
Identification and Treatment of Diabetes In Solid Organ Transplant Recipients
The purpose of this study is to determine the influence of post-transplant diabetes on medical and psychosocial outcomes in individuals who receive solid-organ transplant prior to 18 years of age and their families.
- Trial name
- NCT02605200
- Testing
- Psychologist Support, Pediatric Certified Diabetes Educators (CDEs) Support
- Where
- 2 sites in United States
- Volunteers
- 65 people
- Sponsor
- Emory University
Solid Organ Transplantation, Pregnancy
Long-term Follow-up of the Offspring Born to Mothers With a Solid Organ Transplant, Transplantlines Next Generation
Background Pregnancy after all types of solid organ transplantation (SOT) is possible, although these have higher risk of pregnancy complications for mother and child, such as preeclampsia and preterm birth.
- Conditions
- Solid Organ Transplantation, Pregnancy, Long-term Follow-up, Kidney Transplant
- Trial name
- NCT07291258
- Where
- Netherlands
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Viral Infections
Virus Surveillance in Pediatric Solid Organ Transplant Recipients
Viral infections are an important complication of transplantation. Immunosuppressive therapy interferes with T cell immunity resulting in a high incidence of viral infection.
- Trial name
- NCT00886158
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Seattle Children's Hospital
Malignancy, Transplant Complication
Epidemiology of Complications After Solid Organ Transplantation - EpCOT Study
Cancer remains a major cause of morbidity and mortality post solid organ transplantation. While mortality from the other leading causes of death post-transplantation (e.g.
- Conditions
- Malignancy, Transplant Complication, Cancer, Kidney Failure
- Trial name
- EpCOT (NCT02991105)
- Where
- 2 sites in United Kingdom
- Volunteers
- 85,410 people
- Sponsor
- University of Birmingham
HIV Infections, Kidney Disease
Kidney and Liver Transplantation in People With HIV
With improved anti-HIV drug therapy, HIV infected patients are now living longer. These patients are at risk for liver and kidney failure and may need organ transplants.
- Conditions
- HIV Infections, Kidney Disease, Liver Disease
- Trial name
- NCT00074386
- Where
- 21 sites in United States
- Volunteers
- 275 people
- Sponsor
- University of California, San Francisco
Late Complication From Kidney Transplant, Complication of Transplanted Liver
Immunogenicity and Safety of Human Papilloma Virus Vaccine in Solid Organ Transplant Recipients
The human papilloma virus (HPV) is known to be an important cause of cervical and anal cancers. Studies on patients who have received a solid organ transplant (such as a liver or kidney transplant) have suggested the risk of…
- Conditions
- Late Complication From Kidney Transplant, Complication of Transplanted Liver, Human Papillomavirus-Related Carcinoma
- Trial name
- NCT02624349
- Testing
- Quadravalent human papillomavirus vaccine
- Where
- Canada
- Volunteers
- 37 people
- Sponsor
- The Hospital for Sick Children
Transplantation Infection, Kidney Transplant; Complications
Intestinal Microbiome Dynamics in Solid Organ and Stem Cell Transplant Recipients
This is a pilot study designed to investigate the alterations in the gut microbiome that occur during the course of kidney transplantation, liver transplantation, allogeneic hematopoietic stem cells and mesenchymal stem cells…
- Conditions
- Transplantation Infection, Kidney Transplant; Complications, Stem Cell Transplant Complications, Liver Transplant; Complications
- Trial name
- NCT04281797
- Testing
- Intestinal microbiome new generation sequencing
- Where
- Belarus
- Volunteers
- 90 people
- Sponsor
- Minsk Scientific-Practical Center for Surgery, Transplantation and Hematology
Solid Organ Transplant Complications, Solid Organ Transplant Recipients
Phase I Trial on the Safety of Delayed Infusion of a Naïve T Cell-Depleted Hematopoietic Graft With Memory T Cells in Solid Organ Transplant Recipients
The goal of this clinical trial is to evaluate the safety and feasibility of inducing hematopoietic mixed chimerism to promote immune tolerance and potentially reduce the need for lifelong immunosuppression in pediatric and adult…
- Conditions
- Solid Organ Transplant Complications, Solid Organ Transplant Recipients, Solid Organ Transplant Rejection
- Trial name
- DUALGRAFT (NCT06997471)
- Testing
- Investigational cellular therapy consisting on a HSCT using a graft enriched in CD34+, depleted of naïve T-lymphocytes and supplemented with memory lymphocytes
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Francisco Hernández Oliveros
Epstein-Barr Virus+ Associated Post-transplant Lymphoproliferative Disease (EBV+ PTLD), Solid Organ Transplant Complications
A Phase 3 Study of Tabelecleucel for Participants With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease After Failure With Rituximab or Rituximab and Chemotherapy
The purpose of this study is to determine the clinical benefit and characterize the safety profile of tabelecleucel for the treatment of Epstein-Barr virus-associated post-transplant lymphoproliferative disease (EBV+ PTLD) in the…
- Conditions
- Epstein-Barr Virus+ Associated Post-transplant Lymphoproliferative Disease (EBV+ PTLD), Solid Organ Transplant Complications, Lymphoproliferative Disorders, Allogeneic Hematopoietic Cell Transplant
- Trial name
- ALLELE (NCT03394365)
- Testing
- tabelecleucel
- Where
- 71 sites in United States, Australia and 7 more
- Volunteers
- 115 people
- Sponsor
- Pierre Fabre Medicament
Solid Organ Transplant Complications
Washed Microbiota Transplantation in Solid Organ Transplantation
Solid organ transplantation (SOT), an alternative therapy for end-stage diseases, offers increased longevity and better quantity of life.
- Trial name
- NCT06708676
- Testing
- Washed Microbiota Transplantation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Immunocompromised Host, Organ Transplantation
Cancer Risk in Organ Transplant Recipients and End-Stage Renal Disease
Background: Solid organ transplantation provides life-saving treatment for end-stage organ disease but is associated with an increased cancer risk because of the need for long-term immunosuppression End-stage renal disease…
- Conditions
- Immunocompromised Host, Organ Transplantation, Cancer
- Trial name
- NCT00904579
- Where
- 9 sites in United States
- Volunteers
- 19,929,901 people
- Sponsor
- National Cancer Institute (NCI)
Infection in Solid Organ Transplant Recipients, Complications of Organ Transplant
Respiratory Viral Infections in Pediatric Transplantation
A retrospective cohort of solid organ transplant (SOT) and hematopoietic stem cell transplant (HSCT) recipients will be assembled to determine the incidence of respiratory viral infections diagnosed during an inpatient admission…
- Conditions
- Infection in Solid Organ Transplant Recipients, Complications of Organ Transplant, Respiratory Viral Infection
- Trial name
- NCT02260596
- Where
- United States
- Volunteers
- 2,669 people
- Sponsor
- Duke University
EBV Viremia, CMV Viremia
25BT056: Basket Study of Viral Cytotoxic T Lymphocytes
This study is evaluating the safety and effectiveness of virus-specific cytotoxic T lymphocytes (vCTLs) for treating difficult-to-control viral infections caused by cytomegalovirus (CMV), adenovirus (ADV), Epstein-Barr virus…
- Conditions
- EBV Viremia, CMV Viremia, BK Viremia, Adenovirus
- Trial name
- NCT07873970
- Testing
- Virus-Specific Cytotoxic T Lymphocytes (vCTLs)
- Volunteers
- 35 people
- Sponsor
- Children's Hospital of Philadelphia
Epstein-Barr Virus (EBV) Infections, Lymphoproliferative Disorders
Expanded Access Protocol for Tabelecleucel for Patients With Epstein-Barr Virus-Associated Viremia or Malignancies
The primary objective of this protocol is to provide expanded access to tabelecleucel to participants with Epstein-Barr virus-associated diseases and malignancies for whom there are no other appropriate therapeutic options, and…
- Conditions
- Epstein-Barr Virus (EBV) Infections, Lymphoproliferative Disorders, EBV+ Associated Lymphoma, EBV+ Associated Post-transplant Lymphoproliferative Disease (EBV+ PTLD)
- Trial name
- NCT02822495
- Testing
- tabelecleucel
- Sponsor
- Atara Biotherapeutics
Cervical Cancer
Protecting Young Special Risk Females From Cervical Cancer Through Human Papilloma Virus (HPV) Vaccination
A research project is currently being undertaken looking at Human Papilloma Virus (HPV) vaccination in special risk groups. It aims to see if young women with a chronic illness respond well to the HPV vaccine or whether they may…
- Trial name
- HPV (NCT00964210)
- Testing
- Licensed quadrivalent HPV vaccine, Gardasil
- Where
- Australia
- Volunteers
- 240 people
- Sponsor
- Murdoch Childrens Research Institute
Chronic Kidney Disease, Autoimmune Diseases
Capillary Sampling in Clinical Populations Undergoing Monitoring
Many people with long-term health conditions require regular blood tests to monitor their disease or medications. These blood tests are usually performed by taking blood from a vein during a hospital or clinic appointment.
- Conditions
- Chronic Kidney Disease, Autoimmune Diseases, Solid Organ Transplant Recipients
- Trial name
- CAPSICUM (NCT07802665)
- Testing
- Blood sampling with capillary sampling device(s)
- Volunteers
- 1,000 people
- Sponsor
- University of Edinburgh
Solid Organ Transplant Complications
Microbiota Transplantation in Solid Organ Transplantation
Solid organ transplantation (SOT), an alternative therapy for end-stage diseases, offers increased longevity and better quantity of life.
- Trial name
- NCT06730451
- Testing
- Washed Microbiota Transplantation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Epstein-Barr Virus (EBV)-Associated Diseases, EBV+ Lymphoproliferative Disease With Primary Immunodeficiency (EBV+ PID LPD)
A Study to Evaluate Tabelecleucel in Participants With Epstein Barr Virus (EBV) Associated Diseases
The purpose of this study is to assess the efficacy and safety of tabelecleucel in participants with EBV-associated diseases.
- Conditions
- Epstein-Barr Virus (EBV)-Associated Diseases, EBV+ Lymphoproliferative Disease With Primary Immunodeficiency (EBV+ PID LPD), EBV+ Lymphoproliferative Disease With Acquired (Non-congenital) Immunodeficiency (EBV+ AID LPD), EBV+ Posttransplant Lymphoproliferative Disease in Central Nervous System (EBV+ CNS PTLD)
- Trial name
- NCT04554914
- Testing
- Tabelecleucel
- Where
- 40 sites in United States, Austria and 5 more
- Volunteers
- 190 people
- Sponsor
- Pierre Fabre Medicament
RENAL INSUFFICIENCY, CHRONIC, LIVER FAILURE, ACUTE
Safety and Efficacy of ProQuad® in Children 6-24 Month Being Evaluated for Solid Organ Transplant
A prospective, multisite study to evaluate the Impact of Measles, Mumps, Rubella and Varicella ProQuad® vaccination in pediatric patients 6-24 months of age who are being considered and/or evaluated for any solid organ transplant…
- Conditions
- RENAL INSUFFICIENCY, CHRONIC, LIVER FAILURE, ACUTE, HEART DISEASE
- Trial name
- ProQuad® (NCT02687763)
- Testing
- ProQuad
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Medical University of South Carolina