Clinical trials: Sialorrhea
Sialorrhea, Spastic Cerebral Palsy (sCP)
Effect of SCS Technique on Oromotor Skills in Children With CP
This study evaluates the clinical efficacy of the Strain Counter-Strain (SCS) technique on improving oromotor functions in children with spastic cerebral palsy.
- Conditions
- Sialorrhea, Spastic Cerebral Palsy (sCP), Strain Counterstrain Technique, Oral Motor Functions
- Trial name
- NCT07516860
- Testing
- Strain Counter-Strain (SCS), Designed Oral Motor Program
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Cerebral Palsy (CP)
Local Vibration for Drooling in Children With Cerebral Palsy
This randomized-controlled trial evaluates local vibration therapy for drooling and orofacial muscle biomechanics in children with cerebral palsy.
- Trial name
- NCT07626424
- Testing
- Local Vibration Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Bitlis Eren University
Drooling, Brain Injuries
Botulinum Toxin Injections Into the Salivary Glands of Cerebrospinal Children With Chronic Sialorrhea
French Health Authority describes sialorrhea (or drooling) as uncontrolled loss of saliva through the lips. Drooling is considered pathological after the age of three.
- Conditions
- Drooling, Brain Injuries, Chronic Sialorrhea, Children, Only
- Trial name
- SIALOBOT (NCT07067762)
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Cerebral Palsy, Neurological Conditions
Safety and Efficacy Study of Oral Glycopyrrolate Liquid for the Treatment of Pathologic (Chronic Moderate to Severe) Drooling in Pediatric Patients 3 to 18 Years of Age With Cerebral Palsy or Other Neurologic Conditions
This is an open-label clinical research study of an oral glycopyrrolate liquid for the treatment of chronic moderate to severe drooling in patients with cerebral palsy or other neurological conditions.
- Conditions
- Cerebral Palsy, Neurological Conditions, Mental Retardation, Sialorrhea
- Trial name
- NCT00491894
- Testing
- Oral Glycopyrrolate Liquid
- Where
- 7 sites in United States
- Volunteers
- 137 people
- Sponsor
- Shionogi
Sialorrhea
Ipratropium Bromide Spray as Treatment for Sialorrhea in Children
Double-blind, clinical trial investigating the effects of ipratropium spray versus placebo spray in children with sialorrhea
- Trial name
- NCT03747536
- Testing
- Ipratropium bromide
- Volunteers
- 30 people
- Sponsor
- London Health Sciences Centre
Adenocarcinoma of the Prostate
Pilot Study of DRibble Vaccine for Prostate Cancer Patients
This is a pilot study of the DRibble vaccine in patients with advanced prostate cancer.
- Trial name
- DRibble (NCT02234921)
- Testing
- Cyclophosphamide, DRibble Vaccine, HPV Vaccinations
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- UbiVac
Transcutaneous Vagal Nerve Stimulation (tVNS), Parkinson Disease (PD)
Effects of Transcutaneous Vagus Nerve Stimulation in Parkinson´s Disease
This study aims to determine whether electrical stimulation of the ear, when combined with physical and speech therapy, can improve symptoms in subjects diagnosed with Parkinson´s disease, by comparing two different application…
- Trial name
- tVNS_PD (NCT07588191)
- Testing
- Transcutaneous Electrical Nerve Stimulation (TENS) of Vagus Nerve, Conventional Physical therapy, Conventional Speech Therapy
- Where
- Spain
- Volunteers
- 46 people
- Sponsor
- Universidade da Coruña
Executive Function (Cognition), Soccer Training
Cognitive-Integrated Soccer Training and Performance
This study will examine whether an 8-week soccer-specific cognitive-motor training program can improve executive functions, decision-making, and soccer skill performance in youth soccer players.
- Conditions
- Executive Function (Cognition), Soccer Training, Performance, Motor Development
- Trial name
- NCT07284940
- Testing
- Cognitively Engaging Soccer Practice, Conventional Soccer Practice
- Where
- China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Fan Mao
Cerebral Palsy (CP), Drooling
Effectiveness of Neuromuscular Electrical Stimulation Added to Oral Motor Therapy in Cerebral Palsy
This randomized, controlled, single-blind trial aims to investigate the effectiveness of neuromuscular electrical stimulation (NMES) combined with oral motor therapy in reducing drooling severity among children with cerebral…
- Trial name
- NOMES-CP (NCT07069257)
- Testing
- Oral Motor Therapy, Neuromuscular Electrical Stimulation (NMES)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Aslinur Keles Ercisli, MD, PhD
Sialorrhea
Botulinum Toxin Injection for Sialorrhea in Cerebral Palsy
A 100 units of botulinum toxin was injected in both parotid and submandibular glands for children (2 - 12 years) with incapacitating sialorrhea in juvenile cerebral palsy patients and they are followed up for 1 year
- Trial name
- NCT06101160
- Testing
- onaBoNT-A
- Where
- Egypt
- Volunteers
- 61 people
- Sponsor
- Cairo University
Crossbite, Openbite
Implications of Pacifier Use in Israeli Children
The purpose of this study is to examine pacifier sucking habits among children, and to assess implications of the oral habit - for example malocclusions and drooling.
- Conditions
- Crossbite, Openbite, Drooling
- Trial name
- NCT01249885
- Where
- Israel
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Mastication Disorder
Effect of Functional Chewing Training on Tongue Thrust and Drooling in Children With Cerebral Palsy
This study examined the effect of Functional Chewing Training(FuCT) on tongue thrust and drooling in children with cerebral palsy.
- Trial name
- NCT03194048
- Testing
- Functional Chewing Training, Classical Oral Motor Exercises
- Volunteers
- 32 people
- Sponsor
- Hacettepe University
Mollii Suit, Cerebral Palsy
Effects of Mollii Suit in Children With Non-Ambule Cerebral Palsy
The aim of our study is to examine the effectiveness of the Mollii Suit application on gross motor function, spasticity, postural control, upper extremity skills, selective motor control, daily living activities, quality of life…
- Trial name
- NCT06259864
- Testing
- EXOPULSE Mollii Suit method
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Kırıkkale University
Autism Spectrum Disorder, Chewing Problem
Oral Structural and Functional Problems in Children With Autism
This study aims to examine oral structural and functional problems in children with autism.
- Conditions
- Autism Spectrum Disorder, Chewing Problem, Drooling
- Trial name
- NCT06355141
- Testing
- oral assessment
- Volunteers
- 90 people
- Sponsor
- Hacettepe University
Cerebral Palsy, Drooling
Validation of the French Version of the Drooling Impact Scale in a Pediatric Cerebral Palsy Population
The aim of this study is to present the French translation of the Drooling Impact Scale (DIS-F) and to explore its validity, reliability and responsiveness to change in a group of children with Cerebral Palsy (CP)
- Trial name
- NCT03986333
- Where
- 6 sites in France
- Volunteers
- 55 people
- Sponsor
- Centre Médico-Chirurgical de Réadaptation des Massues Croix Rouge Française
Hypersalivation, Cerebral Palsy
Turkish Validation of The Drooling Impact Scale
The aim of this study is to investigate the reliability and construct validity of the Turkish version of the Drooling Impact Scale in children with cerebral palsy
- Trial name
- NCT04132765
- Testing
- Drooling Impact Scale, Drooling Frequency and Severity Scale, The Caregiver Priorities and Child Health Index of Life with Disabilities (CPCHILD™)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Marmara University
Drooling
Effectiveness of Kinesiotaping and Manipulation Therapies in Drooling Management Among Children With Oral Dysphagia
Children suffering from neurological problems may have a common problem of drooling and dysphagia.There is high prevelance of neurological disorders in developing countries including Pakistan.Parents of children with disability…
- Trial name
- NCT04266626
- Testing
- kinesiotaping therapy, oral motor manipulation therapy
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Isra University
Chronic Troublesome Sialorrhea, Cerebral Palsy
Clinical Study to Investigate the Efficacy and Safety of NT 201 Compared to Placebo in the Treatment of Chronic Troublesome Drooling Associated With Neurological Disorders and/or Intellectual Disability
The objective of this study is to investigate the efficacy and safety of NT 201 compared with placebo for the treatment of chronic troublesome sialorrhea associated with neurological disorders (e.g.
- Conditions
- Chronic Troublesome Sialorrhea, Cerebral Palsy, Stroke, Traumatic Brain Injury
- Trial name
- SIPEXI (NCT02270736)
- Testing
- NT 201
- Where
- 31 sites in Georgia, Hungary and 4 more
- Volunteers
- 256 people
- Sponsor
- Merz Pharmaceuticals GmbH
Sialorrhea
Effectiveness of Atropine and Glycopyrrolate to Reduce Hyper Salivation With Ketamine Sedation
The purpose of this study is to determine if the antisialagogues (anti-salivary agents), Atropine and Glycopyrrolate, are effective in reducing hypersalivation when sedating patients with Ketamine for procedural sedation in the…
- Trial name
- NCT01191398
- Testing
- Atropine (0.01mg/kg), Glycopyrrolate (0.01mg/kg), Normal saline 0.9%
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Craig J. Huang
Sialorrhea, Neurodevelopmental Disorders
Double-blind, Placebo-controlled, Randomized Clinical Trial Comparing the Efficacy and Safety of Sialanar Plus orAl rehabiLitation Against Placebo Plus Oral Rehabilitation for chIldren and Adolescents With seVere Sialorrhoea and Neurodisabilties,
Double blind, placebo-controlled, randomised trial, multicentre in France with open-label tolerability phase. The double-blind placebo-controlled study duration will be scheduled for 3 months with the final visit of the…
- Trial name
- SALIVA (NCT04873115)
- Testing
- Sialanar, Oral Rehabilitation
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Proveca Pharma Limited