Clinical trials: Sedative
Respiratory Insufficiency, Overdose of Opiate
ARM-ED: Advanced Respiratory Monitoring Events in Drug Toxicity
There is a drug-related death crisis in Scotland. The majority of these deaths have involved the misuse of opiates (e.g. heroin) and benzodiazepines (e.g. valium) which cause an individual to stop breathing.
- Conditions
- Respiratory Insufficiency, Overdose of Opiate, Sedative Overdose, Sedative Toxicity
- Trial name
- ARM-ED (NCT05358132)
- Testing
- Pneumowave Device placement and data capture
- Where
- United Kingdom
- Volunteers
- 78 people
- Sponsor
- NHS Greater Glasgow and Clyde
PTSD, Psychiatric Illness
Killing Pain - Use of Analgesic, Sedative and Anxiolytic Medication and the Development of Psychiatric Illness in Adolescents
Prescription of analgesic, sedative, and anxiolytic medication for children and adolescents is increasing in Western countries. In recent decades, rates have also increased in Norway, despite a relatively restrictive prescription…
- Conditions
- PTSD, Psychiatric Illness, Prescription Drug Dependence, Addiction
- Trial name
- NCT04336605
- Testing
- Age & Development, Socioeconomy, Traumatic Events
- Where
- Norway
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Norwegian Center for Violence and Traumatic Stress Studies
Anxiety
Improving Sedation of Children Undergoing Procedures in the Emergency Department
Lacerations (deep cuts) are a frequent cause of visits to emergency departments and laceration repair is one of the most common procedures performed in that setting.
- Trial name
- NCT00675909
- Testing
- Aerosolized Intranasal midazolam, Aerosolized Buccal Midazolam, Oral midazolam
- Volunteers
- 180 people
- Sponsor
- Seattle Children's Hospital
Pain, Postoperative
Evaluate Analgesic/Sedative Efficacy of Naproxen Sodium and Diphenhydramine in Patients With Postsurgical Dental Pain
The objective of the study is to evaluate the efficacy and safety of a single oral dose of two dose combinations of naproxen sodium and diphenhydramine (DPH) to demonstrate that naproxen sodium/DPH combination provides added…
- Trial name
- Morpheus II (NCT01280591)
- Testing
- Naproxen sodium 440 mg / DPH 50 mg (BAY98-7111), Naproxen sodium 220 mg / DPH 50 mg (BAY98-7111), Naproxen sodium 440 mg (BAYH6689)
- Where
- 2 sites in United States
- Volunteers
- 712 people
- Sponsor
- Bayer
Hypnotics and Sedatives, Addiction
Monitoring and Risk Prediction of Iatrogenic Sedative Hypnotics Addiction in a Shanghai Psychiatric Hospital
This study will establish a sedative and hypnotics iatrogenic addiction risk monitoring network composed of 4 psychiatric hospitals in Shanghai through standardized data construction of outpatient prescription data and personnel…
- Trial name
- NCT04504162
- Volunteers
- 100,000 people
- Sponsor
- Shanghai Mental Health Center
Withdrawal Syndrome
Protocolized Sedative Weaning VS. Usual Care in Pediatric Critically Ill, RCT
Sedative and analgesic agents are widely used in the ICU. These agents can provide hypnotic effect, pain alleviation, cooperation, and synchronizing ventilatory support.
- Trial name
- NCT03018977
- Testing
- The sedative weaning protocol group, The usual group
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Ramathibodi Hospital
Noise Exposure, Sedative Withdrawal Delirium
Sound Levels in the Pediatric Cardiac Critical Care Unit and Their Correlation With Sedation Administration, Delirium Scores and Patient Heart Rate
There is limited data regarding sound levels and burden in the pediatric cardiac critical care unit and how this compares with WHO standards.
- Conditions
- Noise Exposure, Sedative Withdrawal Delirium, Sedative Toxicity
- Trial name
- NCT04777695
- Testing
- Decibel Monitor
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Children's National Research Institute
Anesthesia
Effect of Sedative and Anxiolytic Premedication on Children Experience After General Anesthesia
Children undergoing general anesthesia for surgery commonly need sedative and anxiolytic premedication but little clinical evidence supports is benefit for children older than 7 years old.
- Trial name
- pediaPREM (NCT05681572)
- Testing
- Midazolam, Dexmedetomidine
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Montpellier
Conscious Sedation
Effects of Oral Midazolam in Comparison Promethazine With Nitrous Oxide for Uncooperative Children
The purpose of this study is to compare the safety and efficacy of sedation using orally administered midazolam and promethazine with nitrous oxide/oxygen in uncooperative children receiving dental treatments.
- Trial name
- NCT01118884
- Testing
- Promethazine
- Where
- Iran
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University
Choosing Better Drug Option for Sedation in Pediatric Population Intraoperatively
Comparison of Sedative Effect of Dexmedetomidine and Midazolam for TIVA
Comparison of sedative effects of dexmedetomidine and midazolam using ramsay sedation scores intraoperatively in children undergoing inguinal hernia repair.
- Trial name
- NCT05574179
- Testing
- Dexmedetomidine injection, Midazolam
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sheikh Zayed Medical College
Pain, Postoperative
Evaluate Analgesic / Sedative Efficacy of Naproxen Sodium and Diphenhydramine in Patients With Postsurgical Dental Pain
The objective of the study is to evaluate the efficacy and safety of a single oral dose of naproxen sodium 440 mg in combination with DPH (diphenhydramine) 25 mg in subjects with postsurgical dental pain and phase advanced sleep.
- Trial name
- Morpheus/DPH (NCT01495858)
- Testing
- Naproxen Sodium 440 mg / DPH 25 mg (BAY98-7111), Naproxen Sodium 440 mg (BAYH6689), DPH 50 mg
- Where
- 2 sites in United States
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- Bayer
Pediatric Solid Tumor, Pediatric Brain Tumor
Effects of Music and Maternal Voice on Sedation Depth and Sedative Use During Pediatric Magnetic Resonance Imaging.
To evaluate the effects of music and maternal voice in children on sedation depth and sedative use during pediatric magnetic resonance imaging.
- Conditions
- Pediatric Solid Tumor, Pediatric Brain Tumor, Pediatric Cancer
- Trial name
- NCT04944875
- Testing
- Group headphone, Group music, Group maternal voice
- Where
- Turkey (Türkiye)
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Analgesic, Sedative
Analgesic and Sedative Effect of Fentanyl Versus Dexmedetomidine Infusion in Post-Operative Mechanically Ventilated Children After Open Abdominal Surgeries
This study aimed to compare the efficacy and safety of fentanyl versus dexmedetomidine infusion in this population.
- Conditions
- Analgesic, Sedative, Fentanyl, Dexmedetomidine
- Trial name
- NCT06994273
- Testing
- Fentanyl, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Tanta University
Intensive Care, Neonatal, Analgesia
Clonidine for Analgesia to Preterm Infants During Neonatal Intensive Care
A prospective pharmacokinetic (PK), pharmacodynamic (PD) and pharmacogenetic (PG) observation study, including the PK/PD/PG relationship, in clonidine administered for analgesia and sedation to preterm newborn infants receiving…
- Conditions
- Intensive Care, Neonatal, Analgesia, Hypnotics and Sedatives
- Trial name
- NCT04928651
- Testing
- Clonidine
- Where
- 2 sites in Sweden
- Volunteers
- 40 people
- Sponsor
- Region Skane
Sedation
Intranasal Midazolam in Children as a Pre-Operative Sedative - Part 2
Midazolam is often given before surgery to sedate a patient before anesthesia is given. Children are often given a small dose either by mouth or squirted into the nose.
- Trial name
- NCT02356705
- Testing
- Midazolam, xylocaine
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Jennifer Victory, RN, CCRC
Dexmedetomidine, Midazolam
Intranasal Dexmedetomidine Versus Intranasal Midazolam for MRI In Pediatrics
An increasing number of studies have reported the use of dexmedetomidine in clinical practice. However, few studies have reported on the intranasal use of dexmedetomidine in radiological procedures The aim of this work is to…
- Conditions
- Dexmedetomidine, Midazolam, MRI, Pediatrics
- Trial name
- NCT04652661
- Testing
- Dexmedetomidine, Midazolam
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Dental Surgeries
Comparison of Nebulized Fentanyl, Midazolam and Dexmedetomidine as a Premedication in Pediatric Dental Surgeries
The preoperative time can be traumatic for young children undergoing surgery. Pediatric anesthesiologists act strongly to decrease distress for children in the operating room (OR) and to provide a smooth induction of anesthesia.
- Trial name
- NCT04226885
- Testing
- fentanyl, midazolam, dexmedetomidine
- Where
- Egypt
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Used to Induce and Implement General Anesthesia in Combination With Sedative Anesthetics (Such as Propofol)
Pharmacokinetics, Safety and Efficacy of HR020602 Injection in Children Undergoing General Anesthesia
This study is divided into two stages: the first stage is a dose verification trial, with a multicenter, open, single arm trial design, which is planned to enroll 10 children with general anesthesia surgery (all using HR020602…
- Trial name
- NCT04867343
- Testing
- HR020602 injection, fentanyl injection ； remifentanil injection
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Anesthesia
Hypnoanalgesia for Dermatological Surgery in Children
This randomized clinical trial will evaluate the effect of hypnosedation on the need of sedation and analgesia in a pediatric population undergoing dermatological surgery, both during the procedure, and 24 hours after surgery.
- Trial name
- NCT04707014
- Testing
- Hypnosis, Attention-distracting techniques
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- Complejo Hospitalario de Toledo
Sedative; Anxiety Disorder
Intranasal Remimazolam for Premedication in Pediatric Patient
Anesthetic inhalation induction could be one of the most stressful experiences for children during the perioperative period, with almost 50% of them showing anxiety.
- Trial name
- NCT04720963
- Testing
- Remimazolam, Distilled water for injection, Dexmedetomidine
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University