Clinical trials: Sedation
Prematurity, Magnetic Field Exposure
Lateral Position MRI in Preterm Infants, an Observational Study
The goal of this observational study is to evaluate safety of sedation in lateral position in premature babies undergone MRI. The main question it aims to answer are: number of apneas during sedation Maintenance of eupnea during…
- Conditions
- Prematurity, Magnetic Field Exposure, Sedation Complication
- Trial name
- MRIOPS (NCT05776238)
- Where
- Italy
- Volunteers
- 22 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Anesthesia Intubation Complication, Premature Birth of Newborn
Optimizing Propofol Dosing for (Preterm) Newborn Infants That Need Endotracheal Intubation
Newborns admitted to an intensive care unit often require artificial ventilation. For that purpose an endotracheal tube needs to be placed into the trachea, a procedure named endotracheal intubation.
- Conditions
- Anesthesia Intubation Complication, Premature Birth of Newborn, Other Preterm Infants, Propofol Overdose
- Trial name
- NEOPROP2 (NCT02040909)
- Testing
- Propofol
- Where
- 3 sites in Netherlands
- Volunteers
- 91 people
- Sponsor
- Erasmus Medical Center
Cardiac Surgical Procedures
Pharmacokinetics and Pharmacodynamics of Pentobarbital in Neonates, Infants, and Children Following Open Heart Surgery
This medication is used for procedural sedation and sedation for diagnostic imaging. The purpose of this study is to find out what happens to pentobarbital in the body after it is given to children who have had heart surgery.
- Trial name
- NCT00577434
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Children's Hospital of Philadelphia
Dental Sedation
Intranasal Versus Nebulized Midazolam in Behaviuor Modification of Preschool Children Undergoing Dental Treatment
The aim of the current study is to compare the effect of intranasal versus nebulized route of administration of midazolam as moderate sedative agents in preschoolers undergoing dental treatment.
- Trial name
- NCT05883150
- Testing
- Nebulized Midazolam, Intranasal Midazolam
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Nourhan M.Aly
Brugada Syndrome (BrS), Ventricular Arrhythmia
Prospective Multicentre Observational Registry of Peri-procedural Anaesthesia, Sedation and Related Medication Exposure in Patients With Brugada Syndrome
The goal of this observational study is to evaluate the perioperative risk of malignant ventricular arrhythmias in adult patients diagnosed with Brugada Syndrome undergoing anaesthetic procedures.
- Conditions
- Brugada Syndrome (BrS), Ventricular Arrhythmia, Anesthesia, Sedation
- Trial name
- PROSP_BRUGANAE (NCT07655102)
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Hospital Clinic of Barcelona
Sedation, Pediatric Anesthesia
Frequency of Adverse Events in Pediatric Patients Receiving Sedation for Magnetic Resonance Imaging
Introduction:The application of anesthesia outside the operating room for pediatric patients has increased in recent years. For diagnostic and treatment follow-up purposes, magnetic resonance imaging (MRI) requires the pediatric…
- Conditions
- Sedation, Pediatric Anesthesia, Magnetic Resonance Imaging, Adverse Effect
- Trial name
- NCT06467045
- Testing
- Pediatric patients who received sedation for magnetic resonance imaging
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Undesired Intrauterine Pregnancy, First Trimester Pregnancy
Trial Comparing Intravenous and Oral Moderate Sedation for First Trimester Surgical Abortions
In the United States, the majority of first-trimester surgical abortions are performed in outpatient clinics that utilize a wide variety of oral and intravenous regimens for pain control.
- Trial name
- NCT01011634
- Testing
- Intravenous moderate sedation versus oral medication
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Sedation
Use of Clonidine to Prevent Withdrawal Following Prolonged Dexmedetomidine Infusions
The investigators' clinical practice makes use of oral clonidine as a means of transitioning from intravenous dexmedetomidine following prolonged infusions (more than 3-5 days).
- Trial name
- NCT02404077
- Testing
- Clonidine
- Volunteers
- 712 people
- Sponsor
- Joseph D. Tobias
Delirium
The ABCDEF Bundle in Critical Care: a French National Survey Still a Long Way to go!
The goal of this observational study is to evaluate the knowledge and compliance of French intensive care units with the ABCDEF (A: Assessment, Prevention, Management of Pain, B: Both Spontaneous Awakening Trials and Spontaneous…
- Trial name
- NCT06344013
- Where
- France
- Volunteers
- 341 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Pain Management, Endoscopy, Gastrointestinal
Construction and Effectiveness Evaluation of Painless Digestive Endoscopy Mode Led by Anesthesia Nurses Under the Guidance of Anesthesiologists
The purpose is to verify the effectiveness and safety of the painless digestive endoscopy mode led by anesthesia nurses under the guidance of anesthesiologists.
- Trial name
- NCT06712264
- Where
- China
- Volunteers
- 18,000 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Dental Pain
Buffered Local Anesthetic
The purpose of this research study is to compare responses in children during dental injections of local anesthetic (used for numbing), while children are under deep sedation (breathing on their own, often with a loss of…
- Trial name
- NCT05757648
- Testing
- Non-buffered Anesthetic, Buffered Anesthetic, Onset
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Anxiety, Anesthesia
The Association Between Parent Anxiety and Sedation Anesthesia Doses in Pediatric Endoscopy
Our study was planned as a prospective, single-center study between 20 January 2022 and 20 April 2022. All patients between the ages of 1-18 who will undergo upper or lower gastrointestinal endoscopy and their parents will be…
- Trial name
- NCT05210829
- Testing
- stationary and trait anxiety scale
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Preoperative Anxiety, Preoperative Sedation
Determination of ED50 and ED95 With Clinical Efficacy of Intranasal Dexmedetomidine Combined With Esketamine for Preoperative Sedation in Pediatric General Anesthesia
For pediatric patients undergoing general anesthesia, poor anesthesia induction compliance often has adverse effects on individual behavior in the early postoperative period.
- Conditions
- Preoperative Anxiety, Preoperative Sedation, Children, Dexmedetomidine
- Trial name
- NCT06853431
- Testing
- dexmedetomidine, Esketamine
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Heart Diseases
Pharmacokinetic Study of Dexmedetomidine After Intra-Nasal and Buccal Dosing in Children
This research study is a continuation of a previous DEX PK study. It is examining the absorption of Dexmedetomidine (DEX) in the blood when given orally and as a nasal spray.
- Trial name
- DexPK (NCT03668951)
- Testing
- Dexmedetomidine buccal, Dexmedetomidine Intranasal
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Sedation and Analgesia, Side Effect of Drug
The Effect of Ondansetron During Intramuscular Ketamine Use in Children: A Trial in Emergency Department
The purpose of this study is to evaluate the anti-emetic effect of oral ondansetron. For this evaluation, the investigators will perform a multi-center, double-blind, placebo-controled, randomized study.
- Trial name
- NCT01477242
- Testing
- Ondansetron
- Where
- South Korea
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Malignant Neoplasm
Video Distraction to Decrease Use of Sedation in Pediatric Participants During Radiation Therapy
This phase I pilot trial studies how well video distraction works to decrease the use of sedation in pediatric participants during radiation therapy. Radiation treatment requires participants to lie very still (for accuracy).
- Trial name
- NCT03677531
- Testing
- Quality-of-Life Assessment, Questionnaire Administration, Radiation Therapy
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- OHSU Knight Cancer Institute
EEG With Periodic Abnormalities, Child, Only
Performance of EEG in Children With Medical Clowns
EEG is an important test in the diagnosis epilepsy. The test does not hart, however many electrodes are attached to the child's scalp and situation is stressful.
- Trial name
- MECLEES (NCT05257096)
- Testing
- Medical clown
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Bnai Zion Medical Center
Procedural Sedation
Dexmedetomidine Versus Chloral Hydrate for Pediatric Sedation During EEG
The purpose of the study is: 1. To compare the efficacy of dexmedetomidine versus chloral hydrate as pediatric sedation agents for EEG studies.
- Trial name
- NCT00464451
- Testing
- Dexmedetomidine, Chloral hydrate
- Where
- United States
- Sponsor
- Wesley Medical Center
Sedation Complication, Mechanical Ventilation in Neonates
Pharmacokinetics-pharmacodynamics of Morphine With or Without Midazolam Administered by Continuous Infusion in Neonatal Intensive Care
This study aims to describe a dose-effect relationship of morphine alone and morphine and midazolam administered as continuous infusion in neonates hospitalized in Neonatal intensive care unit and undergoing mechanical…
- Trial name
- NCT05371886
- Testing
- Dose-effect relationship of morphine +/- midazolam administration
- Where
- 5 sites in France
- Volunteers
- 180 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Anesthesia
Airway Evaluation by McGrath Videolaryngoscope
Difficult tracheal intubation is a cause of severe patient damage and death. There is not a good method to predict it. The McGrath Series 5 video laryngoscope can improve visualization of the glottic structures one to two grades.
- Trial name
- NCT01824914
- Testing
- McGrath Videolaryngoscope
- Where
- China
- Volunteers
- 97 people
- Sponsor
- Huazhong University of Science and Technology