Clinical trials: Sarcoidosis
Sarcoid Uveitis
(ACTH) for the Treatment of Sarcoid Uveitis
Sarcoidosis is a multisystem granulomatous disease that can affect nearly any organ in the body. While most commonly affecting the lungs, vision threatening eye involvement occurs in approximately 25% of patients with sarcoid.
- Trial name
- ACTH (NCT03473964)
- Testing
- H.P. Acthar gel
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- John Huang, MD
Sarcoidosis
Validation of a Non-invasive Diagnostic Method for Sarcoidosis Using Exhaled Breath
Sarcoidosis is a chronic lung disease that is characterized by fatigue, shortness of breath, chest pain and reduced lung function. Suffering from these diseases has a very negative effect on the quality of life.
- Trial name
- NCT02361281
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Sarcoidosis
Registry for Advanced Sarcodiosis
Registry with evaluation and genetic information of patients with advanced sarcoidosis and matched sarcoidosis
- Trial name
- REAS (NCT03769987)
- Testing
- observation
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- University of Cincinnati
Emphysema, Chronic Obstructive Pulmonary Disease (COPD)
Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability
The purpose of this research study is to learn about the safety of transplanting lungs obtained from non-heart-beating donors (NHBDs) that have been ventilated (attached to a breathing machine or ventilator to deliver oxygen) and…
- Conditions
- Emphysema, Chronic Obstructive Pulmonary Disease (COPD), Cystic Fibrosis, Pulmonary Fibrosis
- Trial name
- NCT01615484
- Testing
- Transplantation of lungs obtained from Non-Heart-Beating Donors (NHBDs) after ex-vivo perfusion w/ STEEN Solution™, STEEN Solution™
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- University of North Carolina, Chapel Hill
Sarcoidosis
Clinical and Genetic Study of Familial Sarcoidosis (SARCFAM)
Major impacts of air pollution are lung diseases such as granulomatous diseases and mainly sarcoidosis. Understanding the respective role of inorganic / nanoparticles and genetic background in these chronic diseases is a major…
- Trial name
- SARCFAM (NCT02829853)
- Testing
- Genetic analysis by SANGER and WHOLE EXOME NEXT GENERATION SEQUENCING
- Where
- France
- Volunteers
- 800 people
- Sponsor
- Hospices Civils de Lyon
Sarcoidosis
A Study to Evaluate the Efficacy and Safety of Fenestrated Cup Forceps Versus Fenestrated Alligator Forceps for Performing Transbronchial Lung Biopsy in Patients With Sarcoidosis
Sarcoidosis is a systemic disease that results from granulomatous inflammation that involves multiple body organs. The diagnosis requires the presence of compatible clinicoradiological features along with histologic evidence that…
- Trial name
- NCT02405897
- Testing
- Cup forceps, Alligator forceps
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Danon Disease, Fabry Disease
Precision Diagnosis and Risk Stratification of Rare Cardiomyopathies Based on Novel Cardiac Magnetic Resonance Techniques
What is this study about? This research is focused on improving the care for people with rare heart muscle diseases, known as rare cardiomyopathies.
- Conditions
- Danon Disease, Fabry Disease, Cardiac Amyloidosis, Noonan Syndrome
- Trial name
- NCT07336394
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Sarcoidosis, Mediastinal Diseases
Endobronchial Ultrasonography in the Diagnosis of Sarcoidosis
Sarcoidosis is a benign, inflammatory condition which will typically involve the lungs and lymph glands in the chest. Diagnosis is often confirmed with bronchoscopic biopsy.
- Trial name
- NCT00373555
- Testing
- Bronchoscopy
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Calgary
Diabetes Mellitus, Sarcoidosis
Salivary Proteins in Disease and Health
This study will examine saliva samples from healthy volunteers and patients with various diseases to learn more about how disease affects the mouth and salivary glands.
- Conditions
- Diabetes Mellitus, Sarcoidosis, Dental Caries, Sjorgren's Syndrome
- Trial name
- NCT00100204
- Where
- United States
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Sarcoidosis-associated Ocular Inflammation
Diagnostic Yield of Vitreous Biopsy in Sarcoid Uveitis
The usefulness of diagnostic vitrectomy in patients with suspected sarcoidosis with posterior segment involvement (in whom a diagnosis cannot be determined by conventional methods) has not been well described.
- Trial name
- NCT00609687
- Testing
- Diagnostic Vitrectomy
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Duke University
Sarcoidosis
Gammaglobulins Level is Predictive Factor of Evolution in Sarcoidosis
Evaluation of the rate of achievement of serum protein electrophoresis (PPE) in diagnosis in a retrospective cohort of patients at Rennes University Hospital
- Trial name
- GAMES (NCT03259282)
- Testing
- Analysis of gamma globulin
- Where
- France
- Volunteers
- 78 people
- Sponsor
- Rennes University Hospital
Sarcoidosis, Uveitis
Eye and Immunogenetic Features of Sarcoidosis
This study will evaluate patients with sarcoidosis to understand how the disease affects the body. Sarcoidosis is a disease that results from inflammation of body tissues.
- Trial name
- NCT00379275
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Eye Institute (NEI)
Lung Diseases, Sarcoidosis
Genetic Epidemiology of Sarcoidosis
To determine if hereditary susceptibility predisposes African Americans to sarcoidosis and to identify sarcoidosis susceptibility genes in African Americans.
- Trial name
- NCT00005531
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Choroiditis, Iridocyclitis
Evaluation and Treatment of Patients With Inflammatory Eye Diseases
This study offers evaluation and treatment for patients with inflammatory eye diseases, such as uveitis. The protocol is not designed to test new treatments; rather, patients will receive current standard of care treatments.
- Conditions
- Choroiditis, Iridocyclitis, Iritis, Retinal Disease
- Trial name
- NCT00006188
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- National Eye Institute (NEI)
Sarcoidosis
ACTHAR Therapy for Central Nervous System Sarcoidosis
There is a need for a more reliable, expeditious therapy that can be used as an alternative to glucocorticoids in severe Central Nervous System (CNS) sarcoidosis.
- Trial name
- NCT02920710
- Testing
- Repository Corticotropin Injection
- Where
- United States
- Sponsor
- The Cleveland Clinic
Tuberculosis, Sarcoidosis
TB and Sarcoidosis Granuloma
Tuberculosis (TB) and sarcoidosis are both granulomatous diseases. Here we compared the immunological micro-environments of granulomas from TB and sarcoidosis patients using in situ sequencing (ISS) transcriptomic analysis and…
- Trial name
- NCT06396910
- Testing
- Spatial transcriptomics
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Karolinska Institutet
Sarcoidosis, Pulmonary
RCT of Nintedanib in Fibrotic Sarcoidosis
Sarcoidosis is generally managed with outdoor immune modulatory drugs, most commonly oral steroids and at times drugs like methotrexate or azathioprine as a steroid sparing agent.
- Trial name
- NINSARC (NCT06479603)
- Testing
- Nintedanib, Standard of care
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Sarcoidosis, Tuberculosis
The Serum Angiotensin Converting Enzyme and Lysozyme Levels in Patients Non-infectious and Infectious Uveitis
This study evaluates the significance of differences in serum angiotensin converting enzyme and lysozyme levels of patients with ocular involvement of other autoimmune inflammatory and infectious diseases.
- Trial name
- uveitis (NCT02627209)
- Testing
- spectrophotometric assay, radial immunodiffusion
- Where
- Turkey (Türkiye)
- Volunteers
- 280 people
- Sponsor
- Ozlem Sahin
Sarcoidosis, Tuberculosis
Efficacy of Antituberculous Therapy in Management of Sarcoidosis
From the time sarcoidosis has been described, there has always been a belief that the disease is in some way related to tuberculosis.
- Trial name
- NCT01245036
- Testing
- Antituberculous therapy along with steroids
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Sarcoidosis
Use of Immunosuppressive Therapy for Sarcoidosis
Retrospective review of the outcome of use of immunosuppressive drugs in treatment of sarcoidosis
- Trial name
- NCT02356445
- Testing
- Cytotoxic drug
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- University of Cincinnati