Clinical trials: Respiratory Viral Infections
Sepsis, Bacteraemia
Optimising Diagnosis and Antibiotic Prescribing for Acutely Ill Children in Primary Care
Acute illness is the most common presentation of children attending ambulatory care settings. Serious infections (e.g. meningitis, sepsis, pyelonephritis, pneumonia) are rare, but their impact is quite large (increased morbidity…
- Conditions
- Sepsis, Bacteraemia, Meningitis, Abscess
- Trial name
- ERNIE2 (NCT02024282)
- Testing
- Use of C-reactive protein (CRP) point of care test, Brief intervention and parent leaflet, Finger Pulse Oximeter
- Where
- 2 sites in Belgium
- Volunteers
- 8,962 people
- Sponsor
- KU Leuven
COVID-19, Sars-CoV-2 Infection
Efficacy, Immunogenicity, and Safety of TURKOVAC Vaccine Versus the CoronaVac Vaccine Against COVID-19 in Healthy Adolescent
This study is a multi-center, randomized, national, observer-blinded, active-controlled phase IIB clinical trial to determine the efficacy, immunogenicity, and safety of two-doses of inactive COVID-19 vaccine (TURKOVAC) vaccine…
- Trial name
- NCT05230940
- Testing
- TURKOVAC, CoronaVac
- Where
- 14 sites in Turkey (Türkiye)
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Health Institutes of Turkey
Bronchiolitis
Nebulized 5% Hypertonic Saline for the Treatment of Bronchiolitis
The investigators reasoned that a hypertonic saline concentration higher than 3% could be safe and more efficacious in the treatment of bronchiolitis, alleviating severe symptoms and preventing the need for hospitalization in…
- Trial name
- NCT01016249
- Testing
- Treatment 1. (5% Hypertonic saline + Epinephrine), Treatment 3. (3% Hypertonic saline + Epinephrine), Treatment 2. (Normal saline + Epinephrine)
- Where
- Qatar
- Volunteers
- 187 people
- Sponsor
- Hamad Medical Corporation
COVID19
Characteristics of Critically Ill COVID 19 Patients
COVID19 is n outbreak with unpredictable outcome
- Trial name
- NCT04465058
- Testing
- COVID19
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
COVID-19
Serum Level of Ferritin and D-dimer and the Severity of (COVID 19) Infection
Many laboratory biomarkers were used for diagnosis of COVID-19 infection; however, their accuracy to assess the severity and prognosis are still to be evaluated.
- Trial name
- NCT05672810
- Testing
- serum level of Ferritin and D-dimer
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Ain Shams University
COVID-19, SARS-COV-2 Infection
A Study to Learn About COVID-19 RNA-Based Variant-Adapted Vaccine Candidate(s) Against SARS-CoV-2 in Participants Ages 12 Through 64 Years Considered at Higher Risk of Severe COVID-19, and Participants Ages ≥65 Years
The purpose of this study is to learn about the safety, tolerability, and immunogenicity of an updated vaccine against COVID-19.
- Trial name
- NCT07069309
- Testing
- BNT162b2 (2025/2026 recommended SARS-CoV-2 strain)
- Where
- 19 sites in United States
- Volunteers
- 774 people, healthy volunteers welcome
- Sponsor
- BioNTech SE
Healthy Participants
Influenza Virus Vaccine Plus Vitamin A and D Supplements for Prevention of Respiratory Virus Infections in Children
Children are particularly vulnerable to respiratory virus infections, especially influenza. Vitamin A \& D deficiencies are associated with vulnerability to infectious diseases of the respiratory tract.
- Trial name
- NCT02649192
- Testing
- Influenza virus vaccine, Vitamins A and D
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Influenza
A Pharmacokinetic/Pharmacodynamic Study of Oseltamivir in Immunocompromised Children With Confirmed Influenza Infection
This open-label, randomized, adaptive, 2-arm, multicenter study will evaluate the pharmacokinetics and pharmacodynamics of oseltamivir (Tamiflu) in immunocompromised children, less than (<) 13 years of age, with confirmed…
- Trial name
- NCT01715909
- Testing
- Oseltamivir
- Where
- 50 sites in United States, Belgium and 13 more
- Volunteers
- 20 people
- Sponsor
- Hoffmann-La Roche
Influenza Immunization, Healthy Volunteers
Annual Study for Collection of Serum Samples in Children and Older Adults Receiving the 2021-2022 Formulations of Fluzone Quadrivalent Vaccine and Fluzone High-Dose Quadrivalent Vaccine, Respectively
This was a phase IV, multi-center, open-label study. The study collected serum samples from children 6 months to less than (<) 9 years of age who received Fluzone Quadrivalent vaccine and adults greater than or equal to (>=) 65…
- Trial name
- NCT05050318
- Testing
- Fluzone Quadrivalent vaccine, No Preservative (0.5-mL dose), 2021-2022 formulation, Fluzone High-Dose Quadrivalent vaccine (0.7-mL dose), 2021-2022 formulation
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Coronavirus Disease 2019
Clinical Outcomes of Patients With COVID19
As of February 17th, 2020, China has 70635 confirmed cases of coronavirus disease 2019 (COVID-19), including 1772 deaths. Human-to-human spread of virus via respiratory droplets is currently considered to be the main route of…
- Trial name
- NCT04280913
- Testing
- retrospective analysis
- Where
- China
- Sponsor
- Guangzhou Institute of Respiratory Disease
COVID-19
Host-pathogen Interactions, Immune Response, and Clinical Prognosis at COVID-19 - the CoVUm Trial
The project aims to clarify how immunity to SARS-CoV2 develops in humans and to investigate the possibility of finding patients with a particularly effective, neutralizing antibody response for future treatment.
- Trial name
- CoVUm (NCT04368013)
- Testing
- Extended sampling and procedures
- Where
- 4 sites in Sweden
- Volunteers
- 550 people
- Sponsor
- Johan Normark
Wheezing
Efficacy of Systemic Glucocorticoid in the Treatment of Wheezing in Children
We can not predict which wheezing child younger than 3 years of age benefits from systemic glucocorticoid and which one does not.
- Trial name
- VINKU (NCT00494624)
- Testing
- prednisolone
- Where
- Finland
- Volunteers
- 300 people
- Sponsor
- University of Turku
Virus Diseases in Children
A Study to Investigate the Effect of Probiotics (Limosilactobacillus Reuteri DSM 17938 and Limosilactobacillus Reuteri DSM 33633) on Symptoms of Viral Upper Respiratory Tract Infections in Children
This study investigates the effect of Limosilactobacillus reuteri probiotic strains (DSM 17938 and DSM 33633) on symptoms of viral upper-respiratory tract infections in children.
- Trial name
- NCT07870824
- Testing
- Probiotics (L. reuteri DSM 17938 and L. reuteri DSM 33633)
- Where
- Hungary
- Volunteers
- 194 people
- Sponsor
- Milosevits Gergely
Sleep Disturbance
Sleep Quality During COVID-19 Containment in Children Whether or Not Usually Followed in Child Psychiatry
The purpose of this study is to determine whether sleep disturbances in children aged 7 to 12 during COVID-19 containment are more prevalent in children who received routine psychiatric care before containment compared to…
- Trial name
- CONFIDODO (NCT04370210)
- Testing
- Questionnaires
- Where
- France
- Volunteers
- 247 people, healthy volunteers welcome
- Sponsor
- Hôpital NOVO
Influenza
The Clinical Trial Protocol for the Influenza Virus Vaccine (Split Virion, Inactivated)
The purpose of this study is to evaluate the safety and the immunogenicity of Influenza Virus Vaccine (Split Virion, Inactivated) that do not contains Preservative .
- Trial name
- IVV (NCT01551810)
- Testing
- Influenza Virus Vaccine, Influenza Virus Vaccine(contains Preservative)
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Institute of Medical Biology, Chinese Academy of Medical Sciences
Respiratory Infection
Unclogging the Pediatric Emergency Room: Impact of Rapid Viral Diagnostics
Acute respiratory tract infections are among the most common problems of childhood, particularly among infants and children younger than 3 years, and account for most antibiotic prescriptions to children.
- Trial name
- NCT00278759
- Testing
- Nasopharyngeal washing for viral antigen detection by immunofluorescence initiated early in ED visit.
- Where
- Canada
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
COVID-19 Pandemic
A Coping and Resilience Intervention in Adolescents
The primary purpose of this study is to assess the feasibility and acceptability of a coping and resilience intervention for adolescents in school settings named CERIA, in the post-coronavirus disease 2019 or COVID-19 era.
- Trial name
- CERIA (NCT05830188)
- Testing
- Coping and Resilience Intervention for Adolescents, Printing materials of Coping and Resilience Intervention for Adolescents
- Where
- Indonesia
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Feasibility, Acceptability
Air Purifiers in Classrooms for Infection Control - a Pilot Study
This study aims to investigate the acceptability and feasibility of deploying air purifiers equipped with HEPA (high-efficiency particulate air) filters in classrooms, to study air purifiers as an infection control measure.
- Trial name
- NCT06374316
- Testing
- Ceiling-Mounted Air Purifiers, Portable Air Purifiers, Portable or Ceiling Mounted Air Purifiers
- Where
- Norway
- Volunteers
- 6 people
- Sponsor
- Norwegian Institute of Public Health
COVID-19, Asymptomatic COVID-19
A Clinical Evaluation of Proof Diagnostics Test System Including the Proof Diagnostics Reader and COVID-19 Test
To determine the accuracy of Proof Diagnostics COVID-19 Test in the intended, symptomatic and suspected/at-risk asymptomatic population and point-of-care use as compared to a standard molecular comparator, Quidel Lyra SARS-CoV-2…
- Trial name
- NCT05331976
- Testing
- Proof Lab Test System
- Where
- 3 sites in United States
- Volunteers
- 276 people
- Sponsor
- Proof Diagnostics
Coronavirus, Respiratory Infection
Prospective Clinical Evaluation of the BioFire Emerging Coronavirus Panel for the Detection of COVID-19 and Other Coronaviruses
The Biomedical Advanced Research and Development Authority (BARDA) has contracted BioFire Defense (BFDf) to develop the BioFire Emerging Coronavirus (ECoV) Panel, a nucleic acid test capable of detecting coronaviruses from…
- Conditions
- Coronavirus, Respiratory Infection, COVID
- Trial name
- NCT07221097
- Testing
- Investigational IVD for coronaviruses
- Where
- 6 sites in United States
- Volunteers
- 2,091 people
- Sponsor
- BioFire Defense LLC