Clinical trials: Respiratory Failure
Bronchopulmonary Dysplasia
Inhaled Treatment for Bronchopulmonary Dysplasia
The primary objective of this study is to provide expanded access of S-nitrosylation therapy for the treatment of bronchopulmonary dysplasia
- Trial name
- NCT04619602
- Testing
- GSNO
- Where
- United States
- Sponsor
- University Hospitals Cleveland Medical Center
ARDS
Impact of Immune Status on Secondary Infections in Patients With Acute Respiratory Failure
This is a retrospective observational study over the period 1/2019 - 02/2024 with the aim of identifying patients with a predisposition to secondary infections.
- Trial name
- NCT06511622
- Where
- Germany
- Volunteers
- 686 people
- Sponsor
- Charite University, Berlin, Germany
Neonatal Respiratory Failure
Use of Orotracheal Continuous Positive Airway Pressure (CPAP) in Newborns With Respiratory Failure
Nasal CPAP is a excellent ventilation modality for newborns, but the incidence of pneumothorax is high (65.% - 9%) our hypothesis is when the baby open the mouth or crie the pressure in the airway is variable, the investigators…
- Trial name
- NCT01379820
- Testing
- OROTRACHEAL cpap WITH COMPENSATION BAG ( GREGORY CPAP)
- Volunteers
- 100 people
- Sponsor
- Hospital Angeles del Pedregal
Asthma, COPD
Exhaled Breath Metabolomic Biomarkers in the Acutely Breathless Patient
An acute study carried out across three acute admissions units within Leicestershire. The study is aimed at discovery and validation of volatile organic compounds (VOCs) in exhaled breath.
- Conditions
- Asthma, COPD, Heart Failure, Community-acquired Pneumonia
- Trial name
- EMBER (NCT03672994)
- Where
- United Kingdom
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Acute Respiratory Failure
Evaluation of Perfusion and Ventilation Distribution in Children: a Pilot Study.
Electrical impedance tomography (EIT) is a recent monitoring technique that provides information on regional ventilation distribution.
- Trial name
- PELUCHE 2 (NCT07532811)
- Testing
- Evaluation of perfusion with Electrical impedance tomography using sodium chloride or sodium bicarbonate
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Respiratory Failure, Mechanical Ventilation Complication
Patient-ventilator Asynchrony During Mechanical Non-Invasive Assisted-ventilation in Pediatric Patients (NavPed-NI)
The purpose of this study is to document the prevalence and type of asynchronies incidence during non-invasive mechanical ventilation in pediatric patients breathing under pressure support.
- Trial name
- NavPed-NI (NCT01238757)
- Testing
- Non-invasive Ventilation under Pressure Support, Non-Invasive ventilation under NAVA
- Where
- Switzerland
- Volunteers
- 7 people
- Sponsor
- University Hospital, Geneva
Respiratory Insufficiency
Incidence and Risk Factors of Extubation Failure in Pediatric Resuscitation
The failure of extubation in pediatric resuscitation is most often described as the need for reintubation within 48 hours after extubation.
- Trial name
- NCT03129802
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Strasbourg, France
Pulmonary Failure, Cystic Fibrosis
Non-respiratory Comorbidities Observed in Pulmonary French Transplant Patients With Cystic Fibrosis
Pulmonary transplantation is the reference treatment for chronic terminal respiratory failure in patients with cystic fibrosis. These are mainly bi-pulmonary transplants (cardiopulmonary transplants are exceptional).
- Trial name
- MUCO TRANSPLAN (NCT03357913)
- Testing
- Lung transplantation
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Hospices Civils de Lyon
Pulmonary Valve Insufficiency, Pulmonary Regurgitation
COMPASSION - COngenital Multicenter Trial of Pulmonic VAlve Regurgitation Studying the SAPIEN InterventIONal THV
To assess the safety and effectiveness of pulmonic THV implantation in subjects with dysfunctional RVOT conduit requiring treatment for moderate or severe pulmonary regurgitation (≥3+ pulmonary regurgitation) and/or RVOT conduit…
- Conditions
- Pulmonary Valve Insufficiency, Pulmonary Regurgitation, Dysfunctional RVOT Conduit, Pulmonary Obstruction
- Trial name
- NCT00676689
- Testing
- SAPIEN Transcatheter Valve Implantation
- Where
- 7 sites in United States
- Volunteers
- 81 people
- Sponsor
- Edwards Lifesciences
Pancreatitis, Pancreatic Neoplasms
Follow-up Study of Complications of Acute Pancreatitis
This is a follow-up study focusing on long-term complications of acute pancreatitis. The primary purposes include: 1. To assess the incidence of type 2 diabetes mellitus（2-DM）,impaired glucose tolerance, metabolic abnormalities…
- Conditions
- Pancreatitis, Pancreatic Neoplasms, Metabolic Diseases, Hypertension, Portal
- Trial name
- FSCAP (NCT02305914)
- Where
- China
- Volunteers
- 1,300 people
- Sponsor
- The First Affiliated Hospital of Nanchang University
Dyspnea, Chronic Renal Failure
POCUS VS CT in Diagnosis of Acute Dyspnea in Chronic Hemodialysis Patients
Estimate the predictive value of POCUS in diagnosis of different causes of acute dyspnea in hemodialysis patients and compare between POCUS and CT in differentiation the causes of acute dyspnea in those population.
- Trial name
- NCT05729035
- Testing
- POCUS
- Volunteers
- 100 people
- Sponsor
- Randa Ahmed Sarhan
Respiratory Distress Syndrome, Newborn, Respiratory Failure
Cerebral and Circulatory Effects of Neonatal Volume Targeted Ventilation
The aim of the study was to assess the effect of volume targeted vs. pressure-controlled mechanical ventilation (MV) on circulatory parameters and cerebral oxygenation in the extremely preterm infants.
- Conditions
- Respiratory Distress Syndrome, Newborn, Respiratory Failure, Premature Birth
- Trial name
- NCT04391634
- Testing
- volume guarantee, pressure-controlled
- Where
- Poland
- Volunteers
- 25 people
- Sponsor
- Poznan University of Medical Sciences
COPD, Non Invasive Ventilation
Prospective Cohort of Respiratory Insufficiency Outcome
The Respiratory Insufficiency Outcome (RIO) project consists in a french multicenter prospective cohort of patients with chronic obstructive pulmonary disease (COPD) undergoing domiciliary noninvasive positive pressure…
- Trial name
- RIO (NCT01192451)
- Where
- 4 sites in France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Elective HFOV for Respiratory Failure in Neonates/Infants, Rescue HFOV in Neonates and/Infants With Refractory Respiratory Failure Under Conventional Therapy
Servo-n HFOV Study: Safety and Performance in Neonates and Infants
The purpose of this study is to evaluate the safety and performance of High-Frequency Oscillatory Ventilation (HFOV) modes of the Servo-n ventilator in neonates and infants, by using a prospective, observational, single-arm…
- Trial name
- NCT06114992
- Testing
- Servo-n HFOV modes
- Where
- 4 sites in France, Poland and 1 more
- Volunteers
- 83 people
- Sponsor
- Maquet Critical Care AB
Healthy
Head Position Angles in Children
Inexperienced rescuers may encounter severe problems in an unconscious patient in opening and maintaining an upper airway patent.
- Trial name
- NCT00532636
- Testing
- Ventilation
- Where
- Austria
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Acute Hypoxemic Respiratory Failure
High-Frequency Oscillatory Ventilation Associated With Inhaled Nitric Oxide in Children
Background/Objectives: Acute hypoxemic respiratory failure (AHRF) is a frequent cause of pediatric ICU admission. Early treatment with inhaled nitric oxide (iNO) plus conventional mechanical ventilation (CMV) improves…
- Trial name
- NCT00924846
- Testing
- High frequency oscillatory ventilation
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- UPECLIN HC FM Botucatu Unesp
Perennial Allergic Rhinitis
Efficacy Study for the Symptomatic Treatment of Perennial Allergic Rhinitis With a 1 Year Safety Extension
Double-blind phase: The objective of the study was to evaluate the efficacy and safety of Bilastine 20 mg, compared to Cetirizine and placebo for the treatment of perennial allergic rhinitis.
- Trial name
- NCT01127620
- Testing
- Bilastine, Cetirizine
- Volunteers
- 650 people
- Sponsor
- Faes Farma, S.A.
Diabetes Mellitus, Asthma
Evaluation of VLER-Indiana Health Information Exchange Demonstration Project
Three out of four Veterans receive a portion of their care from non-VA providers. On April 9, 2009, President Barack Obama directed the Department of Veterans Affairs and the Department of Defense to create the Virtual Lifetime…
- Conditions
- Diabetes Mellitus, Asthma, Cardiovascular Diseases, Heart Failure
- Trial name
- VLER-IHIE (NCT01446705)
- Testing
- Active Health Information Exchange, Non-Active Health Information exchange
- Where
- United States
- Volunteers
- 57,073 people
- Sponsor
- VA Office of Research and Development
Apparent Life-Threatening Event in Infants Under One Year of Age
Apparent Life Threatening Events, Sudden Infant Death Syndrome and Muscarinic Receptors
Apparent Life-Threatening Events (ALTE) in infants often lead to severe neurological complications or to sudden death. In such situations, cardio-pediatricians and intensive care physicians have no specific diagnosis or…
- Trial name
- iALTE (NCT03278977)
- Testing
- Blood sample for specific analyzes
- Where
- 4 sites in France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Strasbourg, France
Noninvasive Positive Pressure Ventilation, High Flow Nasal Cannula
A Multicentered Study on Efficiency of Noninvasive Ventilation Procedures
Noninvasive ventilation (NIV) is an alternative form of ventilatory support in critical care encompassing different modes of ventilation such as continuous positive airway pressure (CPAP), bilevel positive airway pressure (BiPAP)…
- Conditions
- Noninvasive Positive Pressure Ventilation, High Flow Nasal Cannula, Failure, Respiratory
- Trial name
- SAFE-NIV (NCT03066934)
- Testing
- noninvasive ventilation respiratory support
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 352 people
- Sponsor
- Akdeniz University