Clinical trials: Quadraplegia
Cerebral Palsy
Intrathecal Stem Cells for Cerebral Palsy Phase II
The purpose of this study is to determine whether the infusion of intrathecal autologous bone marrow total nucleated cells would improve the neurologic evolution of pediatric patients with quadriparetic cerebral palsy.
- Trial name
- ISCII (NCT02231242)
- Testing
- Autologous Stem Cell Transplantation
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Hemiparesis, Paraparesis
Immediate Effects On Gait and Spasticity After The Use Of Passive Kinesiotherapy Equipment In The Lower Limbs Of Neurological Patients
Undergo assessment of muscle tone (Ashworth Scale), gait (BAIOBIT) and risk of falling (Timed Up and Go) before using the device; Use the device on the spastic lower limb(s) for 30 minutes; Go through the same assessment carried…
- Conditions
- Hemiparesis, Paraparesis, Tetraparesis, Cerebral Palsy
- Trial name
- NCT06696040
- Testing
- Passive mobilization using a device
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Fernanda Trubian
Spinal Cord Injuries, Tetraplegia
Restoring High Dimensional Hand Function to Persons With Chronic High Tetraplegia
This study is for people who have a paralyzed arm and hand from a spinal cord injury, who have also received a recording electrode array in the brain as part of the BrainGate study.
- Conditions
- Spinal Cord Injuries, Tetraplegia, Quadriplegia
- Trial name
- NCT03482310
- Testing
- Using the Neuroport cortical recording array to determine the desired grasp pattern for a functional electrical stimulation (FES) system
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- VA Office of Research and Development
Cerebral Palsy, Quadriplegia
Effectiveness of Standing Frame on Constipation in Children With Cerebral Palsy
Children with Cerebral Palsy and quadriplegia or severe diplegia suffer from highly reduced mobility and consequent constipation.
- Conditions
- Cerebral Palsy, Quadriplegia, Diplegia, Constipation
- Trial name
- CP (NCT01911559)
- Testing
- standing-frame
- Where
- Italy
- Volunteers
- 1 people
- Sponsor
- Stefania Costi
Tetraplegia, Tetraparesis
Reach and Palmar Grasp in Tetraplegics With Neuromuscular Electrical Stimulation: Assessment and Training.
The aim of the study was to evaluate the tetraplegics movement strategies, assisted by Neuromuscular Electrical Stimulation (NMES), on the reach and palmar (RP) grasp to different weights objects.Tetraplegics had their RP grasp…
- Trial name
- NCT02969772
- Testing
- Assessment of upper limb variables, Training protocol
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Enio Walker Azevedo Cacho
Spinal Cord Injury
Eyegaze Systems for Spinal Cord Injury: A Feasibility Study
As technologies are advancing quickly in the healthcare setting, new solutions have become available helping disable people to enhance their ability to communicate.
- Trial name
- NCT01943656
- Testing
- Tobii™ Eyegaze System
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Buckinghamshire Healthcare NHS Trust
Spastic Quadriplegia, Cerebral Palsy (CP)
Focused Versus Radial Extracorporeal Shock Wave Therapy on Gastrocnemius Spasticity in Children With Spastic Quadriplegic Cerebral Palsy
The goal of this pilot randomized controlled trial is to compare the effectiveness of focused extracorporeal shockwave therapy (ESWT) versus radial ESWT on gastrocnemius spasticity in children with spastic quadriplegic cerebral…
- Conditions
- Spastic Quadriplegia, Cerebral Palsy (CP), Gastrocnemius Muscle
- Trial name
- NCT07894003
- Testing
- Focused Extracorporeal Shock Wave Therapy, Radial Extracorporeal Shock Wave Therapy
- Where
- Indonesia
- Volunteers
- 16 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Spinal Cord Injury Cervical, Spinal Cord Injury, Acute
Upper Limb Rehabilitation Using Non-invasive Spinal Cord Stimulation
The goal of this RCT study is to evaluate if combining activity-based therapy (ABT) with transcutaneous spinal cord stimulation (tSCS) can improve recovery of arm and hand movement in people with cervical spinal cord injury…
- Conditions
- Spinal Cord Injury Cervical, Spinal Cord Injury, Acute, Spinal Cord Injury (Quadraplegia)
- Trial name
- CIME_upperlimb (NCT07361627)
- Testing
- Protocol 2: Combination of activity-based therapy and facilitatory transcutaneous spinal cord stimulation
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal
Spastic Cerebral Palsy
Therapeutic Potential of Myofascial Structural Integration in Children With Cerebral Palsy
The investigators hypothesize that children with spastic cerebral palsy will show greater improvements in gross motor function, associated developmental skills and growth after the 3 months of myofascial structural integration…
- Trial name
- NCT01815814
- Testing
- Rolfing / Myofascial Structural Integration
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Stanford University
Cerebral Palsy
Does Oral Baclofen Improve Care and Comfort in Spastic Children in Nursing Homes?
Baclofen is a drug that reduces the muscle stiffness. In disabled children that have very stiff muscles, the stiffness and secondary changes in the joints may cause discomfort and pain.
- Trial name
- NCT00752934
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Shaare Zedek Medical Center
Spinal Cord Injury, Osteoporosis
Early Intervention to Reduce Bone Loss After Spinal Cord Injury
After a complete spinal cord injury (SCI), the patient becomes wheelchair-dependent, and the associated lack of weight-bearing and inactivity of paralysed muscles can lead to extensive bone loss in the long bones of the legs.
- Trial name
- NCT02334410
- Testing
- Whole body vibration (WBV)
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Strathclyde
Acute Brain Injuries, Consciousness Disorders
CONNECT-ME: Consciousness in Neurocritical Care Cohort Study Using fMRI and EEG
Detecting preserved consciousness in brain-injured patients by traditional clinical means requires presence of motor function. Otherwise, patients may be erroneously classified as being in a vegetative state.
- Trial name
- CONNECT-ME (NCT02644265)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Spastic/Dystonic Quadriplegia, Cerebral Palsy (CP)
Outcomes of Neurosurgical Tone Management
Patients with spastic/dystonic quadriplegia (GMFCS IV/V) are often severely disabled by their tone, and require surgical tone management to improve quality of life, allow for better function, improve comfort, and range of motion.
- Trial name
- NCT07817745
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Boston Children's Hospital
Tetraplegia, Spinal Cord Injury
Follow up Study of Diaphragm Pacing for Patients With High Tetraplegia
This is an observational longitudinal study designed to identify and describe long term outcomes for patients with high tetraplegia who use a Diaphragmatic Pacing System (DPS).
- Trial name
- NCT01815554
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Craig Hospital
Cervical Spinal Cord Injury
Abdominal Functional Electrical Stimulation Training and Its Effect on Mechanical Insufflation-Exsufflation
Compromised respiratory function as a result of tetraplegia is a leading cause of rehospitalisation for the tetraplegic patient group.
- Trial name
- NCT01800409
- Testing
- AFES
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- NHS Greater Glasgow and Clyde
Tetraplegia/Tetraparesis, Amyotrophic Lateral Sclerosis (ALS)
Control of Assistive Devices Via Brain-Computer Interface Technology
The CONVOY Study is a clinical trial designed to explore the feasibility of participants from the PRIME Study (NCT06429735) using the N1 Implant to control various assistive devices.
- Conditions
- Tetraplegia/Tetraparesis, Amyotrophic Lateral Sclerosis (ALS), Quadriplegia, Spinal Cord Injury (SCI)
- Trial name
- CONVOY (NCT06710626)
- Testing
- Assistive Robotic Arm
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Neuralink Corp
Neurologic Diseases, Hemiparesis
NuroSleeve Powered Brace & Stimulation System to Restore Arm Function
The purpose of this study is to investigate if a person with weakness or paralysis in one or both arms, can use the NuroSleeve combined powered arm brace (orthosis) and muscle stimulation system to help restore movement in one…
- Conditions
- Neurologic Diseases, Hemiparesis, Quadriplegia, Muscular Dystrophies
- Trial name
- NCT04798378
- Testing
- Neurosleeve
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Spinal Cord Injury
SCI Epidemiology and Complications
The aim of this study was to epidemiologically evaluate patients diagnosed with spinal cord injury who were admitted to our clinic over the last five years and, unlike similar studies, to investigate the presence of complications…
- Trial name
- NCT07425470
- Testing
- Retrospective data analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Bandırma Onyedi Eylül University
Nerve Transfer
Nerve Transfers for Restoration of Hand Function in Cervical Spinal Cord Injury: Effects and Influencing Factors
The goal of this observational study is to learn about influencing factors on the clinical outcomes of nerve transfers used to restore hand function in patients with cervical spinal cord injury (CSCI).
- Trial name
- NCT06596629
- Where
- Netherlands
- Volunteers
- 19 people
- Sponsor
- Roessingh Research and Development
Paraparesis, Tetraparesis
Prospective Cohort Follow-up of French Patients With Profound and Multiple Disabilities: Healthcare Pathways and Quality of Life Among Patients and Their Families
The studies conducted so far concerning the medical and paramedical cares provided to patients with profound and multiple disabilities (PMD) often show important limitations: samples are too small or very heterogeneous, generally…
- Conditions
- Paraparesis, Tetraparesis, Hemiparesis, Ataxia
- Trial name
- Eval-PLH (NCT02400528)
- Testing
- quality of life questionnaires
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- Assistance Publique Hopitaux De Marseille