Clinical trials: Pulpal Diseases
Pulpal Necrosis, Dental Caries
Comparison of LSTR and Pulpectomy in Primary Molars of Pediatric Patients (LSTR-PULP)
This study aims to compare the effectiveness of Lesion Sterilization and Tissue Repair (LSTR) with conventional pulpectomy in treating pulpal lesions in primary molars of pediatric patients aged 4 to 10 years.
- Conditions
- Pulpal Necrosis, Dental Caries, Periapical Periodontitis, Pediatric Dentistry
- Trial name
- LSTR-PULP (NCT07026435)
- Testing
- LSTR, Pulpectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- taymour abuawwad
Orthodontic Treatment
Curve of Spee: Speed of Leveling Using Different Orthodontic Archwires
The objectives if this study was to evaluate the efficacy of 3 different rectangular archwires in the correction of the curve of Spee (COS), to record the time needed to level excessive COS in the mandibular arch using the 3…
- Trial name
- NCT04549948
- Testing
- 0.017X0.025 Stainless steel, 0.019X0.025 Stainless steel, 0.021X0.025 B-Titanium archwire
- Where
- Jordan
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Reversible Pulpitis, Irreversible Pulpitis
Evaluation of Pulpal Biomarkers in Vital Pulp Therapy
This prospective clinical study aims to evaluate the association between the levels of selected pulpal biomarkers and the clinical success of vital pulp therapy in permanent teeth.
- Conditions
- Reversible Pulpitis, Irreversible Pulpitis, Vital Pulp Therapy, Dental Pulp Diseases
- Trial name
- NCT07073573
- Testing
- Vital pulp therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- ertuğrul karataş
Pulpal Necrosis
Triple Antibiotic Paste vs Simvastatin for Lesion Sterilization and Tissue Repair in Primary Molars.
This randomized, double-blinded, parallel-controlled clinical trial aims to compare the effectiveness of Triple Antibiotic Paste (TAP) and Simvastatin in Lesion Sterilization and Tissue Repair (LSTR) of primary molars with pulp…
- Trial name
- LSTR (NCT07264842)
- Testing
- Lesion Sterilization and Tissue Repair using Simvastatin., Lesion Sterilization and Tissue Repair using Triple Antibiotic Paste.
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Dow University of Health Sciences
Molar-Incisor Hypomineralization (MIH), Pulp Disease, Dental
Assessment of Inflammatory Biomarkers in Molar-Incisor Hypomineralization-Affected First Permanent Molars
Molar-Incisor Hypomineralization (MIH) is a qualitative developmental defect of enamel primarily affecting the permanent first molars and often incisors. The global prevalence of MIH ranges from 2.9% to 44%.
- Conditions
- Molar-Incisor Hypomineralization (MIH), Pulp Disease, Dental, Inflamation
- Trial name
- NCT07008599
- Testing
- Pulpal Blood Sample
- Where
- Turkey (Türkiye)
- Volunteers
- 83 people
- Sponsor
- Marmara University
Trauma, Diagnosis Dual
Efficacy of Laser Doppler Flowmetry as a Diagnostic Tool in Assessing Revascularization of Traumatised Teeth
The aim of the study is to evaluate the efficacy of Laser Doppler flowmetry in determining the changes in the pulpal blood flow during the post-traumatic period of traumatised permanent teeth.
- Trial name
- NCT04967456
- Testing
- Measurement of pulpal blood flow of traumatised tooth
- Where
- 2 sites in Bulgaria
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Plovdiv Medical University
Dental Caries, Pulp Exposure, Dental
Clinical Study Evaluating Solventum™ Vitrebond™ Pulp Protect Liner/Base for Direct Capping of Pulpal Exposure
This research study is looking at the safety and effectiveness of Solventum™ Vitrebond™ Pulp Protect Liner/Base for direct pulp capping (DPC) on permanent teeth that have pulp exposure due either to deep cavities, trauma, or…
- Conditions
- Dental Caries, Pulp Exposure, Dental, Tooth Decay, Dental Decay
- Trial name
- NCT07231237
- Testing
- Vitrebond™ Pulp Protect Liner/Base
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Solventum US LLC
Dental Pulp Exposure
Human Pulpal Response After Pulp Capping With Four Different Agents
Application of four different pulp capping methods on human sound premolars after intentional exposure of the buccal pulp horn through a class one occlusal cavity.
- Trial name
- NCT01468480
- Testing
- Pro Root MTA, Pro Root MTA- single visit, MultiCal
- Where
- Iran
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Islamic Azad University, Sanandaj
Pulpitis, Pulp Inflammation
Comparison of IL-8, FGF-1 and VEGF Levels in Pulpal Tissue, GCF and Dentinal Fluid Samples of Healthy, Reversible and Irreversible Pulpitis Diagnosed Teeth
This study will include 51 patients diagnosed with healthy, reversible and irreversible pulpitis. IL-8, FGF-1 and VEGF levels will be compared using pulpal tissue, gingival crevicular fluid, dentinal fluid samples collected from…
- Conditions
- Pulpitis, Pulp Inflammation, Healthy Pulp, Biomarkers
- Trial name
- NCT06936553
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Pulpal Necrosis
Evaluation of Regenerative Endodontic Treatment for Immature Teeth
The goal of this clinical trial is to evaluate if regenerative endodontic treatment using two different forms of demineralized dentin matrix (DDM) can effectively treat immature permanent single-rooted teeth compared to treatment…
- Trial name
- NCT07210359
- Testing
- human treated dentin matrix hydrogel, Theracal LC - Demineralized dentin matrix combination, Retro Mta
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Pulp Exposure, Dental, Pulp Disease, Dental
The Effect of Genetic Polymorphisms on the Success of Vital Pulp Therapy
This study employs saliva-based DNA analysis to investigate the effect of genetic polymorphisms, particularly SNPs in MMP, TIMP, TNF-α, and BMP genes, on the success of vital pulp therapy in permanent teeth with pulpitis…
- Conditions
- Pulp Exposure, Dental, Pulp Disease, Dental, Pulp Caping, Pulpitis
- Trial name
- NCT07130214
- Testing
- Biodentine
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Ataturk University
Caries,Dental, Apical Periodontitis
Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth - Pediatric
The primary goal of the study is to compare the success rates of pulpal anesthesia (defined as ability to complete the intended dental procedure without the need for rescue anesthesia) between Kovanaze nasal mist and Articaine…
- Trial name
- NCT03962634
- Testing
- Kovanaze Nasal Spray, Articaine Injection
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Virginia Commonwealth University
Tooth Loss, Tooth Injury
Clinical and Radiological Evaluation of Dental Autotransplantation in the Anterior Region in Young Patients
This study aims to evaluate the clinical, radiographic, functional, and patient-reported outcomes of premolar autotransplantation used to replace anterior maxillary teeth in young patients.
- Trial name
- YATA (NCT07314580)
- Testing
- Premolar Autotransplantation
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- University of Barcelona
Dental Anxiety, Pain
Different Local Anesthesia Techniques for Mandibular Primary Molar Pulpectomy
This study aims to compare the effects of computer-controlled local anesthesia and conventional inferior alveolar nerve block on dental anxiety and pain in children undergoing pulpectomy of mandibular primary molars.
- Conditions
- Dental Anxiety, Pain, Pulpal Diseases
- Trial name
- NCT07714915
- Testing
- Computer-Controlled Local Anesthesia, Conventional Inferior Alveolar Nerve Block, Articaine hydrochloride with epinephrine 1:100,000
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Pulpal Necrosis
Evaluation of Chitosan as Irrigating Solution for Pulpectomy in Non-Vital Primary Teeth
45 teeth will be sub-divided at random with a computerized method, according to the type irrigant and duration of its application into 3 groups (15 teeth in each group): Group1(control group): The teeth will be irrigated by 2 ml…
- Trial name
- NCT06506526
- Testing
- Sodium hypochlorite irrigating solution, one minute NaOCL+Chitosan, Three minute NaOCL+Chitosan
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Suez Canal University
Endodontic Disease
N-Acetyl Cysteine Protects Pulpal Stem Cells in Endodontic Revascularization
Pulp re-vascularization/regeneration is a procedure performed to allow pulpal stem cells to survive and/or differentiate to allow immature tooth root structures to grow to full maturity.
- Trial name
- NAC (NCT03451435)
- Testing
- N acetyl cysteine
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Pulp Necrosis
Tissue Characterization in Teeth Treated With a Regeneration Protocol
The purpose of the investigators study is to characterize the composition of the hard and soft tissues present in root canals of teeth previously diagnosed with necrotic pulps and incomplete root formation and treated with a…
- Trial name
- NCT00881907
- Testing
- Triple Antibiotic Paste
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Pulpal and Periapical Diseases
Diagnostic Accuracy of Educated Large Language Models in Endodontic Diagnosis and Case Difficulty Assessment
This diagnostic test accuracy (DTA) study aims to evaluate the diagnostic performance of educated large language models (Educated ChatGPT (GPT-5.5 Pro), Educated Gemini 3.1 Pro, and Educated Claude Opus 4.7) in endodontic…
- Trial name
- NCT07706894
- Testing
- ChatGPT, Gemini, Calude
- Volunteers
- 349 people
- Sponsor
- Cairo University
Pulpitis
Effect of Glass Ionomer Cement as an Interim Restoration in Diagnosis of Pulpal Status
Aim: To evaluate whether glass ionomer interim therapeutic restoration (ITR) in asymptomatic teeth with deep cavities can help in determining the pulp status.
- Trial name
- NCT03168620
- Testing
- Restoration
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Pulp Disease, Dental
Efficacy Of Proinflammatory Cytokines in The Primary Molar Pulpotomy
One of the main goals of pediatric dentistry is to preserve the functions and structures of primary teeth until the time of exfoliation. Especially carious lesions are the main factor in the early loss of primary teeth.
- Trial name
- NCT06398327
- Testing
- PULPOTOMY TREATMENT
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ataturk University