Clinical trials: Progression
Slowing the Progression of Myopia in Children
The Safety and Efficacy of HR19034 in Children With Myopia
The study is being conducted to evaluate the efficacy, and safety of HR19034 Eye Drops. To explore the reasonable dosage of HR19034 for slowing the progression of myopia in children
- Trial name
- NCT07844356
- Testing
- HR19034
- Where
- China
- Volunteers
- 509 people
- Sponsor
- Chengdu Suncadia Medicine Co., Ltd.
Myopia, Myopia Progression
Comparing Myopia Control Spectacle Lenses and Standard Single Vision Spectacle Lenses in Children With Myopia
The purpose of this clinical trial is to compare a new myopia control spectacle lens with a standard single vision spectacle lens in slowing the progression of myopia (nearsightedness) in healthy children aged 6 to under 11…
- Trial name
- PEARL (NCT07839091)
- Testing
- Investigational Myopia Control Spectacle Lens, Single Vision Spectacle Lens
- Where
- Singapore
- Volunteers
- 20 people
- Sponsor
- Essilor International
Myopia, Myopia Progression, Lag of Accommodation, Hyperopic Retinal Blur, Reduction in Contrast
Lag of Accommodation With DOT Spectacle Lenses
The objective of the study is to measure the difference in the lag of accommodation between DOT spectacle lenses and control spectacles.
- Trial name
- ASH (NCT04700111)
- Testing
- DOT Pattern, Control Spectacles
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- SightGlass Vision, Inc.
Myopia, Myopia Progression
Effect of Diffusion Optics Technology (DOT) Spectacle Lenses on Choroidal Thickness
The objective of the study is to measure the effect of Diffusion Optics Technology (DOT) spectacle lenses on the choroidal thickness and choroidal vascularity index compared to control lenses.
- Conditions
- Myopia, Myopia Progression, Juvenile Myopia
- Trial name
- ASH-2 (NCT05617794)
- Testing
- Diffusion Optics Technology (DOT) Pattern Spectacle Lens, Control Spectacle Lens
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- SightGlass Vision, Inc.
Myopia, Myopia Progression
Spectacle Lens Visual Acuity Assessments Study
This is a two-arm parallel group, non-dispensing study. Participants will be existing active CYPRESS Extension (CPRO-1802-002) subjects. Subjects will undergo additional visual performance assessments.
- Conditions
- Myopia, Myopia Progression, Juvenile Myopia
- Trial name
- CEDAR (NCT05650190)
- Testing
- Novel spectacle lens design, Spectacle lenses
- Where
- 6 sites in United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- SightGlass Vision, Inc.
Myopia, Myopia Progression
Myopia Control Spectacle Lens Cessation Study
To quantify myopic progression (cycloplegic spherical equivalent refraction - cSER) following the cessation of use of specific spectacle lenses.
- Conditions
- Myopia, Myopia Progression, Juvenile Myopia
- Trial name
- BIRCH (NCT05893979)
- Testing
- Spectacle Lenses
- Where
- 8 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- SightGlass Vision, Inc.
Myopia, Myopia Progression
Mobility Performance in Daily Activities Among Children Wearing Spectacle Lenses
The aim of this study is evaluate and compare the mobility performance of children in daily activities while wearing single vision spectacle lenses (control) versus myopia control spectacle lenses (test).
- Conditions
- Myopia, Myopia Progression, Juvenile Myopia
- Trial name
- NCT07229352
- Testing
- Novel spectacle lens design, Spectacle lenses
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- SightGlass Vision, Inc.
Myopia, Myopia Progression
Children's Viewing Behavior
The aim of this study is to investigate the area of the spectacle lens in which a subject is viewing through regardless of task being performed.
- Conditions
- Myopia, Myopia Progression, Juvenile Myopia
- Trial name
- NCT07229365
- Testing
- Novel spectacle lens design, Spectacle lenses
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- SightGlass Vision, Inc.
Myopia Progression
Evaluation of the Effectiveness of a New Generation of Myopia Control Lens on the Progression of Myopia in Children Aged 6 to 14 Years
The goal of this clinical investigation is to learn how much a new generation of myopia control lens (MCL1 - Myopia Control Lens 1) is helpful in reducing myopia progression in children from 6 to 14 yo.
- Trial name
- VERCORS (NCT07462897)
- Testing
- MCL1, MCL2
- Where
- France
- Volunteers
- 76 people
- Sponsor
- Essilor International
Myopia Progression
Prospective Research on the Intervention of Myoless2.0 Effectiveness (PRIME) in Pediatric Population
The Goal of the study is to evaluate the rate of myopia progression with open ring myopia control spectacle lens designs compared to a commercial peripheral plus myopia control spectacle lens (CML) in European children with…
- Trial name
- PRIME (NCT07394556)
- Testing
- myopia control lens
- Where
- 3 sites in Portugal, Spain and 1 more
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Indizen Optical Technologies, S.L.U.
Myopia, Child Myopia Progression
Effect of MiYOSMART iQ Spectacle Lenses on Myopia Progression in Children
This prospective, single-center study aims to evaluate the efficacy and safety of MiYOSMART iQ spectacle lenses with DIMS (Defocus Incorporated Multiple Segments) and Triple Enhanced Design (TED) technology in slowing myopia…
- Trial name
- NCT07387159
- Testing
- MiYOSMART iQ spectacle lenses
- Where
- Russia
- Volunteers
- 70 people
- Sponsor
- Hoya Lens Rus LLC
Myopia Progression
Atropine in the Treatment of Myopia Study in Malaysia
This clinical trial is designed to assess the efficacy and safety of Atropine Sulphate 0.025% w/v Eye Drops compared to placebo in a randomized, double-blind, placebo-controlled study for the management of myopia progression in…
- Trial name
- ATOM-MY (NCT07329777)
- Testing
- Low dose atropine sulfate eye drops
- Where
- 2 sites in Malaysia
- Volunteers
- 144 people
- Sponsor
- IDB VisionCare SDN BHD
Myopia, Juvenile Myopia
Efficacy in Controlling Myopia in Young Children Using a Novel Spectacle Lens
This is a conventional efficacy trial to validate the results from previous clinical trials for younger children; the 12-month efficacy results will be used to predict the 3-year treatment efficacy.
- Conditions
- Myopia, Juvenile Myopia, Myopia Progression
- Trial name
- EUCALYPTUS (NCT06034327)
- Testing
- Single vision, impact-resistant spectacle lenses; Test Arm, Single vision, impact-resistant spectacle lenses; Control Arm
- Where
- 14 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- SightGlass Vision, Inc.
Type 1 Diabetes
Description of Patients With Type 1 Diabetes Treated With Teplizumab
Type 1 diabetes mellitus (T1D) is a chronic autoimmune disease caused by the destruction of pancreatic β cells. T1D pathogenesis progresses through several stages: Stage 1 T1D includes the presence of β cell autoimmunity and thus…
- Trial name
- TEPLI-REAL (NCT06892002)
- Testing
- Teplizumab
- Where
- 27 sites in United States, Israel
- Volunteers
- 110 people
- Sponsor
- Sanofi
Myopia Progression
Efficacy and Tolerance of Full Field Peripheral Defocus Spectacles for the Control of Myopia Progression (Myofix Study)
The purpose of this study is to evaluate the efficacy and tolerability of the use of a new model of spectacles designed to control the progression of myopia in childhood.
- Trial name
- NCT07092072
- Testing
- MYOFIX FULL FIELD PERIPHERAL DEFOCUS SPECTACLE
- Where
- Argentina
- Volunteers
- 47 people
- Sponsor
- Novar Corporation
Metastatic Brain Tumor, Primary Brain Tumor
Laser Ablation of Abnormal Neurological Tissue Using Robotic NeuroBlate System
The NeuroBlate® System (NBS) is a minimally invasive robotic laser thermotherapy tool that is being manufactured by Monteris Medical.
- Conditions
- Metastatic Brain Tumor, Primary Brain Tumor, Epileptic/Seizure Foci, Movement Disorders
- Trial name
- LAANTERN (NCT02392078)
- Testing
- NeuroBlate System
- Where
- 26 sites in United States
- Volunteers
- 1,153 people
- Sponsor
- Monteris Medical
Multiple Chronic Conditions, Chronic Disease
Virta Health Registry
The purpose of this registry is to establish a research data repository, comprised of data generated in the course of providing clinical services to patients treated by Virta Health, to conduct secondary research on clinical…
- Conditions
- Multiple Chronic Conditions, Chronic Disease, Disease Progression, Long-Term Care
- Trial name
- NCT03474692
- Where
- United States
- Volunteers
- 50,000 people
- Sponsor
- Virta Health
Primary Brain Tumor
Laser Ablation in Stereotactic Neurosurgery (LAISE): NeuroBlate® Retrospective Registry
The NeuroBlate® System (NBS), is a minimally invasive robotic laser thermotherapy tool. It employs a pulsed surgical laser to deliver targeted energy to abnormal brain tissue caused by tumors and lesions.
- Trial name
- NCT02389855
- Testing
- NeuroBlate® System Therapy
- Where
- 9 sites in United States
- Volunteers
- 144 people
- Sponsor
- Monteris Medical
Diabetes Mellitus Progression, Diabetes Complications
Autologous Bone Marrow Transplant in Chronic Insulin Dependent Diabetic Patients
Diabetes, recently declared a pandemic by the World Health Organization, is a risk factor for increased mortality and morbidity.
- Trial name
- NCT03562208
- Testing
- Adult Bone Marrow Stem Cells
- Where
- The Bahamas
- Volunteers
- 100 people
- Sponsor
- Global Cell Med
HIV Infections
Safety and Effectiveness of Adding Adefovir Dipivoxil and Nelfinavir to the Anti-HIV Therapy of HIV-Infected Children
The purpose of this study is to see if it is safe and effective to give adefovir (a new anti-HIV drug) plus nelfinavir to HIV-infected children who are already receiving other anti-HIV medications.
- Trial name
- NCT00002219
- Testing
- Nelfinavir mesylate, Levocarnitine, Adefovir dipivoxil
- Where
- 7 sites in United States
- Volunteers
- 36 people
- Sponsor
- Gilead Sciences