Clinical trials: Progression, Clinical
Neuroendocrine Tumors, Carcinoma, Neuroendocrine
Natural History Study of Children and Adults With Neuroendocrine Neoplasms (NEN)s
Background: Neuroendocrine neoplasms (NENs) are rare tumors that originate in neuroendocrine cells. NENs can affect almost any part of the body. People with low-grade tumors can live many years.
- Trial name
- NCT04488263
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Myopia, Child Myopia Progression
Photolithography Microstructure Myopia Management Lenses in Preventing and Controlling Myopia in Children and Adolescents
Evaluate the effectiveness of different lithographic microstructured myopia management lenses in controlling the progression of myopia in children and adolescents, as well as the safety and comfort of wearing them.
- Trial name
- NCT07514039
- Testing
- Myopia management lens
- Where
- China
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Hepatocellular Carcinoma, Hepatocellular Cancer
Natural History Study of Children and Adults With Fibrolamellar Hepatocellular Carcinoma
Background: Fibrolamellar Hepatocellular Carcinoma (FL-HCC) is a rare liver cancer. It usually occurs in young people who have no history of liver disease.
- Trial name
- NCT03748927
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Biomarker, Progression
Soluble B7-H3 as a Biomarker for Osteosarcoma
Increasing data has indicated an association between increased soluble B7-H3 (sB7-H3) levels and unfavorable prognosis in patients with malignancies.
- Conditions
- Biomarker, Progression, Osteosarcoma, Surveillance
- Trial name
- NCT05942456
- Testing
- ELISA: enzyme-linked immunosorbent assay
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University People's Hospital
Lung Cancer Stage IV
Efficacy of SRT as Salvage Therapy in Patients With Brain Oligo-progression of EGFR-mutant Non-small Cell Lung Cancer After Failure of the Third-generation EGFR-TKIs
About 20%-40% of NSCLC patients develop intracranial metastases, and most clinical studies suggest that the survival of lung cancer patients will be significantly shortened once they develop intracranial metastases.
- Trial name
- NCT04519983
- Testing
- Aumolertinib Oral Tablet
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanghai Cancer Hospital, China
Myopia
Clinical Evaluation of a Myopia Control Lens in Slowing Myopia Progression.
This is a mono-centre, prospective, one-arm, unmask clinical trial to evaluate the effectiveness of test lens in slowing myopia progression with respect to axial length elongation compared to a single vision spectacle lens from…
- Trial name
- NCT05534022
- Testing
- Test myopia control lenses (BSL)
- Where
- Singapore
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Essilor International
Non-Small-Cell Lung Cancer, Non-Small-Cell Lung Cancer Stage IV
Real-World Assessment of Therapeutic Strategies and Survival Outcomes Following First-Line Tislelizumab Therapy in Advanced Non-Small Cell Lung Cancer
This study is an observational study evaluating the treatment patterns and clinical outcomes after progression on first-line Tislelizumab treatment in advanced NSCLC.
- Trial name
- REALM-Post (NCT06962449)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Shanghai Chest Hospital
Glioblastoma, Sarcoma
New Castle Disease Virus (NDV) in Glioblastoma Multiforme (GBM), Sarcoma and Neuroblastoma
Patients with specific metastatic cancers who failed prior therapeutic regimes will be treated with NDV for at least a year or until disease progression.
- Conditions
- Glioblastoma, Sarcoma, Neuroblastoma
- Trial name
- NCT01174537
- Testing
- New Castle Disease Virus
- Where
- Israel
- Sponsor
- Hadassah Medical Organization
COVID-19 Respiratory Infection
Studying the Efficiency of the Natural Preparation Rutan in Children in the Treatment of COVID-19, ARVI
Clinical research includes Determination of efficacy and acceptability of the local medicine "Rutan tablets 0,025" in children and teenagers 6-18 years old with COVID-19 and/or acute respiratory viral infections.
- Trial name
- NCT05862883
- Testing
- Rutan 25 mg, Control group
- Where
- Uzbekistan
- Volunteers
- 301 people
- Sponsor
- Research Institute of Virology, Ministry of Health of the Republic of Uzbekistan
HIV/AIDS, COVID-19
COVID-19 in Patients With HIV
Currently, limited data is available about patients with HIV in the context of the COVID-19 pandemic. People with HIV who have not achieved viral suppression through antiretroviral treatment may have a compromised immune system…
- Conditions
- HIV/AIDS, COVID-19, SARS-CoV-2
- Trial name
- NCT04333953
- Testing
- No intervention
- Where
- United States
- Volunteers
- 412 people
- Sponsor
- University of Missouri-Columbia
Myopia
Clinical Evaluation of a Myopia Control Lens in Slowing Myopia Progression (CSL)
This is a mono-centre, prospective, one-arm, unmask clinical trial to evaluate the effectiveness of test lens in slowing myopia progression with respect to axial length elongation compared to a single vision spectacle lens from…
- Trial name
- NCT05724186
- Testing
- Test myopia control lenses (CSL)
- Where
- Singapore
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Essilor International
Choroideremia
Natural Disease Progression in Participants With Choroideremia
The primary objective of this study is to quantify disease progression measured by best corrected visual acuity (BCVA) in the real-world setting among Choroideremia (CHM) participants.
- Trial name
- NCT04795206
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 1,178 people
- Sponsor
- Biogen
Upper Respiratory Infections
Evaluation of Accuracy and Ease of Use of the FilmArray™ Respiratory Panel (RP EZ) in a CLIA-Waived Clinical Setting
The purpose of this study is to assess the accuracy and ease-of-use of a simplified FilmArray Respiratory Panel test (FilmArray RP EZ) when performed according to the manufacturer's instructions by personnel in laboratories…
- Trial name
- NCT02232711
- Where
- 4 sites in United States
- Volunteers
- 1,082 people
- Sponsor
- BioFire Diagnostics, LLC
High Myopia
The Effect and Safety of Different Doses of Atropine on Myopic Progression of Highly Myopic Children: Multi-centered Randomized Clinical Trial
Objective: to evaluate the efficacy of different concentrations of atropine eye drops in controlling the progression (diopter, axial length) of high myopia in young children, and to compare the compliance, adverse reaction and…
- Trial name
- NCT04699357
- Testing
- Atropine
- Where
- 3 sites in China
- Volunteers
- 219 people
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Periodontitis, Surgery
Metronidazole vs Azithromycin in Periodontal Surgery for Patients Positive to Porphyromonas Gingivalis
The objective of this study is to determine whether, in patients with non treated periodontitis (stage III and IV) positive to Porphyromonas gingivalis, the use of systemic antimicrobials (metronidazole versus azithromycin) as an…
- Trial name
- NCT03862456
- Testing
- Azithromycin, Metronidazole
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Anaplastic Ependymoma, Ependymoma
Marizomib for Recurrent Low-Grade and Anaplastic Supratentorial, Infratentorial, and Spinal Cord Ependymoma
Background: Ependymomas are rare tumors that arise from the ependyma. That is a tissue of the central nervous system. They can develop in the brain or the spine.
- Conditions
- Anaplastic Ependymoma, Ependymoma, Ependymomas
- Trial name
- NCT03727841
- Testing
- Marizomib
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- National Cancer Institute (NCI)
Dengue Fever With Warning Signs
Clinical and Laboratory Factors for the Progression of Severe Dengue Among Hospitalized Patients During an Upsurge
Hypothesis (if any): Not applicable Objectives: To identify factors for progression to severe Dengue in hospitalized patients. Methods: Prospective Observational study
- Trial name
- PROSED (NCT06697041)
- Where
- 2 sites in Bangladesh
- Volunteers
- 324 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Myasthenia Gravis
Clinical Prognosis and Progression of Myasthenia Gravis Patients
This study collects the clinical data of myasthenia gravis (MG) patients, assesses outcomes and adverse effects of different treatment regimens, and searches for risk factors of conversion to generalized MG.
- Trial name
- NCT04101578
- Testing
- Symptomatic Treatment, Steroids, Immunosuppressive Agents, Plasma Exchange(PE), Intravenous Immunoglobulin(IVIg)
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Da, Yuwei, M.D.
Myopia, Progressive
Slow Myopia Progression With Different Irradiance Light
It is a prospective clinical control study on red light control myopia with specail design spectacles for 75 children in 3 groups. Study Groups with two different powers of 0.6 mW and 1.2 mW at wavelength of 650nm.
- Trial name
- NCT05881655
- Testing
- Airdoc Red Lighting Device, Special Spectacles to Control Myopia
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Beijing Airdoc Technology Co., Ltd.
Myopia
S.T.O.P.® Technology Contact Lenses Versus Dual-focus Contact Lenses for Slowing Down Myopia Progression in Children
To compare the rate of myopia progression of contact lenses utilising S.T.O.P.® technology against MiSight® contact lenses.
- Trial name
- NCT05243836
- Testing
- S.T.O.P® F2, S.T.O.P® DT, MiSight®
- Where
- 7 sites in China, India and 1 more
- Volunteers
- 441 people
- Sponsor
- nthalmic Pty Ltd