Clinical trials: Preoperative Sedation
Preoperative Sedation
A Trial of Dexmedetomidine Hydrochloride Nasal Spray in Preoperative Sedation of Children
The study is being conducted to evaluate the efficacy, safety and the population pharmacokinetic characteristics of dexmedetomidine hydrochloride nasal spray for preoperative sedation in children
- Trial name
- NCT04200235
- Testing
- Dexmedetomidine hydrochloride nasal spray, Dexmedetomidine hydrochloride nasal spray blank preparation.
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Preoperative Sedation
The Study is Being Conducted to Evaluate the Efficacy and Safety of Dexmedetomidine Hydrochloride Microneedles for Preoperative Sedation in Children
The study is being conducted to evaluate the efficacy, safety and the population pharmacokinetic characteristics of Dexmedetomidine Hydrochloride Microneedles for preoperative sedation in children
- Trial name
- NCT07168720
- Testing
- Dexmedetomidine hydrochloride Microneedles
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Guangzhou Novaken Pharm Co., Ltd.
Preoperative Sedation
Intranasal Dexmedetomidine Premedication in Children
BACKGROUND INFORMATION AND RATIONALE Pediatric patients scheduled for dental procedures under general anesthesia can have significant anxiety before the procedure.
- Trial name
- NCT02250703
- Testing
- Midazolam, Dexmedetomidine
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Mississippi Medical Center
Anxiety, Separation
A Comparison of Two Doses of Intranasal Dexmedetomidine for Premedication in Children
The purpose of the study is to determine if 4mcg/kg of intranasal dexmedetomidine is better than 2mcg/kg in successfully sedating a child prior to induction of anesthesia.
- Trial name
- NCT02459509
- Testing
- Dexmedetomidine
- Where
- Hong Kong
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Sedation, Preoperative Anxiety Experienced by the Pediatric Patient
Children of Age 2-6years Undergoing Elective Surgery Will be Divided Into Two Groups Randomly. This Study Aims to Evaluate if Intranasal Dexmedetomidine is Better Than Intranasal Ketamine in Producing Sedation and Reducing Parent Separation Anxiety Before Surgery.
This study aims to compare intranasal dexmedetomidine versus intranasal ketamine as a premedication in children undergoing surgery in our population.
- Conditions
- Sedation, Preoperative Anxiety Experienced by the Pediatric Patient, Anxiolytic Effect, Sedation and Analgesia
- Trial name
- DREAM-Kids (NCT07180095)
- Testing
- Intranasal dexmedetomidine, Intranasal ketamine
- Volunteers
- 60 people
- Sponsor
- Liaquat National Hospital & Medical College
Mental Health, Anxiety
Anxiety in Children and Families During MRI Under Anesthesia
This prospective randomized controlled study evaluates the impact of age-appropriate therapeutic play and structured parental briefing on perioperative anxiety during pediatric MRI under sedation.
- Trial name
- NCT07693309
- Testing
- Multi-modal Psychological Preparation
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Afyonkarahisar Health Sciences University
Anesthesia, Sedation
The Million Anesthesia Cases Study (MACS) - a Cohort Study of Preoperative Fasting and Perioperative Outcomes
Perioperative fasting has historically been viewed as a low-risk intervention. However, preliminary data indicate that perioperative loss of nutrition and fluids is likely harmful.
- Conditions
- Anesthesia, Sedation, Monitored Anesthesia Care, Procedure
- Trial name
- MACS (NCT07022951)
- Testing
- Preoperative fasting
- Where
- United States
- Volunteers
- 1,200,000 people
- Sponsor
- Massachusetts General Hospital
Magnetic Resonance Imaging
Prospective Study Assessing the Validity of Y-PAS (Yale Preoperative Anxiety Scale) to Predict Patients Undergoing Magnetic Resonance Imaging Without the Use of Sedation/General Anesthesia
The mYPAS (Modified Yale Preoperative Anxiety Scale) is a quick, easy, validated and "gold standard" assessment tool to measure pediatric anxiety in the perioperative period.
- Trial name
- NCT02586103
- Testing
- MRI simulation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Arlyne Thung
Preoperative Sedation of Children
A Trial of Dexmedetomidine Hydrochloride Nasal Spray in Preoperative Sedation of Children
The study is being conducted to evaluate the efficacy, and safety of dexmedetomidine hydrochloride nasal spray for preoperative sedation in children.
- Trial name
- NCT05111431
- Testing
- Dexmedetomidine Hydrochloride Nasal Spray, Dexmedetomidine hydrochloride nasal spray blank preparation
- Where
- China
- Volunteers
- 159 people
- Sponsor
- Shanghai Hengrui Pharmaceutical Co., Ltd.
Preoperative Sedation, Postoperative Pain
Preemptive Analgesia for Post Tonsillectomy Pain With IV Morphine in Children
In this double blind study, after taking an informed consent, 60 children aged between 7 and 12 years old assigned for tonsillectomy with or without adenoidectomy will be randomly divided into three groups.
- Trial name
- NCT02995304
- Testing
- Morphine premedication, Midazolam premedication
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- Dr. Soliman Fakeeh Hospital
Preoperative Anxiety, Preoperative Sedation
Determination of ED50 and ED95 With Clinical Efficacy of Intranasal Dexmedetomidine Combined With Esketamine for Preoperative Sedation in Pediatric General Anesthesia
For pediatric patients undergoing general anesthesia, poor anesthesia induction compliance often has adverse effects on individual behavior in the early postoperative period.
- Conditions
- Preoperative Anxiety, Preoperative Sedation, Children, Dexmedetomidine
- Trial name
- NCT06853431
- Testing
- dexmedetomidine, Esketamine
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Delirium, Sedation Complication
The Relationship Between Fasting Time and Delirium
We investigated the relationship between fasting times and delirium in children undergoing MRI under anesthesia. Paediatric Anaesthesia Emergence Delirium (PAED) scale, last oral intake time and type of food (solid-liquid) and…
- Conditions
- Delirium, Sedation Complication, Magnetic Resonance Imaging, Fasting
- Trial name
- NCT05567718
- Testing
- Paediatric Anaesthesia Emergence Delirium scale
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Remimazolam, Dexmedetomidine
Application of Remimazolam, Dexmedetomidine, and Esketamine in Pediatric Preoperative Sedation
By comparing the application effects of three drugs in pediatric preoperative sedation, this study explores the optimal medication regimen, aiming to provide safer, more effective, and more personalized medication options for…
- Conditions
- Remimazolam, Dexmedetomidine, Esketamine
- Trial name
- NCT07050212
- Testing
- remimazolam group, dexmedetomidine group, esketamine group
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Maternal and Child Health Hospital of Hubei Province
Anesthesia, Sedation
Comparison of Intranasal Dexmedetomidine and Short Video Viewing in the Preoperative Anxiety
This observational study aims to compare the effects of short video viewing and intranasal dexmedetomidine administration-both of which are part of routine clinical practices in the pediatric endoscopy unit-on preoperative…
- Conditions
- Anesthesia, Sedation, Anxiety
- Trial name
- NCT07077200
- Testing
- Intranasal dexmedetomidine
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Samsun University
Behavior, Child, Anxiety
Impact of Pre-Sedation Virtual Reality Game on Post-Discharge Negative Behaviors in the Pediatric Emergency Department
The purpose of this study is to evaluate if a virtual reality (VR) distraction game played prior to procedural sedation for long bone fracture reduction will improve post-discharge negative behavior changes following discharge…
- Trial name
- NCT03980067
- Testing
- Virtual Reality Game
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- Medical College of Wisconsin
Preoperative Sedation
Nebulized vs. Oral Midazolam Sedation in Pediatric Anesthesia: A Randomized Comparative Study
This study is to be carried out to compare nebulized and oral midazolam in achievement of a satisfactory level of sedation, Ramsey Sedation Score (RSS) of 4, within 30 mins of midazolam administration in pediatrics.
- Trial name
- NCT04760041
- Testing
- Midazolam nebulized, Midazolam oral solution
- Where
- Egypt
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Cairo University
Sedation, Conscious
Intranasal Midazolam in Children as a Pre-Operative Sedative
The purpose of this study is to see if adding a numbing medicine, xylocaine, to the nasal midazolam makes giving the midazolam easier and more comfortable without affecting how the midazolam works as a sedative.
- Trial name
- NCT02314546
- Testing
- Midazolam, xylocaine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Bassett Healthcare
Pre Operative Sedation, Mask Acceptance
Effect of Dexmedetomidine Versus Midazolam Versus a Combination of the Two as a Premedication for Children Undergoing Bilateral Myringotomy Tube Insertion
Following an obtained written consent, a child presenting for ear tube surgery will be randomized into one of three groups for receiving a premedication.
- Conditions
- Pre Operative Sedation, Mask Acceptance, Post Operative Delerium
- Trial name
- NCT02134327
- Testing
- Combination of Dexmedetomidine with Midazolam
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Preoperative Anxiety, Emergence Agitation
Effects of Nasal Administration of Dexmedetomidine on Pre-anesthesia Sedation, Intraoperative Brain Electrical Activity, and Incidence of Agitation During Recovery in Children
Pre - operative anxiety and emergence agitation are common issues among pediatric patients, which have various influences on the recovery progress and prognosis of children.
- Trial name
- NCT06896721
- Testing
- Preoperative sedation with dexmedetomidine was administered nasal before surgery, Preoperative sedation with normal saline was administered nasal before surgery
- Volunteers
- 627 people, healthy volunteers welcome
- Sponsor
- Fuzhou Hua
Anxiety
Clinical Study of Oral Midazolam Combined With Esketamine Administered Intranasally for Pediatric Preoperative Sedation
Children are prone to anxiety and even fear before surgery, and such adverse emotions may not only lead to poor induction of anesthesia, but also increase the incidence of postoperative agitation and even lead to postoperative…
- Trial name
- NCT05925283
- Testing
- Midazolam, Esketamine, midazolam and esketamine
- Where
- China
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University