Clinical trials: Pregnancy in Diabetic
Type 1 Diabetes, Nephropathy, Diabetic
SGLT2 Adjunct in T1D
Effect of Sodium-Glucose Cotransporter (SGLT) 2 Inhibitors on Diabetic Nephropathy Progression in Adolescents with Type 1 Diabetes Mellitus
- Trial name
- NCT07591077
- Testing
- Empagliflozin (EMPA)
- Where
- Egypt
- Volunteers
- 86 people
- Sponsor
- Ain Shams University
Type 2 Diabetes, Diabetes Type 2
Renal Hemodynamics, Energetics and Insulin Resistance: A Follow-up Study
The current protocol plans to enroll participants with youth-onset Type 2 Diabetes (T2D) as well as obese and lean controls from the Renal-HEIR - Renal Hemodynamics, Energetics and Insulin Resistance in Youth Onset Type 2…
- Conditions
- Type 2 Diabetes, Diabetes Type 2, Diabetic Nephropathies, Nephropathy
- Trial name
- HEIRitage (NCT05530356)
- Testing
- Aminohippurate Sodium Inj 20%, Iohexol Inj 300 MG/ML, Dextran 40
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Colorado, Denver
Type 1 Diabetes Mellitus With Diabetic Nephropathy
Validation of Biomarkers of Diabetic Nephropathy in Type I Diabetic Children
About 30 to 40% of patients suffering from type I diabetes are at risk of developing a diabetic nephropathy (DN) leading more or less rapidly to an end-stage renal disease.
- Trial name
- peeDIAB2 (NCT02164279)
- Testing
- Urinary sample collection
- Where
- 2 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Toulouse
Type 1 Diabetes, Diabetic Kidney Disease
MANATEE-T1D: Metformin ANd AutomaTEd Insulin Delivery System Effects on Renal Vascular Resistance, Insulin Sensitivity, and Cardiometabolic Function in Youth With Type 1 Diabetes
Diabetic kidney disease and cardiovascular disease remain the leading causes of morbidity and mortality in people with type 1 diabetes and are exacerbated with longer duration of diabetes and time outside goal glycemic range.
- Conditions
- Type 1 Diabetes, Diabetic Kidney Disease, Cardiovascular Diseases, Endothelial Dysfunction
- Trial name
- MANATEE-T1D (NCT05065372)
- Testing
- Metformin Hcl 1000Mg Tab, Aminohippurate Sodium 20 % Injection, Iohexol 300 Mg/mL Injectable Solution
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Kalie Tommerdahl
Diabetes Mellitus Type 2
Effects of High-Resistance Inspiratory Muscle Strength Training on Cardiorenal and Vascular Function in Youth and Young Adults With Type 2 Diabetes
High-resistance, short-duration inspiratory muscle strength training (IMST) is a novel lifestyle intervention involving 30 inhalations against a resistive load which requires only ~5 min/day and is thus ideal for youth with T2D…
- Trial name
- IMST (NCT06936670)
- Testing
- Inspiratory Muscle Strength Training (IMST)
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Seattle Children's Hospital
Diabetic Nephropathy
The Expression of circANKRD36 as a New Biomarker of Diabetic Nephropathy
1. To evaluate expression levels of circANKRD36 in the development and progression of DN. 2. To investigate correlation between expression levels of circANKRD36 and stages of DN. 3.
- Trial name
- NCT05061459
- Testing
- circANKRD36 as a new biomarker
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Assiut University
Diabetes Mellitus in Pregnancy, Gestational Diabetes
Biomarkers During Pregnancy
This study aims to obtain preliminary data for utility of alternate biomarkers for monitoring glucose control in diabetic women during pregnancy and/or predicting risk of adverse neonatal events in these women.
- Trial name
- NCT04108455
- Testing
- Specimens Collected
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Washington University School of Medicine
Gestational Diabetes, Pregestational Diabetes
Possible Epigenetic Changes in Offspring of Women With Pregestational and Gestational Diabetes
Pregestational diabetes (PGD) during pregnancy may be associated with an increased rate of spontaneous abortions, intrauterine death and congenital anomalies among the offspring.
- Conditions
- Gestational Diabetes, Pregestational Diabetes, IDM (Infant of Diabetic Mothers), Neurodevelopmental Outcome
- Trial name
- NCT01255384
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Diabetes in Pregnancy
Single Non-fasting OGTT Versus Fasting OGTT for Screening of Hyperglycaemia in Pregnancy (HIP)
With the increasing prevalence of diabetes in pregnancy it is necessary to design a simple, sensitive, cost effective method for screening of hyperglycaemia in pregnancy specially in resource constrained settings.
- Trial name
- NCT04129190
- Testing
- Glucose
- Where
- Pakistan
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Isra University
Birth Weight, Macrosomia, Fetal
Association Between Labor Induction and Birth Weight in Cases of Fetal Macrosomia: The MACROMODA Cohort Study
The rising prevalence fof fetal macrosomia represents a significant challenge in obstetrics, affecting both maternal and neonatal outcomes. Such challenges include complications like perineal tears and postpartum hemorrhage.
- Trial name
- MACROMODA (NCT06198881)
- Where
- 3 sites in France
- Volunteers
- 4,500 people
- Sponsor
- Hospices Civils de Lyon
Pregnancy Complications, Placental Insufficiency
PREdelivery Placental Biomarkers- Pregnancy and Delivery Outcome
The PREPPeD study proposes that predelivery placenta-derived maternal circulating biomarkers reflect placental health, capacity and ageing, and can help predict onset and complications of delivery both in complicated pregnancies…
- Trial name
- PREPPeD (NCT03100084)
- Testing
- Blood sampling
- Where
- Norway
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Type 1 Diabetes, Pregnancy in Diabetic
PRenatal and Obstetric Maternal Exposures and ISlet Autoantibodies in Early Life
This research study is called 'PRenatal and Obstetric Maternal Exposures and ISlet Autoantibodies in Early Life: The PROMISE Study'.
- Trial name
- PROMISE (NCT06141434)
- Where
- 4 sites in United States
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Pregnancy in Diabetes, Fetal Complications
Infants of Diabetic Mothers: A Cohort Study
Saudi Arabia has been named by the International Diabetes Federation as among the top ten countries with highest prevalence of diabetes. Women are said to have overall prevalence twice that for men.
- Trial name
- NCT02079415
- Testing
- Prevention of complications in infants of diabetic mothers
- Where
- Saudi Arabia
- Volunteers
- 601 people, healthy volunteers welcome
- Sponsor
- Security Forces Hospital
Diabetic Nephropathy.
SLC2A1 Variants and Diabetic Nephropathy
Cells damaged by hyperglycemia are unable to downregulate glucose entrance in presence of high extracellular glucose resulting in intracellular activation of deleterious biochemical pathways.
- Trial name
- NCT01768611
- Where
- Brazil
- Volunteers
- 449 people
- Sponsor
- University of Sao Paulo General Hospital
Gestational Diabetes Mellitus in Pregnancy, Vitamin D Deficiency
Effects of Vitamin D Supplementation on Glucose Metabolism in Women With Former Gestational Diabetes Mellitus
Gestational Diabetes Mellitus (GDM) and vitamin D deficiency are related to insulin resistance and impaired beta-cell function, with heightened risk for future development of diabetes.
- Trial name
- NCT01992133
- Testing
- Vitamin D3
- Where
- Malaysia
- Volunteers
- 26 people
- Sponsor
- RCSI & UCD Malaysia Campus
Gestational Diabetes, Type2 Diabetes
The Belgian Diabetes in Pregnancy Follow-up Study
Gestational diabetes (GDM) is a form of diabetes that develops during pregnancy. GDM is associated with increased risks for pregnancy complications such as macrosomia s and preterm delivery.
- Conditions
- Gestational Diabetes, Type2 Diabetes, Obesity
- Trial name
- BEDIP-FUS (NCT04429958)
- Testing
- GDM
- Where
- 5 sites in Belgium
- Volunteers
- 630 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Type 2 Diabetes, Diabetic Nephropathy
Effects of Losartan on Insulin Sensitivity and Secretion in Type 2 Diabetes and Nephropathy
Angiotensin type-1 receptor (AT1R) blockers (ARBs) have been recognized recently as regulators of glucose and lipid metabolism in adipocytes and adipose tissue.Moreover telmisartan and irbesartan have been recognized recently as…
- Trial name
- NCT00361023
- Testing
- losartan
- Volunteers
- 25 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Diabetes Mellitus in Pregnancy, Diabetes, Gestational
Diabetes in Pregnancy and Pregnancy Outcomes
To compare the clinical, glycemic profile and therapy as well as pregnancy complications and infant mortality among diabetic mothers in Indonesia.
- Trial name
- NCT03602846
- Testing
- Medical Nutrition Therapy, Insulin, Oral Antidiabetics
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Tarumanagara University
Diabetes Mellitus, Type 1, Nephropathy
Copeptin in Adolescent Participants With Type 1 Diabetes and Early Renal Hemodynamic Function
Over 1.25 million Americans have type 1 diabetes (T1D), increasing risk for early death from cardiorenal disease. The strongest risk factor for cardiovascular disease (CVD) and mortality in T1D is diabetic kidney disease (DKD).
- Conditions
- Diabetes Mellitus, Type 1, Nephropathy, Diabetic Nephropathies, Juvenile Diabetes
- Trial name
- CASPER (NCT03618420)
- Testing
- Aminohippurate Sodium Inj 20%, Iohexol Inj 300 mg/mL
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Type1diabetes, Type1 Diabetes Mellitus
Evaluation of Coffee Therapy for Improvement of Renal Oxygenation
Over 1.25 million Americans have Type 1 Diabetes (T1D), increasing risk for early death from cardiovascular disease (CVD). Despite advances in glycemic and blood pressure control, a child diagnosed with T1D is expected to live up…
- Conditions
- Type1diabetes, Type1 Diabetes Mellitus, Diabetic Kidney Disease, Juvenile Diabetes
- Trial name
- COFFEE (NCT03878277)
- Testing
- Starbucks® Cold brew - 325ml bottle
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Colorado, Denver