Clinical trials: Preconditioning
Myocardial Ischemic Reperfusion Injury, End Stage Heart Disease
Remote Ischemic Preconditioning With Postconditioning in Heart Transplantation Surgery
The purpose of this study is to determine whether remote ischemic preconditioning with postconditioning (RIPC+RIPostC) reduces myocardial injury and improves clinical outcomes in heart transplantation surgery.
- Conditions
- Myocardial Ischemic Reperfusion Injury, End Stage Heart Disease, Heart Failure, Cardiomyopathy
- Trial name
- NCT02149316
- Testing
- RIPC+RIPostC, control
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Subarachnoid Hemorrhage, Aneurysmal, Subarachnoid Hemorrhage
Remote Ischemic Preconditioning in Subarachnoid Hemorrhage
Rupture of brain aneurysms is a common cause of death and disability, accounting for as many as 10% of stroke cases in the United States.
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Subarachnoid Hemorrhage, Cerebral Vasospasm, Intracranial Aneurysm
- Trial name
- RIPC-SAH (NCT01158508)
- Testing
- Remote ischemic preconditioning
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Los Angeles
Operable Esophageal Cancer, Embolization of the Left Gastric Artery Prior to Surgery
Gastric Ischemic Preconditioning Before Esophagectomy
The aim of the study is to investigate the impact of left gastric artery embolization before esophagectomy on postoperative complications, particularly anastomotic leaks and necrosis of the gastric conduit.
- Trial name
- NCT06453031
- Testing
- Gastric Ischemic Preconditioning Before Esophagectomy
- Where
- France
- Volunteers
- 20 people
- Sponsor
- CHU Rennes - Hopital Pontchaillou
Ischemic Reperfusion Injury
Single-cycle Remote Ischemic Preconditioning and Postconditioning for Prevention of Contrast-Induced Nephropathy
This trial is a 2 x 2 factorial design, double-blinded, randomized controlled trial to evaluate efficacy and safety of remote ischemic preconditioning and postconditioning for prevention of contrast-induced acute kidney injury in…
- Trial name
- NCT02729155
- Testing
- RIPre, RIPost
- Where
- Thailand
- Volunteers
- 596 people
- Sponsor
- Phramongkutklao College of Medicine and Hospital
Heart Defects, Congenital
Neuroprotective Effects of Remote Ischemic Preconditioning (RIPC) During Infant Cardiac Surgery
The purpose of this study is to look at whether the use of a simple technique before surgery, which involves inflating a blood pressure cuff on the infant's leg, can improve development of language, motor and thinking skills at…
- Trial name
- NCT01835392
- Testing
- Remote Ischemic Preconditioning, Control
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Nemours Children's Clinic
Aortic Aneurysm, Ischemic Preconditioning
Effect of Remote Ischemic Preconditioning on the Incidence of Contrast Induced Nephropathy in Patients Undergoing EVAR
Introduction: Contrast induced nephropathy (CIN) is a major inconvenience in the use of iodinated contrast media (ICM) and it is associated with a significant increase in morbimortality and cost of hospitalization.
- Trial name
- RIPC-EVAR (NCT05350683)
- Testing
- Remote ischemic preconditioning
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Vascular Investigation Network Spanish Society for Angiology and Vascular Surgery
Brain Injury, Myocardial Injury
Preconditioning With Hyperbaric Oxygen in Cardiovascular Surgery
Animal studies have shown that preconditioning with hyperbaric oxygen can induce central nervous system and heart ischemic tolerance.
- Trial name
- NCT00817791
- Testing
- Hyperbaric oxygen pretreatment (GR2200)
- Volunteers
- 49 people
- Sponsor
- Xijing Hospital
Acute Kidney Injury
Remote Ischemic Preconditioning to Prevent Contrast Nephropathy
Contrast-medium induced nephropathy (CIN) is a frequent and devastating complication of coronary angiography, occurring in 10-50% of cases.
- Trial name
- RIPC-CIN (NCT02674451)
- Testing
- Remote ischemic preconditioning
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Johns Hopkins University
Congenital Heart Disease, Cardiopulmonary Bypass
Seattle Cardiorenal Remote Ischemic Preconditioning Trial
Remote Ischemic Preconditioning (RIPC) is a treatment that may be associated with improved outcomes after cardiac surgery. It can be elicited noninvasively by using a tourniquet to elicit transient ischemia over a lower…
- Conditions
- Congenital Heart Disease, Cardiopulmonary Bypass, Myocardial Injury, Acute Kidney Injury
- Trial name
- SCRIPT (NCT01260259)
- Testing
- RIPC, Control
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Seattle Children's Hospital
Cardiotoxicity
Remote Ischaemic Preconditioning in Childhood Cancer
Survival rates of children with cancers have improved significantly in the recent few decades. Nonetheless, the side effect of this class of drugs on heart function remains to be an issue of concern.
- Trial name
- NCT03166813
- Testing
- Remote Ischaemic Preconditioning, Control
- Where
- Hong Kong
- Volunteers
- 68 people
- Sponsor
- The University of Hong Kong
Kidney Disease, Liver Disease
Remote Ischemic Preconditioning In Abdominal Organ Transplantation
Does remote ischemic preconditioning (RIPC) induced by a brief period of occlusion of blood flow to the lower extremity prior to organ recovery in deceased donors, improve short and long term outcomes after transplantation of…
- Conditions
- Kidney Disease, Liver Disease, Pancreas Disease
- Trial name
- RIPCOT (NCT00975702)
- Testing
- RIPC by Inflation of Pneumatic Tourniquet
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Heart Ischemia, Cerebral Ischemia
Organ Protection by Remote Ischemic Preconditioning for Surgical Treatment of Pediatric Congenital Heart Disease
Cardiac surgery is associated with risk of perioperative inflammation and ischemia leading to cerebral and myocardial morbidity and mortality.
- Trial name
- RIPHeart (NCT01312623)
- Testing
- Remote ischemic preconditioning
- Where
- Germany
- Volunteers
- 31 people
- Sponsor
- University Hospital Schleswig-Holstein
Organ Transplantation
Remote Ischemic Preconditioning in Neurological Death Organ Donors
The purpose of this study is to determine whether application of lower limb remote ischemic preconditioning (RIPC) after determination of brain death improves donor stability, organ quality, organ yield, and early post transplant…
- Trial name
- RIPNOD (NCT01515072)
- Testing
- RIPC (Remote Ischemic Preconditioning)
- Where
- 2 sites in United States
- Volunteers
- 321 people
- Sponsor
- Rutgers, The State University of New Jersey
Ischemia-reperfusion (IR) Injury
Clinical and Genomic Responses to Open Heart Surgery
This study will be the first large scale randomized study of remote ischemic preconditioning (RIPC) ever performed and will define the role of this novel therapy as a clinical tool.
- Trial name
- NCT00650507
- Testing
- Remote ischemic preconditioning (RIPC)
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- The Hospital for Sick Children
Cyanosis
Effect of Remote Ischemic Preconditioning on Children Undergoing Cardiac Surgery
This study is conducted in order to evaluate the effect of remote ischemic preconditioning on children undergoing cardiac surgery, especially focusing on possible differences according to preoperative cyanosis.
- Trial name
- NCT01311310
- Testing
- RIPC (remote ischemic preconditioning)
- Where
- 2 sites in South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Ischemic Preconditioning
The Study of Potency of Cross-preconditioning to Prevent Ischemic-reperfusion Injury for Heart Transplantation Recipient
In recent years, a large number of studies confirmed the protective effect of ischemic preconditioning on myocardium against ischemia/reperfusion injury, but the clinical data of the effectiveness of ischemic preconditioning in…
- Trial name
- NCT03900390
- Testing
- cross-preconditioning
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Mengya Liang
Effectivity of RIPC in Outcomes of TAVI Procedure
Cardioprotective Effect of RIPC in Patients Undergoing TAVI
We aim to investigate whether RIPC (remote ischemic preconditioning) is effective in the TAVI setting to reduce post-procedural myocardial damage and improve patient outcome.
- Trial name
- CARE-TAVI (NCT02283398)
- Testing
- without RIPC, RIPC
- Where
- 3 sites in Germany
- Sponsor
- Institut für Pharmakologie und Präventive Medizin
Peripheral Vascular Disease
RCT to Evaluate the Renal Protective Effects of Remote Ischaemic Preconditioning in Peripheral Angioplasty
This study aims to demonstrate if remote ischaemic preconditioning (RIPC) may confer renal protection in patients undergoing peripheral angioplasty.
- Trial name
- NCT02054871
- Testing
- RIPC
- Where
- Ireland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mid Western Regional Hospital, Ireland
Hepatic Ischemic and Reperfusion Injury
Liver Protection of RIPC in Pediatric Living Donor Liver Transplantation
Remote ischemic preconditioning(RIPC) is emerging as an promising therapeutic paradigm to combat the detrimental impact of ischemic and reperfusion injury.
- Trial name
- RIPC-PLDT (NCT02830841)
- Testing
- remote ischemic preconditioning(RIPC)
- Where
- China
- Volunteers
- 208 people
- Sponsor
- RenJi Hospital
Open Heart Surgery, Preconditioning
Effect of Cardiac Preconditioning Upon the Inotrope Score
preconditioning of no debate has a valuable effect upon myocardial protection . pre-cardiopulmonary bypass pre-conditioning , suspected to have a role upon postoperative inotropic support
- Trial name
- NCT03105089
- Testing
- ischemic preconditioning
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University