Clinical trials: Platelet Function
Coronary Heart Disease, Percutaneous Coronary Intervention
Comparison of Generic and Original Formulation of Clopidogrel
Clopidogrel is essential for the prevention of vascular events in patients after percutaneous coronary interventions (PCI). Most of our current knowledge with clopidogrel originates from the clinical investigations that had used…
- Trial name
- DOSER-GENERIC (NCT01147133)
- Testing
- Plavix, Kardogrel
- Volunteers
- 75 people
- Sponsor
- University of Pecs
Cryopreservation, Ovary Injury
Improving the Quality of Cryopreserved Ovarian Tissue Reimplantation Using Platelet-enriched Autologous Plasma
The study is aimed to evaluate the effects of intraovarian injection of autologous Platelet-enriched Autologous Plasma on the outcomes of orthotopic transplantation of cryopreserved ovarian tissue.
- Conditions
- Cryopreservation, Ovary Injury, Infertility, Female, Menopause Ovarian Failure
- Trial name
- TESOVA2022 (NCT06261658)
- Testing
- Cryopreserved Ovarian Tissue Reimplantation
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Acquired Platelet Function Disorder
Platelet Function With New Pediatric Oxygenator and Heparin and Non Heparin Coating in Pediatric Cardiac Surgery
Optimal anticoagulation is mandatory during CPB in order to avoid hemostatic system activation. Platelet dysfunction is commonly observed after procedures performed under cardiopulmonary bypass (CPB).
- Trial name
- NCT01648712
- Testing
- Balance surface, Carmeda heparin-coated surface, non -heparin extracorporeal pediatric device for operation
- Where
- France
- Volunteers
- 48 people
- Sponsor
- Hôpital Necker-Enfants Malades
Depression
Platelet Function in Patients Treated With SSRI and Non-SSRI Antidepressants
This study will examine the effect of a class of antidepressant medications called selective serotonin reuptake inhibitors (SSRIs) on platelet function.
- Trial name
- NCT00009568
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Immune Thrombocytopenia
Association of Platelet Parameters With Bleeding Severity in Children With ITP
Patients with severe immune thrombocytopenia (ITP) present with similarly low platelet counts but varying bleeding symptoms, making it difficult to predict the disease course and to decide on an appropriate treatment plan.
- Trial name
- ITP-APPS (NCT03810352)
- Where
- 6 sites in United States
- Volunteers
- 95 people
- Sponsor
- Boston Children's Hospital
Thrombocytopenia, Myocardial Infarction
Aspirin in Patients With Myocardial Infarction and Thrombocytopenia
Primary Objective: To determine the risk of bleeding from ASA therapy in thrombocytopenic patients who develop Acute Coronary Syndrome (ACS), and assess its effect on the overall morbidity and mortality in these patients as well…
- Trial name
- NCT00501345
- Testing
- Aspirin
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- M.D. Anderson Cancer Center
Cerebrovascular Disorders, Platelet Refractoriness
Platelet Antisedimentation Rate and Multiplate Exams in Patients on Antiplatelet Therapy and Controls
To search for simple laboratory methods selecting patients with low/non-responsiveness to P2Y12 receptor antagonists.
- Conditions
- Cerebrovascular Disorders, Platelet Refractoriness, Platelet Aggregation, Spontaneous
- Trial name
- NCT03679858
- Testing
- Platelet function test
- Where
- Hungary
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pecs
Hemophilia A
Platelet Function in Patients With Hemophilia A
Abnormalities in the gene encoding Factor VIII (FVIII) results in hemophilia A, an X-linked recessive bleeding disorder with a prevalence of 1 in 5000 males.
- Trial name
- NCT02093065
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Boston Children's Hospital
Platelet Aggregation Inhibitors, Hydroxymethylglutaryl-coa Reductase Inhibitors
The Compliance of DAPT and Statins on Clinical Outcomes in Percutaneous Coronary Intervention Patients
A nationwide retrospective cohort study. To investigate the real world medication compliance and the relation with clinical outcomes.
- Conditions
- Platelet Aggregation Inhibitors, Hydroxymethylglutaryl-coa Reductase Inhibitors, Compliance, Medication, Adherence, Medication
- Trial name
- CPPCI (NCT03785509)
- Testing
- DAPT, Statin
- Where
- South Korea
- Volunteers
- 47,291 people
- Sponsor
- Samsung Medical Center
COPD, Interstitial Lung Disease
An Observational Outcomes Study for Autologous Cell Therapy Among Patients With COPD and Interstitial Lung Disease
The purpose of the Lung Institute is to collect and isolate a patient's own cells and platelet rich plasma (PRP) and deliver the product back to the patient same-day.
- Trial name
- NCT03040674
- Testing
- Cell therapy
- Where
- United States
- Volunteers
- 489 people
- Sponsor
- Lung Institute
Mitral Regurgitation
STrategies for Antithrombotic tReatment Following Transcatheter Edge-to-Edge Repair in Patients With an Indication for Oral Anticoagulant
Mitral regurgitation (MR) is the most common valvular heart disease, affecting approximately 24.2 million people worldwide (with a higher prevalence in older age groups).
- Trial name
- STAR-TEER Ⅰ (NCT06901466)
- Testing
- Experimental: Rivaroxaban monotherapy, Active Comparator: Rivaroxaban+Clopidogrel
- Where
- China
- Volunteers
- 880 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Von Willebrands Disease
Investigating a Von Willebrand Factor (VWF) Functional Screening Assay for Assigning the Phenotypic Variants of Von Willebrand Disease (VWD)
The purpose of this study is to improve the investigators ability to diagnose von Willebrand Disease (VWD), a common inherited bleeding disorder.
- Trial name
- VWF-phV (NCT02466789)
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- Jonathan Roberts
Glanzmann Thrombasthenia
The Genetics and Functional Basis of Inherited Platelet, White Blood Cell, Red Blood Cell, and Blood Clotting Disorders.
Blood contains red blood cells, white blood cells, and platelets, as well as a fluid portion termed plasma. We primarily study blood platelets, but sometimes we also analyze the blood of patients with red blood cell disorders…
- Trial name
- NCT00230165
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Coronary Artery Stent Thrombosis
PRESTIGE: PREvention of Stent Thrombosis by an Interdisciplinary Global European Effort
The PRESTIGE-registry is a joint effort at 9 European heart centers to collect data regarding patients presenting with stent thrombosis in a dedicated database.
- Trial name
- PRESTIGE (NCT01300507)
- Where
- Belgium
- Volunteers
- 2,000 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Heart Defect, Congenital
Tranexamic Acid Effect on Platelet Aggregation Following Infant Cardiopulmonary Bypass
Tranexamic acid is a relatively safe medicine that is used to help the body develop clots and slow down bleeding after large surgeries.
- Trial name
- NCT02122679
- Testing
- Tranexamic Acid
- Where
- United States
- Sponsor
- Emory University
Mitral Regurgitation
STrategies for Antithrombotic tReatment Following Transcatheter Edge-to-Edge Repair in Patients Without an Indication for Oral Anticoagulant
Mitral regurgitation (MR) is the most common valvular heart disease, affecting approximately 24.2 million people worldwide (with a higher prevalence in older age groups).
- Trial name
- STAR-TEER Ⅱ (NCT07007143)
- Testing
- Experimental: Aspirin monotherapy, Active Comparator: Aspirin+Clopidogrel
- Where
- China
- Volunteers
- 1,032 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Sickle Cell Disease
Effect of Ticagrelor vs. Placebo in the Reduction of Vaso-occlusive Crises in Pediatric Patients With Sickle Cell Disease
The purpose of the study is to Evaluate the Effect of Ticagrelor versus Placebo in Reducing the Rate of Vaso-Occlusive Crises in Paediatric Patients with Sickle Cell Disease
- Trial name
- HESTIA3 (NCT03615924)
- Testing
- Ticagrelor
- Where
- 55 sites in United States, Belgium and 14 more
- Volunteers
- 193 people
- Sponsor
- AstraZeneca
Sickle Cell Disease
Study to Evaluate the Effect of Ticagrelor Versus Placebo in Reducing Vaso-Occlusive Crises Rate in Pediatric Patients With Sickle Cell Disease.
The purpose of this study is to compare the effect of ticagrelor vs placebo for the reduction of Vaso-Occlusive crises in paediatric patients with Sickle Cell Disease
- Trial name
- HESTIA5 (NCT04293172)
- Testing
- Brilinta
- Sponsor
- AstraZeneca
Wiskott-Aldrich Syndrome, Thrombocytopenia
Thrombocytopenia and Bleeding in Wiskott-Aldrich Syndrome (WAS) Patients
The purpose of this project is to describe the pathophysiology of thrombocytopenia and bleeding in patients with Wiskott-Aldrich Syndrome (WAS) and determine the response to thrombopoietic agents in vitro and in vivo.
- Conditions
- Wiskott-Aldrich Syndrome, Thrombocytopenia, Bleeding
- Trial name
- WAS (NCT00909363)
- Testing
- Promacta, blood drawing in patients with WAS, blood drawing in healthy controls
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Cardiac Surgical Procedures
The Impact of Storage Techniques on Platelets Number and Function After Acute Normovolemic Hemodilution (ANH)
Acute normovolemic hemodilution (ANH) is part of our current protocol to decrease post-operative bleeding and homologous blood transfusions post cardiopulmonary bypass.
- Trial name
- NCT02060838
- Testing
- Acute normovolemic hemodilution (ANH)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Aymen N Naguib