Clinical trials: Pituitary Tumors
Pituitary Adenoma
Pre-operative Surgical Difficulty Stratification Using Predicted Tumor Perfusion and Consistency
Pituitary adenomas (PAs) are among the most prevalent lesions of the sella turcica, accounting for 10%-25% of all intracranial neoplasms. Pituitary macroadenomas (PMAs) are defined with a maximum diameter of over 1 cm.
- Trial name
- NCT06664190
- Testing
- Advanced sequences, such as arterial spin labeling (ASL) and diffusion-weighted imaging (DWI)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Huashan Hospital
Pituitary Tumor, Endocrine Neoplasia
Epidemiology of Pituitary Tumours: Prevalence of Associated Neoplasia
The study aims to update current knowledge about the epidemiology of pituitary tumours (PiT), based on the wide body of scientific literature on new familial and/or syndromic forms.
- Conditions
- Pituitary Tumor, Endocrine Neoplasia, Hyperparathyroidism, Solid Tumor
- Trial name
- EpidemioPIT (NCT03973450)
- Testing
- Registration of familial forms and associated neoplasia
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Neuromed IRCCS
Hypopituitarism, Hypogonadism
Detection and Treatment of Endocrine Abnormalities in Childhood Cancer Survivors and Hematopoietic Stem Cell Transplant Recipients
This study will determine the prevalence of endocrine-related side effects in children who have been treated for cancer and establish a database and registry organized according to cancer diagnosis, treatments and endocrine side…
- Conditions
- Hypopituitarism, Hypogonadism, Thyroid Dysfunction, Bone Diseases, Metabolic
- Trial name
- NCT00504218
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Craniopharyngioma, Obesity
Multicenter Registry for Patients With Childhood.Onset Craniopharyngioma, Xanthogranuloma, Cysts of Rathke's Pouch, Meningioma, Pituitary Adenoma, Arachnoid Cysts
KRANIOPHARYNGEOM Registry 2019 will prospectively collect and descriptively analyse data on diagnostics, treatment, and follow-up of patients with craniopharyngioma.
- Trial name
- NCT04158284
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- Klinikum Oldenburg gGmbH
Pituitary Tumour
Silastic Stent Study
Endoscopic skull base surgery is a relatively new procedure that is now a standard of care for surgeries at the base of the skull; however there are no studies that examine the healing process of the nasal lining with the use of…
- Trial name
- NCT03282058
- Testing
- Silastic Stent
- Volunteers
- 26 people
- Sponsor
- University of British Columbia
Neurologic Disorders
Evaluation and Treatment of Neurosurgical Disorders
Objective: This protocol is designed to allow the Surgical Neurology Branch to evaluate and treat the neurosurgical disorders of protocol participants.
- Trial name
- NCT00060541
- Testing
- Laboratory tests, Radiological exams
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Basal Ganglia Germinoma, Diabetes Insipidus
A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma
This phase II trial studies how well lower dose radiotherapy after chemotherapy (Carboplatin \& Etoposide) works in treating children with central nervous system (CNS) germinomas.
- Conditions
- Basal Ganglia Germinoma, Diabetes Insipidus, Germinoma, Pineal Region Germinoma
- Trial name
- NCT06368817
- Testing
- 3-Dimensional Conformal Proton Radiation Therapy, 3-Dimensional Conformal Radiation Therapy, Biospecimen Collection
- Where
- 115 sites in United States, Australia and 1 more
- Volunteers
- 240 people
- Sponsor
- Children's Oncology Group
Panhypopituitarism, Gigantism/Acromegaly
An Investigation of Pituitary Tumors and Related Hypothalmic Disorders
There is a variety of tumors affecting the pituitary gland in childhood; some of these tumors (eg craniopharyngioma) are included among the most common central nervous system tumors in childhood.
- Conditions
- Panhypopituitarism, Gigantism/Acromegaly, Prolactinoma, Cushing Disease
- Trial name
- NCT00001595
- Testing
- Tissue specimen collection, MRI
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Polycystic Ovary Syndrome
The Relationship of PRL and Polycystic Ovary Syndrome (PCOS) in Taiwan's Women
Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder of reproductive-age women. According to Rotterdam 2003 criteria: at least two of three criteria are met, hyperandrogenism, chronic anovulation, and…
- Trial name
- NCT01117272
- Where
- Taiwan
- Volunteers
- 474 people
- Sponsor
- Taipei Medical University WanFang Hospital
Endocrine; Deficiency, Hypothalamo-Pituitary Disorder
Brain Irradiation for Childhood Cancer - Endocrine Monitoring During the First Years
BICHE- 1: Brain Irradiation for Childhood cancer - Endocrine monitoring during the first five years is a study of endocrine monitoring after cerebral radiotherapy.
- Conditions
- Endocrine; Deficiency, Hypothalamo-Pituitary Disorder, Radiotherapy Side Effect
- Trial name
- BIChE-1 (NCT06618703)
- Testing
- Blood sample, urine sample, osteodensitometry
- Where
- 3 sites in France
- Volunteers
- 230 people
- Sponsor
- University Hospital, Angers
Cystic Tumors of the Sellar/Parasellar Region
90Yttrium Colloid for the Treatment of Cystic Sellar/Parasellar Tumors
There is no consensus in the literature on the best way to treat cystic lesions of the pituitary area. Patients who are symptomatic from these tumours are rare.
- Trial name
- NCT02081768
- Testing
- 90yttrium colloid
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- David Clarke
Pituitary Neoplasms
Application of Augmented Reality Neuronavigation in Transnasal Endoscopic Skull Base Surgery
"For lesions in the skull base, including meningiomas, chordomas and pituitary tumors, endoscopic surgery has replaced traditional microscopes as the mainstream procedure.
- Trial name
- NCT06282224
- Testing
- Performing endoscopic transnasal skull base surgery with AR-integrated endoscope
- Where
- China
- Volunteers
- 10 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Pleuropulmonary Blastoma, Cystic Nephroma
Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome
Pleuropulmonary Blastoma (PPB) is a rare lung tumor which develops in childhood. The underlying genetic factors which contribute to the development and progression of PPB are not defined.
- Conditions
- Pleuropulmonary Blastoma, Cystic Nephroma, Sertoli-Leydig Cell Tumor of Ovary, Medulloepithelioma
- Trial name
- PPB (NCT00565903)
- Where
- United States
- Volunteers
- 1,247 people, healthy volunteers welcome
- Sponsor
- Ashley Hill
McCune Albright Syndrome, Polyostotic Fibrous Dysplasia
A Study of the Effects of Pegvisomant on Growth Hormone Excess in McCune-Albright Syndrome
This study will examine the effect of pegvisomant on growth hormone excess in patients with McCune-Albright syndrome (MAS). Patients with this disease have polyostotic fibrous dysplasia-a condition in which areas of normal bone…
- Trial name
- NCT00017927
- Testing
- Pegvisomant
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Pituitary Adenoma
Nasoseptal Double Flap Versus Rescue Flap in Endoscopic Transsphenoidal Pituitary Surgery
This paper investigates the outcomes of two surgical techniques-nasoseptal double flap and nasoseptal rescue flap-used in endoscopic transsphenoidal surgery for pituitary tumors.
- Trial name
- NCT06526481
- Testing
- Endoscopic Transsphenoidal pituitary surgery : Double Nasoseptal Flap Technique, Endoscopic Transsphenoidal pituitary surgery : Rescue Flap Technique
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Mansoura University
Pituitary Adenomas
Genome-wide Association Study of Pituitary Tumors
Pituitary adenomas is a very common disease, but the cause and genetics hasn't been identified. The investigators are going to use genome-wide association study to identify genes that may be related to pituitary adenomas.
- Trial name
- NCT01442220
- Where
- China
- Volunteers
- 12,500 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Cushing's Disease, Cushing Syndrome
Collecting Information About Treatment Results for Patients With Cushing's Syndrome
The purpose of this study is to follow participants with Cushing's syndrome during the course of their routine care and to form a data registry to study long term participant outcomes.
- Conditions
- Cushing's Disease, Cushing Syndrome, Cushing Disease
- Trial name
- NCT03364803
- Testing
- Cushing's QoL (Quality of Life Questionnaire), Nottingham Health Profile (NHP), Hospital Anxiety and Depression Scale (HADS)
- Where
- 7 sites in United States
- Volunteers
- 300 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Surgery, Pituitary Adenoma
Comparative Effectiveness of Different Surgical Approaches for Giant Pituitary Adenomas
The surgical treatment strategy for giant invasive pituitary adenoma is one of the current hot spots in the field of clinical research on pituitary adenoma.
- Trial name
- NCT05448690
- Testing
- Two different approaches, Non-combined approach
- Where
- 13 sites in China
- Volunteers
- 600 people
- Sponsor
- Huashan Hospital
Pituitary Neoplasm
Effects of Hormone Stimulation on Brain Scans for Cushing s Disease
Background: Cushing s disease can be caused by a tumor of the pituitary gland, a small gland about the size of a pea located at the base of the brain.
- Trial name
- NCT01459237
- Testing
- Acthrel
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Osteogenesis Imperfecta, Osteoporosis
REMS25: Study on the Use of REMS Technology in Diseases Commonly Associated With Reduced Bone Mineral Density (BMD)
This study evaluates bone mineral density (BMD) in pediatric patients aged 5-18 years with conditions negatively affecting bone health, using REMS (Radiofrequency Echographic Multi Spectrometry), a non-invasive and radiation-free…
- Conditions
- Osteogenesis Imperfecta, Osteoporosis, Hypogonadisms, Neoplasia
- Trial name
- NCT07412782
- Testing
- REMS
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Meyer Children's Hospital IRCCS