Clinical trials: Personalized Medicine
Haematological Malignancy, Malignant Neoplasm
DETERMINE Trial Treatment Arm 07: Dabrafenib in Combination With Trametinib in Adult, Paediatric and Teenage/Young Adult Patients With BRAF V600 Mutation-Positive Cancers.
This clinical trial is looking at two drugs called dabrafenib and trametinib. Dabrafenib and trametinib are approved as standard of care treatment for adult patients with melanoma (a type of skin cancer) or lung cancer and in…
- Conditions
- Haematological Malignancy, Malignant Neoplasm, Lymphoproliferative Disorders, Neoplasms by Histologic Type
- Trial name
- DETERMINE (NCT07440290)
- Testing
- Dabrafenib, Trametinib
- Where
- 27 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Cancer Research UK
Adherence to Personalized EBM Anticoagulant Treatment in Patients at High Risk for Stroke
Personalized Evidence-based Medicine in Patients With Atrial Fibrillation
A retrospective analysis
- Trial name
- NCT04774341
- Testing
- anticoagulation treatment
- Where
- Russia
- Volunteers
- 4,200 people
- Sponsor
- Center of Personalized Medicine, Pirogova
Overweight, Infant, Overweight and Obesity
Lille Study for Childhood Health Promotion
Obesity could be avoided but once declared it become a chronic disease with numerous health complications, including cardiovascular and metabolic diseases, cancers, and finally a loss of life expectancy.
- Conditions
- Overweight, Infant, Overweight and Obesity, Overweight, Childhood
- Trial name
- ELIPSE (NCT05121090)
- Testing
- Educational program
- Where
- France
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Cancer Metastatic
Improving Public Cancer Care by Implementing Precision Medicine in Norway
IMPRESS-Norway is a prospective, non-randomized clinical trial evaluating efficacy of commercially available, anti-cancer drugs prescribed for patients with advanced cancer diagnosed with potentially actionable alterations as…
- Trial name
- IMPRESS-N (NCT04817956)
- Testing
- Atezolizumab
- Where
- 17 sites in Norway
- Volunteers
- 3,000 people
- Sponsor
- Oslo University Hospital
Ulcerative Colitis
PRognOstiC valuE of rEd Density in Ulcerative Colitis
Observational prospective multicenter study: baseline assessement of the disease activity by an automated endoscopic tool and follow up of 52 weeks to evaluate sustained clinical remission.
- Trial name
- PROCEED-UC (NCT04408703)
- Testing
- Red Density
- Where
- 2 sites in Belgium
- Volunteers
- 243 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Depression - Major Depressive Disorder, Depressive Episodes
TDM-Guided Treatment With SSRIs in Hospitalized Adults and Children
Depression in childhood and adolescence is a serious and increasing public-health problem associated with profound short- and long-term consequences, including impaired social and educational functioning, increased risk of…
- Trial name
- NCT07478796
- Testing
- Fluoxetine, Escitalopram, Sertralin
- Where
- Poland
- Volunteers
- 180 people
- Sponsor
- Poznan University of Medical Sciences
Sepsis
Adaptive Platform Trial for Personnalisation of Sepsis Treatment in Children and Adults: a Multi-national, Treatable Traits-guided, Adaptive, Exploratory, Bayesian Basket Trial
PALETTE is a perpetual adaptive platform to efficiently study sepsis interventions within 'treatable traits' in all-ages patients enabling prompt evaluation of pandemic treatments.
- Trial name
- PALETTE (NCT06381661)
- Testing
- Tocilizumab, Baricitinib, Anakinra
- Where
- 19 sites in France
- Volunteers
- 2,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Psychosis
CLinical Utility of Early Intervention Including the 5-Step Precision Medicine (5SPM) Method in First-episode Psychosis: The CLUMP Project
CLUMP is a project of translational research that intends to bridge the gap between what we already know about pharmacogenetics of antipsychotic drugs and what we still do to treat patients with first-episode psychosis (FEP).
- Trial name
- CLUMP (NCT06453174)
- Testing
- Adherence to the first prescribed antipsychotic medication
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Instituto de Investigación Biomédica de Salamanca
Major Depressive Disorder
Precision Medicine for the Prediction of Treatment (PROMPT) Response (PROMPT)
Major depressive disorder (MDD) is the most common psychiatric disease worldwide with a huge socio-economic impact. Pharmacotherapy represents the first-line treatment choice; however, only about one third of patients respond to…
- Trial name
- PROMPT (NCT05537558)
- Testing
- Antidepressant
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- University Hospital Muenster
Neuroblastoma, Diffuse Intrinsic Pontine Glioma
PEACH TRIAL- Precision Medicine and Adoptive Cellular Therapy
A Phase I open-label, multicenter study, to evaluate the safety, feasibility, and maximum tolerated dose (MTD) of treating children with newly diagnosed DIPG or recurrent neuroblastoma with molecular targeted therapy in…
- Trial name
- PEACH (NCT04837547)
- Testing
- Tumor-specific ex vivo expanded autologous lymphocyte transfer (TTRNA-xALT)
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- University of Florida
Heart Defects, Congenital
Genetics of Ventriculo-arterial Discordance
Number of centres planned : 16 centres in France Type of study / Study design : Research Involving the Human Person category 2. Multicentric. Prospective Planning of the study : Total duration: 57,5 months.
- Trial name
- PreciPed (NCT05330338)
- Testing
- Genetic analyses: whole genome sequencing
- Where
- 16 sites in France
- Volunteers
- 600 people
- Sponsor
- Nantes University Hospital
Metastatic Breast Cancer
CATCH: Implementation of Genomics-guided Precision Medicine in Metastatic Breast Cancer
CATCH is an indication-specific diagnostic platform, which drives the implementation of integrative, genomic profiling for metastatic breast cancer into the clinics.
- Trial name
- CATCH (NCT05652569)
- Testing
- Genomic Profiling / Sequencing
- Where
- 12 sites in Germany
- Volunteers
- 5,000 people
- Sponsor
- German Cancer Research Center
Juvenile Idiopathic Arthritis (JIA)
Toward Personalized Medicine to Guide Drug Withdrawal in Children with Juvenile Idiopathic Arthritis in Clinical Remission
Biologic therapies made clinical remission an achievable goal for most juvenile idiopathic arthritis (JIA) patients. Nevertheless, antirheumatic drugs have side effects and are costly.
- Trial name
- Re-JIA (NCT06618937)
- Testing
- Treatment medication withdrawal strategy
- Where
- Italy
- Volunteers
- 166 people
- Sponsor
- Istituto Giannina Gaslini
Major Depressive Disorder
Optimize and Predict Antidepressant Efficacy for Patient With MDD Using Multi-omics Analysis and AI-predictive Tool
OPADE is a non-profit, observational, multicenter, open-label study aimed at defining personalized treatment for Major Depressive Disorder (MDD).
- Trial name
- OPADE (NCT06550037)
- Where
- Italy
- Volunteers
- 350 people
- Sponsor
- Alessio Fasano
Health-risk Behaviours, Drug Abuse
Peer-led Personalized Support Program
Aim: To test the effectiveness of a peer-led personalized support program using instant messaging applications and a self- determination theory-based intervention to help young drug abusers quit drugs.
- Trial name
- NCT05918601
- Testing
- Health-risk behaviors, Theory of planned behavior, Self-determination theory, Assist them to adhere to their schedule of quitting drugs throughout the study period
- Where
- Hong Kong
- Volunteers
- 200 people
- Sponsor
- Chinese University of Hong Kong
Breast Cancer, Prostate Cancer
Tempus Priority Study: A Pan-tumor Observational Study
Observational study that will be collecting clinical and molecular health information from cancer patients who have received comprehensive genomic profiling and meet the specific eligibility criteria outlined for each cohort with…
- Conditions
- Breast Cancer, Prostate Cancer, Bladder Cancer, Lung Cancer
- Trial name
- NCT05179824
- Testing
- Observation
- Where
- 2 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Tempus AI
Chronic Illnesses, Multiple
FLIGHT Study for Childhood Chronic Illness
The FLIGHT study is an open-label, single-arm, pilot and feasibility study of a personalized and multimodality intervention focusing upon modifiable lifestyle factors, environmental modifications, and transdisciplinary clinical…
- Trial name
- NCT06377384
- Testing
- FLIGHT Intervention
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Documenting Hope Project
FSGS, MCD
Tumor Necrosis Factor Inhibition in Focal Segmental Glomerulosclerosis and Treatment Resistant Minimal Change Disease
Adalimumab, a treatment which blocks tumor necrosis factor (TNF), was tested to see if it changed levels of urine biomarker levels, tissue inhibitor of metalloprotease-1 (TIMP1), and monocyte chemoattractant protein-1 (MCP1).
- Conditions
- FSGS, MCD, Focal Segmental Glomerulosclerosis, Minimal Change Disease
- Trial name
- NCT04009668
- Testing
- adalimumab
- Where
- 4 sites in United States
- Volunteers
- 7 people
- Sponsor
- University of Michigan
Lupus Nephritis, Systemic Lupus Erythematosus
Precision Medicine in LN: A Multicenter Proof-of-concept Study for Histopathological Biomarkers Analysis in Renal Biopsy
Lupus nephritis (LN) may affect approximately half of patients with Systemic Lupus Erythematosus (SLE). LN is a major cause of morbidity and the most important predictor of mortality in patients with SLE.
- Trial name
- NCT05358652
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Fundacin Biomedica Galicia Sur
Fatigue, Shift Work Type Circadian Rhythm Sleep Disorder
Does Fatigue Coaching Improve Functioning and Fatigue in Resident Night Shifts
Emergency Medicine (EM) requires 24/7 staff coverage resulting in healthcare workers' circadian rhythm disruptions that impair clinical and cognitive performance, physical recovery, and contribute to burnout.
- Trial name
- NCT06100809
- Testing
- Personalized coaching, Nutrition handout
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester