Clinical trials: Periodontitis, open to volunteers
Immunosuppression, Periodontal Disease
Oral Bacteria and Immune System Problems Involved in Gum Disease (Periodontitis)
Background: Gum disease is a condition in which the tissue around the tooth root becomes swollen and infected. This condition can cause tooth loss if it is not treated.
- Conditions
- Immunosuppression, Periodontal Disease, Healthy Subjects, Healthy Volunteer
- Trial name
- NCT01568697
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Symptomatic Apical Periodontitis
Comparison of Postoperative Pain After Double Antibiotic Paste vs Calcium Hydroxide in Teeth With Symptomatic Apical Periodontitis
This randomized controlled trial aims to compare the mean postoperative pain after using double antibiotic paste (DAP) versus calcium hydroxide (CH) as an intracanal medicament in teeth with symptomatic apical periodontitis.
- Trial name
- NCT07867951
- Testing
- Calcium Hydroxide (Ca(OH)2), Double Antibiotic Paste
- Where
- Pakistan
- Volunteers
- 662 people
- Sponsor
- College of Physicians and Surgeons Pakistan
Preterm Birth, Low Birthweight Neonate
Xylitol and the Prevention of Periodontal Disease and Preterm Birth Trial
The ground-breaking Prevention of Prematurity and Xylitol (PPaX) cluster randomized controlled clinical trial was conducted in Lilongwe, Malawi and enrolled approximately 10,069 pregnant individuals seeking to evaluate the impact…
- Conditions
- Preterm Birth, Low Birthweight Neonate, Periodontitis, Gingivitis
- Trial name
- XaPPP (NCT07424846)
- Testing
- Xylitol Chewing gum, Sorbitol chewing gum
- Where
- Malawi
- Volunteers
- 6,000 people
- Sponsor
- University of Washington
Periodontal Disease, Periodontal Bone Loss
Laser Assisted Open Flap Debridement
The study involves the surgical treatment of patients with Stage I to III of periodontitis. Following completion of Steps 1 and 2 of periodontal therapy according to the EFP guidelines for the treatment of periodontitis, sites…
- Trial name
- LaserOpen (NCT07807215)
- Testing
- Mechanical Open Flap debridement, Laser assisted open flap debridement
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Bari Aldo Moro
Irreversible Pulpitis With Apical Periodontitis
Full Pulpotomy in Permanent Teeth With Irreversible Pulpitis and Apical Periodontitis
This study will evaluate whether full pulpotomy can successfully treat mature permanent teeth with irreversible pulp inflammation and a periapical lesion.
- Trial name
- NCT07768852
- Testing
- Full pulpotomy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Treatment of Stage III Periodontitis, Local Application of Insulin in Pockets
Local Application of Insulin Versus Hyaluronic Acid in Stage III Periodontitis
The present study will be performed on fourty-five patients suffering from periodontitis according to the criteria of American academy of periodontology to evaluate clinically effect of topical application of insulin versus…
- Trial name
- NCT07746206
- Testing
- Insulin, Hyaluronic acid gel, mechanical debridement
- Where
- 2 sites in Egypt
- Volunteers
- 45 people
- Sponsor
- Doaa Atta Aid
Periapical Periodontitis, Periradicular Lesion
Accuracy and Healing Outcomes of Endodontic Surgery Using a Static Surgical Guide.
The goal of this clinical trial is to evaluate the surgical accuracy and healing outcomes of endodontic surgery performed with the assistance of a 3D-printed static surgical guide in patients requiring apicoectomy.
- Conditions
- Periapical Periodontitis, Periradicular Lesion, Endodontic Treatment Failure, Postoperative Wound Healing
- Trial name
- NCT07734987
- Testing
- 3D-Printed Static Surgical Guide and Trephine Bur, Ultrasonic Retrograde Preparation and Bioceramic Retrograde Obturation
- Where
- Vietnam
- Volunteers
- 11 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Dental Caries, Periodontitis
Breaking the Cycle: Real-Time Family Oral Microbial Transmission Patterns as Intervention Targets
This study aims to understand how oral bacteria that cause tooth decay and gum disease spread among family members and whether treating multiple family members can reduce the return of these bacteria after dental treatment.
- Conditions
- Dental Caries, Periodontitis, Oral Microbiome, Bacterial Transmission
- Trial name
- NCT07674888
- Testing
- Professional Dental Plaque Disruption
- Where
- Canada
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Periodontitis, Bone Defects
The Use of Two Bone Substitutes in Adjunct to EMD for the Treatment of One- and Two-wall Intrabony Defects.
The main aim will be to evaluate the difference in PD changes at 12-month follow-up, measured from the gingival margin to the base of the pocket, comparing periodontal regeneration using two different bone substitutes, that is…
- Trial name
- OSSIXPERIO (NCT07546279)
- Testing
- EMD + collagenated DBBM, EMD + hydroxyapatite collagen matrix
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Periodontitis, Kidney Transplant Recipients
Diode Laser-Assisted Periodontal Therapy in Kidney Transplant Recipients
This randomized controlled trial evaluates the efficacy of diode laser-assisted non-surgical periodontal therapy in kidney transplant recipients with periodontitis.
- Trial name
- KTRs (NCT07532694)
- Testing
- Scaling and Root Planing, Diode Laser
- Where
- 2 sites in Vietnam
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Military Hospital 103
Apical Periodontitis
Efficacy of Different Disinfection Technologies in Molar Non-Surgical Retreatment
Post-treatment apical periodontitis is commonly associated with persistent intracanal infection following root canal treatment. Effective disinfection of the complex root canal system during nonsurgical retreatment remains…
- Trial name
- NCT07469150
- Testing
- GentleWave System, Conventional rotary instrumentation with passive ultrasonic irrigation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Alabama at Birmingham
Periodontitis
Non-Surgical Treatment of Periodontitis With Adjunctive Sodium Hypochlorite/Amino Acids and Cross-Linked Hyaluronic Acid
The goal of this clinical trial is to learn if using sodium hypochlorite/amino acid gel, with or without cross-linked hyaluronic acid, as an addition to standard non-surgical periodontal therapy works to treat periodontitis in…
- Trial name
- NCT07474272
- Testing
- Standard Non-Surgical Periodontal Therapy, tandard Therapy + Sodium Hypochlorite/Amino Acid Gel, Standard Therapy + Sodium Hypochlorite/Amino Acid Gel + Cross-Linked Hyaluronic Acid
- Where
- Lebanon
- Volunteers
- 78 people
- Sponsor
- Marwan El Mobadder
Presence of Periodontal Disease, Knowledge of Periodontal Disease
Knowledge of Periodontitis and Its Relation to Periodontal Health
This study aims to evaluate the level of knowledge regarding periodontal disease and its association with periodontal health status among health sciences students.
- Trial name
- NCT07405541
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Periodontitis, Periodontal Diseases
Histatin-1 Levels in Smokers and Non-smokers With Periodontitis Patients: A Comparative Study Before and After Nonsurgical Periodontal Therapy
This study evaluated the impact of smoking on salivary histatin-1 levels and clinical healing in 50 patients with unstable periodontitis (25 smokers and 25 non-smokers) undergoing non-surgical periodontal therapy (NSPT).
- Trial name
- NSPT (NCT07367737)
- Testing
- Non Surgical Periodontal Treatment
- Where
- Iraq
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Apical Periodontitis, Periapical Radiolucency
Comparative Evaluation of Clinical and Radiographic Treatment Outcomes of Garlic Gel and Calcium Hydroxide as an Intracanal Medicament in Nonsurgical Root Canal Treatment of Permanent Teeth.
Researchers want to check how well garlic works inside permanent teeth as a medicament during root canal treatments. Garlic has shown to possess many helpful properties, like reducing inflammation, helping wounds heal, and…
- Trial name
- NCT07289971
- Testing
- Allium Sativum as an intracanal medicament
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Health Sciences Lahore
Periodontal Bone Loss, Periodontitis
The Role of Granulation Tissue in Periodontal Regeneration
The goal of this observational study is to distinguish the infectious, healing, and regeneration-related characteristics of two types of gingival granulation tissues, namely infra-osseous and supra-osseous granulation tissues, in…
- Conditions
- Periodontal Bone Loss, Periodontitis, Periodontal Disease, Periodontal Diseases
- Trial name
- NCT07254117
- Where
- Latvia
- Volunteers
- 46 people
- Sponsor
- Riga Stradins University
Alzheimers Disease, Periodontitis
EFFECT OF PERIODONTAL TREATMENT ON ALZHEIMER DISEASE-ASSOCIATED OUTCOMES
Periodontitis is the most prevalent chronic infectious inflammatory disease in adults, leading to the destruction of tooth-supporting tissues.
- Trial name
- PETAL (NCT07233512)
- Testing
- INITIAL PERIODONTAL THERAPY
- Where
- Belgium
- Volunteers
- 26 people
- Sponsor
- Centre Hospitalier Universitaire de Liege
Periodontitis
Evaluation of the Systemic Burden of Non-surgical Periodontal Therapy: A Randomized Clinical Trial on Five Different Treatment Protocols
Periodontitis is a chronic inflammatory disease of the periodontal tissues leading to the destruction of the tooth supporting structures.
- Trial name
- NCT07077122
- Testing
- Scaling and Root Planing, antibiotic prophylaxis, 810nm Diode Laser
- Where
- Greece
- Volunteers
- 75 people
- Sponsor
- National and Kapodistrian University of Athens
Malocclusion
Relationship Between Malocclusion Severity and Periodontitis Risk
The goal of this observational study is to examine the potential relationship between the severity of orthodontic malocclusion and the risk of developing periodontitis in individuals by evaluating salivary and gingival crevicular…
- Trial name
- NCT07127744
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Periodontitis (Stage 3)
Evaluation of The Periodontal Parameters Following Non-Surgical Periodontal Therapy With and Without Adjunctive Use of Injectable Platelet Rich Fibrin: A Randomized Controlled Clinical Trial
This randomized controlled clinical trial aims to evaluate the effectiveness of non-surgical periodontal therapy (NSPT) with and without the adjunctive use of injectable platelet-rich fibrin (I-PRF) in patients with chronic…
- Trial name
- NCT07090265
- Testing
- non-surgical periodontal therapy, non-surgical periodontal therapy + I-PRF
- Where
- United Arab Emirates
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University