Clinical trials: Pediatric Congenital Heart Surgery
Congenital Disorders
Patients With NMDA Biomarker Data Following Cardiac Surgery
The purpose of this current retrospective study is to perform follow-up analysis on the 22 children from the study # 621-2004 It is important to examine whether an elevated biomarker of brain ischemia before and/or following…
- Trial name
- NCT00366886
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Children's Healthcare of Atlanta
Atrial Septal Defect, Ventricular Septal Defect
Regional Anesthesia Following Pediatric Cardiac Surgery
The purpose of this study is to evaluate pain control following pediatric cardiac surgery with the use of local anesthesia via an ultrasound guided regional anesthetic technique compared with surgeon delivered wound infiltration.
- Conditions
- Atrial Septal Defect, Ventricular Septal Defect, Pain, Procedural
- Trial name
- NCT05688670
- Testing
- Regional Anesthesia, Wound infiltration, Ropivacaine 0.2% Injectable Solution
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Duke University
Heart Defects, Congenital, Hyperglycemia
SPECS: Safe Pediatric Euglycemia in Cardiac Surgery
Critically ill children, including children undergoing heart surgery, commonly develop elevated blood glucose (also known as "blood sugar") levels during their illness, which can lead to poor health outcomes and an increased risk…
- Trial name
- SPECS (NCT00443599)
- Testing
- Insulin, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 989 people
- Sponsor
- Boston Children's Hospital
Congenital Heart Disease in Children, Cardiac Surgical Procedures
Predictive Pre and Peroperative Factors for MODS-2 in Pediatric Cardiac Surgery
Pediatric cardiac surgery has a relatively high morbi-mortality. Despite great advances in surgical techniques, today the mortality rate is about 3% and morbidity is about 30-40%.
- Conditions
- Congenital Heart Disease in Children, Cardiac Surgical Procedures, Outcome Assessment, Organ Dysfunction Scores
- Trial name
- FPMODS2 (NCT05284500)
- Testing
- Pediatric cardiac surgery with cardiopulmonary bypass
- Where
- Belgium
- Volunteers
- 152 people
- Sponsor
- Brugmann University Hospital
Congenital Heart Disease, Surgery--Complications
A Predictive Score System for AKI Following Pediatric Cardiac Surgery
Acute kidney injury (AKI) has been recognized as a typical post- operative complication among the children undergoing surgical repair of a congenital cardiac defect.
- Conditions
- Congenital Heart Disease, Surgery--Complications, Acute Kidney Injury
- Trial name
- NCT05489263
- Testing
- No intervention
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- China National Center for Cardiovascular Diseases
Congenital Heart Disease, Pulmonary Arterial Hypertension
Drug Therapy and Surgery in Congenital Heart Disease With Pulmonary Hypertension
The purpose of this study is to test the hypothesis that treating PAH-CHD patients preoperatively with PAH drugs and keeping them on treatment for six months after surgery reduces the risk of immediate postoperative death and the…
- Trial name
- NCT01548950
- Testing
- Sildenafil singly or in association with Bosentan
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo General Hospital
Congenital Heart Disease in Children
Amotosalen and Platelet Transfusion in Pediatric Heart Surgery
High level of security during blood transfusion has been achieved by donor selection and pathogen detection using serology or direct identification.
- Trial name
- TransPédia (NCT05128084)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Congenital Heart Disease
Effect of Local Warming for Arterial Catheterization in Pediatric Anesthesia
The increase in internal diameter (ID) and cross-sectional area (CSA) may facilitate better arterial catheterization. Since an increase in body temperature can cause peripheral vasodilation, we aimed to determine if local warming…
- Trial name
- WARM-PA (NCT06041685)
- Testing
- local warming
- Where
- South Korea
- Volunteers
- 126 people
- Sponsor
- Pusan National University Yangsan Hospital
Heart Defects, Congenital, Transposition of Great Vessels
Hypertonic Saline Dextran in Pediatric Cardiac Surgery
The purpose of this study is to determine whether infusion of hypertonic saline dextran attenuates the inflammatory response and the water overload, during and after major cardiac surgery in small children.
- Conditions
- Heart Defects, Congenital, Transposition of Great Vessels, Heart Septal Defects, Ventricular, Endocardial Cushion Defects
- Trial name
- NCT00199771
- Testing
- 7.5% NaCl in 6% dextran 70 solution
- Volunteers
- 14 people
- Sponsor
- Oslo University Hospital
Ventricular Septal Defects, Persistent Common Atrioventricular Canal
Optimal Timing for Repair of Left to Right Shunt Lesions
The purpose of this study is to determine the optimal timing for repair of left-to-right shunt lesions such as ventricular septal defects and atrioventricular canals.
- Trial name
- NCT00229827
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Children's Healthcare of Atlanta
Congenital Heart Defects
Randomized Controlled Trial of the Effects of Electroacupuncture Preconditioning in Children Undergoing Cardiac Surgery
The purpose of this study is to determine whether electroacupuncture preconditioning would provide protection against myocardial Ischemic-Reperfusion injury and systemic inflammation in children undergoing CPB for repair of…
- Trial name
- NCT01227096
- Testing
- Electrical acupuncture stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Air Force Military Medical University, China
Congenital Heart Surgery, Congenital Heart Defects
Death Following Congenital Heart Surgery
The purpose of this study is to elucidate the patterns of death following congenital heart surgery.
- Trial name
- NCT00215072
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Healthcare of Atlanta
Hypoplastic Left Heart, Surgery
NIRS in Neonatal Cardiac Surgery
Due to the small size of infants and the use of bypass machines, physicians have difficulty assessing whether the infant's brain and body is getting enough oxygen during heart surgery.
- Trial name
- NCT00166101
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Emory University
Congenital Cardiac Defect, Acute Renal Injury
Investigation of the Relationship Between Blood Transfusion Volume and Development of Renal Failure in Pediatric Patients Undergoing Cardiovascular Surgery
Blood transfusion strategies in cardiac surgery are a research topic that has been studied more for adults. There is not enough data on this subject for children in studies.
- Conditions
- Congenital Cardiac Defect, Acute Renal Injury, Blood Transfusion Complication
- Trial name
- NCT06889272
- Testing
- blood transfusion
- Where
- Turkey (Türkiye)
- Volunteers
- 205 people
- Sponsor
- Hacettepe University
Heart Defects, Congenital
Lactate Levels During Cardiopulmonary Bypass in Pediatric Patients
Many variables measured in critically ill patients have been used to estimate severity of disease, prognosticate morbidity and mortality, evaluate costs of treatment, and finally indicate specific treatment and monitor the…
- Trial name
- NCT02618707
- Testing
- Lactate
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University
Congenital Heart Disease
Use of High Flows in Pediatric Cardiac Surgical Patients
Humidified high flow nasal prong oxygen therapy is a method for providing oxygen and CPAP. The delivery of high flows decreases dilution of the inhaled oxygen and, by matching patient's peak flow, allows accurate delivery of the…
- Trial name
- NCT01633801
- Testing
- Use of high flows versus oxygen therapy, oxygen therapy
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Congenital Heart Defect, Surgery-Induced Tissue Adhesions
Effects of CoSeal on Bleeding & Adhesions in Pediatric Heart Surgery
This is a prospective, randomized, open-label, blinded-evaluator study that will evaluate the effectiveness of a surgical sealant (CoSeal) composed of biocompatible polyethylene glycol on the formation of mediastinal and…
- Conditions
- Congenital Heart Defect, Surgery-Induced Tissue Adhesions, Hemorrhage
- Trial name
- NCT01330433
- Testing
- CoSeal Surgical Spray Group
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Loma Linda University
Microcirculation
Microcirculatory Alteration by a Vascular Occlusion Test Using Near-infrared Spectroscopy in Pediatric Cardiac Surgery
Cardiopulmonary bypass cause microcirculatory alterations. Near infrared spectroscopic measurement of tissue oxygen saturation and vascular occlusion test are novel technologies for assessing the microcirculatory function of…
- Trial name
- NCT06191913
- Testing
- Near-infrared spectroscop
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Congenital Heart Disease
Transfusion Strategies in Pediatric Cardiothoracic Surgery
The purpose of this study is to determine the best red blood cell(hemoglobin) level for infants and children following surgical repair of particular heart defects.
- Trial name
- NCT00350220
- Testing
- transfusion strategy, Low Hb transfusion group
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Rochester
Hypoplastic Left Heart Syndrome, Single Ventricle
Cardiac Stem/Progenitor Cell Infusion in Univentricular Physiology (APOLLON Trial)
The purpose of this study is to evaluate the efficacy and safety of intracoronary injection of JRM-001 after reconstructive surgery in pediatric patients with functional single ventricle
- Trial name
- APOLLON (NCT02781922)
- Testing
- Autologous cardiac stem cells (JRM-001)
- Where
- 4 sites in Japan
- Volunteers
- 40 people
- Sponsor
- Metcela Inc.