Clinical trials: Pathologic Processes
Stevens-Johnson Syndrome, Kidney Failure, Chronic
HLA-B*5801 Screening to Prevent Allopurinol-induced Severe Cutaneous Adverse Reaction
Allopurinol-induced severe cutaneous adverse reaction (SCAR) is a rare but fatal condition. Previous reports have reported that HLA-B*5801 is an important genetic risk factor significantly associated with the development of…
- Trial name
- NCT03046914
- Testing
- HLA-B*5801 test
- Where
- South Korea
- Volunteers
- 600 people
- Sponsor
- Seoul National University Hospital
Sepsis, Infections
Hypervirulent Amoxicillin-Susceptible Klebsiella Pneumoniae CC66, France, 2016-2023
"Klebsiella pneumoniae is considered intrinsically resistant to ampicillin because of the chromosomal blaSHV β-lactamase. However, amoxicillin-susceptible isolates have been sporadically reported.
- Trial name
- NCT07598006
- Testing
- Bacterial species identification by Whole Genome sequencing
- Where
- France
- Volunteers
- 56 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Heart Failure, Diastolic, Multicenter Study
Diagnosis and OutcoMes evaluAtIoN of Multicenter Patients With HFpEF Using Multimodality Imaging
The incidence of Heart failure with preserved ejection fraction (HFpEF) in Heart failure patients increases rapidly. However, the current clinical awareness is insufficient, and the cardiac structural and functional injury are…
- Trial name
- NCT04602338
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Central Nervous System Infections and Inflammations
Meningitis Encephalitis: a Metagenomics-Based Etiology & Epidemiology Research
Autoimmune encephalitis (AE) is caused by abnormal immune response mediated by autoimmune antibodies of patients, which can be detected by a serial of autoimmune antibodies[4,5,6,7].
- Trial name
- MEMBER (NCT04724876)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Beijing Tongren Hospital
Pulmonary Fibrosis
DEVELOPMENT OF INNOVATIVE TARGETED LIPOSOMAL FORMULATIONS FOR THE TREATMENT OF INFLAMMATORY DRIVEN PULMONARY FIBROSIS
The study aims to develop an innovative nano-platform for the treatment of lung fibrogenic disorders (LFD). The approach involves local delivery by inhalation of drug-loaded liposomes, coated with hyaluronic acid (HA) to directly…
- Trial name
- NCT07571291
- Testing
- liposomes as drug delivery system
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Myocardial Infarction
Sevoflurane and Percutaneous Coronary Intervention by Stent
Increase in CK-MB after percutaneous coronary angioplasty more than 100% of baseline can represents a problem to the patients resulting in increase of morbidity and mortality.
- Trial name
- NCT02671084
- Testing
- sevoflurane
- Where
- Brazil
- Volunteers
- 701 people
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
Blood Loss, Anatomic Total Shoulder Arthroplasty
Investigation of Intravenous Tranexamic Acid With Anatomic and Reverse Total Shoulder Arthroplasty
To compare intravenous Tranexamic Acid (TXA) versus normal saline placebo to determine whether or not TXA administration reduces blood loss, decrease in hemoglobin, and rate of transfusions following anatomic and reverse total…
- Conditions
- Blood Loss, Anatomic Total Shoulder Arthroplasty, Reverse Total Shoulder Arthroplasty, Transfusion
- Trial name
- NCT02569658
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Jaundice, Neonatal, Neonatal Hyperbilirubinemia
Comparison of Phototherapy Using Neolight Skylife Versus Standardized Phototherapy for Hyperbilirubinemia in Newborns
Phototherapy has served as a primary treatment for hyperbilirubinemia in newborn populations. The light emitted through phototherapy interacts with bilirubin at the skin level to transform it into water-soluble products…
- Conditions
- Jaundice, Neonatal, Neonatal Hyperbilirubinemia, Neonatal Disorder
- Trial name
- NCT03599258
- Testing
- Skylife, Standard Therapy
- Where
- 2 sites in United States
- Volunteers
- 72 people
- Sponsor
- HonorHealth Research Institute
Preeclampsia, Eclampsia
The Preeclampsia Registry
The purpose of The Preeclampsia Registry is to collect and store medical and other information from women who have been medically diagnosed with preeclampsia or a related hypertensive (high blood pressure) disorder of pregnancy…
- Conditions
- Preeclampsia, Eclampsia, HELLP Syndrome, Toxemia
- Trial name
- TPR (NCT06377878)
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Preeclampsia Foundation
Postoperative Pain, Patient Controlled Analgesia
Monitoring Postoperative Patient-controlled Analgesia (PCA)
The introduction of Acute Pain Service (APS), 1985, specialized pain management could be offered to the inpatient care. An example of this is patient-controlled analgesia (PCA), which is a technique that is used mostly after…
- Conditions
- Postoperative Pain, Patient Controlled Analgesia, Surgery, Nurse-Patient Relations
- Trial name
- NCT03697278
- Testing
- Smith medical CADDsolis
- Where
- 2 sites in Sweden
- Volunteers
- 90 people
- Sponsor
- Pether Jildenstal
Hypovolemia, Diuretic Toxicity
Diagnosis Accuracy of Abdominal Compression and Hemoconcentration to Detect Diuretic Induced Fluid Removal Intolerance.
Fluid overload increases morbidity and mortality of pediatrics patients in intensive care unit (ICU). It could be interesting to predict the decrease in stroke volume when diuretics are prescribed.
- Conditions
- Hypovolemia, Diuretic Toxicity, Fluid Overload
- Trial name
- NCT03145935
- Testing
- Abdominal compression (AC), blood sample
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hopital Louis Pradel
Covid19
Covid-19 Rapid Diagnostic Tests on Blood Drop
This study will evaluate the diagnostic reliability of the Biosynex rapid blood test for Covid-19 infection.
- Trial name
- COVID-TEST (NCT04467008)
- Where
- France
- Volunteers
- 113 people
- Sponsor
- CMC Ambroise Paré
Choroidal Neovascularization
Bevacizumab Effect on Blood Velocity
Retinal blood flow velocity is affected by Bevacizump intravitreal injection. This effect is correlated to treatment success.
- Trial name
- NCT01298440
- Where
- Israel
- Volunteers
- 12 people
- Sponsor
- Optical Imaging, Ltd.
Oral Mucositis (Ulcerative) Due to Radiation
Dexpanthenol Mouthwash to Treat Oral Mucositis
Oral mucositis can be a significant problem for cancer patients. It is typically associated with pain and increased risk of infection and can lead to impaired nutritional status and inadequate hydration.it can be seen in the…
- Trial name
- NCT01318889
- Testing
- Dexpanthenol
- Where
- Iran
- Volunteers
- 30 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Pain
"Lidocaine 4% Cream (LMX4) vs Placebo for Pain Due to Lumbar Puncture in Infants 0-60 Days of Age."
The study's hypothesis is LMX4 cream, a topical anesthetic cream, will reduce the pain of infants undergoing Lumbar Puncture (spinal tap).
- Trial name
- NCT00533468
- Testing
- Lidocaine Cream 4%
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- State University of New York at Buffalo
Microbial Colonization, Ventilator Associated Pneumonia
Frequent Standardized Oral Care to Improve Health Outcomes in Premature Infants in the Neonatal Intensive Care Unit
Premature very low birth weight (VLBW) infants are susceptible to complications related to infrequent and non-standardized oral care.
- Trial name
- NCT05167318
- Testing
- frequent standardized oral care
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Florida
Septic Shock
Diagnostic Study of Adrenal Cortical Function in Children With Septic Shock
OBJECTIVES: I. Examine adrenal cortical function and the incidence of adrenal dysfunction in children with septic shock. II. Examine the mortality, length of stay in the PICU, and incidence of multiorgan failure in children with…
- Trial name
- NCT00005890
- Testing
- corticotropin
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- National Center for Research Resources (NCRR)
Leukemia, Lymphoma
T-cell Depleted Bone Marrow and G-CSF Stimulated Peripheral Stem Cell Transplantation From Related Donors in Treating Patients With Leukemia, Lymphoblastic Lymphoma, Myelodysplastic Syndrome, or Aplastic Anemia
RATIONALE: Bone marrow and peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy or radiation therapy used to kill cancer cells.
- Conditions
- Leukemia, Lymphoma, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms
- Trial name
- NCT00002718
- Testing
- anti-thymocyte globulin, filgrastim, cyclophosphamide
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Precursors to PCOS
Research Study for Children With a Mother or Sister With Polycystic Ovary Syndrome
In this study, we want to find out more about polycystic ovary syndrome(PCOS). This is a common problem in about 7% of teenage girls. Problems may include irregular periods, extra hair on the face, chest and back areas.
- Trial name
- PCOS (NCT00559390)
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Graft Versus Host Disease, Lymphoma
Graft-Versus-Host Disease in Treating Patients With Recurrent or Refractory Lymphoma or Hodgkin's Disease
RATIONALE: Cyclosporine may induce graft-versus-host disease and make the body build an immune response that will kill cancer cells.
- Trial name
- NCT00003414
- Testing
- aldesleukin, recombinant interferon gamma, busulfan
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
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