Clinical trials: Overweight and Obese Adults
Diabetes Mellitus
Effect of 10mg Domperidone on Gastric Emptying of a High-fat Meal and Appetite Sensations in Healthy Adults
The purpose of this study is to determine whether domperidone was sufficient to accelerate gastric emptying of a high-fat solid meal and reduce satiety responses in a healthy adult population.
- Trial name
- NCT01347814
- Testing
- Domperidone 10mg
- Where
- Ireland
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Limerick
Obesity, Malignant Neoplasm
A Study to See if an iPhone Weight Management App Can Help Promote Weight Loss in Adolescents and Young Adults After a Stem Cell Transplant
This early phase I trial studies how well a behavioral weight loss intervention consisting of a smartphone application and coaching works for the promotion of weight loss in adolescents and young adults after a stem cell…
- Trial name
- NCT04453072
- Testing
- Interview, Media Intervention, Questionnaire Administration
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jonsson Comprehensive Cancer Center
Obese Patients
Telerehabilitation as Follow-up for Obesity
The goal of this experimental study is to observed the impact of telerehabilitation modalities in obese patient after a hospitalization on physical intensity at home (MVPA).
- Trial name
- OPaCTe (NCT06871436)
- Testing
- Aerobic Exercice and muscular reinforcement
- Where
- France
- Volunteers
- 138 people
- Sponsor
- Centre de l'Obesite Bernard Descottes
PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries, Obese
Role of Semaglutide in Restoring Ovulation in Youth and Adults With Polycystic Ovary Syndrome
Girls and women 12-35 years old with obesity and polycystic ovarian syndrome who are on or off metformin, will receive a glucagon like peptide-1 receptor agonist intervention for 10 months to induce metabolic changes, weight loss…
- Trial name
- RESTORE (NCT05819853)
- Testing
- Semaglutide Injectable Product (Wegovy and/or Ozempic)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Colorado, Denver
Prader-Willi Syndrome
Register of Patients With Prader-Willi Syndrome
Prader-Willi Syndrome (PWS) is a rare syndrome with a prevalence of 15 to 20 000 at birth. PWS represents a large fraction of mental retardation syndromes due to a genetic cause and the most frequent cause of genetic obesity.
- Trial name
- NCT02829684
- Testing
- Data collection
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Toulouse
Obesity, Insulin Resistance
Colchicine to Suppress Inflammation and Improve Insulin Resistance in Adults and Adolescents With Obesity
Background: About 40 percent of adults and 20 percent of adolescents in the U.S. have a body mass index over 30 kg/m2. Being overweight may lead to a state of low-level inflammation. This may cause health problems.
- Conditions
- Obesity, Insulin Resistance, Inflammation
- Trial name
- NCT05017571
- Testing
- Colchicine
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Primary Prevention, Obesity Prevention
Family Dietary Coaching to Improve Nutritional Intakes and Body Weight Control
We hypothesize that Family Dietary Coaching for one school year will allow a nutritional shift towards following recommendations and improve health indicators in free-living children and adults.
- Conditions
- Primary Prevention, Obesity Prevention, Body Weight Control
- Trial name
- ELPAS (NCT00456911)
- Testing
- Fat and carbohydrate controlled diet
- Where
- France
- Volunteers
- 2,020 people, healthy volunteers welcome
- Sponsor
- Centre d'Etudes et de Documentation du Sucre
Pediatric Obesity
Medications After Adolescent Bariatric Surgery
This study will assess the feasibility to assess practicality of early weight loss medication usage in adolescent patients post-VSG with inadequate weight loss.
- Trial name
- MAABS Protocol (NCT04572217)
- Testing
- Topiramate, Phentermine
- Where
- United States
- Sponsor
- Janey Pratt
Obesity, Overweight
Preventing Excessive Weight Gain in Adolescent Girls at High-Risk for Adult Obesity
This study will examine whether interpersonal psychotherapy (IPT) can help reduce excessive weight gain in adolescent girls. It will compare the effectiveness of IPT with a teen health education program in preventing weight gain.
- Conditions
- Obesity, Overweight, Binge Eating
- Trial name
- NCT00680979
- Testing
- Interpersonal Psychotherapy, Health Education
- Where
- 2 sites in United States
- Volunteers
- 166 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Type 1 Diabetes, Obesity
Prevalence of Overweight and Obesity in Adult Patients Suffering From Type 1 Diabetes
A registry of individuals with type 1 diabetes that visited the Department of Endocrinology of the University Hospitals of Leuven is established.
- Trial name
- POOT1 (NCT05713448)
- Testing
- No intervention
- Where
- Belgium
- Volunteers
- 100,000 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Type 1 Diabetes Mellitus, Obesity
The COCCOS Study: a Transition Program for Young Persons With Chronic Conditions
A study is undertaken to examine the feasibility of the newly developed transition program in adolescents with type 1 diabetes, asthma and obesity in a multicentric setting.
- Conditions
- Type 1 Diabetes Mellitus, Obesity, Asthma
- Trial name
- COCCOS (NCT07145671)
- Testing
- Transition program
- Where
- Belgium
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Obesity/Therapy
Brain Plasticity and GLP-1 Receptor Agonist Treatment for Obesity
Glucagon-like peptide 1 receptor agonists (GLP-1RA), such as Ozempic and Wegovy, have been rapidly adopted for the treatment of obesity in both youth and adults.
- Trial name
- PLASTIC (NCT07021937)
- Testing
- Semaglutide 1.7mg subcutaneous
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Colorado, Denver
Health Impairment, Pain
High School Football and Adult Health
The primary aim of the study is to determine the effect of playing high school football on self-rated health in late adulthood. This is an observational study that will use data from the Wisconsin Longitudinal Study, a…
- Conditions
- Health Impairment, Pain, Obesity
- Trial name
- NCT03914573
- Where
- 2 sites in United States
- Volunteers
- 3,355 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Prader-Willi Syndrome
Growth Hormone Use in Adults With Prader-Willi Syndrome
The main research question this protocol aims to answer is whether treatment with growth hormone will impact body composition, quality of life, and energy balance in PWS adults, and if there is a loss of effects after cessation…
- Trial name
- NCT00444964
- Testing
- Nutropin AQ
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Children's Mercy Hospital Kansas City
Caesarean Section, Obesity
Obesity Among Young Adult Males Born With Cesarean Section.
Previous research has suggested that cesarean section may be associated with an increased risk of developing obesity in childhood, adolescence and adulthood.
- Conditions
- Caesarean Section, Obesity, Cesarean Section Complications
- Trial name
- NCT03918044
- Where
- Sweden
- Volunteers
- 97,291 people
- Sponsor
- Karolinska Institutet
Diabetes, Pre-diabetes
Metformin at the Cellular Level and Dosing for Diabetes Mellitus (DM)
The investigators know that metformin works at the level of the cells in the body by acting on a protein called Cyclic amine monophosphate- Response Binding Elements (CREB) binding protein or Constitutive Reverter of eIF2α…
- Conditions
- Diabetes, Pre-diabetes, Obesity
- Trial name
- NCT01876992
- Testing
- Metformin
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Obesity and Overweight, Leptin Resistance
Reprogramming Energy Homeostasis in Overweight Individuals Via Exercise, Cognitive, and Social Training
The RESILIENT project is a clinical trial investigating leptin sensitivity in both children and adults with overweight or obesity.
- Conditions
- Obesity and Overweight, Leptin Resistance, Childhood Obesity
- Trial name
- Resilient (NCT06931730)
- Testing
- Nutritional Intervention, Physical Activity training, Cognitive training
- Where
- 2 sites in Italy
- Volunteers
- 240 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Obesity (Body Mass Index &Amp;Amp;gt;30 kg/m2), Screening Colonoscopy
Randomized Controlled Trial Comparing Adult to Pediatric Colonoscope in Obese Patients.
The goal of this study is to test which colonoscope works best in people who are above a certain body mass index. Currently, both pediatric and adult colonoscopes are accepted as standard treatments in colonoscopies.
- Trial name
- NCT06776913
- Testing
- Colonoscopy
- Where
- United States
- Volunteers
- 244 people
- Sponsor
- Cleveland Clinic Florida
Obesity
Oral Sodium Blood Pressure in Normal Weight, Overweight and Obese Volunteers
The primary objective of this study is to analyze the sensitivity of blood pressure to oral salt intake. Matched male and female participants will be selected as normal weight, overweight, and obese.
- Trial name
- PLADSEL (NCT01532401)
- Testing
- sodium chloride, Methylcellulose crystalline
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Poitiers University Hospital
Healthy, Overweight
Examining the Longitudinal Relationship Between Sleep and Weight Gain in College Students
This two-year prospective, observational study examines the relationship between habitual short sleep and weight gain, as well as the association between habitual short sleep and behaviors that put people at risk of weight gain.
- Trial name
- STARLIT (NCT04100967)
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Oakland University