Clinical trials: Organ Transplant
Microsporidiosis Intestinal, Heart Transplant Infection
Intestinal Microsporidiosis in French Heart Transplant Recipients (CARMIC)
The investigators propose to carry out a national retrospective study to collect epidemiological, biological, clinical and therapeutic data on microsporidiosis among heart transplant patients.
- Trial name
- CARMIC (NCT06986980)
- Where
- France
- Volunteers
- 39 people
- Sponsor
- University Hospital, Clermont-Ferrand
Skin Cancer, Infection Reactivation
Viral Reactivation and Skin Cancer
Several studies show that the incidence of skin cancer parallels the length and depth of immunosuppression. This study will analyze the correlation of viral reactivation and skin cancer in organ transplant recipients.
- Trial name
- NCT02395562
- Where
- Switzerland
- Volunteers
- 1,200 people
- Sponsor
- University of Zurich
Immunization; Infection, Transplantation Infection
High vs.Standard Dose Influenza Vaccine in Pediatric Solid Organ Transplant (SOT) Recipients
Influenza virus is a significant pathogen in pediatric solid organ transplant (SOT) recipients. However, these individuals respond poorly to standard-dose (SD) inactivated influenza vaccine (IIV).
- Conditions
- Immunization; Infection, Transplantation Infection, Influenza
- Trial name
- PSOT (NCT05947071)
- Testing
- Standard Dose Quadrivalent Inactivated Influenza Vaccine, High Dose Quadrivalent Inactivated Influenza Vaccine
- Where
- 11 sites in United States
- Volunteers
- 312 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Brain Death, Liver Disease
Pre-recovery Bedside Liver Biopsy in Brain Death Organ Donors
This study's objective is to obtain preliminary data to test the hypotheses that percutaneous liver biopsy in brain death donors is safe and provides reliable histological information.
- Trial name
- PPB (NCT01810640)
- Testing
- Percutaneous Liver Biopsy
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Rutgers, The State University of New Jersey
Crohn Disease, Ulcerative Colitis
Safety and Efficacy of Fecal Microbiota Transplantation
The gut microbiota is critical to health and functions with a level of complexity comparable to that of an organ system. Dysbiosis, or alterations of this gut microbiota ecology, have been implicated in a number of disease…
- Conditions
- Crohn Disease, Ulcerative Colitis, Celiac Disease, Irritable Bowel Syndrome
- Trial name
- NCT04014413
- Testing
- Fecal Microbiota Transplantation
- Where
- Hong Kong
- Volunteers
- 450 people
- Sponsor
- Chinese University of Hong Kong
Squamous Cell Carcinoma
Aggressive Squamous Cell Carcinoma in Organ Transplant Recipients
To identify risk factors for aggressiveness in Squamous Cell Carcinoma of the skin in organ transplant recipients.
- Trial name
- NCT02095912
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- University of Zurich
Post-transplant Lymphoproliferative Disease, Transplant-Related Hematologic Malignancy
Immunotherapy With Tacrolimus Resistant EBV CTL for Lymphoproliferative Disease After Solid Organ Transplant
This is an open label, non-randomised, multicentre Phase I to determine the safety of tacrolimus-resistant autologous EBV-specific cytotoxic T-cells (EBV CTL) and compare their expansion/persistence with control EBV CTL in solid…
- Trial name
- ITREC (NCT03131934)
- Testing
- Autologous EBV-CTL transduced with vector SFG-CNA12, Autologous EBV-CTL transduced with control vector SFG-CNA8, Leucapheresis
- Where
- 2 sites in United Kingdom
- Volunteers
- 4 people
- Sponsor
- University College, London
Student, Organ Donation
The Effect of Peer-Guided Education on Organ Donation on Organ Donation Attitude
This research will be conducted to determine the effect of peer-guided organ donation education given to anesthesia students on their attitudes towards organ donation.
- Conditions
- Student, Organ Donation, Attitude
- Trial name
- NCT07663981
- Testing
- Peer-led education on organ donation
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Suleyman Demirel University
Kidney Failure, Transplant;Failure,Kidney
Kidney Transplant Outcome and Organ Acceptance Practice Pattern: A Nationwide Analyses in the US and France
Despite the considerable advances in short-term outcomes, kidney transplant recipients continue to suffer from late allograft failure, and little improvement has been made over the past 15 years.
- Trial name
- USFRKT (NCT03723668)
- Where
- 2 sites in United States, France
- Volunteers
- 94,017 people
- Sponsor
- Paris Translational Research Center for Organ Transplantation
Organ Transplantation
Re-evaluation of Donor-specific Anti-HLA Alloantibodies Immunoassay After Organ Transplantation, From Antigen Level to Epitope Level
Transplantation is the only treatment for end-stage organ dysfunction, with dialysis for the kidney. However, donor / recipient (D / R) tissue incompatibility accounts for the majority of long-term graft losses, through the…
- Trial name
- ACORG-HLA (NCT03861962)
- Testing
- DNA sequencing called "new generation" (or NGS)
- Volunteers
- 20,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Behavior and Behavior Mechanisms
Peers for Promoting Adolescent Transplant Health
Adolescents with solid organ transplants have poorer outcomes than adults, and do not respond as well to post-rejection treatment.
- Trial name
- Peers4PATH (NCT01450033)
- Testing
- Peer Mentoring, e-Communication with mentor
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Children's Hospital of Philadelphia
Heart Cancer, Kidney Cancer
Cancer Development In Organ Transplant Recipients
The investigators will determine the cancer risk in organ transplant recipients compared to the general population with the help of statistical analysis.
- Conditions
- Heart Cancer, Kidney Cancer, Lung Cancer, Pancreas Cancer
- Trial name
- NCT02333279
- Where
- Switzerland
- Volunteers
- 1,800 people
- Sponsor
- University of Zurich
Kidney Transplantation, Liver Transplantation
Quality of Life in Pediatric Transplant Recipients
Adherence to medical regimens refers to what degree a patient chooses to follow the advice given by his/her healthcare provider.
- Conditions
- Kidney Transplantation, Liver Transplantation, Heart Transplantation, Lung Transplantation
- Trial name
- NCT00209196
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Emory University
Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
SWOG-9239 Reduction of Immunosuppression Plus Interferon Alfa and Combination Chemotherapy in Treating Patients With Malignant Tumors That Develop After Organ Transplant
RATIONALE: Reducing the amount of drugs used to prevent transplant rejection may help a person's body kill tumor cells. Giving biological therapy, such as interferon alfa, which may interfere with the growth of cancer cells, or…
- Trial name
- NCT00002657
- Testing
- bleomycin sulfate, recombinant interferon alfa, cyclophosphamide
- Where
- 86 sites in United States
- Volunteers
- 20 people
- Sponsor
- SWOG Cancer Research Network
Organ Transplantation, Transplantation Immunology
Immune Monitoring and Assay Development in Organ Transplant Recipients
The purpose of this study to develop a well-characterized library of blood, biopsy tissue, and urine samples from transplant patients. Subjects without transplants will also be enrolled for comparison.
- Trial name
- IMP (NCT01283295)
- Where
- 2 sites in United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Emory University
Heart Transplant Infection, Kidney Transplant Infection
CMV T Cell Immunity in Pediatric Solid Organ Transplant Recipients
CMV infection and disease remain a significant clinical challenge for pediatric solid organ transplant (SOT) recipients. Current prevention strategies are limited to prophylaxis in which antiviral medication is administered for a…
- Conditions
- Heart Transplant Infection, Kidney Transplant Infection, Liver Transplant Infection, CMV
- Trial name
- NCT03924219
- Testing
- CMV T cell Immunity Assay
- Where
- 12 sites in United States
- Volunteers
- 161 people
- Sponsor
- Vanderbilt University Medical Center
Complications of Transplanted Organs and Tissue
Identification and Treatment of Diabetes In Solid Organ Transplant Recipients
The purpose of this study is to determine the influence of post-transplant diabetes on medical and psychosocial outcomes in individuals who receive solid-organ transplant prior to 18 years of age and their families.
- Trial name
- NCT02605200
- Testing
- Psychologist Support, Pediatric Certified Diabetes Educators (CDEs) Support
- Where
- 2 sites in United States
- Volunteers
- 65 people
- Sponsor
- Emory University
Organ Donation, Next of Kin
Bernese Next of Kin Survey Following Organ Donation Request
6 to 18 months after organ donation request a next of kin survey using a standardized questionnaire was conducted.
- Conditions
- Organ Donation, Next of Kin, Post Traumatic Stress Disorder
- Trial name
- NCT03612024
- Testing
- questionnaire
- Where
- Switzerland
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Organ Transplantation, Immunosuppression
The Safety of Oka Varicella in Children Prior to Solid Organ Transplantation
This study sought to determine the safety of the varicella vaccine pre- and post-transplantation when given to pediatric patients listed for solid organ transplantation.
- Trial name
- NCT00213304
- Testing
- varicella vaccine (VARIVAX)
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- The Hospital for Sick Children
Transplantation
Monitoring Organ Donors to Increase Transplantation Results (MOnIToR)
The objective of this study is to determine whether protocol guided resuscitation of brain dead organ donors using Pulse Pressure Variation (PPV) will increase the number of organs transplanted per donor.
- Trial name
- MOnIToR (NCT00987714)
- Testing
- Protocolized care
- Where
- 8 sites in United States
- Volunteers
- 556 people
- Sponsor
- University of Pittsburgh