Clinical trials: Opioid-Related Disorders
Opioid-Related Disorders
Neurobiology of Opioid Dependence: 3 - 3
The purpose of this study is to study the effects of cycloserine on naloxone-precipitated opiate withdrawal.
- Trial name
- NCT00000194
- Testing
- Cycloserine
- Where
- United States
- Sponsor
- Yale University
Methamphetamine Abuse, Opioid-use Disorder
Screen, Treat and Retain Meth-using People With Opioid Use Disorders at Methadone Clinics
The investigators propose to develop and evaluate optimal combinations of evidence-based interventions to improve HIV outcomes and reduce methamphetamine use (hereafter: meth use) among people with opioid use disorder who are in…
- Conditions
- Methamphetamine Abuse, Opioid-use Disorder, HIV Seropositivity
- Trial name
- STAR-OM (NCT04706624)
- Testing
- Contingency management (12 weeks), Contingency management (6 weeks), SMS reminders
- Where
- 4 sites in Vietnam
- Volunteers
- 667 people
- Sponsor
- Hanoi Medical University
Substance-Related Disorders, Alcohol-Related Disorders
Conflict Between Maternal Autonomy and Child Health in Substance-use
Qualitative project, comprising open-ended semi-structured interviews with healthcare workers, who provide antenatal care to substance-using women.
- Conditions
- Substance-Related Disorders, Alcohol-Related Disorders, Amphetamine-Related Disorders, Inhalant Abuse
- Trial name
- NCT02797990
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Opioid-Related Disorders
Neurobiology of Opioid Dependence: 4 - 4
The purpose of this study is to determine the effect of chronic naltrexone pre-treatment on the response to yohimbine in healthy volunteers.
- Trial name
- NCT00000195
- Testing
- Naltrexone
- Where
- United States
- Sponsor
- Yale University
Alcohol-Related Disorders, Opioid-Related Disorders
Effects of Alcohol History on Effects of Sevoflurane and Nitrous Oxide - 13
The purpose of this study is to evaluate the effects of alcohol history on the subjective and reinforcing effects of sevoflurane and nitrous oxide in healthy volunteers.
- Conditions
- Alcohol-Related Disorders, Opioid-Related Disorders, Substance-Related Disorders
- Trial name
- NCT00000261
- Testing
- 30% Nitrous oxide, 0.2% sevoflurane, 0.4% sevoflurane
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Chicago
Ureteropelvic Junction Obstruction, Hypospadias
Effect of Oxybutynin on Opioid Use After Urologic Surgery in Children
The goal of this clinical trial is to determine whether giving oxybutynin before urologic reconstruction surgery reduces the amount of opioid pain medication needed in children.
- Trial name
- NCT07911137
- Testing
- Oxybutynin
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University of Calgary
Opioid-Related Disorders
Buprenorphine Maintenance for Opioid Addicts - 3
The purpose of this study is to evaluate buprenorphine in a medical maintenance model three times a week.
- Trial name
- NCT00000204
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- Yale University
Anxiety, Depression
An Online Intervention Addressing Mental Health and Substance Use in University Students
The purpose of this study is to assess the effectiveness of mobile app containing a range of evidence based tools to improve the mental health and substance use outcomes of university students.
- Conditions
- Anxiety, Depression, Alcohol Use, Substance Use
- Trial name
- NCT05606601
- Testing
- Minder
- Where
- Canada
- Volunteers
- 1,489 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Opioid-use Disorder, Opioid Use
PRescribing INterventions for Chronic Pain Via the Electronic Health Record Study - Current Opioid-User Population
The objective of this research is to assess the effects of electronic health record (EHR)-based decision support tools on primary care provider (PCP) decision-making around pain treatment and opioid prescribing.
- Conditions
- Opioid-use Disorder, Opioid Use, Opioid Abuse
- Trial name
- PRINCE (NCT04601480)
- Testing
- Choice Architecture Nudge, PMP Integration & Nudge
- Where
- United States
- Volunteers
- 309 people
- Sponsor
- University of Minnesota
Opioid Use Disorder
Medications for Opioid Use Disorders (MOUD) Via Telemedicine
Medication Assisted Treatment (MAT) of Veterans with Opioid Use Disorder (OUD) decreases mortality and improves treatment follow-up.
- Trial name
- NCT03566459
- Testing
- CBOC offering Tele-MOUD to Veterans, CBOC not offering Tele-MOUD to Veterans
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- VA Office of Research and Development
Substance-Related Disorders
Behavioral Insights to Encourage Judicious Prescribing of Opioids
In collaboration with the San Diego Medical Examiner's Office and the State of California's controlled Substance Utilization Review and Evaluation System (CURES), the investigators propose to review opioid poisonings over the…
- Trial name
- NCT02790476
- Testing
- Letters
- Where
- United States
- Volunteers
- 851 people
- Sponsor
- University of Southern California
Heroin Dependence, Morphine Dependence
Buprenorphine/Naloxone Versus Clonidine for Outpatient Opiate Detoxification - 1
The purpose of this study is to assess buprenorphine/naloxone versus clonidine for outpatient opiate detoxification.
- Conditions
- Heroin Dependence, Morphine Dependence, Substance Withdrawal Syndrome
- Trial name
- NCT00032968
- Testing
- Buprenorphine/naloxone
- Where
- 7 sites in United States
- Volunteers
- 341 people
- Sponsor
- University of California, Los Angeles
Opioid Use Disorder (OUD), Chronic Pain
Addiction Treatment in Primary Care Expansion
The Veterans Health Administration (VA) is a national leader in addressing the twin epidemics of chronic pain and opioid use, misuse, and opioid use disorder (OUD); but important challenges remain.
- Trial name
- APEX (NCT03547882)
- Where
- 2 sites in United States
- Sponsor
- VA Office of Research and Development
Opioid Use Disorder, HIV Infections
Buprenorphine Integration Research and Community Health
The goal of this clinical trial is to evaluate an intervention strategy in introducing screen/evaluate/treat (SET) procedures for HIV/ hepatitis C/ and Opioid Use Disorder in Primary Care Clinics in West Virginia.
- Conditions
- Opioid Use Disorder, HIV Infections, Hepatitis C
- Trial name
- BIRCH (NCT05668780)
- Testing
- NIATx Coaching
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Yale University
Opiate-Related Disorders, Opiate Use Disorder
MedSMA℞T Mobile ED
The goal of this clinical trial is to learn if a new smartphone-based intervention can help with factors related to opioid misuse in parents and adolescent/early adult children.
- Conditions
- Opiate-Related Disorders, Opiate Use Disorder, Opioid
- Trial name
- NCT06848504
- Testing
- MedSMA℞T Mobile
- Where
- 3 sites in United States
- Volunteers
- 244 people
- Sponsor
- Olufunmilola Abraham
Pectus Excavatum, Chest Deformities
SPSIPB Versus SAPB for Postoperative Analgesia After Minimally Invasive Repair of Pectus Excavatum
This prospective observational cohort study will compare postoperative analgesic outcomes in patients undergoing minimally invasive repair of pectus excavatum.
- Trial name
- NCT07697222
- Testing
- Postoperative Analgesia Protocol, Bispectral Index Monitoring, Serratus Posterior Superior Intercostal Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Marmara University
Opioid-Related Disorders
Suboxone: (Buprenorphine/Naloxone) Comparison of Two Taper Schedules - 1
The purpose of this protocol is to to compare the clinical utility of two dosage tapering regimens in Buprenorphine/Naloxone stabilized subjects for opiate detoxification.
- Trial name
- NCT00078117
- Testing
- Buprenorphine
- Where
- 11 sites in United States
- Volunteers
- 516 people
- Sponsor
- University of California, Los Angeles
Neonatal Abstinence Syndrome
Actigraphy and Neonatal Abstinence Syndrome of Hospitalized Newborn in Intensive Care Units
The aim of this study is to analyse the correlation between actigraphy and Lipsitz scoring system in neonatal opioid abstinence syndrome of hospitalized newborn in intensive care units
- Trial name
- ACTINEO2 (NCT04983563)
- Testing
- Actigraphy, eTact
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Opioid-use Disorder
Clinical Decision Support for Opioid Use Disorders in Medical Settings: Usability Testing in an EMR
The primary objective of this pilot study is to program an opioid use disorder (OUD) clinical decision support (CDS) tool for use in an electronic medical record (EMR) and obtain high primary care physician (PCP) usability and…
- Trial name
- COMPUTE (NCT03559179)
- Testing
- Opioid Wizard
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
Opioid Misuse
A Digital Intervention to Prevent the Initiation of Opioid Misuse in Adolescents in School-based Health Centers
The primary hypothesis of this study is that at 3 months, there will be a higher proportion of intervention participants vs. control participants who report greater risk of harm from misuse of prescription opioids AND heroin.
- Trial name
- NCT04941950
- Testing
- PlaySmart, Video Game Control
- Where
- 15 sites in United States
- Volunteers
- 533 people, healthy volunteers welcome
- Sponsor
- Tyra Boomer