Clinical trials: Obstetric
Premature, Feeding Disorders
Effect OF Lactase Enzyme Supplements ON Intolerance IN Preterm Neonates
This study aims to study the effect of lactase enzyme in preventing feeding intolerance in preterm neonates in neonatal intensive care unit at Alexandria University Children's Hospital.
- Conditions
- Premature, Feeding Disorders, Lactase Deficiency, Congenital
- Trial name
- NCT07088302
- Testing
- lactase administration
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Alexandria University
Obesity, Neuraxial Ultrasound
Neuraxial Anaesthesia: Does BMI Relate to Ease of Neuraxial Anaesthesia?
Neuraxial anaesthesia can be more difficult and associated with more complications if the patient's bony landmarks are difficult to palpate.
- Conditions
- Obesity, Neuraxial Ultrasound, Obstetric Anaesthesia
- Trial name
- NCT03315845
- Testing
- Palpation of bony landmarks for neuraxial anaesthesia.
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Maternity Hospital, Ireland
Labor Pain
Analgesic Efficacy and Obstetric Effects of Tramadol, Paracetamol and Placebo in Active Labor
This randomized, double-blind, placebo-controlled trial aims to compare the analgesic efficacy and obstetric effects of tramadol (100 mg IV) versus paracetamol (1 g IV) versus placebo (saline solution) in nulliparous women during…
- Trial name
- TRAMPA (NCT07440069)
- Testing
- Tramadol Hydrochloride, Paracetamol (acetaminophen)
- Where
- 2 sites in Honduras
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional Autonoma de Honduras
Hypotension
Treatment of Hypotension of Prematurity (TOHOP)
Hypotension in the very preterm infant (gestational age [GA] <32 wks) is a frequently occurring clinical problem. Although no real consensus has been reached on the definition of hypotension in these infants, in clinical practice…
- Trial name
- TOHOP (NCT01434251)
- Testing
- Anti-hypotensive treatment
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- UMC Utrecht
Placenta Previa
Vaginal Progesterone Against a Second Attack of Antepartum Haemorrhage in Placenta Previa Women
Placenta praevia is associated with an increased risk of preterm delivery (PTD) especially if associated with bleeding and uterine contractions .
- Trial name
- NCT04725929
- Where
- Egypt
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Nourhan Ashraf ElSherbiny
Premature Birth
Impact of Moderate Preterm Birth on Vocabulary Acquisition
Children born prematurely may present a neurodevelopmental disorder with a language delay diagnosed as early as 2-3 years of age.
- Trial name
- BABYLANG (NCT05397197)
- Testing
- Electroencephalography
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Prematurity
Evaluating Wearable Smart Sensors for Continuous Measurement of Vital Signs in ICU Patients
The purpose of this study is to develop biocompatible wireless electronic devices that will allow continuous, non-invasive hemodynamic and physiology measurements in the ICU.
- Trial name
- NCT04723654
- Testing
- Wireless Wearable Vital Sign Monitor
- Where
- 2 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Respiratory Distress Syndrome, Newborn, Infant, Premature
Measuring Diaphragm Electrical Activity in Neonates Using a Smaller Inter-electrode Distance
Neurally Adjusted Ventilatory Assist (NAVA) is a mode of ventilation where the electrical activity of the diaphragm (EDI) - a signal representing the baby's respiratory drive - is used to control the timing and amount of assist…
- Trial name
- NCT05427929
- Testing
- NVR 4mm Edi catheter
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Mount Sinai Hospital, Canada
Bleeding, Placenta Previa
Bakri Balloon in Placenta Previa
The Bakri intrauterine balloon can achieve haemostasis in cases of postpartum haemorrhage, including haemorrhage associated with placenta previa by compressing the lower uterine segment.
- Trial name
- BB-ATS (NCT02694341)
- Testing
- Abdominal traction stitch, Bakri Balloon
- Where
- Egypt
- Sponsor
- Assiut University
Extreme Prematurity (gestational Age Below 29 Weeks)
Oral Feeding Skills of Very Premature Infants
Extremely premature infants, born at a gestational age (GA) of less than 29 weeks, are exposed to numerous complications in the neonatal period (digestive, cardiac, infectious, respiratory, neurological) and in the longer term…
- Trial name
- NUTRIO (NCT06657729)
- Testing
- Succiometry
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hospices Civils de Lyon
Preterm Birth
Oxygen Assist Module in Preterm Infants on High Flow Nasal Cannula Support.
Oxygen treatment is common in babies born early (preterm) and requiring intensive care. Having too much or too little oxygen can increase the risk of damage to the eyes and lungs, and contribute to death or disability.
- Trial name
- ROAM (NCT04687618)
- Testing
- High Flow Nasal Cannula withAutomatic control of FiO2 using OAM, High Flow Nasal Cannula with manual control of FiO2
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- South Tees Hospitals NHS Foundation Trust
Pre-Exposure Prophylaxis (PrEP)
Impact of Nursing Involvement on Implementation of HIV Prevention Services
Women comprise 20% of new Human Immunodeficiency Virus (HIV) diagnoses in the United States (U.S.) with 86% attributed to heterosexual contact.
- Trial name
- PrEP-RN (NCT05095818)
- Testing
- PrEP-RN
- Where
- United States
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Preterm Infants, Parenteral Nutrition n-3 Fatty Acids
Comparison of Two Different Lipid Emulsions for Parenteral Nutrition in Preterm Infants
The study shall provide evidence for the save and efficient use of a fish oil containing lipid emulsion in parenteral nutrition of preterm infants.Safety will be assessed by monitoring hepatological and hematological laboratory…
- Trial name
- NCT00497289
- Testing
- Lipofundin MCT/LCT 20 %, Lipidem 20%
- Where
- 2 sites in Germany
- Volunteers
- 48 people
- Sponsor
- B. Braun Melsungen AG
Bronchopulmonary Dysplasia (BPD), Premature Births
PK, Safety and Preliminary Efficacy Study of Montelukast in Critically Ill Infants With Developing Bronchopulmonary Dysplasia
The purpose of the study is to learn how safe montelukast may be in premature infants at significant risk for Bronchopulmonary Dysplasia (BPD) and to determine how much and how quickly montelukast moves from the stomach into the…
- Conditions
- Bronchopulmonary Dysplasia (BPD), Premature Births, Critical Illness
- Trial name
- PRISM (NCT07101640)
- Testing
- montelukast 4 mg granule
- Where
- 5 sites in United States
- Volunteers
- 28 people
- Sponsor
- Duke University
Sepsis, Pre-Term
Olive Oil Massage Effect for Reduction of Preterm Sepsis (OMEPS)
The OMEPS trial is a randomized clinical trial in the western region of Saudi Arabia. Conducted to assess the safety and feasibility of olive oil as massage for preterm infants and if associated with reduced risk of Late-Onset…
- Conditions
- Sepsis, Pre-Term, Late-Onset Neonatal Sepsis
- Trial name
- OMEPS (NCT04717037)
- Testing
- Olive Oil Massage
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 300 people
- Sponsor
- King Abdullah International Medical Research Center
Infant; Premature, Light-For-Dates
Nephrocalcinosis in Very Low Birth Weight Infants
Extremely premature children benefit from specific follow-up that requires high nutritional intake and the use of specific therapies that expose them to the risk of nephrocalcinosis.
- Trial name
- NCT04860583
- Testing
- Renal ultrasound
- Volunteers
- 265 people
- Sponsor
- Hospices Civils de Lyon
Acute Respiratory Deficiency, Prematurity
Comparison of RAM Cannula Nasal Continuous Positive Airway Pressure Versus Infant Flow Nasal Continuous Positive Airway Pressure (NCPAP)
This study is designed to compare the effectiveness and ease of use of two commonly used NCPAP interfaces: the RAM NC and the Infant Flow prongs and nasal mask.
- Conditions
- Acute Respiratory Deficiency, Prematurity, Assisted Ventilation
- Trial name
- NCT02032511
- Volunteers
- 19 people
- Sponsor
- University of Michigan
Primigravida Labour
Obstetric Outcomes of Primigravidae
To determine obstetric outcomes in primigravida at term at women's health centre
- Trial name
- NCT06784505
- Volunteers
- 100 people
- Sponsor
- Assiut University
Enteral Nutrition, Born Very Premature
Prolonged Minimal Enteral Nutrition Versus Slowly Advancing Enteral Nutrition in Very Low Birth Weight Infants:
Recent studies showed the benefits of early initiation and advancement enteral feeds with daily increments in preterm infants on decreasing invasive infections and early achievement of full enteral feedings.
- Conditions
- Enteral Nutrition, Born Very Premature, Infant, Very Low Birth Weight
- Trial name
- NCT02913677
- Testing
- nutrition
- Where
- Turkey (Türkiye)
- Volunteers
- 199 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Labor, Premature
Two Dose Regimens of Nifedipine for the Management of Preterm Labor
Preterm birth is one of the most important causes of perinatal morbidity and mortality worldwide. Prevention and treatment of preterm labor is important, not as an end in itself, but as a means of reducing adverse events for the…
- Trial name
- NCT00137501
- Testing
- Nifedipine
- Where
- Lebanon
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
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