Clinical trials: Neurosurgical Patients
Stress Ulcers, Stress-related Mucosal Disease (SRMD)
China Survey of Stress Ulcer Bleeding in Critically Ill Neurosurgical Patients
Stress ulcers or stress-related mucosal disease (SRMD) is defined as "acute superficial inflammation lesions of the gastric mucosa induced when an individual is subject to abnormally elevated physiologic demands."[1] Studies have…
- Trial name
- SUP (NCT02316990)
- Where
- 11 sites in China
- Volunteers
- 1,416 people
- Sponsor
- AstraZeneca
Brain Tumor, Vascular Lesion
Factor XIII and Pulmonary Embolism in Neurosurgical Patients
Two studies (Gerlach et al. 2000; Gerlach et al. 2002) described the impact of factor XIII on the risk of prospective hemorrhage for patients undergoing craniotomy.
- Conditions
- Brain Tumor, Vascular Lesion, Factor XIII Deficiency, Pulmonary Embolism
- Trial name
- NCT01106937
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Trephined Syndrome, Sinking Skin Flap Syndrome
Prevalence of Trephined Syndrome After Decompressive Craniectomy
Decompressive craniectomy is frequently used to treat increased intracranial pressure or an intracranial mass effect. Trephined Syndrome describes a neurological deterioration, which is attributed to a large craniectomy.
- Conditions
- Trephined Syndrome, Sinking Skin Flap Syndrome, Traumatic Brain Injury, Stroke
- Trial name
- TS (NCT03186157)
- Testing
- Decompressive craniectomy, Cranioplasty
- Where
- Switzerland
- Volunteers
- 41 people
- Sponsor
- University Hospital, Geneva
Intrathecal Infection, External Ventricular Drainage Associated Infection
Cerebrospinal Fluid IL-6, IL-8 and PCT as Early Marker of an Intrathecal Infection in Neurosurgical Patients
The value of CSF IL-6, IL-8 and Procalcitonin in detecting an early diagnosis of intrathecal infection in neurosurgical patients with an external ventricular drainage is evaluated.
- Trial name
- NCT02875808
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University Medicine Greifswald
Intracranial Aneurysm, Brain Edema
Goal-Directed Intraoperative Fluid Management Using FloTrac© Monitoring in High-Risk Neurosurgical Patients
This is a prospective, randomized controlled trial to determine if using FloTrac/EV1000 system in neurosurgical patients undergoing craniotomies for aneurysm repair or tumor resection complicated by cerebral edema, or complex…
- Conditions
- Intracranial Aneurysm, Brain Edema, Scoliosis, Surgery
- Trial name
- NCT02701582
- Testing
- Phenylephrine, Epinephrine, Albumin
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- NYU Langone Health
Brain Injuries, Brain Trauma
Evaluation of qSOFA in Neurosurgical Patients
The aim of the study is to look if Quick Sequential Organ Failure Assessment Score score in detecting a eary Sepsis is afflicted by neurosurgical disorders
- Conditions
- Brain Injuries, Brain Trauma, Subarachnoid Hemorrhage
- Trial name
- NCT04265404
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Goethe University
Neurosurgical Patients
COMparative Performance of General Purpose Models
To compare the performance of the Eleveld models for propofol and remifentanil on neurosurgery patients admitted to intensive care with their intraoperative performance.
- Trial name
- NCT06584097
- Where
- 2 sites in Italy
- Volunteers
- 42 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Pituitary Adenoma
Copeptin as a Diagnostic Marker in the Management of Neurosurgical Patients With Disturbance of Water Homeostasis
Water imbalance and consecutive electrolyte disturbances are common in the postoperative course of neurosurgical patients after pituitary surgery.
- Trial name
- NCT01465672
- Where
- 2 sites in Switzerland
- Volunteers
- 125 people
- Sponsor
- University Hospital, Basel, Switzerland
Diabetes Insipidus, Neurohypophyseal, Copeptin Blood Levels
The Trend of Copeptin Levels and Its Clinical Value for Postoperative CDI in Pediatric Patients After NSI in ICU
Central diabetes insipidus (CDI),a disease caused by the decrease of AVP (a hormone involved in the control of water-electrolyte balance ) secretion and characerized by polyuria, is a common complication after neurosurgerical…
- Conditions
- Diabetes Insipidus, Neurohypophyseal, Copeptin Blood Levels, Copeptin, Neurosurgical Intervention
- Trial name
- NCT06742060
- Testing
- serum copeptin levels
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Children's Hospital of Fudan University
Traumatic Brain Injury With Prolonged Loss of Consciousness
A Trial to Determine the Feasibility and Effectiveness of Early Multisensory Stimulation Intervention in Patients in the Trauma-Neurosurgical Intensive Care Unit (TNICU) Following Severe Acquired Brain Injury
St. Michael's Hospital (SMH) provides service to individuals with some of the most severe brain injuries and intensive care needs in Canada.
- Trial name
- NCT02589223
- Testing
- Multisensory Stimulation, Control
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- Unity Health Toronto
Hydrocephalus in Children, Epilepsy
Myelin Imaging Changes In Patients With Neurosurgical Diseases
Investigate myelin alterations in patients with neurosurgical diseases
- Conditions
- Hydrocephalus in Children, Epilepsy, Craniosynostoses, Traumatic Brain Injury
- Trial name
- McDESPOT (NCT03698838)
- Testing
- McDESPOT
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Memorial Healthcare System
Malignant Glioma, Recurrent Brain Neoplasm
18F-DOPA-PET in Planning Surgery in Patients With Gliomas
This pilot clinical trial studies fluorine F 18 fluorodopa (18F-DOPA)-positron emission tomography (PET) in planning surgery in patients with gliomas.
- Trial name
- NCT02020720
- Testing
- Biopsy, Computed Tomography, Diffusion Weighted Imaging
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Mayo Clinic
CNS
Intraoperative Use of I.V. Sodium Fluorescein in Suspected CNS Tumors
The FLUO.CER.TUM study is a prospective observational clinical trial conducted at the IRCCS Foundation Neurological Institute "Carlo Besta" in Milan, Italy.
- Trial name
- FLUOCERTUM (NCT07233954)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Fear Pain
Human Behaviors Related to the Expectation of Pain
The conditioned expectation of pain is an important aspect of pain-related disability produced by environments and stimuli associated with a painful injury on the job, although the neuroscience of this expectation is unclear.
- Trial name
- NCT03739645
- Testing
- Skin conductance levels and slopes over time in conditioned fear as metrics.as metrics for anxiety
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Infection, Bacterial, Antibiotic Resistant Infection
Rapid Test for Detection of the Focus of Infection in Post Neurosurgical Patients.
Background: Due to anatomical restrictions, the inflammatory response to intra-cerebral bacterial infections exposes swollen brain tissues to pressure and ischemia, resulting in life-threatening damage.
- Conditions
- Infection, Bacterial, Antibiotic Resistant Infection, Diagnostic Self Evaluation, Meningitis, Bacterial
- Trial name
- NCT03252028
- Where
- 2 sites in Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Fariba Nayeri
Intubation;Difficult
Comparison of Different Video Laryngoscopes in < 1 Year Old Undergoing Neurosurgical Operations: a Prospective Randomized Study
İntubation of pediatric patients is a challenging problem. Video laryngoscopes increased the intubation success rate. We want to compare different video laryngoscopes in this field.
- Trial name
- NCT04153357
- Testing
- airtraq, c-mac
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Kocaeli University
Acute Brain Injury, Post-neurosurgical Status
High-Flow Nasal Cannula After Extubation in Acute Brain Injury
Patients with acute brain injury after neurosurgery are at increased risk of extubation failure after removal of the endotracheal tube.
- Conditions
- Acute Brain Injury, Post-neurosurgical Status, Extubation Failure, Postoperative Respiratory Complications
- Trial name
- NCT07664085
- Where
- Vietnam
- Volunteers
- 285 people
- Sponsor
- Bach Mai Hospital
Hospitalized Patient, Home Mechanical Ventilation
The PAINN Study - a Pilot Cross Sectional Study
Pain prevalence in hospitalized patients has been reported between 65% and 75%, indicating poor and/or insufficient management. In addition, pain prevalence has been estimated for separate groups of individuals with specific…
- Conditions
- Hospitalized Patient, Home Mechanical Ventilation, Pain, Pain Management
- Trial name
- PAINN (NCT06980987)
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cerebral Hemodynamics
Perioperative Cerebrovascular Autoregulation Monitoring in Neurosurgical Patients
One of the challenges in pediatric anesthesiology is to ensure adequate cerebral perfusion pressure to prevent cerebral ischemia or hyperemia from pressure-passive perfusion.
- Trial name
- NCT04174001
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Boston Children's Hospital
Muscle Weakness, Critical Illness
Critical Illness Neuromuscular Abnormalities in Neurocritical Care Patients
The aim of this research is to investigate critical illness neuromuscular abnormalities in neurocritical care patients.
- Trial name
- NCT00893633
- Where
- Russia
- Volunteers
- 135 people
- Sponsor
- Clinical Institute of the Brain, Russia