Clinical trials: Neurocognitive Dysfunction
Alzheimer Disease
Plasma Dilution and Infusion to Improve Cognition in Mild Cognitive Impairment (MCI)
In the ADDITION-MCI project, patients with a diagnosis of mild cognitive impairment probably caused by Alzheimer's disease will receive plasma exchange.
- Trial name
- ADDITION-MCI (NCT06234436)
- Testing
- Plasma exchenge
- Where
- Norway
- Volunteers
- 10 people
- Sponsor
- Oslo University Hospital
Epilepsy, Cognitive Dysfunction, Cognitive Disorder
HOBSCOTCH-YOUTH and Young Adults
The goal of this clinical trial is to learn more about the home-based epilepsy self-management program, HOBSCOTCH, for improving cognitive function (thinking and memory) and quality of life specifically in young adults, ages 18 …
- Conditions
- Epilepsy, Cognitive Dysfunction, Cognitive Disorder, Memory and Thinking Problems
- Trial name
- NCT07735715
- Testing
- HOBSCOTCH/HOBSCOTCH-YOUTH
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Neurocognitive Dysfunction
Evaluation of Memantine in the Preservation of Memory and Neurocognition Following CSI
The goal of this clinical trial is to evaluate the role of memantine in preservation of memory and neurocognition in patients undergoing craniospinal irradiation.
- Trial name
- MEMENTO (NCT06275035)
- Testing
- Memantine Oral Tablet
- Where
- India
- Volunteers
- 101 people
- Sponsor
- Tata Memorial Centre
Neurodegenerative Diseases, Parkinson Disease
Neurodegenerative Diseases Progression Markers (MARKERS-NDD)
MARKERS-NDD is a prospective, observational, longitudinal study, which aims to collect data from patients affected by neurodegenerative diseases (NDD) followed longitudinally for routine examinations performed as part of normal…
- Conditions
- Neurodegenerative Diseases, Parkinson Disease, Synucleinopathies, Lewy Body Disease
- Trial name
- MARKERS-NDD (NCT06596746)
- Testing
- Observation
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Casa di Cura San Raffaele Cassino
Cognitive Disorder, Metabolic Disease
Characterization of Dysmorphology in Subjects With Creatine Transporter Deficiency
Background: Creatine transporter deficiency (CTD) is a genetic disorder that mainly affects the brain in males. CTD causes intellectual disability that can be mild to severe.
- Conditions
- Cognitive Disorder, Metabolic Disease, Autism Spectrum Disorder
- Trial name
- NCT05600946
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Down Syndrome, Cognitive Dysfunction
Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (Aricept) In The Treatment Of The Cognitive Dysfunction Exhibited By Children With Down Syndrome, Aged 6 To 10
The purpose of this study is to determine the efficacy and safety of donepezil hydrochloride (Aricept) in the treatment of cognitive dysfunction shown by children with Down syndrome, aged 6 to 10 years.
- Trial name
- NCT00754013
- Testing
- Aricept (Donepezil hydrochloride)
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- Eisai Inc.
Delirium, Cognitive Impairment
Validation of the PreSchool Confusion Assessment Method for the Intensive Care Unit (psCAM-ICU)
The investigators hypothesize that critical care trained registered nurses and physicians can perform measurements of cognitive impairment in critically ill pediatric patients in a reliable and valid manner.
- Trial name
- NCT02481115
- Volunteers
- 300 people
- Sponsor
- Vanderbilt University
Preterm Birth
Exercise in Prematurely Born Preadolescents to Mitigate Cardiovascular Risk and Improve Cognitive Impairment
EXCELSIOR is a randomized controlled trial to investigate the effect of physical exercise on cardiovascular health in prematurely born children.
- Trial name
- EXCELSIOR (NCT06500910)
- Testing
- Physical Exercise
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Henner Hanssen
Sturge-Weber Syndrome
Trial of Sirolimus for Cognitive Impairment in Sturge-Weber Syndrome
The purpose of this research study is to gain a preliminary understanding of the safety of sirolimus in Sturge-Weber syndrome (SWS) and determine best outcomes to be used to assess the utility of sirolimus for the treatment of…
- Trial name
- NCT03047980
- Testing
- Sirolimus
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Anne Comi, MD
Cognitive Decline
Flortaucipir 18F PET Imaging in BIOCARD Study
This study is designed to assess the imaging characteristics of Flortaucipir (18F-AV-1451) in subjects who participated in the Biomarkers of Cognitive Decline Among Normal Individuals (BIOCARD) study at Johns Hopkins University.
- Trial name
- NCT03052972
- Testing
- Flortaucipir F18, Brain PET scan
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Avid Radiopharmaceuticals
Amnestic Mild Cognitive Impairment
Outcome Predictors of a Cognitive Intervention in aMCI
Cognitive training has been shown to be successful in patients with amnestic mild cognitive impairment (aMCI), a group at high-risk for Alzheimer's disease (AD).
- Trial name
- OutPreC MCI (NCT01525368)
- Testing
- cognitive intervention
- Where
- Germany
- Volunteers
- 110 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Neurofibromatosis Type 1
How Neurofibromatosis Type 1 (NF1) Affects Schoolwork and Self-Esteem
The study will seek to determine whether there is a corresponding deficit in school performance for teenagers with NF1. Secondly, the study seeks to explore the issue of self-esteem in teenagers with NF1.
- Trial name
- NCT01626846
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- John Jay High School
Post-Acute COVID-19, Post-Acute COVID-19 Syndrome
Evaluating a Comprehensive Multimodal Outpatient Rehabilitation Program for PASC Program to Improve Functioning of Persons Suffering From Post-COVID-19 Syndrome: A Randomized Controlled Trial
About 10-20% of persons who contract SARS CoV-2 will experience persistent post-acute sequelae of SARSCoV-2 infection (referred here as PASC).
- Conditions
- Post-Acute COVID-19, Post-Acute COVID-19 Syndrome, Post-Acute COVID-19 Infection, Long COVID
- Trial name
- NCT06156202
- Testing
- Comprehensive Rehabilitation, Augmented Usual Care
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- University of Pennsylvania
Dementia Prevention
e-Learning About Cognitive Impairment and Dementia Prevention
In this proposal, the investigators plan to study the effectiveness of our web-based intervention on dementia prevention knowledge, intentions, and behaviour change.
- Trial name
- NCT05383118
- Testing
- Education Intervention, Education Control
- Where
- Canada
- Volunteers
- 536 people, healthy volunteers welcome
- Sponsor
- McMaster University
ADHD, Cognitive Deficit
Cognitive Intervention in Attention Deficit and Hyperactivity Disorder
Attention Deficit Hyperactivity Disorder is a disorder in which children show insufficient attention span, hyperactivity and impulsivity according to their developmental level.
- Trial name
- NCT05063669
- Testing
- Cognitive Occupational Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people
- Sponsor
- Biruni University
Mild Cognitive Impairment
Effects of Shuttle Balance Training on Balance , Gait and Postural Control in Children With Mild Cognitive Impairment
This study aims to investigate the impact of Shuttle Balance Training (SBT) on balance, gait, and postural control among children diagnosed with mild cognitive impairment (MCI).
- Trial name
- NCT06974890
- Testing
- Shuttle Balance Training, Baseline Treatment
- Where
- Pakistan
- Volunteers
- 24 people
- Sponsor
- Riphah International University
RETT Syndrome With Proven MECP2 Mutation
Repurposing Mirtazapine in Rett Syndrome
Rett Syndrome (RTT) is a rare neurodevelopmental disorder caused by an MECP2 gene mutation on the X chromosome, primarily affecting females.
- Trial name
- MirtaRett (NCT07430046)
- Testing
- mirtazapine
- Where
- 4 sites in Italy
- Volunteers
- 54 people
- Sponsor
- University of Trieste
Parkinson's Disease
The Effects of Rasagiline on Cognitive Deficits Associated With Parkinson's Disease
The objective of the study is to assess the effects of rasagiline on cognitive functions in patient with Parkinson's disease. Patients on any dopaminergic medications will be assigned to receive rasagiline 1 mg or placebo over 3…
- Trial name
- NCT00696215
- Testing
- rasagiline
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul University
Respiratory Distress Syndrome, Adult, Ventilator-Induced Lung Injury
Long Term Follow up of Children Enrolled in the REDvent Study
This is a prospective observational follow-up study of children enrolled in a single center randomized controlled trial (REDvent).
- Conditions
- Respiratory Distress Syndrome, Adult, Ventilator-Induced Lung Injury, Neurocognitive Dysfunction, Quality of Life
- Trial name
- NCT03709199
- Testing
- Ventilation Inhomogeneity, Diaphragm Ultrasound, Respiratory Inductance Plethysmography
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- Children's Hospital Los Angeles
Cognitive Deficit in Attention, Executive Dysfunction
Maternal Choline Supplementation and Offspring Cognition in Adolescence
The goal of this 13-year follow up of a randomized control trial is to study the effect of maternal choline supplementation on offspring cognition in adolescence.
- Conditions
- Cognitive Deficit in Attention, Executive Dysfunction, Emotional Regulation
- Trial name
- CholTeens (NCT05859126)
- Testing
- Maternal Choline Supplementation 930 mg/d, Maternal Choline Supplementation 480 mg/d
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cornell University