Clinical trials: Neurocognition
Brain Tumor, Pediatric
Neurocognitive and Psychosocial Outcomes Among Pediatric Brain Tumor
This will be the first in-depth study to evaluate pretreatment and 12 months post-treatment, neurocognitive and psychological outcomes of children with brain tumor in Pakistan.
- Trial name
- PBT (NCT05709522)
- Testing
- Neurocognitive tools
- Where
- Pakistan
- Volunteers
- 48 people
- Sponsor
- Aga Khan University
Congenital Central Hypoventilation Syndrome, Congenital Central Hypoventilation
Neurocognition in Congenital Central Hypoventilation Syndrome (CCHS)
Congenital central hypoventilation syndrome (CCHS) is a rare disorder of autonomic and respiratory regulation that frequently alters oxygen delivery to the brain.
- Conditions
- Congenital Central Hypoventilation Syndrome, Congenital Central Hypoventilation, CCHS, CCHS With Hirschsprung Disease
- Trial name
- NCT03568669
- Testing
- NIH Toolbox Cognition Battery
- Where
- 4 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Ilya Khaytin
Neurocognitive Dysfunction
Evaluation of Memantine in the Preservation of Memory and Neurocognition Following CSI
The goal of this clinical trial is to evaluate the role of memantine in preservation of memory and neurocognition in patients undergoing craniospinal irradiation.
- Trial name
- MEMENTO (NCT06275035)
- Testing
- Memantine Oral Tablet
- Where
- India
- Volunteers
- 101 people
- Sponsor
- Tata Memorial Centre
Diabetes Mellitus
Diabetic Ketoacidosis and Its Impact on the Brain
About the Study: This research study is being conducted to see if diabetic ketoacidosis has any impact on learning, behavior and development in children with Type 1 diabetes mellitus.
- Trial name
- NCT01753934
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Stanford University
Substance Use Risk, Structural Stressors
Structural Stressors, Reward Related Decision Making and Substance Use Risk
The goal of this observational study, which has a pilot phase (R61) and a second, larger phase (R33), is to learn about the impact of indicators of structural stressors (SS) on substance use risk in Puerto Rican adolescents…
- Trial name
- NCT06221839
- Where
- 2 sites in United States, Puerto Rico
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Columbia University
Depressive Symptoms, Hypomania Nos Single Episode or Unspecified
A Study of Aerobic Exercise for Adolescents With Subthreshold Mood Syndromes
This study will investigate the effects of aerobic exercise on mental states, cognition, and long-term outcomes in adolescents with subthreshold depressive and/or hypomanic syndromes and in non-clinical school children
- Trial name
- NCT03300778
- Testing
- aerobic exercise
- Where
- China
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Guangzhou Psychiatric Hospital
Premature Baby, Neurocognition, Child
Longitudinal Assessment of Early Premature Infant Skills for Audiovisual Speech Perception
From birth, babies perceive speech face to face with their interlocutors in audiovisual situations (AV): in addition to hearing them (auditory speech), they will also, in most cases, be able to observe their speaking faces (ex…
- Trial name
- Pré-AV (NCT07245693)
- Testing
- Audiovisual association capability tests
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Grenoble
Schizophrenia, Psychotic Disorders
Neurocognitive Effectiveness in Treatment of First-episode Non-affective Psychosis: 1-year Follow-up
Cognitive enhancement is a primary goal in treating individuals with schizophrenia. Cognitive deficits are already present at the first break of the illness, seem to remain stable during early phases and noticeably influence…
- Trial name
- PAFIP2_nc1Y (NCT02534363)
- Testing
- Aripiprazole, Quetiapine, Ziprasidone
- Where
- Spain
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Fundación Marques de Valdecilla
Aggression, Antisocial Behavior
Omega-3 Supplementation and Behavior Problems
The objectives of this project are as follows: 1. To assess whether omega-3 dietary supplementation for six months can reduce externalizing behavior problems (antisocial and aggressive behavior) in schoolchildren aged 8 to 18…
- Conditions
- Aggression, Antisocial Behavior, Antisocial Personality
- Trial name
- NCT02334098
- Testing
- Omega-3 supplemented drink, Smartfish
- Where
- China
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- Dr. Annis Fung
Attention Deficit Hyperactivity Disorder
Added Value of the Oculomotor and Cognitive Examination in the Management of Patients With ADHD
ADHD is a neurodevelopmental disorder characterized by symptoms of inattention and / or hyperactivity-impulsivity that affects nearly 6% of school-aged children and persists into adulthood.
- Trial name
- NCT03411434
- Testing
- Methylphenidate Oral Tablet
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Centre Hospitalier Rouffach
Attention Deficit Hyperactivity Disorder
Sleep Dysfunction and Neurocognitive Outcomes in Adolescent ADHD
This study seeks to characterize sleep physiology in adolescents with and without Attention deficit hyperactivity disorder (ADHD) and its relationship to differential neurocognitive and clinical outcomes within these groups.
- Trial name
- NCT02897362
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Duke University
Sickle Cell Disease, Sickle Cell
Objective Neurocognitive Assessment of Young Children With Sickle Cell Disease by Eye-Tracking
Evidence indicates that Sickle Cell Disease (SCD) threatens neurodevelopmental outcome. Although children with SCD may be heterogeneously affected, neurocognitive impairment may already be present in toddlers.
- Conditions
- Sickle Cell Disease, Sickle Cell, Neurocognition, Child
- Trial name
- ONSET (NCT07721155)
- Testing
- eyetracking, blood work, Strengths and difficulties questionnaire (SDQ)
- Where
- Netherlands
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Sickle Cell Disease, Cognitive Ability, General
Improving Parental Psychosocial Functioning and Early Developmental Outcomes in Children With Sickle Cell Disease
There are all significant risk factors for poor early cognitive development and, as such, neurocognitive deficits have been demonstrated in pre-school children with sickle cell disease (SCD).
- Conditions
- Sickle Cell Disease, Cognitive Ability, General, Psychological Stress, Parenting
- Trial name
- NCT02394899
- Testing
- Play therapy, Problem solving skills
- Where
- Jamaica
- Volunteers
- 64 people
- Sponsor
- The University of The West Indies
Eating Disorder
Impact of Neuropsychological Alteration of Decision-making Abilities on the Functioning of Patients With Eating Disorders
Eating disorders are multifactorial disorders currently conceptualized in a biopsychosocial model, but pathophysiology remains relatively unknown, and robust etiological models to guide treatment are therefore lacking.
- Trial name
- NEUROPSY_TCA (NCT03160443)
- Testing
- Ambulatory cares in a day-hospital (University Hospital of Montpellier) specialized in the evaluation of eating disorders
- Where
- France
- Volunteers
- 340 people
- Sponsor
- University Hospital, Montpellier
Primary Brain Tumor, Neurocognition
Executive and Socio-cognitive Functions in Survivors of Primary Brain Tumor: Impact on Patients' Quality of Life
Significant advances in primary malignant brain tumors (PBT) treatment have led to dramatically improved survival, both in children and adults.
- Conditions
- Primary Brain Tumor, Neurocognition, Quality of Life
- Trial name
- NEUROCOG-QOL (NCT02693405)
- Testing
- Executive functions, social cognition, quality of life
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Severe Acute Malnutrition in Childhood, Malnutrition, Child
Treatment of Severe Acute Malnutrition in Children 6 to 59 Months Old With Standard Ready To Use Therapeutic Food Compared to a Newly Formulated Lipid Optimized Ready To Use Therapeutic Food
The goal of this randomized clinical trial is to learn if a newly formulated Lipid-Optimized Ready-to-Use Therapeutic Food (LO-RUTF) can treat severe acute malnutrition in children aged 6 to 59 months.
- Conditions
- Severe Acute Malnutrition in Childhood, Malnutrition, Child, Neurocognition, Child
- Trial name
- NCT07345884
- Testing
- Lipid-Optimized Ready to Use Therapeutic Food (RUTF), Ready to Use Therapeutic Food (RUTF)
- Where
- Pakistan
- Volunteers
- 125 people
- Sponsor
- University of California, Los Angeles
Traumatic Brain Injury
TBI Project Amsterdam
Traumatic Brain Injury (TBI) is the world leading cause of acquired brain injury. Literature suggests a pivotal role for attentional functioning in neurocognitive and behavioural consequences of paediatric TBI.
- Trial name
- NCT01720979
- Where
- 5 sites in Netherlands
- Volunteers
- 90 people
- Sponsor
- Marsh Königs
Down Syndrome
Down Syndrome, Physical Activity and Sleep Apnea
To realize a sleep phenotyping in a population with Down syndrome, its determinants, and the consequences of these disorders, with a specific focus on sleep apnea syndrome.
- Trial name
- TAPAS (NCT06061562)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Grenoble
Behavior, Child, Neurocognition, Child
Community-Based Conscious Discipline Program in Grenada
To improve neurocognitive outcomes in 2-year-old children by implementing a community-based intervention program that follows the principles of Conscious Discipline.
- Conditions
- Behavior, Child, Neurocognition, Child, Development, Child
- Trial name
- NCT04697134
- Testing
- Conscious Discipline-Based Environmental Enrichment Intervention
- Where
- Grenada
- Volunteers
- 333 people, healthy volunteers welcome
- Sponsor
- Windward Islands Research and Education Foundation
PTEN Gene Mutation, PTEN Hamartoma Tumor Syndrome
RAD001 and Neurocognition in PTEN Hamartoma Tumor Syndrome
Phosphatase and TENsin homolog (PTEN) gene germline mutations are associated with a spectrum of clinical manifestations characterized by neurocognitive deficits, intellectual disability, autism symptomatology, skin lesions…
- Trial name
- NCT02991807
- Testing
- RAD001
- Where
- 3 sites in United States
- Volunteers
- 46 people
- Sponsor
- Boston Children's Hospital