Clinical trials: Nervous System Cancer
Anaplastic Ependymoma, Atypical Teratoid/Rhabdoid Tumor
Chemotherapy and Donor Stem Transplant for the Treatment of Patients With High Grade Brain Cancer
This phase I trial investigates the side effects and effectiveness of chemotherapy followed by a donor (allogeneic) stem cell transplant when given to patients with high grade brain cancer.
- Conditions
- Anaplastic Ependymoma, Atypical Teratoid/Rhabdoid Tumor, Central Nervous System Germ Cell Tumor, Choroid Plexus Carcinoma
- Trial name
- NCT04521946
- Testing
- Etoposide, Fludarabine Phosphate, Hematopoietic Cell Transplantation
- Volunteers
- healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Neurofibromatosis Type 1
A Randomized Placebo-Controlled Study of Lovastatin in Children With Neurofibromatosis Type 1
The specific aim of this study is to determine whether Lovastatin ™ significantly improves visual spatial learning and/or sustained attention in children with NF1.
- Trial name
- STARS (NCT00853580)
- Testing
- Lovastatin ™
- Where
- 12 sites in United States, Australia
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Tumor of Spinal Cord
Establishment and Application of Early Postoperative Activity Plan for Patients After Hemi-laminectomy for Lumbar Spinal Tumor Resection
Objective to construct the related early activity program for patients with lumbar intraspinal tumor after hemilaminectomy, and evaluate the postoperative limb function exercise according to the content of the program.
- Trial name
- NCT04968730
- Testing
- Postoperative rehabilitation nursing
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cancer, Brain Tumor
Medical Treatment Decision Making Using Adaptive Conjoint Analysis
In the setting of progressive or recurrent cancer, adolescent and young adult (AYA) patients, parents, and healthcare providers (HCP) are faced with multiple therapeutic options.
- Conditions
- Cancer, Brain Tumor, Solid Tumor, Leukemia
- Trial name
- NCT02608307
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Alzheimer Disease, Late Onset, Stroke
Explore the Sharing Model Intervene to Improve the Knowledge, Attitudes, Service Intentions and Service Start-up Effects of the Eight Major Non-cancer Disease End-stage Caregivers on Well-being and Palliative Care
Since September 1st, 2009, Taiwan has begun to pay attention to the care of patients with organ failure, dementia and the elderly, and brought eight of non-cancer terminal patients into health insurance subsidies to implement the…
- Conditions
- Alzheimer Disease, Late Onset, Stroke, Heart Failure, Pulmonary Disease, Chronic Obstructive
- Trial name
- NCT05407272
- Testing
- Health Education Manual, manual
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wen-Shiou Pan
Anesthesia, Local, Ophthalmopathy
Comparison Between Peribulbar And Sub-tenon Blocks on Oculocardiac Reflex (OCR) During Pediatric Strabismus Surgery
The aim of this study is to compare between peribulbar block and subtenon block as an adjunct to general anesthesia in children undergoing strabismus surgery on oculocardiac reflex (OCR), post-operative analgesia and…
- Conditions
- Anesthesia, Local, Ophthalmopathy, Strabismus, Pediatric ALL
- Trial name
- NCT06293586
- Testing
- peribulbar block, sub-tenon block, Paracetamol
- Where
- Egypt
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Cairo University
Neurofibromatosis 1, Social Skills
Pilot Randomized Control Trial of Telehealth Group for Improving Peer Relationships (PEERS) in NF1
This is a pilot randomized control trial of the UCLA PEERS protocol delivered via Telehealth with teens with neurofibromatosis type 1 whose parents report that they have difficulty making and keeping friends.
- Trial name
- NCT04860362
- Testing
- PEERS
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Milwaukee
Breast Cancer
Spousal Relationships and Pain in Metastatic Breast Cancer
Ecological Momentary Assessment (EMA) refers to the collection of repeated measurements of phenomena as they occur in naturalistic settings using hand-held computers.
- Trial name
- NCT00386620
- Testing
- Questionnaire, Interview
- Where
- United States
- Volunteers
- 548 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Huntington Disease, Hereditary Breast and Ovarian Cancer
Genetic Risk: Whether, When, and How to Tell Adolescents
This study is being conducted to learn more about family communication of genetic risk information. Semi-structured interviews lasting up to one hour will be conducted with three populations: parent/child pairs at risk for…
- Conditions
- Huntington Disease, Hereditary Breast and Ovarian Cancer, Hereditary Cancer, Hereditary Non-polyposis Colon Cancer
- Trial name
- NCT03421327
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Children, Only, Traumatic Brain Injury
Neurophysiological Measurements Using the NeuroCatch™ Platform in Pediatric Concussion
EEG signals have been collected and studied since the early 1990's as a way of assessing brain function at a gross level. As early as the 1930's a derivative of the raw EEG signal - event-related potentials (ERPs) - have been…
- Conditions
- Children, Only, Traumatic Brain Injury, Concussion, Mild, Pediatric ALL
- Trial name
- NCT03889483
- Testing
- NeuroCatch™ Platform
- Where
- Canada
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Dr. Michael Esser
Preterm Birth, Developmental Delay
The Alkmaar MLPTI Cohort Study: Outcomes at 9 Years
Objective of the study: To examine cognition, motor function, executive functions, speech and language development, behaviour, psychosocial functioning,academic achievement, physical morbidities and growth of MLPTI at the age of…
- Conditions
- Preterm Birth, Developmental Delay, Growth Delay
- Trial name
- NCT05990582
- Testing
- CBCL, SDQ, CCC-2-NL
- Where
- Netherlands
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Noordwest Ziekenhuisgroep
Brain Tumor, Childhood Cancer
Biomarkers of Brain Injury in Children With Brain Tumors
The goal of this observational study is to identify biomarkers of treatment-induced brain injury in children treated for primary brain tumors.
- Conditions
- Brain Tumor, Childhood Cancer, Childhood Brain Tumor
- Trial name
- BiomarkCBT (NCT07381959)
- Where
- Sweden
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Acute Lymphoblastic Leukemia, Brain Tumors
Learning Impairments Among Survivors of Childhood Cancer
Children surviving some types of cancer have a higher risk of developing learning problems after cancer treatment than do children who have not had cancer or its treatment.
- Trial name
- NCT00576472
- Testing
- Methylphenidate
- Where
- 3 sites in United States
- Volunteers
- 469 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Autism Spectrum Disorder, Mitochondrial Pathology
Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders
The study involves up to 5 visits for a fasting blood draw, behavioral assessments, and/or questionnaires. Other samples may be collected when appropriate. This study is currently recruiting.
- Conditions
- Autism Spectrum Disorder, Mitochondrial Pathology, Epilepsy, Brain Tumor
- Trial name
- NCT04322734
- Where
- 2 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Southwest Autism Research & Resource Center
Parkinson Disease, Diabetes Mellitus, Type 1
Biological Sample Collection for Research and Biobanking
The New York Stem Cell Foundation (NYSCF) Research Institute is performing this research to study different conditions and diseases by using cells from the body (such as skin or blood cells).
- Conditions
- Parkinson Disease, Diabetes Mellitus, Type 1, Macular Degeneration, ALS
- Trial name
- NCT04270604
- Testing
- Biological sample collection
- Where
- United States
- Volunteers
- 1,279 people, healthy volunteers welcome
- Sponsor
- New York Stem Cell Foundation Research Institute
Intracranial Neoplasm
Intracranial Hydatid Cyst
Central nervous system (CNS) hydatid cysts is a rare presentation of hydatid cyst, although may be the cause of intracranial space-occupying lesions in 4% in endemic countries. It affects mostly children.
- Trial name
- NCT04454268
- Testing
- cyst extirpation
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Sohag University
Neurofibromatosis Type 1
Neurofibromatosis Type 1 Patient Registry
The Neurofibromatosis Type 1 (NF1) Patient Registry Initiative (NPRI) is a web-based registry that asks participants to fill out a 30-minute online questionnaire to collect information about the spectrum of medical and social…
- Trial name
- NPRI (NCT01410006)
- Where
- United States
- Volunteers
- 2,391 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Brain Tumor, Microbiota
MICRO-BRAIN 2024: Study on Pediatric Brain Tumors
In recent years, there has been growing interest in the human gut microbiota, whose health is characterised by high microbial diversity.
- Trial name
- NCT07417085
- Testing
- Biological samples, Fecal samples
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Meyer Children's Hospital IRCCS
Macular Holes, Epiretinal Membrane
Intraoperative OCT Guidance of Intraocular Surgery II
The overall five-year goals of the project are to develop novel technology to provide actionable new information through provision of live volumetric imaging during surgery, improving surgical practice and outcomes.
- Conditions
- Macular Holes, Epiretinal Membrane, Diabetic Retinopathy, Retinal Detachment
- Trial name
- MIOCT (NCT03713268)
- Testing
- Microscope integrated optical coherence tomography
- Where
- United States
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Duke University
Meningitis, Encephalitis
The Effectiveness and Safety of Human Lumbar Puncture Assist Device (LPat)
The purpose of this study is to proof and investigate the effectiveness and safety of the invented device named "Human Lumbar Puncture Assist Device (LPat)" as an assist tool to be utilized to improve the success rate of…
- Conditions
- Meningitis, Encephalitis, Guillain-Barré, Subarachnoid Hemorrhage
- Trial name
- LPat (NCT03710278)
- Testing
- LPat Device
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Spartanburg Regional Healthcare System