Clinical trials: Nasal High Flow
Airway Disorder
Optimizing High Flow Nasal Cannula Oxygenation in Pediatric Airway Procedures
The purpose of this study is to investigate which flow rate (higher versus lower) is most effective at increasing apneic time and preventing greater than 5% drop in desaturation, as well as assessing transcutaneous carbon dioxide…
- Trial name
- NCT06947902
- Testing
- High flow, Low Flow
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- The University of Texas Health Science Center, Houston
Premature Birth, Respiratory Distress Syndrome, Newborn
High-Flow Nasal Cannula Versus Nasal CPAP as Primary Support in Preterm Respiratory Distress Syndrome
This single-center randomized controlled trial compared heated humidified high-flow nasal cannula (HHHFNC) with nasal continuous positive airway pressure (nCPAP) as primary noninvasive respiratory support in preterm infants…
- Trial name
- NCT07693530
- Testing
- Group 1 Heated humidified high-flow nasal cannula (HHHFNC), Group 2 Nasal continuous positive airway pressure (nCPAP)
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people
- Sponsor
- Kayseri City Hospital
Oxygen Deficiency
High-flow Nasal Cannula for Pediatric Anesthetic Induction
Endotracheal intubation in infants often involves more than one attempt, and oxygen desaturation is common. It is unclear whether nasal high-flow therapy, which extends the time to desaturation during elective intubation in…
- Trial name
- NCT05578131
- Testing
- high flow nasal oxygen, face mask
- Where
- South Korea
- Volunteers
- 132 people
- Sponsor
- Seoul National University Hospital
Induction of General Anesthesia
Effect of High-flow Nasal Oxygenation on Gastric Insufflation in Children
This is a randomized controlled study to compare the incidence of gastric insufflation when using high-flow nasal oxygenation and facemask ventilation in pediatric patients.
- Trial name
- NCT06204653
- Testing
- HFNO group, MV group
- Volunteers
- 70 people
- Sponsor
- Ajou University School of Medicine
Bronchopulmonary Dysplasia, Prematurity
Impact of Extended CPAP on Bronchopulmonary Dysplasia
The purpose of this pilot study is to compare if keeping infants on CPAP (continuous positive airway pressure) support for an extended period of time until they are 32 weeks corrected gestational age or 1250 grams (approximately…
- Trial name
- NCT05547139
- Testing
- Protocolized weaning of respiratory support
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Christiana Care Health Services
Prematurity; Extreme
High Flow Nasal Cannula in Preterm Infants
The HIFLO study evaluates the impact of HFNC oxygen therapy on duration of nCPAP therapy, oxygen therapy and hospitalization. The cost of use of CPAP and two HFNC devices are also evaluated.
- Trial name
- HIFLO (NCT03007056)
- Testing
- High flow nasal cannula
- Where
- France
- Volunteers
- 207 people
- Sponsor
- Hôpital de la Croix-Rousse
Bronchiolitis
High-flow Nasal Oxygen Therapy in Hospitalized Infant With Moderate-to-severe Bronchiolitis
Over the last decade, high-flow nasal oxygen therapy (HFN) has emerged as a new method to provide respiratory support in children with moderate to severe bronchiolitis.
- Trial name
- BRONCHOPTI (NCT02856165)
- Testing
- High-flow nasal canula oxygen therapy, Low-flow oxygen therapy with standard nasal canula
- Where
- France
- Volunteers
- 268 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Anesthesia, General, Apnea
High Flow Nasal Cannula for Safe Apnea
This is a prospective randomized controlled trial comparing high flow nasal cannula and buccal oxygenation as method of oxygenation during apnea in children.
- Trial name
- NCT04849520
- Testing
- High flow nasal cannula, Buccal oxygenation
- Where
- South Korea
- Volunteers
- 38 people
- Sponsor
- Seoul National University Hospital
Asthma Acute
Analysis of Non-invasive Ventilatory Support Modes: High Flow Nasal Cannula and Non-invasive Ventilation
This study compares two types of noninvasive treatments for asthma attacks with the objective of analyzing the efficacy of each therapy during the period of exacerbations in infants and asthmatics hospitalized.
- Trial name
- NCT04033666
- Testing
- High Flow Nasal cannula, NIV Noninvasive Ventilation
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Nove de Julho
High-Flow Nasal Cannula Therapy
The Application Effect of Modified Pressure-Reducing Fixation Protective Nasal Strip in the Nursing Care of Patients Receiving High-Flow Nasal Cannula Therapy
This study was a prospective, randomized controlled trial that included 60 patients receiving high-flow nasal cannula (HFNC) therapy.
- Trial name
- HFNC; pressure (NCT06720129)
- Testing
- the modified pressure-reducing fixation protective nasal strip, Standard care alone
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Ying Zhou
Cystic Fibrosis
High Flow Nasal Oxygen for Children With Cystic Fibrosis Presenting With Respiratory Failure - a Randomized Controlled Study
Respiratory exacerbations are frequent among cystic fibrosis patients and supplemental oxygen is usually required. We will compare a new high flow nasal cannula system with Venturi masks for oxygen supplementation to patients…
- Trial name
- HIFLOWCF (NCT01810536)
- Testing
- Hi-flow nasal cannula, Venturi mask
- Where
- Brazil
- Volunteers
- 4 people
- Sponsor
- University of Sao Paulo
Respiratory Distress Syndrome
High Flow Nasal Cannula in Comparison With Nasal Continuous Positive Airway Pressure in the Management of Respiratory Distress Syndrome
To compare the primary outcome, failure of extubation defined by the need for re-intubation and mechanical ventilation within 5 days of initial extubation and secondary outcomes, morbidities and mortality after using of heated…
- Trial name
- NCT02587832
- Testing
- HHHFNC, NCPAP
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Sidra Medicine
Pediatric Asthma
High Flow Nasal Cannula Rates in Pediatric Asthma
This is a randomized, open-label, 3-armed feasibility trial will examine conventional oxygen therapy (COT) vs high flow nasal cannula at 4L/min flow vs HFNC at 2L/kg/min flow (max 60L/min) in moderate to severe pediatric asthma…
- Trial name
- NCT06379607
- Testing
- "High Flow" High Flow Nasal Cannula, "Low Flow" High Flow Nasal Cannula
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Rochester
Moderate Respiratory Distress, Severe Respiratory Distress
High Flow Nasal Oxygen Therapy an Implementation Study in Pediatric Wards
The purpose of this study is to prospectively evaluate the process of implementing HFNO in several MSF projects, varying according to geographical and programmatic contexts, population, health structures, human resources, and…
- Trial name
- HFNO (NCT06715423)
- Where
- Afghanistan
- Volunteers
- 960 people
- Sponsor
- Epicentre
Respiratory Insufficiency
Comparison of Humidified High Flow Nasal Cannula to Nasal CPAP in Neonates
We hypothesize that the success rate for keeping babies extubated (without a breathing tube for assisted mechanical ventilation), defined as the proportion of infants remaining extubated for a minimum of 72 hours, will be…
- Trial name
- HHFNC (NCT00609882)
- Testing
- Nasal CPAP, Humidified High Flow Nasal Cannula (HHFNC)
- Where
- 9 sites in United States, China
- Volunteers
- 420 people
- Sponsor
- University of Utah
Enteral Feeding in Bronchiolitis
Comparison Between Gastric and Post Pyloric Tube Feedings in Children With Bronchiolitis Requiring High Flow Nasal Cannula
The purpose of the study is to compare two ways (nasogastric tube (NGT) and nasoduodenal tube (NDT)) to provide nutrition to infants admitted to the hospital for viral bronchiolitis and who require high flow nasal cannula therapy.
- Trial name
- NCT03346850
- Testing
- Nasogastric tube (NGT) feeding, Nasoduodenal tube (NDT) feeding
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The University of Texas Health Science Center, Houston
Respiratory Distress Syndrome, Cronic Lung Disease
Humidified High Flow Nasal Cannula as Compared to Nasal Continuous Positive Airway Pressure
The specific aims of this study are to evaluate the amount of high flow nasal cannula (HFNC) gas flow required to generate an equivalent positive distending pressure as that provided by nasal continuous positive airway pressure…
- Trial name
- NCT00356668
- Testing
- High Flow Nasal Cannula
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Anesthesia
High Flow Nasal Cannula in Comparison to Apneic Oxygenation During Foreign Body Removal by Rigid Bronchoscope
To compare the effect of HFNC with standard apneic oxygenation on patient oxygenation and airway protection during foreign body removal by rigid bronchoscope.
- Trial name
- NCT04885673
- Testing
- Vapotherm, Apneic oxygenation
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Ain Shams University
Acute Respiratory Failure, Respiratory Insufficiency
HERMES: Quality and Safety of Advanced Respiratory Support During Patient Transport
The HERMES Phase III study is an international, multicenter, prospective observational investigation designed to characterize the quality and safety of patient transport during advanced respiratory support.
- Conditions
- Acute Respiratory Failure, Respiratory Insufficiency, Respiratory Distress, Critical Illness
- Trial name
- HERMES (NCT07805603)
- Testing
- Advanced Respiratory Support During Patient Transport
- Where
- 4 sites in Colombia, Egypt and 2 more
- Volunteers
- 565 people
- Sponsor
- Medipol University
Pneumonia
Oxygen Therapy for Children With Moderate Hypoxemia in Malawi
The goal of this pilot clinical trial is to compare standard of care, low-flow oxygen, and high-flow nasal canula oxygen in pediatric patients aged 1-59 months with pneumonia and an oxygen saturation of 90-93% in Malawi.
- Trial name
- NoGoLo2 (NCT06176664)
- Testing
- Low flow oxygen, High-flow nasal cannula oxygen
- Where
- Malawi
- Volunteers
- 21 people
- Sponsor
- Johns Hopkins University