Clinical trials: Myopia, Degenerative
Myopia, Progressive
A Unified Index to Predict the Success Probability of Myopia Control
Orthokeratology lenses (OK-lens) and multifocal contact lenses (MFCL) are optical devices designed to slow down the progression of myopia. Both treatments a long-term commitment from doctors and patients.
- Trial name
- NCT05773118
- Testing
- orthokeratology lens, multifocal soft contact lens, Single vision spectacles
- Volunteers
- healthy volunteers welcome
- Sponsor
- Nova Southeastern University
Pathological Myopia
Genomewide Screening of Pathological Myopia
The purpose of this study is to evaluate the possible candidate gene of pathological myopia
- Trial name
- NCT00155753
- Where
- Taiwan
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Myopia, Progressive, Children, Only
Myopia Control With Orthokeratology Contact Lenses in Spain
The purpose of this prospective study is to assess the efficacy, safety and patient-reported outcomes of the Menicon Z Night orthokeratolgy contact lens for reducing myopia progression in children.
- Conditions
- Myopia, Progressive, Children, Only, Contact Lens Complication, Perception, Self
- Trial name
- MCOS (NCT04806763)
- Testing
- Menicon Z Night, Control
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Menicon Co., Ltd.
Myopia Progression, Atropine
Efficacy and Safety of 0.01%, 0.03%, and 0.05% Atropine Eye Drops in Reducing Myopia Progression
Myopia is one of the fastest-growing ocular disorders worldwide and has become a major public health concern, especially among children and adolescents.
- Trial name
- NCT07626892
- Testing
- Atropine sulphate eye drop 0.01%, Atropine sulphate eye drop 0.03%, Atropine sulphate eye drop 0.05%
- Where
- Pakistan
- Volunteers
- 95 people
- Sponsor
- Khyber Medical College, Peshawar
Myopia, Progressive
Efficacy of IVMED-85 on Pediatric Myopia
The goal of this clinical trial is to evaluate the safety and preliminary efficacy of a 1-year course of IVMED-85 eye drops for the treatment of pediatric myopia by assessing its safety effects on visual acuity and its effect on…
- Trial name
- NCT05761795
- Testing
- IVMED 85
- Volunteers
- 216 people
- Sponsor
- iVeena Delivery Systems, Inc.
Myopia, Progressive, Myopia
Clinical Evaluation of a Myopia Control Lens in Slowing Myopia Progression
This is a monocenter, randomized, controlled, parallel-group, double-masked clinical trial to evaluate the effectiveness of test lens in slowing myopia progression with respect to axial length elongation at baseline compared to a…
- Trial name
- NCT05331378
- Testing
- Test myopia control lenses, Single vision lenses
- Where
- Singapore
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Essilor International
Myopia, Progressive
Differences and Wearing Safety and Comfort of New Defocus Incorporated Multiple Segments Spectacle Lenses
To evaluate the differences in controlling the progression of myopia in adolescents and the safety and comfort of wearing different types of defocus incorporated multiple segments spectacle lenses, to explore the feasibility of…
- Trial name
- NCT06221592
- Testing
- defocus spectacle lenses
- Where
- China
- Volunteers
- 252 people
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Myopia, Progressive
Double Helix Design Defocus Lens Spectacle (RACE) for Myopia Control
This study uses 1.585 double helix defocus lens PC lenses with a unique optical design that includes a globally coherent visible area and complementary left and right helices that can form clear images.
- Trial name
- NCT05894382
- Testing
- Double Helix Design Defocus Lens Spectacle (RACE), single-vision spetacle lens
- Where
- China
- Volunteers
- 236 people
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Myopia, Progressive, Children, Only
Eleven Years of Menicon Z Night Contact Lens Wear in Reducing Myopia Progression in Children
To compare axial length growth of white European myopic children wearing Menicon Z Night orthokeratology contact lenses to a control group of distance, single-vision glasses and contact lenses over an 11-year period.
- Trial name
- MCOS11 (NCT04806711)
- Testing
- Menicon Z Night, Control
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Menicon Co., Ltd.
no Obvious Abnormalities, Diabetic Retinopathy (DR)
Retinal Clinical Assessment With AI-derived Quantitative Information
This randomized controlled trial evaluates whether providing clinicians with AI-derived quantitative retinal information improves the quality and efficiency of retinal clinical assessment.
- Conditions
- no Obvious Abnormalities, Diabetic Retinopathy (DR), AMD, Cup-to-disc Ratio Bigger Than 0.5
- Trial name
- NCT07291960
- Testing
- AI-derived retinal quantitative information-assisted reporting
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Myopia, Progressive
Clinical Evaluation of MyoCare in Europe (CEME)
A 2-year prospective, multicenter, randomized controlled, and double-blind clinical trial is used to investigate the efficacy of a new design of ophthalmic lenses to slow the progression of myopia.
- Trial name
- CEME (NCT05919654)
- Testing
- MyoCare, ClearView
- Where
- Spain
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Myopia, Progressive, Atropine Allergy
Eye Drops Study for Myopia Control in Schoolchildren
The myopia prevalence in schoolchildren is high in Taiwan. The myopia progression is fast in children and often associated high myopia in later life.
- Trial name
- NCT03402100
- Testing
- eye drops
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- Chang Gung Memorial Hospital
Myopia, Progressive
Study of OT-101 in Treating Myopia
This is a phase III, randomized, double-masked, placebo-controlled, parallel-group, multicenter safety, tolerability, and efficacy study of atropine sulfate 0.01% (OT-101) as an investigational treatment for myopia in pediatric…
- Trial name
- NCT04770610
- Testing
- OT-101 Ophthalmic Solution, Vehicle
- Where
- 15 sites in United States
- Volunteers
- 678 people
- Sponsor
- Ocumension (Hong Kong) Limited
Myopia
Multicenter Evaluation of Near Vision and Outdoor Time in Kids Study
Currently, optical and pharmacological interventions have been developed to prevent the progression of childhood myopia. However, no myopia control strategy has been shown to have complete efficacy in controlling myopia…
- Trial name
- MENOK (NCT06119243)
- Testing
- Vivior
- Where
- 5 sites in United States, Australia
- Volunteers
- 230 people
- Sponsor
- The University of New South Wales
Progressive Myopia
MAD Trial: Myopia Atropine Dose
The goal of this interventional study is to compare the efficacy of Atropine 0.05% to Atropine 0.5% treatment against progression of axial length in European children with progressive myopia, and to evaluate the safety…
- Trial name
- MAD (NCT05667454)
- Testing
- Atropine Ophthalmic 0.05%, Atropine Ophthalmic 0.5%
- Where
- 20 sites in Netherlands
- Volunteers
- 550 people
- Sponsor
- Erasmus Medical Center
Retinal Diseases, Choroidal Disease
An Interpretable Fundus Diseases Report Generating System Based On Weakly Labelings
To establish a multimodal fundus image report generation model to realize an interpretable system for multiple fundus diseases, multimodal image analysis, diagnosis, and treatment decision automatic reporting based on weakly…
- Conditions
- Retinal Diseases, Choroidal Disease, Pathological Myopia, Diabetic Retinopathy
- Trial name
- NCT06918028
- Testing
- With fundus diseases, Without fundus diseases
- Where
- China
- Volunteers
- 9,999 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Diabetic Retinopathy (DR), Retinal Vein Occlusion (RVO)
High-throughput Large-model-based AI-assisted Diagnosis Using OCT
This observational study aims to establish key technologies for high-throughput, large-model-based AI-assisted diagnosis using optical coherence tomography (OCT) and OCT angiography (OCTA).
- Conditions
- Diabetic Retinopathy (DR), Retinal Vein Occlusion (RVO), Age-Related Macular Degeneration (AMD), Pathologic Myopia
- Trial name
- NCT07249307
- Testing
- No intervention
- Volunteers
- 2,000 people
- Sponsor
- Peking Union Medical College Hospital
Progressive Myopia
Efficacy Study of Different Lens Treatments on Chinese Adolescent Myopia
The purpose of this study is to determine the efficacy of different lens treatments (normal spectacle lens, ortho-K, \& Myovision) on myopia control in Chinese adolescent patients.
- Trial name
- DLTCAM (NCT02001415)
- Testing
- Spectacles, Myovision, Orthokeratology
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking University People's Hospital
Myopia, Myopia, Progressive
Can Distance Center and Near Center Multifocal Contact Lenses Control Myopia Progression in Children?
Myopia has been increasing in prevalence and severity throughout the world over the last 30 years. Increasing levels of myopia are associated with increased frequency and severity of various ocular pathologies.
- Trial name
- ADPADP (NCT03519490)
- Testing
- Hybrid Contact Lens
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Thomas A. Aller, OD
Myopia, Progressive
DIMS-myopia Progression ADN Axial Length Growth
To confirm the efficacy of DIMS lenses in controlling myopia progression, we planned a prospective randomized controlled clinical study.
- Trial name
- NCT05300321
- Testing
- frame lens
- Where
- China
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Tianjin Eye Hospital