Clinical trials: Myopathies
Migraine in Children, Complex Regional Pain Syndromes
Supraspinal Processing of Sensory Aspects of Pain
The goal of this basic science study is to learn about the brain mechanisms of chronic pain across different chronic pain syndromes in pediatric patients.
- Conditions
- Migraine in Children, Complex Regional Pain Syndromes, Musculoskeletal Pain, Functional Abdominal Pain Syndrome
- Trial name
- SCP (NCT05814497)
- Testing
- Multisensory Task, Graphesthesia, Divided attention
- Where
- United States
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Myositis, Dermatomyositis
Environmental Risk Factors for the Anti-synthetase Syndrome
Background: Like other complex diseases, autoimmune diseases are the result of numerous causes, including genetic and environmental factors.
- Conditions
- Myositis, Dermatomyositis, Polymyositis, Juvenile Dermatomyositis
- Trial name
- NCT01276470
- Where
- 8 sites in United States
- Volunteers
- 580 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Centronuclear Myopathy
Early Phase Human Drug Trial to Investigate Dynamin 101 (DYN101) in Patients ≥ 16 Years With Centronuclear Myopathies
There are no available treatments aside from supportive care for patients with Centronuclear myopathy (CNM). This trial will assess the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD)/preliminary efficacy of…
- Trial name
- Unite-CNM (NCT04033159)
- Testing
- DYN101
- Where
- 8 sites in Belgium, Denmark and 4 more
- Volunteers
- 14 people
- Sponsor
- Dynacure
Duchenne Muscular Dystrophy
Tele-assessment of Functional Performance and Quality of Life in Patients With Duchenne Muscular Dystrophy: Validity and Reliability Study
Thanks to tele-assessment methods, it may be possible to evaluate DMD patients without traveling to clinical centers. In recent years, the applicability of remote assessment methods in DMD patients, as in many populations, is…
- Trial name
- NCT06295718
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Sahra Şirvan
Lateral Epicondylitis, Tennis Elbow
Acupuncture Plus Fire Needle and Acupuncture on Lateral Epicondylitis
The aim of this study was to investigate whether or not the outcomes of acupuncture used in combination with fire needle treatment are better than those of acupuncture alone in patients with lateral epicondylitis.
- Conditions
- Lateral Epicondylitis, Tennis Elbow, Acupuncture
- Trial name
- NCT03820856
- Testing
- acupuncture plus fire needle therapy, acupuncture
- Where
- Taiwan
- Volunteers
- 43 people
- Sponsor
- Chang Gung Memorial Hospital
Duchenne Muscular Dystrophy
Efficacy and Safety Study of WVE-210201 (Suvodirsen) With Open-label Extension in Ambulatory Patients With Duchenne Muscular Dystrophy
This is a Phase 2/3, multicenter, randomized, double-blind, placebo-controlled study with an open-label extension period to evaluate the safety and efficacy of WVE-210201 (suvodirsen) in ambulatory male pediatric patients with…
- Trial name
- DYSTANCE 51 (NCT03907072)
- Testing
- WVE-210201 (suvodirsen)
- Where
- 22 sites in United States, Belgium and 6 more
- Volunteers
- 6 people
- Sponsor
- Wave Life Sciences USA, Inc.
Duchenne Muscular Dystrophy
Sunphenon Epigallocatechin-Gallate (EGCg) in Duchenne Muscular Dystrophy
The aim of this multicentre, prospective, double blind, placebo controlled, randomized pilot study is to investigate safety and tolerance of Epigallocatechin-Gallate (EGCG, the major polyphenol in green tea) in patients with…
- Trial name
- SUNIMUD (NCT01183767)
- Testing
- Epigallocatechin-Gallate
- Where
- 3 sites in Germany
- Volunteers
- 33 people
- Sponsor
- Charite University, Berlin, Germany
Muscular Dystrophy, Duchenne
Effect of EPA and DHA in the Inflammation and Metabolic Disorders in DMD/DMB Patients
The purpose of this study is to evaluate the effect of docosahexaenoic fatty acid and eicosapentaenoic fatty acid supplementation for six months on the inflammation state as well as the process of muscular regeneration and the…
- Trial name
- NCT01826422
- Testing
- EPA and DHA
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Temporomandibular Joint Disorder
Effect of Functional Treatment on Mandibular Asymmetric Growth
Temporomandibular joint (TMJ) arthritis is known to alter the mandibular development in children diagnosed with juvenile idiopathic arthritis.
- Trial name
- NCT01113177
- Testing
- Distraction splint therapy
- Where
- Denmark
- Volunteers
- 22 people
- Sponsor
- University of Aarhus
Cleft Lip and Palate, Temporomandibular Disorder
Electromyographic Analysis of the Masticatory Muscles in Cleft Lip and Palate Children With Temporomandibular Disorders
The aim of this study was to assess the electrical activity of the temporal and masseter muscles in cleft lip and palate (CLP) children with pain-related temporomandibular disorders (TMD) and in CLP individuals with no TMD by…
- Trial name
- NCT03308266
- Testing
- electromyography
- Where
- Poland
- Volunteers
- 87 people
- Sponsor
- Pomeranian Medical University Szczecin
Muscular Dystrophy
Heart Imaging in Children With Muscular Dystrophy
Background: Muscular dystrophy can affect the muscles used for heart function and breathing. Treatment usually involves drugs that help improve heart function.
- Trial name
- NCT01633242
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Fibrodysplasia Ossificans Progressiva (FOP)
A Non-Interventional Study of Clinical Characteristics and Mortality of US Patients With Fibrodysplasia Ossificans Progressiva (FOP)
Primary Objective(s): To describe the demographic characteristics of people living with FOP and a matched cohort of non-FOP people living in the United States (U.S.) To describe the prevalence of clinical characteristics of…
- Trial name
- NCT06064656
- Testing
- Non-Interventional
- Where
- United States
- Volunteers
- 131 people
- Sponsor
- Regeneron Pharmaceuticals
Intraabdominal Hypertension, Breast Neoplasms
DIEP Flap Surgery and Intraabdominal Pressure
Aim: The primary aim of this study is to test if closure of the abdominal donor site increases the Intraabdominal Pressure (IAP) in women undergoing secondary Deep Inferior epigastric perforator (DIEP) flap breast reconstruction.
- Trial name
- NCT05764577
- Testing
- DIEP flap surgery
- Where
- Denmark
- Volunteers
- 13 people
- Sponsor
- Aalborg University Hospital
Spastic Cerebral Palsy
Homebased (6-week) Stretching Intervention in Children With Spastic Cerebral Palsy
This study will investigate the effect of a 6-week stretching intervention, consisting of a combination of a 2-week casting period and a home-based stretching program of the plantar flexors and hamstrings, on muscle and tendon…
- Trial name
- NCT04904094
- Testing
- Casting of the lower limb and homebased stretching exercise program.
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Osteoarthritis
Synvisc to Treat Osteoarthritis of the Temporomandibular Joint
This study will examine the effectiveness of injected hylan (Synvisc) for treating pain associated with osteoarthritis of the temporomandibular joint (jaw joint) and improving function of the joint.
- Trial name
- NCT00078351
- Testing
- High molecular weight hylan (Synvisc) injection
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Rhabdomyolysis
Lactoferrin Effect on Kidney and Heart of Rhabdomyolysis Rats
This study focuses on detecting the possible beneficial effect of Lactoferrin (Lf) administration on the kidney and the heart of glycerol-induced rhabdomyolysis (RM) in rats and its relation to ferroptosis and AMPK/Nrf2/ HO-1…
- Trial name
- NCT06491394
- Testing
- Lactoferrin, iron, MDA, TAC, and GSH
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Aswan University Hospital
Post Traumatic Induced Spasticity
Selective Dorsal Rhizotomy as a Cost Effective and Safe Procedure as a Alternative to Intrathecal Baclofen Pump in Patients With Post Traumatic Spasticity
The investigators will investigate the selective dorsal rhizotomy in post traumatic brain and spinal cord injury induced spasticity to evaluate the efficacy of this procedure in reducing the tone of the spastic muscle groups.
- Trial name
- NCT07583277
- Testing
- Selective dorsal rhizotomy with neuromonitoring
- Volunteers
- 32 people
- Sponsor
- Assiut University
Fatigue Syndrome, Chronic, Epstein-Barr Virus Infection
Mental Training for CFS Following EBV Infection in Adolescents
The general aim of this study is to investigate the effect of an individually tailored mental training program in adolescents developing chronic fatigue syndrome (CFS) after an acute Epstein Barr-virus (EBV) infection.
- Trial name
- NCT02499302
- Testing
- Mental training
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- University Hospital, Akershus
Nemaline Myopathy
Treatment of TNNT1-Myopathy With L-Tyrosine.
The purpose of the study is to investigate if treatment with L-Tyrosine improves selected outcome measures of TNNT1 myopathy.
- Trial name
- NCT02035501
- Testing
- L-Tyrosine
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Hadassah Medical Organization
Polydactyly Toe, Thumb Hypoplasia
Clonidine for Tourniquet-related Pain in Children
This study is designed as a randomized, placebo-controlled, double-blinded, clinical trial with two parallel groups. This study investigates the association between a single dose of the drug, Clonidine, and the total amount of…
- Conditions
- Polydactyly Toe, Thumb Hypoplasia, Trigger Finger, Polydactyly; Fingers
- Trial name
- CLOTCH (NCT04564430)
- Testing
- Catapresan, Saline
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
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