Clinical trials: Movement Disorders
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Malocclusion Class II, Malocclusion, Angle Class I
Effect of Early Versus Late Premolar Extraction on Orthodontic Tooth Movement
The goal of this randomized controlled trial is to evaluate whether the timing of premolar extraction affects the rate of orthodontic space closure during en-masse anterior retraction.
- Trial name
- NCT07773389
- Testing
- Early Maxillary First Premolar Extraction, Late Maxillary First Premolar Extraction
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Shifa College of Dentistry
Glut1 Deficiency Syndrome, De Vivo Disease
Early Diagnosis of the GLUT1 Deficiency Syndrome With a Blood Based Test
The study aims at validating the diagnostic performances of the METAglut1, a blood in vitro diagnostic test, for the simple and early diagnosis of the Glut1 deficiency syndrome (Glut1DS, or De Vivo disease).
- Conditions
- Glut1 Deficiency Syndrome, De Vivo Disease, Seizures, Movement Disorders
- Trial name
- METAglut1 (NCT03722212)
- Testing
- METAglut1
- Where
- 28 sites in France
- Volunteers
- 636 people
- Sponsor
- METAFORA biosystems
Parkinson Disease
Strength Training and Different Subtypes of Parkinson´s Disease
The aim of this randomized controlled trial was to assess the impact of progressive resistance exercise (PRE) in PD patients with akinesia and rigidity (AR-subtype).
- Trial name
- NCT02966600
- Testing
- Progressive resistance exercise, Physical Activity
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- University of Oviedo
Cerebral Palsy
Modified Constraint Induced Movement Therapy With And Without Cross Education In Cerebral Palsy
A nonprogressive injury to the growing brain, cerebral palsy can impair a child's speech, intellectual ability, and motor development. The kind of impairment will correspond with the affected brain region.
- Trial name
- NCT06522464
- Testing
- Group A: mCIMT with cross-education, Group B: mCIMT without cross-education
- Where
- Pakistan
- Volunteers
- 22 people
- Sponsor
- Riphah International University
Autistic Disorders Spectrum, Adhd
Studies of Brain and Body Interaction
The goal of this study is to characterize biophysiolgoical signals as a comprehensive profile of the nervous systems in order to understand interactions between the brain and body, while an individual performs naturalistic…
- Conditions
- Autistic Disorders Spectrum, Adhd, Asperger Syndrome, Alzheimer Disease
- Trial name
- NCT03672266
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rutgers University
Spinal Muscular Atrophy
Reliability and Validity of the ACTIVE-mini for Quantifying Movement in Infants With Spinal Muscular Atrophy
The purpose of this study is to investigate the measurement properties of the Ability Captured Through Interactive Video Evaluation-mini (ACTIVE-mini) for quantifying movement in infants with Spinal Muscular Atrophy (SMA).
- Trial name
- NCT03808233
- Testing
- ACTIVE mini
- Volunteers
- 25 people
- Sponsor
- University of Texas Southwestern Medical Center
Mild Traumatic Brain Injury, Concussion, Binocular Visual Function
An Early Prospective Study of the Traq™ Device for Characterization of Binocular Ocular Function in Normal Subjects and Subjects With Recent Traumatic Brain Injury
The early prospective study of Traq™ (an investigational binocular ophthalmic neurodiagnostic device) will measure binocular ocular functions (bilateral foveal fixation, foveal binocularity, and fovea-tracked saccadic latency) in…
- Conditions
- Mild Traumatic Brain Injury, Concussion, Binocular Visual Function, Neuro-Ophthalmology, Saccadic Eye Movements
- Trial name
- REB-001 (NCT07742878)
- Testing
- Binocular ophthalmic neurodiagnostic device
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Rebiscan, Inc.
Pantothenate Kinase-Associated Neurodegeneration
Efficacy and Safety Study of Fosmetpantotenate (RE-024) in PKAN Participants
This study investigated whether fosmetpantotenate (RE-024), a phosphopantothenate replacement therapy, was safe and effective in treating participants with PKAN.
- Trial name
- PKAN (NCT03041116)
- Testing
- Fosmetpantotenate
- Where
- 20 sites in United States, Canada and 7 more
- Volunteers
- 84 people
- Sponsor
- Travere Therapeutics, Inc.
Serotonin Syndrome
Azilect + Antidepressant Chart Review
To identify the occurrence of serotonin toxicity in Parkinson's Disease (PD) patients receiving antidepressant therapy and rasagiline, compared to those receiving rasagiline without antidepressant medications and compared to PD…
- Trial name
- STACCATO (NCT00955604)
- Testing
- Group R+AD Rasagiline + Antidepressant, Group R Rasagiline, Group AD Anti-PD + Antidepressant
- Volunteers
- 1,500 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Alzheimer's Disease, Dementia
Diagnosis and Natural History Study of Patients With Neurological Conditions
The purpose of this study is to improve understanding of neurological conditions. Patients participating in this study will continue receiving medical care, routine laboratory tests, and diagnostics tests (X-rays, CT-scans, and…
- Conditions
- Alzheimer's Disease, Dementia, Movement Disorder, Multiple System Atrophy
- Trial name
- NCT00001549
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Angelman Syndrome
The Global Angelman Syndrome Registry
The Global Angelman Syndrome Registry is an online patient organisation driven registry to collect information about the natural history of children and adults with Angelman Syndrome.
- Trial name
- GASR (NCT05293184)
- Testing
- Observational study only
- Where
- Australia
- Volunteers
- 5,000 people
- Sponsor
- Foundation for Angelman Syndrome Therapeutics, Australia
Oppositional Defiant Disorder, Conduct Disorder
Study to Determine Whether There Are Any Cognitive or Motor Effects From Taking the Medicine Risperidone.
This study was developed in order to assess the effects of risperidone (Risperdal) as compared with placebo on cognitive-motor performance (attention, memory, and hand steadiness) and body movements.
- Conditions
- Oppositional Defiant Disorder, Conduct Disorder, Attention Deficit/Hyperactivity Disorder (ADHD), Intermittent Explosive Disorder
- Trial name
- NCT00399698
- Testing
- Risperdal
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Ohio State University
Parkinson Disease
Can Dance Therapy Improve Motor Learning in Parkinson's Disease (PD)?
In order to find the most effective rehabilitative therapies for Parkinsonian patients, the present study is aimed to evaluate whether, in a multidisciplinary intensive rehabilitation treatment, the dance therapy, applied to the…
- Trial name
- NCT03549793
- Testing
- Dance Therapy, exercises without dance
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Ospedale Generale Di Zona Moriggia-Pelascini
Parkinson Disease
Chinese PD Registry
The purpose of the Chinese Parkinson's disease Registry (CPDR) is to develop a database of patients with Parkinson's disease in China.
- Trial name
- CPDR (NCT03887663)
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Xiangya Hospital of Central South University
Tourette Disorder, Tic Disorders
Evaluating the Efficacy and Safety of Yi-Gan San in Children and Adolescents With Tourette's Disorder
Yigansan was used in Ming dynasty by Xue Kai as a remedy for restlessness and agitation in children. We expect that the total YGTSS scores of Yigansan-treated subjects will be significantly reduced compared to that of…
- Trial name
- NCT03564132
- Testing
- Yigansan
- Where
- Taiwan
- Volunteers
- 38 people
- Sponsor
- China Medical University Hospital
Tourette's Syndrome, Tourette's Disorder
Psychosocial Intervention for Young Children With Chronic Tics
Analysis of data from the recently completed NIH Child Comprehensive Behavioral Intervention for Tics (CBIT) study found a manualized behavioral treatment approach strongly superior to psychoeducation/supportive therapy for…
- Conditions
- Tourette's Syndrome, Tourette's Disorder, Tourette's Disease, Tourette Disorder
- Trial name
- CBIT JR (NCT03042507)
- Testing
- Comprehensive Behavioral Intervention for Tics (CBIT)
- Volunteers
- 15 people
- Sponsor
- Weill Medical College of Cornell University
Progressive Supranuclear Palsy, Cortical Basal Ganglionic Degeneration
tDCS as Treatment for Motor Function
Previous preliminary results are sufficiently impressive to suggest that tDCS stimulation does have the potential to improve motor function when that ability is trained during stimulation.
- Conditions
- Progressive Supranuclear Palsy, Cortical Basal Ganglionic Degeneration, Parkinson Disease
- Trial name
- PSP (NCT07291687)
- Testing
- Transcranial direct current stimulation (TDCS), Stimulation Arm
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Baycrest
Parkinson Disease
Prebiotics in the Parkinson's Disease Microbiome
There are about one million Parkinson's disease (PD) patients in America. The risks associated with whether or not an individual may develop PD include environment and genetic (biologic, hereditary) factors.
- Trial name
- NCT04512599
- Testing
- Prebiotic Bar
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Rush University Medical Center
Parkinson's Disease
Catechol Thioethers in Parkinson's Disease
The goal of the clinical trial aim in this project is to test whether catechol thioethers can be used as biomarkers of dopaminergic neurodegeneration.
- Trial name
- NCT00042692
- Volunteers
- 20 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
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