Clinical trials: Microcirculation
ST-segment Elevation Myocardial Infarction (STEMI)
Angio-IMR and Cardiac MR-derived MVO in STEMI Patients
Coronary microcirculatory dysfunction has been known to be prevalent even after successful revascularization of ST-segment elevation myocardial infarction (STEMI) patients.
- Trial name
- NCT04828681
- Testing
- Cardiac magnetic resonance imaging
- Where
- 2 sites in United States, China
- Volunteers
- 324 people
- Sponsor
- Samsung Medical Center
Sickle Cell Disease
Sickle Cell Anemia and Cerebral Microcirculation : Multimodal Exploration
The aim of this study is to evaluate determinants of cerebral oxygenation and perfusion at the microcirculatory level in children with sickle cell anemia (SCA) using combined novel investigational tools: Arterial Spin Labeling…
- Trial name
- DREAM² (NCT02909283)
- Testing
- Physical exams and blood analyzes
- Where
- 2 sites in France
- Volunteers
- 64 people
- Sponsor
- Imagine Institute
Tetrology of Fallot
Assessment of Microvascular Circulation in the Pediatric Cardiac Surgery Patient
The pediatric cardiac surgery patient endures a tremendous number of physiologic alterations during surgery and cardiopulmonary bypass (CPB) that lasts well into the recovery period.
- Trial name
- NCT07184476
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Boston Children's Hospital
Sickle Cell Disease
Safety and Efficacy of Sodium Nitrite in Sickle Cell Disease
This study will determine if administration of sodium nitrite is safe and can improve small vessel blood flow and tissue oxygenation when given as an additional treatment in patients with acute vaso-occlusive crisis (pain crisis)…
- Trial name
- NCT01033227
- Testing
- sodium nitrite injection, usp
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Children's Hospital Los Angeles
Hypertension, Diabetes
Hypertension Related Damage to the Microcirculation in South Asian: Emergence, Predictive Power and Reversibility
Damage to very small blood vessels is a consequence, but can also precede high blood pressure. Such damage, measured by disturbances in the vessels in the retina (back of the eye) is a strong predictor of heart disease and…
- Conditions
- Hypertension, Diabetes, Cardiovascular Disease, Retinopathy
- Trial name
- NCT00331370
- Testing
- GP training and Health Education
- Where
- Pakistan
- Volunteers
- 2,880 people
- Sponsor
- Aga Khan University
Child, Only, Obesity
Microvascular Reactivity in Prepubertal Children
This is a cross-sectional study aimed to investigate microvascular reactivity in prepubertal children according to adiposity status.
- Conditions
- Child, Only, Obesity, Endothelial Dysfunction
- Trial name
- MicroChild (NCT03171441)
- Testing
- nailfold videocapillaroscopy, inflammatory biomarkers
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Cardiovascular Diseases, Heart Diseases
Racial Differences in the Coronary Microcirculation
To study mechanisms of excess coronary ischemia secondary to alterations in autoregulation and arteriolar vasoreactivity in Black Americans with hypertension, varying degree of left ventricular hypertrophy, and angiographically…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Hypertension
- Trial name
- NCT00005373
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Child, Only, Essential Hypertension
Juvenile Essential Arterial Hypertension and Vascular Function
The main goal of this study is to investigate the association of the juvenile essential arterial hypertension with systemic micro- and macrovascular reactivity and cerebral vascular function, and to examine the potential impact…
- Trial name
- NCT05109013
- Where
- Croatia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Cardiovascular Diseases, Microvascular Complications
Non-invasive Microvascular Assessment in Individuals at High Risk of Cardiovascular Disease From the SCAPIS2 Study
Microvascular dysfunction, particularly endothelial dysfunction, is increasingly recognized as a key mechanism underlying various cardiovascular diseases (CVD), including heart failure, ischemic heart disease, atherosclerosis…
- Trial name
- NCT07359768
- Where
- Sweden
- Volunteers
- 900 people
- Sponsor
- HJN Sverige AB/Neko Health
Transcutaneous Monitoring, Microcirculation
Transcutaneous Monitoring of Oxygen and Carbon Dioxide in Surgical Patients
The study will investigate if non-invasive continuous transcutaneous blood gas monitoring can detect tissue perfusion and hypoxemia and the relation to other circulatory parameters such as pulse, blood pressure, cardiac output…
- Conditions
- Transcutaneous Monitoring, Microcirculation, Peripheral Perfusion, Tissue Metabolism
- Trial name
- NCT04040478
- Testing
- Transcutaneous monitoring
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Severe Sepsis or Septic Shock in Pediatric Intensive Care Unit
Predictive Mini-bolus Fluid Responsiveness in Pediatric Septic Shock
Severe sepsis and septic shock remain of particular gravity in children with a current mortality of about 20 % , despite the international prevention campaigns " survival sepsis campaign ".
- Trial name
- PRECISE (NCT04027699)
- Testing
- Mini-bolus
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Overweight and Obesity, Cardiovascular Risk Factor
Impact of Active Video Game on Cardiorespiratory, Macro and Microcirculation Function of Adolescents With Overweight
This study evaluates the effects of physical exercise through active videogame in the microcirculation, macrocirculation, cardiorespiratory function and physical fitness in overweight adolescents.
- Conditions
- Overweight and Obesity, Cardiovascular Risk Factor, Physical Activity
- Trial name
- NCT03532659
- Testing
- Active video game
- Where
- 2 sites in Brazil
- Volunteers
- 90 people
- Sponsor
- Professor Fernando Figueira Integral Medicine Institute
Myopia
Effects of 650nm Low Energy Light on Human Retina and Choroid Microcirculation
This project is a single-center, prospective, self-controlled clinical study. It intends to select patients with simple medium and low degree myopia as subjects, and apply 650nm low-energy red light irradiation to the retina to…
- Trial name
- NCT04604405
- Testing
- photobiomodulation
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Central South University
Congenital Heart Disease
Microcirculation and Vascular Function After Fontan Surgery
Fontan Surgery is done for children with only one working lower chamber of the heart called the 'Single Ventricle'. This surgery involves making connections between the two big veins that drain oxygen deficient blood to the heart…
- Trial name
- MICROFON (NCT05683067)
- Testing
- Hand Held Capillary Microscopy, Mobile 'O' Graph, quality of life using questionnaires
- Where
- United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Type1diabetes
Sublingual Microcirculation in Children with Compensated T1D Using the SDF Method
The main goal of the study is to describe the sublingual microcirculation of children with type 1 diabetes mellitus (T1D) with stable and satisfactory treatment of the disease and to compare it with previously measured parameters…
- Trial name
- NCT05958264
- Where
- Czechia
- Volunteers
- 30 people
- Sponsor
- Vlasta Krausová
Diabetes Mellitus
Assessing Diabetic Foot Ulcer Microcirculation With High-frequency Contrast Enhanced Ultrasound
The objective of this observational study is to investigate and validate the utility of high-frame-rate ultrasound imaging technology for dynamic observation of the blood perfusion process at the site of ulcer wounds in…
- Trial name
- NCT06309082
- Testing
- Amputation, Debridement
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Congenital Heart Disease
Evaluation of the Microcirculation During the Corrective Surgery of Congenital Heart Defects in Children
General objective of the research project: To evaluate the alterations of systemic microvascular reactivity during cardiopulmonary bypass (CPB), in children submitted to cardiac surgery for repair of congenital heart defects.
- Trial name
- NCT03144258
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
Diabetes Mellitus, Healthy
Vascular Effects of Endothelium-Derived Versus Hemoglobin-Transported Nitric Oxide in Healthy Subjects
Nitric oxide (NO) is a soluble gas, continuously synthesized by the endothelium, that contributes importantly to vasodilator tone of the coronary and systemic circulations by activating guanylyl cyclase in vascular smooth muscle…
- Conditions
- Diabetes Mellitus, Healthy, Hypercholesterolemia, Hypertension
- Trial name
- NCT00001963
- Testing
- hemoglobin-transported nitric oxide
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Pulmonary Arterial Hypertension
Peripheral Muscle Microcirculation and Exercise-induced Blood Flow Distribution in Pulmonary Arterial Hypertension
Pulmonary artery hypertension (PAH) is a rare, severe disease, characterized by a progressive increase in pulmonary vascular resistance ultimately leading to right ventricular (RV) failure and premature death.
- Trial name
- NCT01520493
- Testing
- Submaximal exercises
- Where
- 2 sites in Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Laval University
Cleft Palate, Cleft Lip and Palate
Assessment of the Influence of Cleft Repair on Microcirculation of the Palate
Investigators aim to evaluate the influence of cleft surgery on the tissue microcirculation of the palate with a non-invasive measurement.
- Trial name
- NCT03877666
- Where
- Switzerland
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland