Clinical trials: Metabolomics
Severe Sepsis, Sepsis
Early Identification and Effective Management of Pediatric Sepsis
In patients diagnosed as sepsis on PICU admission, early and accurate identification of patients who will develop organ dysfunction (severe sepsis) is critical for effective management and positive outcome.
- Conditions
- Severe Sepsis, Sepsis, Septic Shock
- Trial name
- NCT03996720
- Where
- 4 sites in China
- Volunteers
- 175 people
- Sponsor
- Children's Hospital of Fudan University
Non-Alcoholic Fatty Liver Disease, Non Alcoholic Steatohepatitis
Omics-based Predictors of NAFLD/Potential NASH
The cascade of care for the non-alcoholic fatty liver disease (NAFLD) and its progression to non-alcoholic steatohepatitis (NASH) requires crossing the barriers for their diagnosis and treatment.
- Trial name
- NCT05301231
- Testing
- Genomics (DNA Extraction), Epi-genomics, Proteomics (Glycoproteomics)
- Where
- Egypt
- Volunteers
- 450 people
- Sponsor
- National Research Centre, Egypt
Formula Feeding of Healthy Full Term Infants, Breast Feeding of Healthy Full Term Infants
Impact of Infant Feeding on Newborn Metabolomic Profile
The purpose of this study is the evaluation with untargeted modalities, of the urine metabolomic profile in a group of infants fed with a standard formula, a group of infants fed with a formula supplemented with functional…
- Trial name
- NCT01606683
- Testing
- Infant formula with GOS, beta-palmitate, acidified milk, Standard infant formula without functional ingredients, No intervention
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Heinz Italia SpA
Dysbiosis, Cardiometabolic Health Indicators
Pulse Education and Children
This parallel-arm, randomized controlled trial will evaluate the effectiveness of a 6-week pulse-focused nutrition intervention in school-aged children (6-13 years).
- Conditions
- Dysbiosis, Cardiometabolic Health Indicators, Education on Feeding and Health Status, Gut Motility
- Trial name
- NCT07648446
- Testing
- Education Only, Education + Pulse Provision, Cooking Class
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Florida State University
End Stage Renal Disease, Dialysis
Peritoneal Membrane Dysfunction in Peritoneal Dialysis Using Metabolomics
Ability and sensitivity of metabolomics analysis to highlight biomarkers or a score of biomarkers that will be able to identify those pediatric patients on peritoneal dialysis at high risk for possible peritoneal dialysis…
- Trial name
- NCT03964701
- Testing
- no intervention
- Where
- Greece
- Volunteers
- 18 people
- Sponsor
- Baxter (Hellas) Ltd
Osteoporosis, Postmenopausal, Osteoporosis Fracture
New Biomarkers and Therapeutic Targets in Osteoporosis Via Omics Technologies
This study aims to discover novel biomarkers and therapeutic targets for osteoporosis through the use of advanced omics technologies, including proteomics and metabolomics.
- Conditions
- Osteoporosis, Postmenopausal, Osteoporosis Fracture, Osteoporosis, Severe
- Trial name
- NCT06525688
- Testing
- Bone, Serum and Plasma sample
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- National and Kapodistrian University of Athens
Infant Development
Metabolomic Profile of Urine Samples From Neonates Fed With Breast Milk and an Infant Formula Enriched With Synbiotics
The aim of this trial is to verify - based on metabolomics and other anthropometric parameters - whether exclusive nutrition of infant formula enriched with synbiotics (probiotics B.lactis and prebiotics FOS), Long-Chain…
- Trial name
- mtburnIFsynb (NCT03320837)
- Testing
- Infant formula, Breast milk
- Where
- Greece
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Rontis Hellas SA
Autism, Gastro Intestinal Diseases
Identifying Biomarkers of Gastro Intestinal Comorbidities in Autism Spectrum Disorder
This study investigates the microbiome-gut-brain axis in pediatric autism spectrum disorder (ASD). By longitudinally tracking participants, the study evaluates whether multi-omic profiles (gut microbiota and metabolome) correlate…
- Trial name
- NCT07744217
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- The Center for Discovery
Lung Cancer, Breast Cancer
Plasma Metabolic Biomarkers for Multi-Cancer Diagnosis
The aim of this observational study is to comprehensively analyze the metabolites in plasma samples from multi-cancer patients using advanced mass spectrometry detection technology, in conjunction with metabolomics approaches.
- Conditions
- Lung Cancer, Breast Cancer, Colorectal Cancer, Thyroid Cancer
- Trial name
- NCT06363123
- Where
- 4 sites in China
- Volunteers
- 2,700 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital
Anorexia Nervosa, Obesity
Study of the Effects of Adolescent Weight Disorders (Obesity, Anorexia Nervosa) on Heart Function
The study aims to better understand the functioning of the heart of children and adolescents with anorexia nervosa or obesity, compared to the heart function of control subject.
- Trial name
- NCT05071157
- Testing
- echocardiography
- Where
- France
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Pediatric Obesity
The Stress-obesity Axis: a Metabolomics Approach Towards Personalized Nutrition in Adolescents
The ultimate aim of this project is to establish a validated strategy that allows for personalized intervention in adolescents (11 to 17 years) whom are assigned a state of overweight or obesity.
- Trial name
- FAME (NCT06391671)
- Testing
- Collection of anthropometric data, biological samples (stool, saliva and hair), questionnaires (demographic data, psychological data, medical data)
- Where
- 7 sites in Belgium
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- University Ghent
Solitary Pulmonary Nodules, Lung Cancer
Plasma Metabolomics as a Tool to Distinguish PET-positive Malignant From PET-positive Benign Nodules
Positron emission tomography-computed tomography (PET-CT) is an important technique in lung cancer staging, where almost no lung lesion goes undetected.
- Trial name
- NCT07087080
- Testing
- Blood sampling
- Where
- Belgium
- Volunteers
- 350 people
- Sponsor
- Hasselt University
Respiratory Diseases, Neurological Disorders
Exhaled Breath Analysis by Secondary Electrospray Ionization - Mass Spectrometry in Children and Adolescents
This study is to investigate breath analysis (breath metabolomics) combined with established bioinformatic tools as a platform for companion diagnostics.
- Conditions
- Respiratory Diseases, Neurological Disorders, Type 1 Diabetes
- Trial name
- EBECA (NCT04461821)
- Testing
- Real-time SESI-MS breath analysis, Off-line breath analysis, Blood analysis
- Where
- Switzerland
- Volunteers
- 3,600 people
- Sponsor
- University Children's Hospital Basel
Acute Kidney Injury, Cancer
Cisplatin Induced Kidney Toxicity
Cisplatin (CisP) is a chemotherapeutic agent used to treat head and neck and lung cancer in adults and over 15 different pediatric cancers.
- Trial name
- ACCENT (NCT04442516)
- Testing
- Questionnaire, sampling of blood, urine and saliva
- Where
- Canada
- Volunteers
- 600 people
- Sponsor
- The Hospital for Sick Children
Obesity
Effects of VSL#3 on Metabolic, Endocrine, Lipidomic and Inflammatory Parameters of Pediatric Patients With BMI>90°
Obesity in children has become a significant social problem considering that nowadays 4 to 5 % of all children are obese in the industrialized countries with increased incidence in Europe by 10 to 50% over the past 10 years.
- Trial name
- VAIIO (NCT01650025)
- Testing
- VSL#3 active probiotic
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Autism Spectrum Disorder
Randomized Double-blind Clinical Trial With L.Reuteri Supplementation in Children With Autism Spectrum Disorder
The aim of this study is to assess the effects of a 6-months probiotic supplementation on behavioral profiles, microbiota and metabolic profiles, inflammatory biomarkers, gastrointestinal disturbances, in children with Autism…
- Trial name
- NCT04293783
- Testing
- L.Reuteri
- Where
- 2 sites in Italy
- Volunteers
- 43 people
- Sponsor
- University of Rome Tor Vergata
Child Development
Soy Exposure on Bone Development and Gut Microbiota
In this project, the investigators aim to investigate the effects of soy consumption at early life on the development of gut microbiota and bone growth.
- Trial name
- NCT05213780
- Testing
- No intervention is involved
- Where
- Hong Kong
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Critical Illness, Child, Only
Epidemiological Study of the Microbiota in Critically Ill Children
Objectives: To study the composition of the microbiota in critically ill children, and to know the relationship of its microbiota with clinical complications and inflammation biomarkers.
- Conditions
- Critical Illness, Child, Only, Intensive Care Unit
- Trial name
- BIOUCIP (NCT04435470)
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Universidad de Granada
Concussion, Brain
Objective Concussion Assessment Using MRI and Metabolomics
Mild traumatic brain injury (mTBI), also referred to as concussions, affect millions of people around the world and can cause harmful long term effects.
- Trial name
- NCT05993351
- Testing
- Magnetic resonance imaging (MRI), Urine and saliva samples, Questionnaires
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Healthcare Hamilton
Major Depressive Disorder
Optimize and Predict Antidepressant Efficacy for Patient With MDD Using Multi-omics Analysis and AI-predictive Tool
OPADE is a non-profit, observational, multicenter, open-label study aimed at defining personalized treatment for Major Depressive Disorder (MDD).
- Trial name
- OPADE (NCT06550037)
- Where
- Italy
- Volunteers
- 350 people
- Sponsor
- Alessio Fasano