Clinical trials: Menopausal Syndrome
Vulvovaginal Atrophy
Photobiomodulation Effect on Vulvovaginal Atrophy in Postmenopausal Women.
Menopause is a physiological event and is defined as the loss of ovarian follicular activity, with consequent permanent cessation of menstrual cycles.
- Trial name
- NCT04487392
- Testing
- Estrogen vaginal cream group (group A), Photobiomodutation group (group B)
- Sponsor
- University of Nove de Julho
Postmenopausal Symptoms, Telerehabilitation
Relaxation Training Via Tele-Rehabilitation in Postmenopausal Women
Menopause is associated with various physiological and psychological changes that may adversely affect women's quality of life. Menopausal symptoms, sleep disturbances, and fatigue are among the most common complaints during the…
- Conditions
- Postmenopausal Symptoms, Telerehabilitation, Relaxation Training, Menopause
- Trial name
- NCT07737691
- Testing
- Relaxation Training Delivered via Tele-Rehabilitation
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Marmara University
Genitourinary Syndrome of Menopause
Management of Cancer Therapy Related Vulvovaginal Atrophy
The goal of this clinical trial is to: 1. evaluate the efficacy of PRP injection and PRP injection mixed with non-cross-linked hyaluronic acid compared to the control group receiving standard therapy with topical non-cross-linked…
- Trial name
- NCT05782920
- Testing
- Platelet rich plasma, non cross-linked hyaluronic acid, topical HA gel
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Alexandria University
Atrophic Vaginitis, Menopause
Comparison of Vaginal Laser Therapy to Vaginal Estrogen Therapy
This is a multi-centered, randomized prospective single blinded clinical trial comparing CO2 fractionated vaginal laser therapy and vaginal estrogen cream therapy in the treatment of vulvovaginal atrophy/GSM.
- Trial name
- VeLVET (NCT02691936)
- Testing
- CO2 fractionated vaginal laser, Estrogens, Conjugated (USP)
- Where
- 6 sites in United States
- Volunteers
- 69 people
- Sponsor
- The Cleveland Clinic
Recurrent Urinary Tract Infection, Genitourinary Syndrome of Menopause
RCT Comparing Intravaginal Laser Therapy to Sham in Post-menopausal Women with Recurrent Urinary Tract Infections
Recurrent urinary tract infection (rUTI) is a common and difficult to treat problem with limited treatment option; postmenopausal women are disproportionately affected.
- Trial name
- UTIEXTERMINATE (NCT06124820)
- Testing
- Deka SmartXide Touch C60 (MonaLisa Touch)
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- King's College Hospital NHS Trust
Genitourinary Syndrome of Menopause
RCT of Laser Therapy for GSM
The aim of the current study is to assess whether the CO2-laser results in superior alleviation of GSM symptoms compare to Er:YAG-laser.
- Trial name
- NCT03288883
- Testing
- Photothermal Non-ablative Erbium:YAG-laser, Fractional Microablative CO2-laser
- Where
- United Kingdom
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Turner Syndrome, Infertility, Female
Turner Syndrome Minipuberty Study
Rationale: Due to accelerated germ cell loss, infertility is a major problem in girls with Turner syndrome (TS). Therefore, cryopreservation of ovarian tissue or oocytes before exhaustion of the ovarian reserve may preserve…
- Conditions
- Turner Syndrome, Infertility, Female, Premature Ovarian Failure, Gonadal Dysgenesis
- Trial name
- Minipuberty (NCT04189406)
- Testing
- Venapunction
- Where
- 13 sites in Denmark, Germany and 3 more
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Menopausal Syndrome, Menopausal Depression
4-week Seaweed Supplementation on Menopause Symptoms and Psychological Wellbeing
Menopausal symptoms have a substantial effect on quality of life as well as potentially serving as markers for future health. Previous research has suggested that diet can impact menopausal symptoms.
- Trial name
- NCT05759936
- Testing
- 500mg seaweed
- Where
- United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Genitourinary Syndrome of Menopause
Intravaginal Negative Pressure Medical Device for Treatment of Genitourinary Syndrome of Menopause (GSM)
This pilot study aims to evaluate the safety and effectiveness of the VITA AV Clinical System over a period of up to three months after the last treatment, compared to a sham device.
- Trial name
- NCT06768073
- Where
- 2 sites in United States, Georgia
- Volunteers
- 60 people
- Sponsor
- AVeta Medical
Genitourinary Syndrome of Menopause
Effects of Pelvic Floor Muscle Training With Patient Education in Genitourinary Syndrome of Menopause
Genitourinary syndrome of menopause (MGS) is a clinical picture accompanied by genital and urinary symptoms and is commonly seen in the postmenopausal period.
- Trial name
- NCT06034483
- Testing
- Pelvic floor exercise training, Patient education
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Hacettepe University
Genitourinary Syndrome of Menopause
MonaLisa Touch Randomized Double-Blind Placebo Controlled Study
Aim of the study: To assess the efficacy of MonaLisa Touch procedure for the management of genitourinary syndrome of menopause (GSM) in a randomized double-blind placebo controlled study.
- Trial name
- NCT03331328
- Testing
- MonaLisa Touch
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Michigan Institution of Women's Health PC
Vaginal Atrophy
Vaginal CO2 Laser and the Genitourinary Syndrome of Menopause
This study evaluates the clinical, histopathological, cytological and microbiological efficacy of Microablative Fractional CO2 laser intravaginally administered in postmenopausal women with Genitourinary Syndrome of Menopause.
- Trial name
- NCT03754205
- Testing
- Microablative Fractional CO2 laser
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Kallmann Syndrome, Hypogonadotropic Hypogonadism
Human Menopausal Gonadotropin Combining With Human Chorionic Gonadotropin Treat Congenital Hypogonadotropic Hypogonadism
Observe the therapeutic efficacy of human menopausal gonadotropin combining with human chorionic gonadotropin in adolescent boys with congenital hypogonadotropic hypogonadism.
- Trial name
- NCT02880280
- Testing
- Human Menopausal Gonadotropin, Human Chorionic Gonadotropin
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Beijing Children's Hospital
Vulvovaginal Signs and Symptoms, Genitourinary Syndrome of Menopause
Effects of Ospemifene on Brain Activation Patterns in Women With Sexual Interest-arousal Disorders
Ospemifene is the first oral and non-hormonal treatment for moderate or severe vulvo-vaginal atrophy (VVA) in postmenopausal women who are not candidates to treatment with local oestrogens.
- Conditions
- Vulvovaginal Signs and Symptoms, Genitourinary Syndrome of Menopause, Sexual; Disorder, Arousal, Female
- Trial name
- EROS (NCT04677491)
- Testing
- Ospemifene 60 mg, fMRI experiments
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- Hospital Clinic of Barcelona
Restless Legs Syndrome
Effect of Progressive Muscle Relaxation Exercises in Menopausal Women Experiencing RLS.
Restless legs syndrome is a symptom that can be seen in all stages of a woman's life, but its frequency and severity increases with menopause.
- Trial name
- NCT06156007
- Testing
- progressive muscle relaxation exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Gazi University
Laser-Induced Scar, Breast Cancer
Laser Treatment of Genito-urinary Syndrome in Women
Women with genitourinary syndrome of menopause, overactive bladder, with breast or endometrial cancer are randomized to either laser treatment og sham treatment for 3 months.
- Conditions
- Laser-Induced Scar, Breast Cancer, Endometrial Cancer, Menopause
- Trial name
- NCT03238053
- Testing
- Vaginal laser treatment, laser system
- Where
- Denmark
- Sponsor
- Herning Hospital
Perimenopause, Climacteric Syndrome
Clinical Evaluation of Effectiveness and Safety of Amberen and Smart B in Perimenopausal Women.
To evaluate effectiveness and safety of combined use of dietary supplements Amberen and Smart B in women with a typical (without complications) form of climacteric syndrome, with mild to moderate symptoms in perimenopause.
- Trial name
- NCT03897738
- Testing
- Amberen, Smart B
- Where
- Russia
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Genitourinary Syndrome of Menopause, Vaginal Atrophy
Vaginal Laser Therapy in Breast Cancer Survivors
This study evaluates the efficacy of vaginal CO2 laser therapy in breast cancer survivors with symptoms of Genitourinary Syndrome of Menopause.
- Conditions
- Genitourinary Syndrome of Menopause, Vaginal Atrophy, Breast Cancer, Dyspareunia
- Trial name
- NCT03738605
- Testing
- Microablative Fractional CO2 Laser Therapy
- Where
- Greece
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Climacteric Symptoms, Hot Flashes
Evaluation of the Beneficial Effects of a Product Containing Γ-aminobutyric Acid (GABA) on Climacteric Syndrome Disorders
The goal of this clinical trial is to learn if the food supplement based on GABA works to treat climateric symptoms. It will also learn about the safety of supplement based on GABA.
- Trial name
- GABAPAUSE (NCT06864520)
- Testing
- GAMMA-AMINOBUTYRIC ACID - GABA
- Where
- Italy
- Volunteers
- 112 people
- Sponsor
- Ospedale Policlinico San Martino
Genitourinary Syndrome of Menopause (GSM)
Vaginal Platelet-Rich Plasma and Vaginal Histology in Genitourinary Syndrome of Menopause
This study evaluates whether subepithelial injection of autologous platelet-rich plasma (PRP) into the vaginal wall produces histological changes consistent with tissue regeneration in postmenopausal women with genitourinary…
- Trial name
- NCT07905820
- Testing
- Autologous Platelet-Rich Plasma (PRP), 0.9% sodium chloride (normal saline)
- Where
- Greece
- Volunteers
- 20 people
- Sponsor
- National and Kapodistrian University of Athens