Clinical trials: Melatonin
Premedication, Anaesthesia
Melatonin Premedication in Children Undergoing Surgery
Melatonin has been proposed as alternative to midazolam as a premedication in procedures preceding anaesthesia induction. The objective of this prospective, randomized, double-blind study is to investigate the possible effect of…
- Trial name
- NCT02265822
- Testing
- melatonin in children premedication, midazolam in children premedication
- Volunteers
- 92 people
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico "G. Martino"
Dental Caries in Children, Vital Pulp Therapy
Comparative Evaluation of Melatonin Versus MTA on Vital Pulp Therapy in Young Permanent First Molars: An in Vivo Study
The process of dental caries is dynamic and can be either reversible or irreversible depending on the balance between protective and pathologic factors in the oral cavity.
- Trial name
- NCT06372561
- Testing
- Mineral trioxide aggregate (dressing material), Melatonin (dressing material)
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
Premature Birth, Brain Injury
Melatonin As A Novel Neuroprotectant In Preterm Infants- Dosage Study
Preterm babies are at risk of brain injury. Melatonin, a naturally occurring hormone, may reduce this risk. The unborn baby receives melatonin from the mother but following premature delivery there maybe a period of prolonged…
- Trial name
- MIND (NCT00649961)
- Testing
- Melatonin injection
- Where
- 2 sites in United Kingdom
- Volunteers
- 18 people
- Sponsor
- Imperial College London
Insomnia, Delayed Sleep Phase Disorder
Blue-blocking Glasses for Sleep Disorders in Child and Adolescent Psychiatry
Sleep problems and regulation difficulties are frequent in the child and adolescent psychiatry population. Insomnia and delayed sleep-wake phase disorders (DSPWD) are highly prevalent, and risk factors for developing more severe…
- Conditions
- Insomnia, Delayed Sleep Phase Disorder, Hyperarousal, Transdiagnostic Psychopathology
- Trial name
- BATCAT-pilot (NCT07433491)
- Testing
- Blue-blocking glasses (BB-glasses) or real darkness from 9 p.m. to desired wake-up time + night mode setting on mobile phone, Control
- Where
- 2 sites in Norway
- Volunteers
- 40 people
- Sponsor
- Helse Fonna
Bruxism
"Salivary Melatonin and Cortisol Levels in Individuals with Bruxism"
The effects of the hormones melatonin and cortisol, which play a highly effective role in regulating the sleep-wake cycle, on teeth grinding will be scientifically evaluated.
- Trial name
- NCT06623643
- Testing
- The investigation of melatonin and cortisol levels in the saliva
- Volunteers
- 100 people
- Sponsor
- Yuzuncu Yil University
Blindness
Young Blind Child Melatonin Treatment Study
The primary goal of this study is to identify the presence of desynchronized circadian rhythms in 25 children by measuring melatonin secretion in serial blood or saliva samples, and to rule out any primary sleep disorders.
- Trial name
- NCT00688935
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Oregon Health and Science University
Type 1 Diabetes (T1D)
Effect of Melatonin Supplementation on Excecutive Functions, Sleep Quality and Glycemic Metrics Among Adolescents With Type 1 Diabetes Mellitus
Cognitive impairment, poor sleep quality, Alzheimer's disease and dementia are complications of uncontrolled type 1 diabetes (T1D).
- Trial name
- MS642/2024 (NCT07592442)
- Testing
- Melatonin tablet 3 mg once daily
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Anesthesia
The Premedication Properties of Oral Melatonin in Pediatrics Undergoing Therapeutic Cardiac Catheterization
The evaluation of oral melatonin efficacy as premedicant agent in pediatrics undergoing elective cardiac interventions is the primary outcomes of our trail.
- Trial name
- NCT06031961
- Testing
- melatonin
- Where
- Iraq
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Atopic Dermatitis
Treatment of Nighttime Pruritus in Atopic Dermatitis
This study will look at melatonin vs. first generation antihistamine vs. placebo in improving nighttime itching in children with atopic dermatitis.
- Trial name
- NCT03688464
- Testing
- Melatonin, Diphenhydramine
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Nebraska
Preterm Neonate Analgesia
Melatonin As an Analgesic in Preterm Neonate
Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone secreted by the pineal gland with several important functions, including regulation of the circadian rhythms, antioxidant and anti-inflammatory effects, accumulating…
- Trial name
- NCT05971485
- Testing
- Melatonin 10 mg
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Postoperative Pain
Melatonin and Its Effect on the Perioperative Opioid Needs in Pediatric Patients Undergoing Laparoscopic Surgery.
To study the role of Preoperative Melatonin adminsteration in pediatric patients undergoing laparoscopic surgeries regarding its analgesic and sedative effects
- Trial name
- NCT05728892
- Testing
- Melatonin 3 MG
- Where
- Egypt
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Effect of Drug, Anxiety
Comparison Between Oral Melatonin and Hydroxyzine in Pediatric Patients Undergoing Adenotonsillectomy
Comparison between the effect of oral Melatonin and Hydroxyzine for Preventing Preoperative Anxiety in pediatric Patients Undergoing Adenotonsillectomy
- Trial name
- NCT05680584
- Testing
- Melatonin 3 MG, Hydroxyzine Pill
- Where
- Egypt
- Volunteers
- 78 people
- Sponsor
- Minia University
Electroencephalography, Melatonin
Sedation and Nursing Management in EEG Recording in Children
Electroencephalogram (EEG) has an important place in establishing the correct diagnosis, providing appropriate intervention, and predicting the prognosis in the long term in children.
- Conditions
- Electroencephalography, Melatonin, Chloral Hydrate, Hydroxyzine
- Trial name
- NCT05492812
- Testing
- Sedation and Nursing Management in EEG Recording in Children, Chloral Hydrate, Hydroxyzine
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Suleyman Demirel University
Anxiety
Anxiolytic and Analgesic Effects of Melatonin
The study's main objective is to investigate melatonin's anxiolytic and sleep-regulating effects in patients undergoing surgery.
- Trial name
- ANAN-Melatonin (NCT02386319)
- Testing
- Melatonin
- Where
- Denmark
- Volunteers
- 36 people
- Sponsor
- Herlev Hospital
Migraine Disorders
Preventive Role of Melatonin and Propranolol Administration in Pediatric Migraine
This randomized controlled trial evaluated whether adding melatonin to propranolol provided better prevention of migraine in children than propranolol alone.
- Trial name
- NCT07743255
- Testing
- Melatonin, Propranolol
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Nishtar Medical University
Physical Exercise, Sleep Disturbance
Treatment of Sleep Disturbance in Children With ASD
This RCT study aims to compare effectiveness physical exercise and melatonin supplement on treating sleep disturbance in children with ASD.
- Conditions
- Physical Exercise, Sleep Disturbance, Autism Spectrum Disorder, Melatonin Deficiency
- Trial name
- NCT04878198
- Testing
- Jogging program, Melatonin supplement intervention
- Where
- Hong Kong
- Volunteers
- 62 people
- Sponsor
- Education University of Hong Kong
Postoperative Pain, Oxidative Stress Response
Analgesic and Antioxidant Effects of Melatonin in Pediatric Surgery
Background. Long-term consequences of postoperative pain are detrimental in children. We tested the hypothesis that melatonin reduces postoperative pain and oxidative stress involving sirtuin pathway in children undergoing…
- Trial name
- NCT06724432
- Testing
- oral melatonin
- Where
- 2 sites in Italy
- Volunteers
- 44 people
- Sponsor
- University of Parma
Sedation for Children Undergoing MRI
A Comparison Between Oral Melatonin With Nasal Sevoflurane Versus Oral Chloral Hydrate With Nasal Sevoflurane in Sedation of Children Undergoing Brain MRI
The patients will be randomized into 2 equal groups by a computer-generated random numbers table, named group A, B. Group A: will receive oral Melatonin and nasal Sevoflurane.
- Trial name
- NCT06606899
- Testing
- Melatonin 3 MG, Chloral Hydrate, Sevoflurane
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Seasonal Affective Disorder
Effects of Season on Melatonin Secretion in Healthy Men and Women and Patients With Seasonal Affective Disorder
As the seasons change during the course of the year, many animals show major changes in their behavior and physiology. Many of these changes are triggered by changes in the length of time each night that the pineal gland produces…
- Trial name
- NCT00001485
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Healthy, Teenager
Effects of Afternoon and Evening Light on Teenagers' Melatonin Levels, Alertness, Sleepiness and Sleep
Many teenagers are familiar with this: on school days, they have to get up early; during the day, they hardly get any light exposure; in the evening, they go to bed late - and are then tired at school the next day! Around the…
- Conditions
- Healthy, Teenager, Healthy Lifestyle
- Trial name
- TeenLight (NCT05483296)
- Testing
- Dim light condition, Moderate light condition, Bright light condition
- Where
- Switzerland
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University Psychiatric Clinics Basel