Clinical trials: Larynx
Hypersensitivity, Anaphylaxis
Effects of Inhaled Epinephrine on Systemic Allergic Reactions During Allergy Testing, Immunotherapy or Oral Challenges
The goal of this exploratory study is to evaluate the effects of inhaled epinephrine in subjects, who may not be eligible for the GHL-101 trial, and who are experiencing systemic allergic reaction (SAR) that occur following…
- Trial name
- NCT07038746
- Testing
- Inhaled Epinephrine
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Dr. George Luciuk
Dysphonia
Behavioral Abnormalities in Dysphonic Children
we will assess dysphonic children as regard presence of behavioral abnormalities and then receive voice therapy
- Trial name
- NCT05264961
- Testing
- voice therapy
- Where
- Egypt
- Volunteers
- 25 people
- Sponsor
- Sohag University
Adverse Anesthesia Outcome
Laryngeal Mask Airway Supreme Versus Laryngeal Tube
The investigators test the hypothesis that oropharyngeal leak pressure and fiberoptic position differ between the size 2 LMA SupremeTM and the Laryngeal Tube LTS IITM in non-paralyzed anaesthetized pediatric patients
- Trial name
- NCT02252120
- Testing
- Supreme, Laryngeal Tube
- Volunteers
- 60 people
- Sponsor
- Schulthess Klinik
Laryngotracheobronchitis, Croup
Efficacy Of Oral Dexamethasone Versus Parenteral Dexamethasone In The Management Of Mild To Moderate Croup
Croup (laryngotracheobronchitis) is a viral infection of the upper airway that causes throat swelling, leading to a barking cough, stridor, and hoarseness.
- Trial name
- NCT06959407
- Testing
- oral dexamethasone, intramuscular dexamethasone
- Where
- Pakistan
- Volunteers
- 200 people
- Sponsor
- Arooj Khan
Oral Complications of Radiation Therapy, Stage I Laryngeal Cancer
Pulsed Dye Laser in Treating Patients With Post Radiation Dysphonia
This pilot trial studies pulsed dye laser in treating patients with post radiation dysphonia. Dysphonia, or vocal cord scarring, can include trouble with the voice when trying to talk, such as hoarseness, change in voice pitch…
- Conditions
- Oral Complications of Radiation Therapy, Stage I Laryngeal Cancer, Stage II Laryngeal Cancer
- Trial name
- NCT02198131
- Testing
- laser therapy, questionnaire administration
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Wake Forest University Health Sciences
Endocrine Procedural Complications, Thyroid
Intraoperative Monitoring to Predict Postoperative Complications After Thyroidectomy
The goal of this study is to evaluate the role of intraoperative continous and intermittent neuromonitoring and intraoperative parathormone (PTH) to predict postoperative nerve morbidity and hypocalcemia.
- Conditions
- Endocrine Procedural Complications, Thyroid, Parathyroid; Deficiency, Laryngeal Injury
- Trial name
- PARACAL (NCT03309384)
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Central Hospital, Nancy, France
Dysphonia
Investigation of the Effectiveness of Group Voice Therapy in Children
This study aims to investigate whether there is a difference between groups receiving "group voice therapy" and "individual voice therapy" in pediatric populations diagnosed with dysphonia.
- Trial name
- NCT06124053
- Testing
- Group Voice Therapy, Individual Voice Therapy, Vocal Hygiene Education
- Where
- Turkey (Türkiye)
- Volunteers
- 18 people
- Sponsor
- Hacettepe University
Feeding Disorders, Swallowing Disorder
Feeding and Swallowing Problems in Infants With Laryngomalacia
Observational cross-sectional study Infants with laryngomalacia Feeding and swallowing assessment
- Conditions
- Feeding Disorders, Swallowing Disorder, Laryngomalacia
- Trial name
- NCT05337475
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Sohag University
Haematological Malignancy, Malignant Neoplasm
DETERMINE Trial Treatment Arm 07: Dabrafenib in Combination With Trametinib in Adult, Paediatric and Teenage/Young Adult Patients With BRAF V600 Mutation-Positive Cancers.
This clinical trial is looking at two drugs called dabrafenib and trametinib. Dabrafenib and trametinib are approved as standard of care treatment for adult patients with melanoma (a type of skin cancer) or lung cancer and in…
- Conditions
- Haematological Malignancy, Malignant Neoplasm, Lymphoproliferative Disorders, Neoplasms by Histologic Type
- Trial name
- DETERMINE (NCT07440290)
- Testing
- Dabrafenib, Trametinib
- Where
- 27 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Cancer Research UK
Voice Disorders, Neurologic Disorder
Voice Analysis in Patients With Neurologic Diseases
In this observational pilot study, the investigators will record and assess voice samples from healthy participants and those participants affected by neurologic diseases to evaluate possible differences in voice features.
- Trial name
- NCT04846413
- Testing
- Speech task
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Head and Neck Cancer
Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Previously Untreated Advanced Cancer of the Mouth, Pharynx, or Larynx
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00004094
- Testing
- carboplatin, fluorouracil, hydroxyurea
- Where
- 4 sites in United States
- Sponsor
- National Cancer Institute (NCI)
Laryngeal Masks
Supraorbital Pressure Versus Jaw Thrust for Assessing the Adequate Depth of Anesthesia for LMA Insertion in Children
BACKGROUND AND OBJECTIVES The purpose of this study is to assess whether the loss of motor response to supraorbital pressure can be an alternative to that of jaw thrust to predict optimal condition for laryngeal mask airway (LMA)…
- Trial name
- NCT02618525
- Testing
- Supraorbital pressure, Jaw thrust maneuver
- Where
- Nepal
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- B.P. Koirala Institute of Health Sciences
Voice Quality
the Comparison of Voice Quality in Early Laryngeal Cancer Between Surgery and Radiotherapy
early laryngeal cancer is a well known field with great controversy in treatment. two options are available in treatment of patients the first one is partial laryngectomy and the second one is radiotherapy.one of major concern of…
- Trial name
- NCT00497588
- Testing
- surgery, radiotherapy
- Where
- Iran
- Volunteers
- 33 people
- Sponsor
- Tehran University of Medical Sciences
Croup
Community Care for Croup (RCT)
This randomized clinical trial was to compare the effectiveness of prednisone 2mg/kg/day for 3 days vs. dexamethasone 0.6mg/kg for 1 day for treatment of children with mild or moderate croup.
- Trial name
- NCT01042145
- Testing
- Prednisone, Dexamethasone
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Washington University School of Medicine
Larynx Disease, Laryngeal Stenosis
The Effectiveness of Reconstructive Microsurgery on the Clinical and Functional State of Laryngeal Stenosis
To improve diagnostic methods for patients with laryngeal stenosis for the optimal determination of the technique of surgical treatment.
- Trial name
- NCT04734483
- Testing
- spirometry, MRI and CT, Laryngoscopy
- Where
- 2 sites in Kazakhstan, Russia
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Astana Medical University
Performance and Safety of an Airway Management Device
Comparison of the Baska Mask Airway to a Single-use LMA Device in Low-risk Female Patients
The purpose of this study is to compare the performance of the Baska mask supraglottic airway device with a single use laryngeal mask device (LMA) in low-risk female patients.
- Trial name
- NCT01753635
- Testing
- supraglottic airway placement and use
- Where
- Ireland
- Volunteers
- 150 people
- Sponsor
- John Laffey
Adverse Anesthesia Outcome
A Study Between the Laryngeal Tube Suction-Disposable and the Ambu AuraGain in Pediatric Patients
The study compared the Laryngeal Tube Suction Disposable (LTS-D) with the Disposable Laryngeal Mask Ambu® AuraGain™ (DLMA AG) during general anesthesia in pediatric patients.
- Trial name
- NCT02977559
- Testing
- Laryngeal Tube Suction Disposable, Laryngeal Mask Airway AuraGain
- Volunteers
- 60 people
- Sponsor
- Bnai Zion Medical Center
Device - Intubating Laryngeal Airway
Evaluation of the Intubating Laryngeal Airway in Children
The Air-Q® intubating laryngeal airway (Air-Q® ILA) is an extraglottic device specifically engineered for use both as a standalone laryngeal mask airway (LMA) and as a rescue device or "Plan B" device in the event of a difficult…
- Trial name
- NCT01233011
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Laryngectomy
Effect of Zinc and Probiotics Supplementation on Laryngeal Cancer Patients Undergoing Laryngectomy Surgery to Improve Prognosis and Better Wound Healing
using zinc and probiotics supplementation for providing better prognosis for laryngeal cancer patients under going total or partial laryngectomy.
- Trial name
- NCT06674564
- Testing
- Zinc Acetate 50 Mg Oral Capsule, Probiotic
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Ain Shams University
Voice Disorders in Children
Effect of Chronic Rhinosinusitis on Voice of Children
Evaluation of the effect of chronic rhinosinusitis on the laryngeal mucosa and voice quality in children. This is important to know factors affecting voice disorders
- Trial name
- NCT03696693
- Testing
- acoustic vocal analysis
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University