Clinical trials: Iron Metabolism Disorders
Iron Deficiency Anemia
Prevalence of Oral Manifestations of Iron Deficiency Anemia in a Sample of Egyptian Population
According to WHO Reportin 2002, iron deficiency anemia was considered to be the most important contributing factor to the global burden of anemia.
- Trial name
- NCT03365570
- Where
- Egypt
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Cairo University
Iron Deficiency
Ferrous Sulfate Versus Iron Amino Acid Chelate
Iron deficiency and depleted levels of iron are the most prevalent nutritional deficiency and the leading cause of anemia in the world; this can occur at any age, but preschool children are at particular risk of developing it.
- Trial name
- NCT01412723
- Testing
- Ferrous sulfate as dietary supplementation, Iron amino acid chelated as dietary supplementation
- Where
- Colombia
- Volunteers
- 64 people
- Sponsor
- CES University
Ultra-short-term, Iron Deficiency Anemia
Effect of Ultra-short-term Treatment of Patients With Iron Deficiency or Anemia Undergoing Adolescent Scoliosis Correction
Scoliosis is a condition in which there is curvature of the spine occurring in the lateral plane. It occurs in structural forms, characterized by a fixed curve, and "functional" forms, characterized by a flexible or correctable…
- Conditions
- Ultra-short-term, Iron Deficiency Anemia, Scoliosis Idiopathic
- Trial name
- NCT04343170
- Testing
- ferric carboxymaltose , α erythropoietin, vitamin B12, oral folic acid
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Tanta University
Sickle Cell Disease, Thalassemia
RADeep Multicenter European Epidemiological Platform for Patients Diagnosed With Rare Anemia Disorders (RADs)
Rare Anaemia Disorders (RADs) is a group of rare diseases characterized for presenting anaemia as the main clinical manifestation.
- Conditions
- Sickle Cell Disease, Thalassemia, Hemolytic; Anemia, Hereditary, Due to Enzyme Disorder, Anemia Due to Membrane Defect
- Trial name
- RADeep (NCT06213402)
- Testing
- Data collection from EHR.
- Where
- Spain
- Volunteers
- 32,564 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Iron Deficiency Anemia
Short-term Intravenous Iron Isomaltose Anhydride for IDA
This prospective, randomized, controlled study aims to evaluate the impact of short-term intravenous iron isomaltose anhydride on postoperative recovery and the requirement for allogeneic red blood cells (RBC) transfusion in…
- Trial name
- NCT03915327
- Testing
- Intravenous iron isomaltose anhydride
- Volunteers
- 1,600 people
- Sponsor
- West China Hospital
Iron-deficiency
The Effect of Lactoferrin and Dosing Regimen on Iron Absorption From a Maize-based Porridge in Kenyan Infants
The purpose of this study is to measure iron absorption from maize-based porridge fortified with either apo-lactoferrin, holo-lactoferrin or ferrous sulfate and to test whether there is an effect of these.
- Trial name
- NCT03617575
- Testing
- apo-Lactoferrin, holo-Lactoferrin, FeSO4
- Where
- Kenya
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Vitamin A Deficiency, Iron-deficiency
Impact of Food-to-Food Fortified Cereal Products on Diet Quality in Eldoret, Kenya
The overall hypotheses is that a product designed with optimized nutritional characteristics, based on consumer preferences and leveraging local nutrient dense ingredients, can successfully deliver nutrition through sustainable…
- Trial name
- KenyaMPS (NCT05882682)
- Where
- Kenya
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Purdue University
Iron Deficiency Anaemia in Childbirth, Iron Deficiency
Maternal Iron Deficiency and Childhood Health
The aim of this prospective observational cohort study is to study maternal iron deficiency and iron deficiency anemia and the use of iron supplements in pregnancy and their impact on the health of the offspring and pregnancy…
- Conditions
- Iron Deficiency Anaemia in Childbirth, Iron Deficiency, Iron Deficiency in Pregnancy, Iron Deficiency Anemia in Pregnancy
- Trial name
- MATILDA (NCT06879080)
- Where
- Finland
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Iron Deficiency Anemia of Pregnancy
Iron Infusion Into a Vein Compared to Iron Tablet Taken by Mouth for Treating Iron Deficiency Anemia in Pregnancy (IVON)
Background: Anaemia in pregnancy is a public health burden with high incidence in Africa. Currently high dose oral iron is recommended for treatment of mild to moderate anaemia and blood transfusion for severe anaemia.
- Trial name
- IVON (NCT04976179)
- Testing
- Ferric carboxymaltose, Ferrous sulfate
- Where
- 11 sites in Nigeria
- Volunteers
- 1,056 people, healthy volunteers welcome
- Sponsor
- University of Lagos, Nigeria
Chronic Iron Overload
Extended Evaluation of Deferasirox Film-coated Tablet (FCT) Formulation
Extend evaluation of deferasirox film-coated tablet (FCT) formulation
- Trial name
- NCT02720536
- Testing
- Deferasirox
- Where
- 14 sites in Austria, Greece and 1 more
- Volunteers
- 53 people
- Sponsor
- Novartis Pharmaceuticals
Transfusional Hemosiderosis
Palatability and Tolerability of Deferasirox Taken With Meals, With Different Liquids or Crushed and Added to Food
This single-arm, open-label, multi-center study enrolled 65 patients from approximately 20 centers. All patients who met the study criteria and were taking, beginning or resuming treatment with Deferasirox were allowed.
- Trial name
- NCT00845871
- Testing
- deferasirox:
- Where
- 23 sites in United States
- Volunteers
- 65 people
- Sponsor
- Novartis Pharmaceuticals
Iron-deficiency Anemia
Umbilical Cord Clamping and Infant Iron Status
The aim of the study was to determine whether delayed umbilical cord clamping, as compared to early umbilical cord clamping, improves infant iron status at 6 months of age.
- Trial name
- NCT00298051
- Testing
- Delayed umbilical cord clamping
- Where
- Mexico
- Volunteers
- 476 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Beta-thalassemia, Iron Overload
Cardiac T2* in Beta-thalassemia Patients on Deferasirox Treatment
The purpose of this trial is to evaluate changes in cardiac iron as measured by MRI T2* in beta-thalassemia patients with deferasirox treatment.
- Trial name
- NCT00447694
- Testing
- Deferasirox
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Novartis
Anemia, Iron Deficiency
Effect of Timing of Umbilical Cord Clamping on Anaemia at 8 and 12 Months and Later Neurodevelopment
The investigators plan a study to randomize 540 children in Nepal to early (≤30 seconds) or late (≥180 seconds) clamping of the umbilical cord at birth.
- Conditions
- Anemia, Iron Deficiency, Neonatal Jaundice
- Trial name
- NCT02222805
- Testing
- Early (≤30 seconds) cord clamping, Delayed (≤180 seconds) cord clamping
- Where
- Nepal
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Iron Overload, Excessive Body Iron Burden
Massive Iron Deposit Assessment
Iron overload is a severe complication of multiple blood transfusions. As the body has no physiologic mechanism for clearing iron, repeated transfusions cause iron accumulation in organs and lead to iron toxicity.
- Trial name
- NCT01572922
- Testing
- R2*-UTE, R2*-GRE, Liver biopsy
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- St. Jude Children's Research Hospital
Iron Deficiency
Improving Iron Levels in Female Endurance, Intermittent, and Power/Strength Athletes Aged 16-35
The goal of this clinical trial is to learn if different types and doses of oral iron supplements can improve iron levels, athletic performance, and gut health in young female athletes with low iron stores.
- Trial name
- FeSc2 (NCT06942208)
- Testing
- Low-dose iron (ferrous sulfate), Yeast-bound iron (ferrous sulfate), High-dose iron (ferrous sulfate)
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Diabetes Mellitus, Heart Disease
Deferoxamine for the Treatment of Hemochromatosis
When patients receive repeated blood transfusions the level of iron in the patient s blood can rise. When iron is processed in the body a protein known as hemosiderin can begin collecting in the organs.
- Conditions
- Diabetes Mellitus, Heart Disease, Hemochromatosis, Thalassemia
- Trial name
- NCT00001203
- Where
- United States
- Volunteers
- 151 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
ADHD, Iron-deficiency
Impact of Iron Supplementation Treatment on Brain Iron Concentrations
The goal of the present study is to provide novel data to evaluate brain iron concentration as a mediator of the association between iron supplementation treatment and improvement in symptoms of ADHD and RLS in children…
- Conditions
- ADHD, Iron-deficiency, Restless Legs Syndrome, Periodic Limb Movement Sleep Disorder
- Trial name
- NCT04144790
- Testing
- ferrous sulfate
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
IDA - Iron Deficiency Anemia, Anemia
Iron Deficiency Anemia (IDA) and the Brain
This is a trial with an observational and an interventional arm, in patients with moderate to severe anemia and control subjects.
- Conditions
- IDA - Iron Deficiency Anemia, Anemia, Iron Deficiency Anemia, Anemia, Iron Deficiency
- Trial name
- IDA (NCT05929729)
- Testing
- Ferric derisomaltose, NovaFerrum
- Where
- 4 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Metabolic Syndrome
A 4-month Intervention of Antioxidant Supplementation in Overweight Children
In obese children, low antioxidant vitamin intake and reduced antioxidant capacity are common. Weight reduction reduces subclinical inflammation in obese subjects, and, similarly, antioxidant vitamins have been shown to reduce…
- Trial name
- NCT01316081
- Testing
- Vitamin C Vitamin E Selenvital all from Burgerstein Vitamine
- Where
- Switzerland
- Volunteers
- 45 people
- Sponsor
- Swiss Federal Institute of Technology