Clinical trials: Intellectual Developmental Disorder
Rare Intellectual Disabilities
Multi-Omics and IPSCs to Improve Diagnosis of Rare Intellectual Disabilities
Background Genetic factors play a major role in intellectual disability (ID) but the underlying cause is not determined in many cases.
- Trial name
- MIDRID (NCT03635294)
- Testing
- Blood sample
- Where
- 6 sites in France
- Volunteers
- 7 people
- Sponsor
- University Hospital, Angers
Williams Syndrome, Angelman Syndrome
Study of Phenotype and Genotype Correlations in Patients With Contiguous Gene Deletion Syndromes
OBJECTIVES: I. Investigate phenotype and genotype correlations in patients with Smith-Magenis syndrome (SMS) associated with del(17p11.2). II.
- Conditions
- Williams Syndrome, Angelman Syndrome, Prader-Willi Syndrome, Shprintzen Syndrome
- Trial name
- NCT00004351
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Down Syndrome, Aerobic Exercise
Effects of Aerobic-Based Virtual Reality Exercise Training and Traditional Aerobic Exercise Training on Physical Fitness, Functional Capacity and Cognitive Function in Individuals With Down Syndrome
This study aims to investigate the effectiveness of aerobic-based virtual reality exercise training and traditional aerobic exercise training on physical fitness, functional capacity, cognitive functions and quality of life in…
- Conditions
- Down Syndrome, Aerobic Exercise, Virtual Reality Based Therapy, Exergame
- Trial name
- NCT06617637
- Testing
- Aerobic Based Virtual Reality Exercise Training, Traditional Aerobic Exercise Training
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Bezmialem Vakif University
Down Syndrome
Effects of High Intensity Interval Training in Down Syndrome
Down Syndrome (DS), a genetic condition marked by the presence of an extra chromosome 21, is associated with various cognitive and physical challenges.
- Trial name
- NCT06777394
- Testing
- High intensity interval training, Routine treatmet
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Riphah International University
Deafness, Hearing Loss
Outcomes In Children With Developmental Delay And Deafness
Children with special needs require complex, individualized therapy to maximize their long-term quality of life. One subset of children with special needs includes those with both developmental delays and deafness.
- Trial name
- NCT01256229
- Testing
- cochlear implantation, hearing aids
- Where
- 2 sites in United States
- Volunteers
- 303 people
- Sponsor
- Stanford University
Intellectual Deficiency, Cerebral Abnormality
Corpus Callosum Agenesis and Intellectual Disability
Corpus callosum agenesis or dysgenesis (CCA) is a major brain malformation (˜1/4000 births) presently diagnosed by prenatal ultrasonography.
- Trial name
- ACCREM (NCT02167568)
- Testing
- Genetic
- Where
- France
- Volunteers
- 360 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Infertility, Intellectual Disability
Prospective Study to Assess Medical Performance of Optical Mapping and Long Read Sequencing in Detecting Numerical and Structural Chromosome Abnormalities
Chromosomal aberrations are major causes of developmental disorders (Intellectual disability (ID), multiple congenital anomalies (MCA), autism spectrum disorders (ASD)) as well as reproductive disorders (RD) in particular…
- Conditions
- Infertility, Intellectual Disability, Malformation, Miscarriage
- Trial name
- CHROMAPS (NCT05290051)
- Testing
- Optical Genome Mapping (Bionano®), Longread sequencing (Nanopore®)
- Where
- France
- Volunteers
- 350 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Intellectual Disability
Computerized Testing System for Measuring Motor and Sensory Integrative Functions in Intellectual Disabilities
Assessment of the motor and sensory integrative functions (MSI) is a key component of an overall health and functional evaluation for school-aged children with intellectual disabilities (ID).
- Trial name
- NCT05473377
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Down Syndrome
Comparison of Bispectral Index Values in Patients With and Without Down's Syndrome
About 1 in every 700 babies born in the United States has Down's Syndrome (DS; Trisomy 21), 99% of whom have some degree of intellectual disability.
- Trial name
- NCT02288702
- Testing
- monitoring BIS in both groups
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Milton S. Hershey Medical Center
Asperger's Disorder, Mental Retardation
Cognitive Neuroscience of Autism Spectrum Disorders
Background: Autism spectrum disorders (ASDs) are a group of developmental disorders that affect communication, social interaction, and behavior.
- Conditions
- Asperger's Disorder, Mental Retardation, Children, Adult
- Trial name
- NCT01031407
- Where
- United States
- Volunteers
- 678 people
- Sponsor
- National Institute of Mental Health (NIMH)
Mental Retardation
Safety and Efficacy of BMMNCin Patients With Mental Retardation
Mental retardation is a condition diagnosed before age 18 that includes below-average general intellectual function, and a lack of the skills necessary for daily living. Mental retardation affects about 1 - 3% of the population.
- Trial name
- NCT01908400
- Testing
- Intravenous transfer of BMMNC
- Where
- India
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Chaitanya Hospital, Pune
Down Syndrome
Effects of Vojta Therapy on Functional Mobility and Gait Parameters in Children With Down Syndrome
This randomized clinical trial investigates the effects of Vojta therapy on functional mobility and gait parameters in children with down syndrome.
- Trial name
- NCT07248267
- Testing
- Vojta Therapy, repetitive sensorimotor exercises
- Where
- Pakistan
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Down Syndrome
Effects of Stretch-shortening Cycle Exercises Postural Control in Down Syndrome
To investigate the effect of a 3-month, trampoline-based stretch-shortening cycle (SSC) exercises on muscle strength and postural control in children with Down syndrome.
- Trial name
- NCT04966403
- Testing
- Standard physical therapy, trampoline-based stretch-shortening cycle exercises
- Where
- Saudi Arabia
- Volunteers
- 32 people
- Sponsor
- Qassim University
Down Syndrome, Regression
Therapies for Down Syndrome Regression Disorder
Individuals with Down syndrome (DS) have an increased risk of numerous co-occurring conditions, including the neuropsychiatric condition known as Down Syndrome Regression Disorder (DSRD).
- Trial name
- NCT05662228
- Testing
- Lorazepam, Intravenous immunoglobulin (IVIG), Tofacitinib
- Where
- 2 sites in United States
- Volunteers
- 66 people
- Sponsor
- University of Colorado, Denver
Hypothyroidism, Global Developmental Delay
Register for Patients With Thyroid Hormone Resistance.
Thyroid hormones (TH) play a pivotal role in the development and function of the mammalian brain. Patients with impaired thyroid hormone transport into the brain tissue or in the case of defective local thyroid hormone receptor…
- Conditions
- Hypothyroidism, Global Developmental Delay, Intellectual Disability, Dystonia
- Trial name
- DEEPTYPE (NCT06566066)
- Testing
- no intervention
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Charite University, Berlin, Germany
Down Syndrome
Infectious and Non-infectious Lower Respiratory Diseases in Children With Down Syndrome Followed in Pediatric Pulmonology Consultations in Ile-de-France
The purpose of this study is to describe infectious and non-infectious lower respiratory tract diseases in children with Down syndrome followed in pediatric pulmonology consultations in Ile de France.
- Trial name
- ARBT21 (NCT06336577)
- Testing
- lower respiratory tract disease
- Where
- France
- Volunteers
- 108 people
- Sponsor
- Centre Hospitalier Sud Francilien
Physical Inactivity, Cerebral Palsy
Effects of Physical Activity on Prescription (PAP) as a Health-enhancing Intervention in People With Disabilities
Physical inactivity is an increasing problem in the general population in society. However, in people with disabilities, inactivity is even more frequently reported.
- Conditions
- Physical Inactivity, Cerebral Palsy, Autism, Autism Spectrum Disorder
- Trial name
- PAP (NCT05867940)
- Testing
- Physical activity on prescription
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Region Skane