Clinical trials: Insulin Pump Therapy
Diabetes Mellitus
Evaluation of a Diabetes Treatment and Education Program for Insulin Pump Therapy (INPUT)
This study is a randomized, controlled, prospective trial with a 6-month follow-up. A newly developed treatment and education programme for diabetic patients with an insulin pump therapy (INPUT) will be tested compared to a…
- Trial name
- INPUT (NCT02868931)
- Testing
- INPUT
- Where
- Germany
- Volunteers
- 268 people
- Sponsor
- Norbert Hermanns
Type 1 Diabetes
Closed-loop Control of Glucose Levels (Artificial Pancreas) for 15 Weeks in Adolescents and Adults With Type 1 Diabetes
Closed-loop strategy is composed of three components: glucose sensor to read glucose levels, insulin pump to infuse insulin and a dosing mathematical algorithm to decide on the required insulin dosages based on the sensor's…
- Trial name
- NCT02846857
- Testing
- 15-week intervention with sensor-augmented pump, 15-week intervention with single-hormone closed-loop, 15-week intervention with dual-hormone closed-loop
- Sponsor
- Institut de Recherches Cliniques de Montreal
Type 1 Diabetes
Closing the Loop in People with Type 1 Diabetes
The main objective of this study is to determine whether home use of fully closed-loop glucose control applying age-approved ultra-rapid insulin (Phase 2) is superior to standard insulin pump therapy with continuous glucose…
- Trial name
- CLEAR Phase 2 (NCT05653050)
- Testing
- CamAPS HX, Standard insulin pump therapy with CGM
- Where
- 4 sites in United Kingdom
- Volunteers
- 26 people
- Sponsor
- University of Cambridge
Diabetes Mellitus
Preservation of Pancreatic Beta Cell Function Through Insulin Pump Therapy
Type I diabetes (T1DM) is the second most common chronic illness effecting children in the USA. Worldwide, Type I diabetes is increasing in incidence, and its underlying etiology remains elusive.
- Trial name
- ktpump (NCT00574405)
- Testing
- MDI (split-mix NPH insulin + regular insulin or Lantus + Novolog® [or Humalog®]), CSII (Animas Corporation insulin pump, model IR 1200)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Type 1 Diabetes
Prospective Study of the Impact of Insulin Pump Therapy in Young Children With Type 1 Diabetes
The purpose of the study is to examine glycemic and neuropsychological outcomes in very young children with Type I diabetes who are being started on insulin pumps and to compare their outcomes to children who are not utilizing…
- Trial name
- NCT00727220
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Indiana University
Type 1 Diabetes
Clinical Efficacy of Insulin Pumps in Type 1 Diabetes Mellitus Patients in Spain
Observational cross-sectional multicenter study about clinical efficacy of insulin pumps in type 1 diabetes mellitus patients.
- Trial name
- NCT04761094
- Testing
- Insulin pump
- Where
- 25 sites in Spain
- Volunteers
- 2,977 people
- Sponsor
- Castilla-La Mancha Health Service
Type 1 Diabetes Mellitus, Cognitive Change
The VRIF Trial: Hypoglycemia Reduction With Automated-Insulin Delivery System
The objective of this pilot study is (i) to test the use of an Artificial Pancreas (AP) System as a viable therapy treatment for two vulnerable populations: 6 to 10 year-old and adults older ≥65 years old with T1D; (ii) to assess…
- Trial name
- NCT03674281
- Testing
- SAP, CLC
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Virginia
Type 1 Diabetes
Safety of Artificial Pancreas Therapy in Preschoolers, Age 2-6
A single-arm, multi-center, clinical study to assess the safety profile of the Tandem t:slim X2 with Control-IQ system in children with T1D aged 2-6 years old under free living condition
- Trial name
- NCT04084171
- Testing
- Tandem t:slim X2 with Control-IQ Technology + Dexcom G6
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Virginia
Type 1 Diabetes
MD Logic Pump Advisor -Pediatric Study
The objective of this feasibility study is to evaluate the efficacy and safety of automated determined Insulin pump settings (i.e., basal plan, correction factor, carbohydrate ration and insulin activity time) using the MD-Logic…
- Trial name
- NCT01308164
- Testing
- MD Logic Pump Advisor
- Where
- 2 sites in Israel, Slovenia
- Volunteers
- 25 people
- Sponsor
- Rabin Medical Center
Type 1 Diabetes
Medtronic MiniMed Implantable Insulin Pump
This research is being done to find out whether subjects previously treated with the implantable insulin pump (IIP) therapy, and now taking insulin by injection, will benefit from re-implantation of IIP.
- Trial name
- NCT00298740
- Testing
- Aventis U-400 Insulin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Johns Hopkins University
Type 1 Diabetes Mellitus, Diet Modification
Safety of Low and Very Low Carbohydrate Diets in Young Children With Type 1 Diabetes
The purpose of the study is to evaluate the safety of short-term (6 month) low or very-low carbohydrate diets in prepubertal children 2 to <12 years old with type 1 diabetes.
- Conditions
- Type 1 Diabetes Mellitus, Diet Modification, Child, Only
- Trial name
- NCT03862521
- Testing
- Low carbohydrate diet, Very low carbohydrate diet
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Nemours Children's Clinic
Type 1 Diabetes
Closed-loop Control of Overnight Glucose Levels (Artificial Pancreas) in Children With Type 1 Diabetes in a Diabetes Camp
Closed-loop strategy is composed of three components: glucose sensor to read glucose levels, insulin pump to infuse insulin and a dosing mathematical algorithm to decide on the required insulin dosages based on the sensor's…
- Trial name
- NCT02189694
- Testing
- Single-hormone closed-loop strategy, Dual-hormone closed-loop strategy, Insulin pump therapy
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Type 1 Diabetes
The Effects of Regular Home Use Vs Diabetic Team- Supported Use of the Medtronic CareLink Therapy Management System.
Randomized, two arms, controlled, open study comprised of two consecutive segments. At the first segment that will last during the first 4 months of the study, patients will be randomized to the Care link treated group or non…
- Trial name
- CareLink (NCT00814476)
- Testing
- Medtronic CareLink therapy management system, regular home use and Medtronic CareLink Therapy Management
- Where
- Israel
- Volunteers
- 70 people
- Sponsor
- Rabin Medical Center
Type 1 Diabetes Mellitus
Insulin-based Strategies to Prevent Hypoglycemia During Exercise
It has been reported that insulin basal rate reduction initiated at exercise onset can reduce the hypoglycemic risk during exercise.
- Trial name
- NCT03349489
- Testing
- Exercise 1, Exercise 2, Dexcom G4 Platinum
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Type 1 Diabetes
Accu-Chek Combo in Young Patients
This is an open, prospective, descriptive study aiming to evaluate the change in treatment satisfaction of primary care givers of young children who use the Accu-Chek Combo System.
- Trial name
- NCT01657630
- Testing
- Accu-Chek Combo System
- Where
- Israel
- Volunteers
- 13 people
- Sponsor
- Rabin Medical Center
Type1diabetes
Assessment of Two Insulin Pump Insulin Delivery Systems in Type 1 Diabetes.
This is a study of the Minimed 670G 4.0 insulin pump, assessing the efficacy of the Advanced Hybrid Closed Loop (AHCL) algorithm in controlling blood glucose levels in Type 1 Diabetes.
- Trial name
- NCT04073576
- Testing
- AHCL, SAP+PLGM
- Where
- New Zealand
- Volunteers
- 60 people
- Sponsor
- Christchurch Clinical Studies Trust Ltd
Type1 Diabetes Mellitus
Evaluation of the Dreamed Advisor Pro for Automated Insulin Pump Setting Adjustments in Children and Adolescents With Type 1 Diabetes- The Advice4U Pro Study
The DreaMed Advisor Pro is a software which automatically analyses treatment information, learns patient's needs and accordingly suggests adjustments in insulin dosing.
- Trial name
- Advice4U (NCT03003806)
- Testing
- DreaMed Advisor Pro, Medical guided recommendation
- Where
- 7 sites in United States, Germany and 2 more
- Volunteers
- 122 people
- Sponsor
- Rabin Medical Center
Type 1 Diabetes
Closed-loop Control of Postprandial Glucose Levels in Children and Adults With Type 1 Diabetes
Current intensive insulin therapy in T1D involves prandial insulin boluses depending on the carbohydrate content of each ingested meal.
- Trial name
- NCT02490098
- Testing
- 6-day intervention with sensor-augmented pump therapy, 6-day intervention with single-hormone closed-loop strategy, 6-day intervention with dual-hormone closed-loop strategy
- Where
- Canada
- Sponsor
- Institut de Recherches Cliniques de Montreal
Type 1 Diabetes
Closing the Loop in Adolescents During Non-compliance Behaviours
The ultimate goal of the investigators ongoing research is the development of a closed-loop system for insulin delivery, which can help people with type 1 diabetes (T1D) attain a tight glucose control avoiding the risk of…
- Trial name
- NCT01629277
- Testing
- Closed-loop, standard insulin pump
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Cambridge
Diabetes Mellitus, Diabetes Mellitus, Type 1
Home Testing of Day and Night Closed Loop With Pump Suspend Feature
The main study objective is to determine whether day and night automated closed loop glucose control combined with pump suspend feature will improve glucose control and reduce the burden of hypoglycaemia compared to sensor…
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Glucose Metabolism Disorders, Endocrine System Diseases
- Trial name
- APCam11 (NCT02523131)
- Testing
- FlorenceM, Medtronic insulin pump 640G
- Where
- 8 sites in United States, United Kingdom
- Volunteers
- 84 people
- Sponsor
- University of Cambridge