Clinical trials: Inflammatory Biomarkers
Brain Injury Traumatic Mild
Using Routine Inflammatory and Metabolic Blood Tests (Bedside Included) to Predict Brain Injury in Children After Minor Head Trauma
Traumatic brain injury (TBI) poses significant strains on the paediatric population, for which the possible side effects of diagnostic imagistics could induce life-altering conditions.
- Trial name
- paeds_mTBI_Bio (NCT07397091)
- Where
- 7 sites in Romania
- Volunteers
- 800 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Inflammatory Myopathy, Duchenne Muscular Dystrophy
Quantitative Muscle Ultrasound as a Marker of Progression in Children With Muscular Diseases
The aim of our study is to Assess skeletal muscle structural status in children with inflammatory myositis and Duchenne muscular dystrophy using musculoskeletal ultrasound and to perform a longitudinal follow up of these changes…
- Trial name
- NCT03786913
- Testing
- Quantitative muscle ultrasound measurements
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Benha University
Myocarditis, Pediatric Inflammatory Multisystem Syndrome
Multiparametric Echocardiography and Cardiac Biomarkers in Pediatric Inflammatory Heart Diseases
Acquired inflammatory or infectious cardiac diseases, in pediatrics, include Kawasaki disease, myocarditis, and Covid-19-related Pediatric Multisystemic Inflammatory Syndrome (PIMS).
- Conditions
- Myocarditis, Pediatric Inflammatory Multisystem Syndrome, Kawasaki Disease
- Trial name
- NCT05911386
- Testing
- study of biological samples and echocardiographic data and link with need of hemodynamic support
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Central Hospital, Nancy, France
Frenulum; Hypertrophy, Diode Laser
Diode Laser Versus Conventional Frenectomy in Children
This prospective, randomized, open-label, parallel-group clinical trial aims to compare diode laser frenectomy with conventional scalpel frenectomy in children aged 8-12 years with a clinical indication for maxillary labial…
- Conditions
- Frenulum; Hypertrophy, Diode Laser, Frenectomy, RT-PCR
- Trial name
- NCT07853599
- Testing
- Diode Laser Frenectomy, Conventional Scalpel Frenectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Yuzuncu Yil University
Autoinflammatory Disease, Autoimmune Diseases
Flemish Joint Effort for Biomarker PRofiling in Inflammatory Systemic Diseases
A multi-centre, prospective study to study cytokine profiles and other potential disease-specific biomarkers in patients with presumed or confirmed diseases of systemic inflammation The goal of this prospective, observational…
- Conditions
- Autoinflammatory Disease, Autoimmune Diseases, Inflammation
- Trial name
- FEBRIS (NCT05670301)
- Testing
- cytokine and lipidomic profiling
- Where
- 7 sites in Belgium
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Septic Shock
Stress Hydrocortisone In Pediatric Septic Shock
SHIPSS is a multi-institutional, prospective, controlled, randomized, double-blinded interventional trial that will examine the potential benefits and risks of adjunctive hydrocortisone prescribed for children with fluid and…
- Trial name
- SHIPSS (NCT03401398)
- Testing
- Hydrocortisone, sodium succinate, Normal saline
- Where
- 44 sites in United States, Brazil and 8 more
- Volunteers
- 500 people
- Sponsor
- Jerry Zimmerman
Eosinophilic Esophagitis
Inflammatory Mediators as Potential Non-Invasive Biomarkers in Subjects With Eosinophilic Esophagitis
The investigators seek to assess esophageal inflammation or lack of it in response to treatment with a novel non-invasive method that would measure eosinophil-associated inflammatory mediators in the blood and urine to determine…
- Trial name
- NCT03822325
- Where
- 2 sites in United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Myocardial Infarction, No Reflow Phenomenon
Validation of New Biomarkers for Predicting No-Reflow in STEMI Patients Undergoing Primary PCI
To evaluate the diagnostic value of the selected emerging biomarkers in predicting the no-reflow phenomenon among patients presenting with STEMI undergoing primary PCI.
- Trial name
- VaBiNoR (NCT07132489)
- Testing
- HbA1c/C-peptide ratio Albumin-bilirubin (ALBI) score. Neutrophil/HDL ratio
- Volunteers
- 114 people
- Sponsor
- Assiut University
Reproductive Health
Anti-Inflammatory Diet and Physical Activity for Reproductive Health in Adolescent Girls
This study will evaluate whether a 16-week anti-inflammatory dietary intervention, delivered alone or together with a physical activity programme, can improve diet quality and support reproductive health in girls aged 14-19…
- Trial name
- 4fertil (NCT07834489)
- Testing
- Anti-Inflammatory Dietary Intervention, Physical Activity and Training Programme
- Where
- 2 sites in Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Burnout, Secondary Traumatic Stress
Burnout, Secondary Traumatic Stress and Inflammatory Biomarkers in ICU Healthcare Workers
Healthcare professionals working in intensive care units (ICUs) are frequently exposed to high levels of psychological stress due to critically ill patients, frequent encounters with death, complex clinical decision-making, and…
- Conditions
- Burnout, Secondary Traumatic Stress, Occupational Stress, Inflammation
- Trial name
- NCT07437443
- Testing
- Psychometric Assessment and Blood Sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Elazıg Fethi Sekin Sehir Hastanesi
Cystic Fibrosis (CF)
Impact of Trikafta on P2X7R and Clinical Outcomes in Cystic Fibrosis
The aim of this study is to assess the response of the ETI on P2X7R level as inflammatory marker and clinical outcomes in patients with cystic fibrosis.
- Trial name
- NCT07841353
- Where
- Egypt
- Volunteers
- 35 people
- Sponsor
- Ain Shams University
Sepsis
Vancomycin and Acute Kidney Injury in Sepsis Treatment - Intervention
The goal of this clinical trial is to determine if vancomycin dosing in children with sepsis can be improved by using updated, personalized dosing models that account for new markers of an individual's kidney function.
- Trial name
- VAST-i (NCT07084129)
- Testing
- personalized dosing adjustment of vancomycin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's Hospital of Philadelphia
Neonatal Herpes Simplex Infection, Neonatal HSV Infection
Host RNA Expression Profiles and Protein Biomarkers in Neonatal Herpes Simplex Virus Infection
This study seeks to identify and test host RNA expression profiles in context to protein biomarkers in dried blood spot samples as novel diagnostic markers of neonatal herpes simplex virus infection and to improve the…
- Conditions
- Neonatal Herpes Simplex Infection, Neonatal HSV Infection, Neonatal Infection, Newborn; Infection
- Trial name
- NCT05226949
- Where
- 2 sites in Denmark
- Volunteers
- 159 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Sepsis
Biomarkers of Lung Injury in Hyperinflation in the Mechanical Ventilator Versus Manual Hyperinflation
Due to the failure of the respiratory system, many patients admitted to the Intensive Care Units (ICUs) require the institution of invasive mechanical ventilation (MV), aiming at maintaining gas exchange, reversing respiratory…
- Trial name
- NCT03464071
- Testing
- Hyperinflation with mechanical ventilator, Manual hyperinflation
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Inflammatory Bowel Diseases
Mitochondrial DAMPs as Mechanistic Biomarkers of Mucosal Inflammation in Crohn's Disease and Ulcerative Colitis
The MUSIC study is a multi-centre, longitudinal study set in the real world IBD clinical setting to investigate and develop a new biomarker approach that aims to inform both patients and clinicians of the current state of the…
- Trial name
- MUSIC (NCT04760964)
- Where
- 3 sites in United Kingdom
- Volunteers
- 250 people
- Sponsor
- University of Edinburgh
Pediatric Anesthesia, Postoperative Nausea and Vomiting (PONV)
Inflammatory Biomarkers as Predictors of PONV Following Pediatric Orchiopexy
Orchiopexy is a common surgical procedure for the treatment of cryptorchidism in the pediatric population, with a high incidence of postoperative nausea and vomiting (PONV).
- Conditions
- Pediatric Anesthesia, Postoperative Nausea and Vomiting (PONV), Inflammatory Biomarkers
- Trial name
- NCT07148063
- Testing
- Measurement of Preoperative Inflammatory Biomarkers
- Where
- Turkey (Türkiye)
- Volunteers
- 170 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Acute Febrile Illness, Bacterial Infections
AI-Guided Proteomic Biomarker Panel for Differentiating Bacterial and Viral Infections in Acute Febrile Illness
This study is a proteomics-based diagnostic biomarker study conducted on the same patient cohort as the transcriptomic biomarker study (NCT065529754).
- Conditions
- Acute Febrile Illness, Bacterial Infections, Viral Infections, Sepsis
- Trial name
- NCT07205575
- Testing
- Proteomic Biomarker Panel
- Where
- China
- Volunteers
- 394 people
- Sponsor
- Qilu Hospital of Shandong University
Training, Inflammation Biomarkers
The Effect of a Single Training Session on Changes in Inflammatory, Hormonal, and Metabolic Markers in Athletes
The study aims to assess the acute response of wrestlers to a single training session. Short-term changes in inflammatory, hormonal, and metabolic markers are analyzed to assess fatigue development and recovery following intense…
- Conditions
- Training, Inflammation Biomarkers, Hormone, Exercise Training
- Trial name
- NCT07264751
- Testing
- physical training
- Where
- Poland
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Hypertension, Pulmonary
Inflammatory Biomarkers of Pediatric Pulmonary Hypertension
To investigate if the inflammatory protein, high mobility group box 1 (HMGB1), along with other inflammatory mediators, is elevated in pediatric patients with congenital heart disease (CHD) and pulmonary hypertension as compared…
- Trial name
- NCT03581695
- Testing
- Blood test
- Where
- Canada
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Periodontitis, Premature Birth of Newborn
Feasibility and Acceptability of Use of Daily Oral Rinse in Pregnant Women in Rural Nepal
In Nepal, investigators are conducting a cohort study to estimate the relationship between signs of periodontal disease in pregnant women and preterm delivery.
- Trial name
- NCT02788786
- Testing
- Chlorhexidine, Cetylpyridinium chloride, Salt and Water
- Where
- Nepal
- Volunteers
- 175 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health