Clinical trials: Infants Cardiac Surgery
Congenital Heart Disease, Periventricular Leucomalacia
Randomized Trial of Maternal Progesterone Therapy
Neurodevelopmental disability is now recognized as the most common long-term complication after cardiac surgery in neonates. Research studies have shown that progesterone is critical to the development of the brain and in a…
- Conditions
- Congenital Heart Disease, Periventricular Leucomalacia, Brain Development, Cardiac Surgery
- Trial name
- NCT02133573
- Testing
- Progesterone, Vaginal lubricant
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Children's Hospital of Philadelphia
Deglutition Disorders in Children, Congenital Heart Disease
Speech Therapy Online Approach for Children With Congenital Heart Desease in Pre and Post Surgical Period
The goal of this clinical trial is to test the results of a protocoled speech therapy online intervention in children with congenital heart disease aged between 0 and 12 months old, who feeds tube only.
- Trial name
- NCT07481565
- Testing
- Oral motor intervention
- Where
- 2 sites in Brazil
- Volunteers
- 20 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Delirium - Postoperative, Sleep Problems
Preoperative Sleep Intervention on Postoperative Delirium in Infants and Toddlers Undergoing Congenital Heart Surgery
This is a multicenter, randomized, controlled clinical trial aimed to determine whether preoperative sleep interventions could reduce the incidence of adverse outcomes, such as postoperative delirium, in sleep-disordered infants…
- Conditions
- Delirium - Postoperative, Sleep Problems, Congenital Heart Disease (CHD)
- Trial name
- NCT06861998
- Testing
- Message-based bedtime routine, sleep hygiene education
- Where
- China
- Volunteers
- 452 people
- Sponsor
- Yan Fuxia
Heart Defects, Congenital
Neuroprotective Effects of Remote Ischemic Preconditioning (RIPC) During Infant Cardiac Surgery
The purpose of this study is to look at whether the use of a simple technique before surgery, which involves inflating a blood pressure cuff on the infant's leg, can improve development of language, motor and thinking skills at…
- Trial name
- NCT01835392
- Testing
- Remote Ischemic Preconditioning, Control
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Nemours Children's Clinic
Respiratory Failure
NAVA Versus BiPAP Non-Invasive Respiratory Support in Infants Following Congenital Heart Surgery
Pediatric patients often require prolonged mechanical ventilation after cardiac surgery which comes with many undesirable effects.
- Trial name
- NAVA (NCT03180385)
- Testing
- Neurally-Adusted Ventilatory Assist (NAVA), Biphasic Positive Airway Pressure Support (BiPAP)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Cardiopulmonary Arrest
Measurement of Cerebral Flow Using Transfontanellar Doppler in Infants Under Cardiopulmonary Bypass
Transfontanellar Doppler can measure the velocity at both the carotid artery and the anterior cerebral artery during cardiopulmonary bypass in congenital heart disease patients.
- Trial name
- NCT01996020
- Where
- South Korea
- Volunteers
- 43 people
- Sponsor
- Seoul National University Hospital
Congenital Heart Disease in Children, Inflammatory Response
STeroids to REduce Systemic Inflammation After Infant Heart Surgery
This study's objective is to determine the pharmacokinetics (PK)/pharmacodynamics (PD), safety and efficacy of methylprednisolone in infants undergoing heart surgery with cardiopulmonary bypass.
- Trial name
- STRESS (NCT03229538)
- Testing
- Methylprednisolone, Isotonic saline
- Where
- 23 sites in United States
- Volunteers
- 1,263 people
- Sponsor
- Kevin Hill
Acute Kidney Injury
Acute Kidney Injury in Children Operated for Congenital Heart Disease
The purpose of this study was to investigate if repeated inflation of a blood pressure cuff applied around one leg causing mild ischemia ("remote ischemic preconditioning") could protect children operated for congenital heart…
- Trial name
- NCT01316497
- Testing
- Remote ischemic preconditioning (RIPC), Control
- Where
- Denmark
- Volunteers
- 105 people
- Sponsor
- University of Aarhus
Congenital Heart Disease, Post Cardiac Surgery
Transitional Telehealth Home Care: REACH
The investigators want to determine if additional, increased contact with infants and families discharged to home after cardiac surgery improves infant and parent outcomes as compared to usual care.
- Trial name
- NCT01941667
- Testing
- Daily Messages, Virtual Home Visits, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 218 people
- Sponsor
- Children's Hospital of Philadelphia
Infant ALL
The Effect of Kangaroo Care After Cardiac Surgery
The aim of this study was to investigate the effects of kangaroo care on the vital signs of infants undergoing cardiac surgery. Hypothesis 1 (H1): Oxygen saturation levels of babies who are given kangaroo care are higher than…
- Trial name
- NCT06400446
- Testing
- Standard care, Kangaroo care
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istinye University
Congenital Heart Defect, Executive Function
Improving Neurodevelopmental Outcomes in Children With Congenital Heart Disease: An Intervention Study
Each year, approximately 1 child in every 100 is born with Congenital Heart Disease (CHD), making it the most common birth defect.
- Conditions
- Congenital Heart Defect, Executive Function, Children, Neurodevelopmental Disorders
- Trial name
- NCT03023644
- Testing
- Cogmed Working Memory Training
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Boston Children's Hospital
Congenital Heart Disease (CHD), Hypoxic Encephalopathy
Early Detection of Brain Injury After Congenital Heart Surgery in Infants
Infants with congenital heart disease undergoing cardiac surgery with extracorporeal circulation are at risk for perioperative hypoxic-ischaemic brain injury.
- Trial name
- NCT07424976
- Testing
- Observational study: blood analisys, EEG, MRI
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Acute Kidney Injury
The Effect of the Hydroxyethyl Starch on Kidney Injury in Pediatric Cardiac Surgery
The investigator will evaluate the influence of colloid administration on postoperative acute kidney injury in pediatric patients undergoing cardiac surgery under cardiopulmonary bypass.
- Trial name
- NCT02599155
- Testing
- Crystalloid, Colloid
- Where
- South Korea
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Hypotension (MeSH: D007022)
Carotid Artery Blood Flow, Blood Pressure, and Cardiac Output During Anesthesia in Children Aged 0-5 Years
Blood pressure is routinely monitored during anesthesia in children, but blood pressure alone may not accurately reflect blood flow to vital organs.
- Trial name
- CARFLOW (NCT07847203)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Heart Defects, Congenital
Micronutrients in Children in Critical Care With Cardiac Conditions
This study aims to explore the frequency and types of micronutrient deficiencies in a sample of UK children with CHD using standard and novel markers in blood.
- Trial name
- MC5 (NCT02409706)
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- NHS Greater Glasgow and Clyde
Postoperative; Dysfunction Following Cardiac Surgery
Oral Triiodothyronine for Infants Less Than 5 Months & Malnourished Children Undergoing Cardiopulmonary Bypass in Indonesia
Infants and children undergoing cardiac surgery require mechanical support for circulation called cardiopulmonary bypass. The artificial pump ensures that blood flow to the body is maintained during surgical procedure on the…
- Trial name
- I-TRICC (NCT02222532)
- Testing
- Tetronine
- Where
- Indonesia
- Volunteers
- 224 people
- Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia
Coarctation of Aorta
Clinical Assessment of Perfusion Techniques During Repair of Coarctation With Aortic Arch Hypoplasia in Infants
The purpose of this study is to evaluate safety and efficacy of three main perfusion methods in surgical repair of coarctation of aorta with aortic arch hypoplasia in infants.
- Trial name
- NCT02835703
- Testing
- Surgical repair of coarctation of aorta
- Where
- Russia
- Volunteers
- 45 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Cerebral Oxygenation
Cerebral NIRS Monitoring During Anesthesia in Neonates and Infants
The brain is a very vulnerable organ, especially in premature babies, newborns and infants. However, during anesthesia, the oxygenation of the brain can only be monitored indirectly and insufficiently.
- Trial name
- NCT04132414
- Testing
- NIRS open
- Sponsor
- Medical University of Graz
CHD - Congenital Heart Disease
Feasibility of Home Telemonitoring of Infants With Congenital Heart Disease Awaiting Surgery During the First Year of Life
Actually, there is no telemonitoring program that includes newborns or infants with congenital heart disease awaiting cardiac intervention.
- Trial name
- Blue-Line (NCT06998290)
- Testing
- Blue-Line home telemonitoring program
- Where
- 2 sites in France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Bordeaux
Low Cardiac Output Syndrome, Transposition of Great Vessels
Nitric Oxide During Bypass for Arterial Switch Operation
This trial will test if adding nitric oxide (NO) gas to the cardiopulmonary bypass (CPB) circuit in infants undergoing an arterial switch operation (ASO) for Transposition of the Great Arteries (TGA) changes the incidence of…
- Trial name
- NASO (NCT03661385)
- Testing
- Nitric Oxide
- Where
- 4 sites in Australia, Canada and 2 more
- Volunteers
- 300 people
- Sponsor
- Murdoch Childrens Research Institute