Clinical trials: Infant Neurodevelopment
Preterm Infant
The Effect of a Nurse-led Continuous Support Program on Neurodevelopment of Preterm Infants
The objective of the study is to establish a continuous nurse-led integrated support program and to exam its impact on preterm infant neurodevelopment. Research hypotheses include:1.
- Trial name
- NCT03151122
- Testing
- Nurse-led Continuous Support, routine follow-up care
- Volunteers
- 140 people
- Sponsor
- Wuhan University
Infant, Newborn
Darbepoetin Administration to Preterm Infants
Infants born prematurely do not increase production of the primary red cell growth factor, erythropoietin (Epo), and often develop an anemia called the "anemia of prematurity." The anemia of prematurity is the most common anemia…
- Trial name
- NCT00334737
- Testing
- Darbepoetin Alfa Injection, erythropoietin alfa injection
- Where
- 3 sites in United States
- Volunteers
- 102 people
- Sponsor
- University of New Mexico
Hypoxic-Ischemic Encephalopathy, Hypoglycemia
Quantitative Assessment of Sucking for Early Diagnosis of Brain Injury in Infants at High Risk
The main goal of this study is to quantitatively assess the sucking and feeding activity of infants at high risk of neurological impairment (preterm infants and term infants at risk of abnormal neurodevelopment) during oral…
- Conditions
- Hypoxic-Ischemic Encephalopathy, Hypoglycemia, Neonatal Abstinence Syndrome
- Trial name
- NCT03246243
- Testing
- nfant feeding solution
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Preterm, Neurodevelopmental Disorder
Biomarkers, Neurodevelopment and Preterm Infants
Approximately 2% of neonates in the US are born very preterm. Preterm births are associated with impaired cognitive, language and motor function, and increased risk for autism spectrum disorders.
- Conditions
- Preterm, Neurodevelopmental Disorder, Epigenetic Changes
- Trial name
- NCT02557191
- Testing
- Observational study
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Montefiore Medical Center
Infant, Torticollis Congenital
Comparison of the Effectiveness of Face to Face Rehabilitation and Telerehabilitation in Infants With Congenital Muscular Torticollis
Who is this study for? This study is designed for infants aged 0-6 months who have been diagnosed with Congenital Muscular Torticollis (CMT).
- Conditions
- Infant, Torticollis Congenital, Neurodevelopment Treatment, Telerehabilitation
- Trial name
- NCT06957522
- Testing
- face to face rehabilitation, telerehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Istanbul University - Cerrahpasa
Anemia, Iron Deficiency
Effect of Timing of Umbilical Cord Clamping on Anaemia at 8 and 12 Months and Later Neurodevelopment
The investigators plan a study to randomize 540 children in Nepal to early (≤30 seconds) or late (≥180 seconds) clamping of the umbilical cord at birth.
- Conditions
- Anemia, Iron Deficiency, Neonatal Jaundice
- Trial name
- NCT02222805
- Testing
- Early (≤30 seconds) cord clamping, Delayed (≤180 seconds) cord clamping
- Where
- Nepal
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Child Development Disorder
Craniosacral Therapy Improves Infant Neurodevelopment
Craniosacral exploration and therapy is one of the innovative palpation and treatment techniques in specialized physiotherapy, which can contribute in an efficient, subtle and sudden way to the detection of dysfunctions in the…
- Trial name
- NCT05340049
- Testing
- Academic behavioral intervention of teachers, Therapy sessions
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Clinica Gema Leon
Neurodevelopmental Disorders, Developmental Delay
Development of Motility and Cognition in Infants
PILKE study uses wearables for assessing motor development in infants in order to define functional growth trajectories in the normal infants and infants at risk of neurological compromise.
- Conditions
- Neurodevelopmental Disorders, Developmental Delay, Development, Infant, Child Development
- Trial name
- PILKE (NCT05527080)
- Testing
- physiotherapy, brace
- Where
- Finland
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Prematurity, Bronchopulmonary Dysplasia
Inhaled Nitric Oxide and Neuroprotection in Premature Infants
The purpose of this study is to determine whether inhaled nitric oxide improves the neurological outcome for premature infants.
- Conditions
- Prematurity, Bronchopulmonary Dysplasia, Intraventricular Hemorrhage, Periventricular Leukomalacia
- Trial name
- NOVA2 (NCT00515281)
- Testing
- inhaled nitric oxide, oxygen
- Where
- United States
- Volunteers
- 273 people
- Sponsor
- University of Chicago
Infant Neurodevelopment, Nutrition
Maternal Methyl-Nutrient Status and Infant Neurodevelopment Study
This prospective cohort study examines the relationship between maternal methyl-nutrient status during pregnancy and offspring neurodevelopment.
- Conditions
- Infant Neurodevelopment, Nutrition, Methylation, Birth Outcomes
- Trial name
- NCT07568561
- Where
- 2 sites in Taiwan
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
Premature Birth
Early Intervention in Preterm Infants: Short and Long Term Developmental Outcome After a Parental Training Program
Preterm infants, during their stay in the Neonatal Intensive Care Unit (NICU), face a period of stressful environment, which may negatively impact early brain development and subsequent neurobehavioral outcomes.
- Trial name
- NCT02983513
- Testing
- Early Intervention
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Klinefelter Syndrome, Trisomy X
The eXtroardinarY Babies Study: Natural History of Health and Neurodevelopment in Infants and Young Children With Sex Chromosome Trisomy
This study is designed to research the natural history of neurodevelopment, health and early hormonal function in infants with XXY/Klinefelter syndrome, XYY, XXX and other sex chromosome variations in an effort to identify early…
- Conditions
- Klinefelter Syndrome, Trisomy X, XYY Syndrome, XXXY and XXXXY Syndrome
- Trial name
- NCT03396562
- Testing
- Assessments of Development and Growth
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Colorado, Denver
Dysbiosis, Inflammation Gum
Microbiome Alterations With Xylitol (MAX) in Pregnancy
The purpose of this study is to understand if chewing xylitol-gum initiated before 20 weeks of pregnancy and continued until delivery affects the bacteria that are found in the oral and vaginal cavities, signs of inflammation…
- Conditions
- Dysbiosis, Inflammation Gum, Placenta-mediated Pregnancy Complications, Microbioata
- Trial name
- MAX (NCT06329596)
- Testing
- Xylitol gum, Sorbitol gum
- Where
- Malawi
- Volunteers
- 80 people
- Sponsor
- Baylor College of Medicine
Prematurity, Respiratory Distress Syndrome, Newborn
Infantile NO Replenishment as a New Therapeutic Possibility
Case-control study of inhaled Nitric Oxide (iNO) treatment of full-term and preterm infants. The main objective of this study is to investigate the association between premature birth and its later comorbidities (neuroendocrine…
- Trial name
- miniNO (NCT04914806)
- Where
- 3 sites in France, Greece and 1 more
- Volunteers
- 240 people
- Sponsor
- National and Kapodistrian University of Athens
Infant Sleep Problems, Circadian Rhythm
Chrononutrition in Preterm Infants: a Randomised Controlled Trial of Time-matched Breast Milk Feeding and Its Effects on Sleep and Circadian Development
This study investigates whether the timing of feeding expressed breast milk influences infant sleep and circadian (day-night) development in preterm infants.
- Conditions
- Infant Sleep Problems, Circadian Rhythm, Neurodevelopment
- Trial name
- NCT07533578
- Testing
- Chronobiologically Timed Feeding of Expressed Breast Milk, Usual Feeding Practice (Untimed Expressed Breast Milk)
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Luzerner Kantonsspital
Developmental Delay, Iron Deficiency
Early Versus Delayed Cord Clamping at Term: Neurodevelopmental Outcomes in Swedish Infants at 4 Years of Age
Delayed clamping of the umbilical cord might prevent or slow the onset of iron deficiency by increasing the infant's iron endowment at birth.
- Trial name
- NCT01581489
- Testing
- Time to clamping of the umbilical cord after delivery
- Where
- Sweden
- Volunteers
- 263 people
- Sponsor
- Uppsala University
Premature Infants
Post-Discharge Growth and Development of Infants Who Received Targeted Fortification in the NICU
Extremely low birth weight (ELBW) infants are at risk for slow growth, metabolic abnormalities, and poor neurodevelopmental outcomes.
- Trial name
- NCT04190875
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Diet, Neurodevelopment
Iodine Status During Pregnancy and Its Effect on Infant Development.
The overall aim of the present project is to investigate if intake of cod in pregnancy has impact on infant development up to 12 month.
- Trial name
- Mommy'sFood (NCT02610959)
- Testing
- Intervention group, Control group
- Where
- Norway
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- National Institute of Nutrition and Seafood Research, Norway
Preterm, Neurodevelopmental Disorders
Dietary Pattern Intervention for Neurodevelopment in Preterm Infants
The purpose of this randomized controlled trial is to evaluate the effect of a structured, high-prebiotic dietary pattern on the neurodevelopmental outcomes of preterm infants.
- Conditions
- Preterm, Neurodevelopmental Disorders, Dysbiosis
- Trial name
- NCT07702734
- Testing
- Structured High-Prebiotic Dietary Pattern
- Where
- China
- Volunteers
- 116 people
- Sponsor
- Fudan University
Preterm Infant Health, Preterm Infant Development
Preterm Infants: Light Effects on Health and Development
Preterm babies cared for in the intensive care nursery are exposed to amounts of light that are very different from the exposures to an unborn baby or the newborn term baby.
- Trial name
- NCT02146287
- Testing
- Cycled Light
- Volunteers
- 121 people
- Sponsor
- Duke University