Clinical trials: Induced Hypotension
Parkinson Disease, MSA - Multiple System Atrophy
Exploring the Olfactory Mucosa, Blood and Urine for the Identification of Early Biomarkers of Parkinson's Disease, Atypical Parkinsonisms and Neurocognitive Disorders Due to Lewy Body Disease
Clinical diagnosis of Parkinson's disease (PD), multiple system atrophy (MSA) and dementia with Lewy bodies (DLB) is challenging, especially in the early stages.
- Conditions
- Parkinson Disease, MSA - Multiple System Atrophy, Lewy Body Dementia (LBD), Neurodegenerative Disease
- Trial name
- EXTRAORDINARY (NCT06846658)
- Where
- 3 sites in Italy
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Pregnancy, Cesarean Delivery
Transthoracic Echocardiographic Monitoring of Cardiac Output Effects of Colloid Preload and Crystalloid Coload During Cesarean Delivery Under Spinal Anesthesia
Transthoracic echocardiography (TTE) has been introduced in anesthesia and intensive care practice to assess the volume status and predict fluid responsiveness, with a few studies performed on pregnant women (5).
- Conditions
- Pregnancy, Cesarean Delivery, Spinal Anesthesia Induced Hypotension, Cardiac Output Measurement
- Trial name
- NCT06654687
- Testing
- Transthoracic Echocardiography, Ringer lactate 1000 ml, Albumin
- Where
- Egypt
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Sameh Fathy
Neuromuscular Scoliosis
An Open-label Trial of Clevidipine for Controlled Hypotension During Spinal Fusion
The current study would prospectively evaluate the dosing requirements, efficacy and safety of clevidipine for controlled hypotension during spinal surgery in the pediatric population.
- Trial name
- NCT01645111
- Testing
- Clevidipine
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Nationwide Children's Hospital
Hypotension
Dose-response Study of Sodium Nitroprusside in Children Requiring Controlled Hypotension in the Operating Room
Sodium nitroprusside (SNP) has been approved for control of blood pressure in adults, yet there are no controlled studies in children.
- Trial name
- NCT00135668
- Testing
- Nitroprusside
- Where
- United States
- Volunteers
- 211 people
- Sponsor
- The Emmes Company, LLC
Transient Tachypnea of Newborn and Fetal Acidosis
Impact Of Maternal Spinal Anesthesia-Induced Hypotension At Scheduled Cesarean Delivery On Risk Development Of Transient Tachypnea Of Newborn And Fetal Acidosis
We will evaluate the association between transient tachypnea of newborns and fetal acidosis development to the degree and duration of maternal hypotension and anesthesia to delivery time during spinal anesthesia at scheduled…
- Trial name
- NCT06383624
- Where
- Egypt
- Volunteers
- 115 people
- Sponsor
- Benha University
Hypotension
Changes in Cerebral Oxygenation During Deliberate Hypotensive Anesthesia
This is a study using cerebral oximetry to evaluate the safety of traditionally adopted hypotensive anesthesia.
- Trial name
- NCT00207987
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- China Medical University Hospital
Pre-Eclampsia, Hypotension
Inferior Vena Cava Collapsibility Index Guide for Preoperative Fluid Therapy in Preeclampsia
The routine assessment of fluid status depends on clinical evaluation and invasive monitoring. The clinical assessment lacks objectivity and the invasive monitoring carries risks.
- Conditions
- Pre-Eclampsia, Hypotension, Fluid Overload
- Trial name
- NCT06539026
- Testing
- fluid therapy, 300 ml of crystalloid Ringer's solution.
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Hypotension on Induction
Hypotension in Children With Down Syndrome With Anesthesia Induction
Children generally undergo induction of anesthesia by inhalation of sevoflurane. Children with Down Syndrome experience bradycardia with induction of anesthesia using sevoflurane.
- Trial name
- NCT04603469
- Testing
- Non invasive blood pressure
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Baylor College of Medicine
Spinal Anesthesia, Cesarean Section
Predicting Spinal Hypotension in Cesarean Section
This prospective observational study investigates the predictive value of anthropometric and hemodynamic indices for spinal anesthesia-induced hypotension (SAIH) during cesarean section.
- Conditions
- Spinal Anesthesia, Cesarean Section, Hypotension
- Trial name
- prediction (NCT07499947)
- Where
- Turkey (Türkiye)
- Volunteers
- 321 people
- Sponsor
- TC Erciyes University
Hypotension on Induction
Anesthesia-induced Hypotension and Fluid Responsiveness
The purpose of this study is to find out which of the variables related to fluid responsiveness (e. g., perfusion index [PI], pleth variability index [PVI], pulse oximetry plethysmographic variance [ΔPOP]) can best predict…
- Trial name
- PVI (NCT03439007)
- Where
- South Korea
- Volunteers
- 84 people
- Sponsor
- Seoul National University Hospital
Acute Kidney Injury, Acute Kidney Disease
The Effect of Preoperative Biological Age on Hemodynamics and Renal Function
Background The aim of this study is to explore the potential value of preoperative biological age as a predictor of intraoperative hemodynamic changes and postoperative renal function injury.
- Conditions
- Acute Kidney Injury, Acute Kidney Disease, Intraoperative Hypotension, Post-induction Hypotension
- Trial name
- NCT07080086
- Volunteers
- 268,833 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Rhinoplasty Surgery
Effects of Dexmetomidine and Remifentanil Used for Controlled Hypotension in Septorhinoplasty Surgery on Cardiac Electrophysiology: Prospective Randomized Study
Our aim in this treatment was to reveal the effects of remifentanil and dexmetomidine, which we used to provide controlled hypotension in septorhinoplasty surgery, on cardiac electrophysiology.
- Trial name
- Effects of Dex (NCT06138574)
- Testing
- Dexmedetomidine, Remifentanil
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Pediatric Surgical Patients
Induction Hypotension in Pediatric Population
This is a retrospective chart review to assess the incidence and the degree of blood pressure changes after induction of anesthesia and to study the effect of different induction agents on blood pressure.
- Trial name
- NCT01934062
- Testing
- Surgery
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Tariq Wani
Scoliosis, Spinal Deformity
Bilateral Bi-level Erector Spine Plane Block as a Component of General Anesthesia in Surgical Correction of Spinal Deformations
Improving the anesthesiology management for surgical correction of spinal deformations with introducing the diagnostic methods and treatment strategy of acute pain, preventing the evolution of chronic pain.
- Conditions
- Scoliosis, Spinal Deformity, Acute Pain, Chronic Pain
- Trial name
- BBESPB (NCT04697498)
- Testing
- Bilateral bi-level Erector spine plane block, General anaesthesia
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Lviv National Medical University
Hypotension, Regional Anesthesia Morbidity
Spinal Anesthesia Related Hypotension in SARS-CoV-2 (COVID-19) Pregnant Patients
Since the onset of COVID-19, recommendations suggest the use of neuraxial anesthesia, if possible, over general anesthesia for cesarian section to avoid the risks of aerosolization associated with tracheal intubation and…
- Conditions
- Hypotension, Regional Anesthesia Morbidity, SARS-CoV2 Infection
- Trial name
- NCT05085652
- Testing
- spinal anesthesia induced hypotension in SARS-CoV-2 patients.
- Where
- Turkey (Türkiye)
- Volunteers
- 251 people
- Sponsor
- Ankara City Hospital Bilkent
Pregnancy-Associated Hypertension, Gestational Hypertension
Community Health Worker Support to Lower Blood Pressure After a Pregnancy With High Blood Pressure
High blood pressure during or after pregnancy (such as preeclampsia, gestational hypertension, eclampsia, or Hemolysis, Elevated Liver enzymes, and Low Platelet (HELLP) syndrome) raises a mother's risk of heart disease later in…
- Conditions
- Pregnancy-Associated Hypertension, Gestational Hypertension, Preeclampsia, Eclampsia
- Trial name
- AW2H (NCT07778966)
- Testing
- Alabama Womb to Heart Solution (AW2H) Community Health Worker (CHW) Program, Usual postpartum care with self-measured blood pressure education and home blood pressure monitor
- Where
- United States
- Volunteers
- 174 people
- Sponsor
- University of Alabama at Birmingham
Lower Extremity Fracture
Atropine Versus Glycopyrrolate in Preventing Spinal Anesthesia Induced Hypotension in Lower Limb Surgeries
A study to compare between intravenous atropine and glycopyrrolate in preventing spinal anesthesia induced hypotension in patients undergoing major lower limb orthopedic surgeries.
- Trial name
- NCT03580889
- Testing
- Atropine, Glycopyrrolate, Normal Saline Flush, 0.9% Injectable Solution
- Where
- Nepal
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- B.P. Koirala Institute of Health Sciences
Anesthesia Complication, Hypotension on Induction
Ultrasound Assessment of the Subclavian Vein for Predicting Hypotension in Children After Anaesthesia Induction
Intra operative hypotension is a risk factor in pediatric anesthesia (McCann ME et al.Pediatr Anesth 2014; 24: 68-73). In summary, the study aims at examine if ultrasound assessment of the diameter and collapsibility index of the…
- Conditions
- Anesthesia Complication, Hypotension on Induction, Hypovolemia
- Trial name
- NCT04573842
- Testing
- Ultrasound assessment of SCV
- Where
- Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet