Clinical trials: Immune Function
Type 1 Diabetes Mellitus
Effects of Recombinant Human Glutamic Acid Decarboxylase on the Progression of Type 1 Diabetes in New Onset Subjects
The purpose of this study is to determine whether treatment with multiple injections of GAD-Alum will preserve the body's own (endogenous) insulin production in patients who have been recently diagnosed with type 1 diabetes…
- Trial name
- TN08 (NCT00529399)
- Testing
- GAD-Alum, GAD-Alum and Aluminum hydroxide, Aluminum hydroxide
- Where
- 15 sites in United States, Canada
- Volunteers
- 145 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Asthma
Inflammatory, Functional and Image Composite Measure to Define Asthma Control
The goals of control status of asthma have been changed with the improvement of its management as a chronic disease; many steps should be taken to achieve asthma control as defined by the GINA/NIH guidelines.
- Trial name
- APITA (NCT00597064)
- Testing
- prednisone
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- Federal University of São Paulo
Diabetes Mellitus, Type 1
A Study of Baricitinib (LY3009104) to Preserve Beta Cell Function in Children and Adults Newly Diagnosed With Type 1 Diabetes (BARICADE-PRESERVE)
The purpose of this study is to find out if baricitinib can preserve beta-cell function in participants newly diagnosed with type 1 diabetes. Participation in the study will last about 60 weeks.
- Trial name
- NCT07222332
- Testing
- Baricitinib
- Where
- 131 sites in United States, Australia and 18 more
- Volunteers
- 300 people
- Sponsor
- Eli Lilly and Company
Diabetes Mellitus, Type 1, Nephropathy
Copeptin in Adolescent Participants With Type 1 Diabetes and Early Renal Hemodynamic Function
Over 1.25 million Americans have type 1 diabetes (T1D), increasing risk for early death from cardiorenal disease. The strongest risk factor for cardiovascular disease (CVD) and mortality in T1D is diabetic kidney disease (DKD).
- Conditions
- Diabetes Mellitus, Type 1, Nephropathy, Diabetic Nephropathies, Juvenile Diabetes
- Trial name
- CASPER (NCT03618420)
- Testing
- Aminohippurate Sodium Inj 20%, Iohexol Inj 300 mg/mL
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Chronic Lung Disease, Chronic Obstructive Pulmonary Disease
Fitness and Lung Function Among Survivors of Heart Transplant, Leukemia and Infant BPD Through Exercise
This study aims to more accurately assess cardiac function, ventilation and exercise capacity in a non-invasive fashion, and to better characterize exercise intolerance in the setting of three populations of individuals with…
- Conditions
- Chronic Lung Disease, Chronic Obstructive Pulmonary Disease, Acute Lymphoblastic Leukemia, Heart Transplant
- Trial name
- FLASHLITE (NCT05025774)
- Testing
- Physical activity
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Asthma
The Effect of Single Dose Paracetamol on the Lower Airways of Asthmatic and Healthy Children
Asthma is a common inflammatory airway disease. Several researches have demonstrated a possible connection between asthma and exposure to paracetamol.
- Trial name
- NCT01073748
- Testing
- paracetamol
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Type 1 Diabetes
Combination Therapy With Sitagliptin and Lansoprazole to Restore Pancreatic Beta Cell Function in Recent-Onset Type 1 Diabetes
Sanford Research/USD proposes to study the combination therapy of oral administration of sitagliptin and lansoprazole versus placebo for the preservation of pancreatic beta cells still present in patients with recent-onset…
- Trial name
- REPAIR-T1D (NCT01155284)
- Testing
- Sitagliptin and Lansoprazole
- Where
- 3 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Sanford Health
Infectious Gastroenteritis
Probiotics for Infectious Diarrhea in Children in South India
The overall goal of this study is to investigate whether the modulatory effects of probiotics, which are used as food supplements (Lactobacillus GG marketed as Culturelle or yoghurt) in the gastrointestinal tract promote…
- Trial name
- NCT01130792
- Testing
- Lactobacillus GG, Inulin
- Where
- India
- Volunteers
- 124 people
- Sponsor
- Christian Medical College, Vellore, India
Gait, Drop Foot, Chemotherapy-induced Peripheral Neuropathy
Impact of an Orthotic Intervention in Children With Peripheral Neuropathy
This research study will investigate the effect of two orthotic (brace) devices for the ankle and foot on walking and ankle flexibility in children with cancer not involving the brain or spinal cord.
- Conditions
- Gait, Drop Foot, Chemotherapy-induced Peripheral Neuropathy, Acute Lymphocytic Leukemia, Pediatric, Rhabdomyosarcoma
- Trial name
- IOPN (NCT03655587)
- Testing
- Solid ankle foot orthotic, Resting night splint
- Where
- 2 sites in United States
- Volunteers
- 27 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Inflammation, Psychosocial Functioning
Mindfulness Meditation Neuroimaging Study for Undergraduates
This study is designed to test the effectiveness of mindfulness meditation intervention classes on psychosocial health outcomes.
- Conditions
- Inflammation, Psychosocial Functioning, Depression, Anxiety
- Trial name
- NCT05304052
- Testing
- Mindfulness Meditation classes
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Acute Lymphoblastic Leukemia, Hodgkin Disease
Imaging of Chemotherapy-induced Morphological and Functional Lung Changes in Childhood ALL and HD
With increasing cure rates of childhood cancer there is growing recognition of late effects of treatments. However, there is a lack of non-invasive and child-friendly procedures that can indicate possible late damage.
- Conditions
- Acute Lymphoblastic Leukemia, Hodgkin Disease, Allogeneic Stem Cell Transplantation
- Trial name
- MinimALL (NCT06093334)
- Testing
- Low-field magnetic resonance imaging, Cardiopulmonary testing, Pulmonary testing
- Where
- Germany
- Volunteers
- 27 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Asthma (Diagnosis)
Chronic Effects of Photobiomodulation With an LED Vest on Functional Capacity, Inflammatory Markers, and Muscle Perfusion in Children With Asthma
Asthma is a chronic inflammatory disease of the airways that results in tissue remodeling, airflow limitation, and bronchial hyperresponsiveness.
- Trial name
- Asthma PBM (NCT07613671)
- Testing
- Photobiomodulation, Exercise
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Nove de Julho
Intracranial Germ Cell Tumor, Intracranial Germ Cell CNS Tumor, Childhood
Surveillance of Association of Immune Status and Prognosis of CNS Germ Cell Tumor Survivors
Platinum-based chemotherapy, alternating at 21-days intervals with cycles of ifosfamide, cisplatin, and etoposide (ICE) and subsequently received radiotherapy were considered as standard treatment for intracranial germ cell…
- Conditions
- Intracranial Germ Cell Tumor, Intracranial Germ Cell CNS Tumor, Childhood, Surgery
- Trial name
- NCT04909307
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Chengcheng Guo
Asthma
Study In Airway Physiology In Children SERETIDE DISKUS ® Inhlaer and FLIXOTIDE® Inhaler Are Trademarks of GSK Group of Companies.
Comparison of two asthma treatments by lung function measures.
- Trial name
- NCT00169546
- Testing
- Salmeterol/fluticasone propionate, Fluticasone propionate
- Where
- 2 sites in New Zealand, United Kingdom
- Volunteers
- 64 people
- Sponsor
- GlaxoSmithKline
Recurrent Childhood Acute Myeloid Leukemia, Recurrent Childhood Acute Lymphoblastic Leukemia
Ex Vivo Drug Sensitivity Testing and Multi-Omics Profiling
Functional precision medicine (FPM) is a relatively new approach to cancer therapy based on direct exposure of patient- isolated tumor cells to clinically approved drugs and integrates ex vivo drug sensitivity testing (DST) and…
- Conditions
- Recurrent Childhood Acute Myeloid Leukemia, Recurrent Childhood Acute Lymphoblastic Leukemia, Recurrent Childhood Large Cell Lymphoma, Refractory Childhood Acute Lymphoblastic Leukemia
- Trial name
- NCT05857969
- Testing
- Functional Precision Medicine
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Florida International University
Pulmonary Fibrosis, COPD
Multiple Breath Washout as a Method for Diagnosing Lung Diseases
Comparison of the new multiple-breath washout method (ndd Medizintechnik Zürich, Trueflow™/Truecheck™) with established methods of lung function diagnostics in patients with idiopathic pulmonary fibrosis, chronic obstructive…
- Conditions
- Pulmonary Fibrosis, COPD, Asthma
- Trial name
- NCT06179342
- Testing
- Multiple-Breath-Washout
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- Wissenschaftliches Institut Bethanien e.V
Asthma
Clinical Trial of Fluticasone Versus Placebo at the Onset of a Cold for Children With Asthma
The purpose of this study is to determine, in children aged 1 to 6 years with recurrent asthma induced by upper respiratory tract infections (URTI), whether the administration of high doses of inhaled fluticasone started at the…
- Trial name
- NCT00238927
- Testing
- inhaled fluticasone 750 mcg/day twice daily until 2 days without symptoms (maximum 15 consecutive days)
- Where
- 5 sites in Canada
- Volunteers
- 150 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Juvenile Idiopathic Arthritis, Childhood Rheumatic Disease
Dynamic Gait Index as a Functional Gait Assessment Measure in Children With JIA
Juvenile idiopathic arthritis (JIA) is one of the most common chronic rheumatic diseases seen in childhood. Pain, joint swelling and loss of function caused by inflammation significantly reduce the patients' quality of life and…
- Trial name
- NCT06870045
- Testing
- Physical examination, Dynamic Gait Index
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Pulmonary Function
A National Registry on Chinese Patients With Lymphangioleiomyomatosis
Pulmonary lymphangioleiomyomatosis (LAM), a disease characterized by diffuse cystic changes in the lung, is a rare disorder that affects almost exclusively women.
- Trial name
- NCT03193892
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Peking Union Medical College Hospital
Primary Immunodeficiency
Send-In Sample Collection to Achieve Genetic and Immunologic Characterization of Primary Immunodeficiencies
Background: The immune system helps the body fight infections. Primary immunodeficiency disorders (PIDs) are diseases that make it easier for people to get sick. Many PIDs are inherited.
- Trial name
- NCT03610802
- Where
- 3 sites in United States, Italy and 1 more
- Volunteers
- 3,000 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)