Clinical trials: Hypocalcemia
Proton Pump Inhibitor Adverse Reaction, Hypomagnesemia
Hypomagnesemia Associated With Proton-Pump Inhibitor Use
Use of proton pump inhibitors has been associated with hypomagnesemia. However, various case-control or prospective studies have found conflicting results with regards to proton pump inhibitors use and development of…
- Conditions
- Proton Pump Inhibitor Adverse Reaction, Hypomagnesemia, Arrhythmias, Cardiac, Seizures
- Trial name
- PPI_HypoMg (NCT04426994)
- Testing
- proton pump inhibitor use
- Where
- Singapore
- Volunteers
- 211,672 people
- Sponsor
- Changi General Hospital
Idiopathic Hypoparathyroidism, Autosomal Dominant Hypocalcaemia
Characterization of Patients With Non-surgical Hypoparathyroidism and Pseudohypoparathyroidism
Hypoparathyroidism (hypoPT) and pseudohypoparathyroidism (Ps-hypoPT) are rare diseases, characterized by low levels of parathyroid hormone [PTH] and plasma calcium or high plasma PTH and low plasma calcium, respectively.
- Conditions
- Idiopathic Hypoparathyroidism, Autosomal Dominant Hypocalcaemia, Pseudohypoparathyroidism
- Trial name
- NCT02551120
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- University of Aarhus
Autosomal Dominant Hypocalcemia (ADH)
Efficacy and Safety of Encaleret Compared to Standard of Care in Participants With ADH1
The primary purpose of the study is to understand the effectiveness, safety, and tolerability of encaleret when compared to standard of care (SoC) treatment in participants with Autosomal Dominant Hypocalcemia Type 1 (ADH1).
- Trial name
- CALIBRATE (NCT05680818)
- Testing
- Encaleret, Standard of Care
- Where
- 25 sites in United States, Australia and 8 more
- Volunteers
- 67 people
- Sponsor
- Calcilytix Therapeutics, Inc., a BridgeBio company
Hypocalcemia
Hypocalcemia in Infants and Children
Hypocalcemia is defined as reduction in the level of the ionized calcium in the blood to less than 0.95 mmole/ litre. In some cases it is associated with symptoms such as neuromuscular impairment in the form of convulsions…
- Trial name
- NCT03685877
- Volunteers
- 30 people
- Sponsor
- Assiut University
Hypocalcemia, Hypovitaminosis D
Calcium and Vitamin D Intakes in Children
Calcium (Ca2+) and vitamin D (VitD) play an important role in child health. Aims. The investigators evaluated the daily intake of Ca2+ and VitD in healthy children; and the efficacy of Ca2+ and VitD supplementation.
- Trial name
- NCT01638494
- Testing
- Colecalcium supplement
- Volunteers
- 184 people
- Sponsor
- Federico II University
Hemorrhage, Hypocalcemia
The No-Tie Technique Using the Harmonic Scalpel in Total Thyroidectomy With Central Neck Dissection: A Prospective Randomized Study
To investigate the safety and efficacy of the no-tie technique using the harmonic scalpel (HS) in terms of the operating time and complications in total thyroidectomy with central neck dissection (CND).
- Conditions
- Hemorrhage, Hypocalcemia, Vocal Cord Palsy
- Trial name
- NCT00506103
- Where
- South Korea
- Sponsor
- Soonchunhyang University Hospital
Ligature; Hemorrhage, Recurrent Laryngeal Nerve Injuries
Comparison of Liagure Safety in Thyroidectomy With Conventional Thyroidectomy
To compare intraoperative and postoperative complication rates in thyroidectomy between ligasure and traditional vascular ligation and clipping .
- Conditions
- Ligature; Hemorrhage, Recurrent Laryngeal Nerve Injuries, Hypocalcemia
- Trial name
- NCT05684536
- Testing
- liagsure device
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Imam Mohammad ibn Saud Islamic University
DiGeorge Anomaly, Complete DiGeorge Anomaly
Phase I/II Thymus Transplantation With Immunosuppression #950
The study purpose is to determine if cultured thymus tissue implantation (CTTI) (previously described as transplantation) with tailored immunosuppression based on the recipient's pre-implantation T cell population is a safe and…
- Conditions
- DiGeorge Anomaly, Complete DiGeorge Anomaly, Complete Atypical DiGeorge Anomaly, Complete DiGeorge Syndrome
- Trial name
- #950 (NCT00579527)
- Testing
- Cultured Thymus Tissue for Implantation (CTTI), Cultured Thymus Tissue Implantation and Parental Parathyroid Transplantation, Blood Draw
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Sumitomo Pharma Switzerland GmbH
Hypocalcemia, Pseudohypoparathyroidism
Studies of States With Resistance to Vitamin D and Parathyroid Hormone
Patients with confirmed or suspected states with resistance to vitamin D or parathyroid hormone (PTH) will be admitted for diagnosis, treatment review with suggestions for modifications to the current or new treatment and for…
- Conditions
- Hypocalcemia, Pseudohypoparathyroidism, Osteomalacia, Rickets
- Trial name
- NCT00001242
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Hyperparathyroidism
Energy Specific Far Infrared Radiation Treatment for Hyperparathyroidism
A study to determine the possibility of using far infrared radiation to treat Hyperparathyroidism.
- Trial name
- NCT00573573
- Testing
- Far Infrared Radiation
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- GAAD Medical Research Institute Inc.
Infantile Malignant Osteopetrosis
A Trial to Evaluate Safety and Efficacy of RP-L401-0120 in Subjects With Infantile Malignant Osteopetrosis
The primary objective of this Phase 1 study is to evaluate the therapeutic safety and feasibility of the investigational product (IP), RP-L401.
- Trial name
- NCT04525352
- Testing
- RP-L401
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Rocket Pharmaceuticals Inc.
Chronic Kidney Diseases, Chronic Kidney Disease-Mineral and Bone Disorder
Chinese CKD-MBD Prevalence Survey (CRISS-MBD)
This is a multi-center cross sectional epidemiological study. The purpose of this study is to investigate the prevalence of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) in Chinese population.
- Trial name
- NCT04714918
- Where
- 40 sites in China
- Volunteers
- 10,254 people
- Sponsor
- Limeng Chen
Hypoparathyroidism
Predicting Risk Factors of Postoperative Hypocalcemia After Total Thyroidectomy
With increasing economic pressures to shorten the length of hospital stay, there has been much recent interest in studying risk factors for the development of postoperative hypocalcemia.
- Trial name
- NCT04372225
- Testing
- analysis of hypocalcemia
- Where
- France
- Volunteers
- 477 people, healthy volunteers welcome
- Sponsor
- Aix Marseille Université
Autosomal Dominant Hypocalcemia Type 1 (ADH1)
Pharmacokinetics, Efficacy, and Safety of Encaleret in Pediatric Participants With Autosomal Dominant Hypocalcemia Type 1 (ADH1)
The overall objective of this study is to evaluate the pharmacokinetics (PK), efficacy, and safety of encaleret in pediatric participants from birth to 17 years of age with ADH1.
- Trial name
- CALIBRATE-PEDS (NCT07080385)
- Testing
- Encaleret
- Where
- 6 sites in United States, United Kingdom
- Volunteers
- 28 people
- Sponsor
- Calcilytix Therapeutics, Inc., a BridgeBio company
Adenine Phosphoribosyltransferase Deficiency, AH Amyloidosis
National Registry of Rare Kidney Diseases
The goal of this National Registry is to is to collect information from patients with rare kidney diseases, so that it that can be used for research.
- Conditions
- Adenine Phosphoribosyltransferase Deficiency, AH Amyloidosis, AHL Amyloidosis, AL Amyloidosis
- Trial name
- RaDaR (NCT06065852)
- Where
- United Kingdom
- Volunteers
- 35,000 people
- Sponsor
- UK Kidney Association
Hypocalcemia After Total Thyroidectomy
The Study of a Safe and Cost-effective Method to Identify Patients at Low Risk of Significant Hypocalcemia After Total Thyroidectomy.
Hypocalcemia is the complication, after total thyroidectomy, that usually determines the length of hospital stay.Serum calcium levels is a quick and cost-effective practice to recognise hypocalcemia in the postoperative follow…
- Trial name
- NCT01027091
- Where
- Greece
- Volunteers
- 120 people
- Sponsor
- G. Hatzikosta General Hospital
Hypocalcemia, Hypercalcemia
Parathyroid Hormone (PTH) Homeostasis in Bartter Syndrome
Parathyroid hormone (PTH) gland calcium sensing receptor (CASR) regulates PTH secretion. CASR is also expressed in nephron thick ascending limb (TAL).
- Trial name
- NCT01021280
- Where
- Israel
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Hypoparathyroidism, Hypocalcemia
Comparing Pump With Subcutaneous Injection Delivery of PTH 1-34 in the Management of Chronic Hypoparathyroidism
This randomized crossover study will evaluate the safety, efficacy, and pharmacodynamics of synthetic human PTH 1-34 (PTH) delivered by an insulin pump (omnipod) compared with twice- daily subcutaneous injections.
- Conditions
- Hypoparathyroidism, Hypocalcemia, Autoimmune Polyendocrine Syndrome Type 1, Autosomal Dominant Hypocalcemia Type 1 (ADH1)
- Trial name
- NCT00743782
- Testing
- Synthetic Human Parathyroid Hormone 1-34 pump
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Hypomagnesemia, Hypocalcemia
Hypomagnesemia and Hypocalcemia Association Following Thyroidectomy
Magnesium plays a role in the active transport of calcium (Ca+2) and potassium ions across cell membranes. Most of it is intracellular or in the bone , however less than 1% of magnesium is in the blood serum.
- Conditions
- Hypomagnesemia, Hypocalcemia, Hypomagnesemia With Secondary Hypocalcemia
- Trial name
- NCT04351451
- Testing
- thyroidectomy
- Where
- Saudi Arabia
- Volunteers
- 74 people
- Sponsor
- King Saud University
Hypocalcemia
Early Prediction of Hypocalcaemia Following Thyroid Surgery
150 patients divided into two groups.The experimental group was submitted at the assay of iPTH six hours after surgery whilst the control group was submitted to a daily assay of serum calcium and phosphorus.
- Trial name
- NCT02853721
- Testing
- iPTH, no dosage of iPTH
- Volunteers
- 150 people
- Sponsor
- University of Cagliari